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Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner.

Molecular medicine (Cambridge, Mass.)

Leung G, Petri B, Reyes JL, Wang A, Iannuzzi J, McKay DM.
PMID: 26701314
Mol Med. 2016 May;21(1):924-936. doi: 10.2119/molmed.2015.00193. Epub 2015 Dec 09.

The adoptive transfer of alternatively activated macrophages (AAMs) has proven to attenuate inflammation in multiple mouse models of colitis; however, the effect of cryopreservation on AAMs, the ability of previously frozen AAMs to block dinitrobenzene sulfonic acid (DNBS) (Th1)...

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Leung G, Petri B, Reyes JL, et al. Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner. Mol Med. 2015;21(1):924-936doi: 10.2119/molmed.2015.00193.
Leung, G., Petri, B., Reyes, J. L., Wang, A., Iannuzzi, J., & McKay, D. M. (2016). Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner. Molecular medicine (Cambridge, Mass.), 21(1), 924-936. https://doi.org/10.2119/molmed.2015.00193
Leung, Gabriella, et al. "Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner." Molecular medicine (Cambridge, Mass.) vol. 21,1 (2016): 924-936. doi: https://doi.org/10.2119/molmed.2015.00193
Leung G, Petri B, Reyes JL, Wang A, Iannuzzi J, McKay DM. Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner. Mol Med. 2016 May;21(1):924-936. doi: 10.2119/molmed.2015.00193. Epub 2015 Dec 09. PMID: 26701314; PMCID: PMC4818268.
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Azlactone Reaction Developments.

Chemistry (Weinheim an der Bergstrasse, Germany)

de Castro PP, Carpanez AG, Amarante GW.
PMID: 27245128
Chemistry. 2016 Jul 18;22(30):10294-318. doi: 10.1002/chem.201600071. Epub 2016 Jun 01.

Azlactones (also known as oxazolones) are heterocycles usually employed in the stereoselective synthesis of α,α-amino acids, heterocycles and natural products. The versatility of the azlactone scaffold arises from the numerous reactive sites, allowing its application in a diversity of...

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de Castro PP, Carpanez AG, Amarante GW. Azlactone Reaction Developments. Chemistry. 2016;22(30):10294-318doi: 10.1002/chem.201600071.
de Castro, P. P., Carpanez, A. G., & Amarante, G. W. (2016). Azlactone Reaction Developments. Chemistry (Weinheim an der Bergstrasse, Germany), 22(30), 10294-318. https://doi.org/10.1002/chem.201600071
de Castro, Pedro P, et al. "Azlactone Reaction Developments." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 22,30 (2016): 10294-318. doi: https://doi.org/10.1002/chem.201600071
de Castro PP, Carpanez AG, Amarante GW. Azlactone Reaction Developments. Chemistry. 2016 Jul 18;22(30):10294-318. doi: 10.1002/chem.201600071. Epub 2016 Jun 01. PMID: 27245128.
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Structure-based design of hERG-neutral antihypertensive oxazalone and imidazolone derivatives.

Journal of molecular graphics & modelling

Aksoydan B, Kantarcioglu I, Erol I, Salmas RE, Durdagi S.
PMID: 28957753
J Mol Graph Model. 2017 Oct;77:240-249. doi: 10.1016/j.jmgm.2017.08.004. Epub 2017 Aug 12.

Angiotensin II receptor type 1 (AT1) antagonists are the most recent drug class against hypertension. Recently first crystal structure of AT1 receptor is deposited to the protein data bank (PDB ID: 4YAY). In this work, several molecular screening methods...

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Aksoydan B, Kantarcioglu I, Erol I, et al. Structure-based design of hERG-neutral antihypertensive oxazalone and imidazolone derivatives. J Mol Graph Model. 2017;77:240-249doi: 10.1016/j.jmgm.2017.08.004.
Aksoydan, B., Kantarcioglu, I., Erol, I., Salmas, R. E., & Durdagi, S. (2017). Structure-based design of hERG-neutral antihypertensive oxazalone and imidazolone derivatives. Journal of molecular graphics & modelling, 77240-249. https://doi.org/10.1016/j.jmgm.2017.08.004
Aksoydan, Busecan, et al. "Structure-based design of hERG-neutral antihypertensive oxazalone and imidazolone derivatives." Journal of molecular graphics & modelling vol. 77 (2017): 240-249. doi: https://doi.org/10.1016/j.jmgm.2017.08.004
Aksoydan B, Kantarcioglu I, Erol I, Salmas RE, Durdagi S. Structure-based design of hERG-neutral antihypertensive oxazalone and imidazolone derivatives. J Mol Graph Model. 2017 Oct;77:240-249. doi: 10.1016/j.jmgm.2017.08.004. Epub 2017 Aug 12. PMID: 28957753.
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Scalable synthesis of oxazolones from propargylic alcohols through multistep palladium(II) catalysis: β-selective oxidative Heck coupling of cyclic sulfonyl enamides and aryl boroxines.

