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Showing 1 to 12 of 669 entries
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Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients

veteran

Gagnon DR.
GSID: yYr4tCiESYgJ
JA Hermos, MM Young, DR Gagnon… - Archives of Internal …, 2004 - jamanetwork.com

Background Long-term management of chronic pain with opioids may be stable over time or may be complicated by problematic dose increases, drug dependencies, and toxic effects. …

A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief).

Journal of pain research

Inoue S, Saito Y, Tsuneto S, Aruga E, Ide A, Kakurai Y.
PMID: 28860850
J Pain Res. 2017 Aug 18;10:1953-1962. doi: 10.2147/JPR.S136937. eCollection 2017.

BACKGROUND: In Japan, there are limited options for switching opioid analgesics. Hydromorphone is an opioid analgesic that is routinely used instead of morphine for cancer pain; however, it is not yet available in Japan. The aim of this study...

Low-back pain at the emergency department: still not being managed?.

Therapeutics and clinical risk management

Rizzardo A, Miceli L, Bednarova R, Guadagnin GM, Sbrojavacca R, Della Rocca G.
PMID: 26929631
Ther Clin Risk Manag. 2016 Feb 12;12:183-7. doi: 10.2147/TCRM.S91898. eCollection 2016.

BACKGROUND: Low-back pain (LBP) affects about 40% of people at some point in their lives. In the presence of "red flags", further tests must be done to rule out underlying problems; however, biomedical imaging is currently overused. LBP involves...

Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study.

Journal of pain research

Olczak B, Kowalski G, Leppert W, Bienert A, Teżyk A, Adamski M, Rzymski S, Wieczorowska-Tobis K.
PMID: 29026333
J Pain Res. 2017 Sep 27;10:2303-2309. doi: 10.2147/JPR.S144799. eCollection 2017.

BACKGROUND AND OBJECTIVES: Oxycodone is poorly studied as an adjuvant to central blockades. The aim of this pilot study was to assess the efficacy and safety of oxycodone hydrochloride in epidural blockade among patients undergoing total hip arthroplasty (THA).PATIENTS...

Clinical Pharmacogenetics of Cytochrome P450-Associated Drugs in Children.

Journal of personalized medicine

Aka I, Bernal CJ, Carroll R, Maxwell-Horn A, Oshikoya KA, Van Driest SL.
PMID: 29099060
J Pers Med. 2017 Nov 02;7(4). doi: 10.3390/jpm7040014.

Cytochrome P450 (CYP) enzymes are commonly involved in drug metabolism, and genetic variation in the genes encoding CYPs are associated with variable drug response. While genotype-guided therapy has been clinically implemented in adults, these associations are less well established...

Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses.

Journal of pain research

Zin CS, Ismail F.
PMID: 28182128
J Pain Res. 2017 Jan 25;10:249-257. doi: 10.2147/JPR.S122853. eCollection 2017.

PURPOSE: This study investigated the patterns of opioid co-prescription with benzodiazepine and other concomitant medications among opioid users. Opioid dose in