Angewandte Chemie (International ed. in English)

Alamsetti SK, Persson AK, Jiang T, Bäckvall JE.
PMID: 24174347
Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13745-50. doi: 10.1002/anie.201307471. Epub 2013 Oct 31.

A whale of a scale: The title oxidative Heck coupling proceeded with unusual β selectivity to generate a variety of branched substituted oxazolones (see scheme; Ts=p-toluenesulfonyl). The three-step synthesis from readily available starting materials with a simple palladium catalyst...

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Alamsetti SK, Persson AK, Jiang T, et al. Scalable synthesis of oxazolones from propargylic alcohols through multistep palladium(II) catalysis: β-selective oxidative Heck coupling of cyclic sulfonyl enamides and aryl boroxines. Angew Chem Int Ed Engl. 2013;52(51):13745-50doi: 10.1002/anie.201307471.
Alamsetti, S. K., Persson, A. K., Jiang, T., & Bäckvall, J. E. (2013). Scalable synthesis of oxazolones from propargylic alcohols through multistep palladium(II) catalysis: β-selective oxidative Heck coupling of cyclic sulfonyl enamides and aryl boroxines. Angewandte Chemie (International ed. in English), 52(51), 13745-50. https://doi.org/10.1002/anie.201307471
Alamsetti, Santosh Kumar, et al. "Scalable synthesis of oxazolones from propargylic alcohols through multistep palladium(II) catalysis: β-selective oxidative Heck coupling of cyclic sulfonyl enamides and aryl boroxines." Angewandte Chemie (International ed. in English) vol. 52,51 (2013): 13745-50. doi: https://doi.org/10.1002/anie.201307471
Alamsetti SK, Persson AK, Jiang T, Bäckvall JE. Scalable synthesis of oxazolones from propargylic alcohols through multistep palladium(II) catalysis: β-selective oxidative Heck coupling of cyclic sulfonyl enamides and aryl boroxines. Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13745-50. doi: 10.1002/anie.201307471. Epub 2013 Oct 31. PMID: 24174347.
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A Novel Class of Conformationally Constrained, Masked Cysteines: Synthesis of 2-Alkyl- and 2-Arylsulfanyl-1-aminocyclopropanecarboxylic Acids.

The Journal of organic chemistry

Clerici F, Gelmi ML, Pocar D.
PMID: 11674139
J Org Chem. 1999 Feb 05;64(3):726-730. doi: 10.1021/jo9810011.

A convenient synthesis of 4-sulfanylmethylene-5(4H)-oxazolones 3 was realized starting from 4-(chloromethylene)oxazolone 1 and mercaptans 2. Oxazolones 3 were used as starting materials for the preparation of unknown 2-sulfanyl-1-aminocyclopropanecarboxylic acid derivatives 5 and7. Oxazolones 3 were cyclopropanated at the exocyclic...

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Clerici F, Gelmi ML, Pocar D. A Novel Class of Conformationally Constrained, Masked Cysteines: Synthesis of 2-Alkyl- and 2-Arylsulfanyl-1-aminocyclopropanecarboxylic Acids. J Org Chem. 1999;64(3):726-730doi: 10.1021/jo9810011.
Clerici, F., Gelmi, M. L., & Pocar, D. (1999). A Novel Class of Conformationally Constrained, Masked Cysteines: Synthesis of 2-Alkyl- and 2-Arylsulfanyl-1-aminocyclopropanecarboxylic Acids. The Journal of organic chemistry, 64(3), 726-730. https://doi.org/10.1021/jo9810011
Clerici, F., et al. "A Novel Class of Conformationally Constrained, Masked Cysteines: Synthesis of 2-Alkyl- and 2-Arylsulfanyl-1-aminocyclopropanecarboxylic Acids." The Journal of organic chemistry vol. 64,3 (1999): 726-730. doi: https://doi.org/10.1021/jo9810011
Clerici F, Gelmi ML, Pocar D. A Novel Class of Conformationally Constrained, Masked Cysteines: Synthesis of 2-Alkyl- and 2-Arylsulfanyl-1-aminocyclopropanecarboxylic Acids. J Org Chem. 1999 Feb 05;64(3):726-730. doi: 10.1021/jo9810011. PMID: 11674139.
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Compound I and Compound II Analogues from Porpholactones.

Inorganic chemistry

Jayaraj K, Gold A, Austin RN, Ball LM, Terner J, Mandon D, Weiss R, Fischer J, DeCian A, Bill E, Müther M, Schünemann V, Trautwein AX.
PMID: 11670121
Inorg Chem. 1997 Sep 24;36(20):4555-4566. doi: 10.1021/ic970597s.

The tetraaza macrocycles 2-oxa-3-oxotetramesitylporphine (|H(2) 1|) and 2-oxa-3-oxotetrakis(2,6-dichlorophenyl)porphine (|H(2) 2|) and the corresponding iron complexes (|Fe(III)(X) 1| and |Fe(III)(X) 2|; X= Cl(-), OH(-), or SO(3)CF(3)(-)) have been synthesized. These macrocycles are derived from porphyrins by transformation of one pyrrole...

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Jayaraj K, Gold A, Austin RN, et al. Compound I and Compound II Analogues from Porpholactones. Inorg Chem. 1997;36(20):4555-4566doi: 10.1021/ic970597s.
Jayaraj, K., Gold, A., Austin, R. N., Ball, L. M., Terner, J., Mandon, D., Weiss, R., Fischer, J., DeCian, A., Bill, E., Müther, M., Schünemann, V., & Trautwein, A. X. (1997). Compound I and Compound II Analogues from Porpholactones. Inorganic chemistry, 36(20), 4555-4566. https://doi.org/10.1021/ic970597s
Jayaraj, K., et al. "Compound I and Compound II Analogues from Porpholactones." Inorganic chemistry vol. 36,20 (1997): 4555-4566. doi: https://doi.org/10.1021/ic970597s
Jayaraj K, Gold A, Austin RN, Ball LM, Terner J, Mandon D, Weiss R, Fischer J, DeCian A, Bill E, Müther M, Schünemann V, Trautwein AX. Compound I and Compound II Analogues from Porpholactones. Inorg Chem. 1997 Sep 24;36(20):4555-4566. doi: 10.1021/ic970597s. PMID: 11670121.
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Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors.

Mediators of inflammation

Moodley I, Sotsios Y, Bertin B.
PMID: 18475626
Mediators Inflamm. 1995;4(2):112-6. doi: 10.1155/S0962935195000196.

The effects of PDE inhibitors on oxazolone-induced contact hypersensitivity (CS) were studied in mice. Rolipram, Ro 20-1724 and theophylline dose dependently inhibited CS but none caused >53% inhibition. ED(30) values at 24 h before challenge for rolipram, Ro 20-1724...

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Moodley I, Sotsios Y, Bertin B. Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors. Mediators Inflamm. 1995;4(2):112-6doi: 10.1155/S0962935195000196.
Moodley, I., Sotsios, Y., & Bertin, B. (1995). Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors. Mediators of inflammation, 4(2), 112-6. https://doi.org/10.1155/S0962935195000196
Moodley, I, et al. "Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors." Mediators of inflammation vol. 4,2 (1995): 112-6. doi: https://doi.org/10.1155/S0962935195000196
Moodley I, Sotsios Y, Bertin B. Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors. Mediators Inflamm. 1995;4(2):112-6. doi: 10.1155/S0962935195000196. PMID: 18475626; PMCID: PMC2365615.
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5-Benzoylamino-3-bromo-4-(4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid.

Acta crystallographica. Section C, Crystal structure communications

Bruno G, Rotondo A, Grassi G, Foti F, Risitano F, Nicoló F.
PMID: 15237175
Acta Crystallogr C. 2004 Jul;60:o496-7. doi: 10.1107/S010827010401265X. Epub 2004 Jun 22.

The title compound, C18H15BrN2O5, a promising N-protected alpha-amino acid, was synthesized directly from an unusual bromo dipole and a 4-(arylmethylene)oxazolone. The crystal packing of the title compound is a racemic mixture. Peculiar graph-set motifs driven by the most important...

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Bruno G, Rotondo A, Grassi G, et al. 5-Benzoylamino-3-bromo-4-(4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid. Acta Crystallogr C. 2004;60:o496-7doi: 10.1107/S010827010401265X.
Bruno, G., Rotondo, A., Grassi, G., Foti, F., Risitano, F., & Nicoló, F. (2004). 5-Benzoylamino-3-bromo-4-(4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid. Acta crystallographica. Section C, Crystal structure communications, 60o496-7. https://doi.org/10.1107/S010827010401265X
Bruno, Giuseppe, et al. "5-Benzoylamino-3-bromo-4-(4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid." Acta crystallographica. Section C, Crystal structure communications vol. 60 (2004): o496-7. doi: https://doi.org/10.1107/S010827010401265X
Bruno G, Rotondo A, Grassi G, Foti F, Risitano F, Nicoló F. 5-Benzoylamino-3-bromo-4-(4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid. Acta Crystallogr C. 2004 Jul;60:o496-7. doi: 10.1107/S010827010401265X. Epub 2004 Jun 22. PMID: 15237175.
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An optimized lymphocyte blastogenesis assay for detecting the response of contact sensitized or photosensitized lymphocytes to hapten or photohapten modified antigen presenting cells.

Toxicology in vitro : an international journal published in association with BIBRA

Gerberick GF, Ryan CA, Fletcher ER, Sneller DL, Robinson MK.
PMID: 20702180
Toxicol In Vitro. 1990;4(4):289-92. doi: 10.1016/0887-2333(90)90066-3.

In vitro assays for predictive identification of contact sensitizers of photosensitizers are more quantifiable than current skin test methods and have the potential to reduce animal use. Mice were sensitized to various strong contact allergens, then an optimized lymphocyte...

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Gerberick GF, Ryan CA, Fletcher ER, et al. An optimized lymphocyte blastogenesis assay for detecting the response of contact sensitized or photosensitized lymphocytes to hapten or photohapten modified antigen presenting cells. Toxicol In Vitro. 1990;4(4):289-92doi: 10.1016/0887-2333(90)90066-3.
Gerberick, G. F., Ryan, C. A., Fletcher, E. R., Sneller, D. L., & Robinson, M. K. (1990). An optimized lymphocyte blastogenesis assay for detecting the response of contact sensitized or photosensitized lymphocytes to hapten or photohapten modified antigen presenting cells. Toxicology in vitro : an international journal published in association with BIBRA, 4(4), 289-92. https://doi.org/10.1016/0887-2333(90)90066-3
Gerberick, G F, et al. "An optimized lymphocyte blastogenesis assay for detecting the response of contact sensitized or photosensitized lymphocytes to hapten or photohapten modified antigen presenting cells." Toxicology in vitro : an international journal published in association with BIBRA vol. 4,4 (1990): 289-92. doi: https://doi.org/10.1016/0887-2333(90)90066-3
Gerberick GF, Ryan CA, Fletcher ER, Sneller DL, Robinson MK. An optimized lymphocyte blastogenesis assay for detecting the response of contact sensitized or photosensitized lymphocytes to hapten or photohapten modified antigen presenting cells. Toxicol In Vitro. 1990;4(4):289-92. doi: 10.1016/0887-2333(90)90066-3. PMID: 20702180.
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Influence of a Gamma Amino Acid on the Structures and Reactivity of Peptide a(3) Ions.

International journal of mass spectrometry

Bernier MC, Paizs B, Wysocki VH.
PMID: 23258959
Int J Mass Spectrom. 2012 Apr 15;316:259-267. doi: 10.1016/j.ijms.2012.02.028.

Collision-induced dissociation of protonated AGabaAIG (where Gaba is gamma-amino butyric acid, NH(2)-(CH(2))(3)-COOH) leads to an unusually stable a(3) ion. Tandem mass spectrometry and theory are used here to probe the enhanced stability of this fragment, whose counterpart is not...

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Bernier MC, Paizs B, Wysocki VH. Influence of a Gamma Amino Acid on the Structures and Reactivity of Peptide a(3) Ions. Int J Mass Spectrom. 2012;316:259-267doi: 10.1016/j.ijms.2012.02.028.
Bernier, M. C., Paizs, B., & Wysocki, V. H. (2012). Influence of a Gamma Amino Acid on the Structures and Reactivity of Peptide a(3) Ions. International journal of mass spectrometry, 316259-267. https://doi.org/10.1016/j.ijms.2012.02.028
Bernier, Matthew C, et al. "Influence of a Gamma Amino Acid on the Structures and Reactivity of Peptide a(3) Ions." International journal of mass spectrometry vol. 316 (2012): 259-267. doi: https://doi.org/10.1016/j.ijms.2012.02.028
Bernier MC, Paizs B, Wysocki VH. Influence of a Gamma Amino Acid on the Structures and Reactivity of Peptide a(3) Ions. Int J Mass Spectrom. 2012 Apr 15;316:259-267. doi: 10.1016/j.ijms.2012.02.028. PMID: 23258959; PMCID: PMC3523335.
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Formation, structure, and reactivity of meso-tetraaryl-chlorolactones, -porpholactams, and -chlorolactams, porphyrin and chlorin analogues incorporating oxazolone or imidazolone moieties.

Organic & biomolecular chemistry

Akhigbe J, Haskoor J, Krause JA, Zeller M, Brückner C.
PMID: 23535718
Org Biomol Chem. 2013 Jun 14;11(22):3616-28. doi: 10.1039/c3ob40138c.

Reaction of known meso-tetraarylporpholactone free bases 3, made from the corresponding porphyrins, with hydrazine produces three products: It converts the lactone functional group into an N-aminolactam moiety, generating porphyrin-like N-aminoporpholactams 8. It also reduces regioselectively the β,β'-double bond of...

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Akhigbe J, Haskoor J, Krause JA, et al. Formation, structure, and reactivity of meso-tetraaryl-chlorolactones, -porpholactams, and -chlorolactams, porphyrin and chlorin analogues incorporating oxazolone or imidazolone moieties. Org Biomol Chem. 2013;11(22):3616-28doi: 10.1039/c3ob40138c.
Akhigbe, J., Haskoor, J., Krause, J. A., Zeller, M., & Brückner, C. (2013). Formation, structure, and reactivity of meso-tetraaryl-chlorolactones, -porpholactams, and -chlorolactams, porphyrin and chlorin analogues incorporating oxazolone or imidazolone moieties. Organic & biomolecular chemistry, 11(22), 3616-28. https://doi.org/10.1039/c3ob40138c
Akhigbe, Joshua, et al. "Formation, structure, and reactivity of meso-tetraaryl-chlorolactones, -porpholactams, and -chlorolactams, porphyrin and chlorin analogues incorporating oxazolone or imidazolone moieties." Organic & biomolecular chemistry vol. 11,22 (2013): 3616-28. doi: https://doi.org/10.1039/c3ob40138c
Akhigbe J, Haskoor J, Krause JA, Zeller M, Brückner C. Formation, structure, and reactivity of meso-tetraaryl-chlorolactones, -porpholactams, and -chlorolactams, porphyrin and chlorin analogues incorporating oxazolone or imidazolone moieties. Org Biomol Chem. 2013 Jun 14;11(22):3616-28. doi: 10.1039/c3ob40138c. PMID: 23535718.
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Palladium-catalyzed direct alkenylation of 2-oxazolones: an entry to 3,4,5-trisubstituted 2-oxazolones.

The Journal of organic chemistry

Lu Z, Luo F, Wang L, Zhu G.
PMID: 24102427
J Org Chem. 2013 Nov 01;78(21):10894-901. doi: 10.1021/jo4018793. Epub 2013 Oct 18.

Described herein is a novel method for the synthesis of 3,4,5-trisubstituted 2-oxazolones featuring the first Pd-catalyzed dehydrogenative alkenylation of 2-oxazolones, which is realized by employing 10 mol % of Pd(OAc)2 as the catalyst and the use of readily available...

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Lu Z, Luo F, Wang L, et al. Palladium-catalyzed direct alkenylation of 2-oxazolones: an entry to 3,4,5-trisubstituted 2-oxazolones. J Org Chem. 2013;78(21):10894-901doi: 10.1021/jo4018793.
Lu, Z., Luo, F., Wang, L., & Zhu, G. (2013). Palladium-catalyzed direct alkenylation of 2-oxazolones: an entry to 3,4,5-trisubstituted 2-oxazolones. The Journal of organic chemistry, 78(21), 10894-901. https://doi.org/10.1021/jo4018793
Lu, Zenghui, et al. "Palladium-catalyzed direct alkenylation of 2-oxazolones: an entry to 3,4,5-trisubstituted 2-oxazolones." The Journal of organic chemistry vol. 78,21 (2013): 10894-901. doi: https://doi.org/10.1021/jo4018793
Lu Z, Luo F, Wang L, Zhu G. Palladium-catalyzed direct alkenylation of 2-oxazolones: an entry to 3,4,5-trisubstituted 2-oxazolones. J Org Chem. 2013 Nov 01;78(21):10894-901. doi: 10.1021/jo4018793. Epub 2013 Oct 18. PMID: 24102427.
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Showing 1 to 12 of 150 entries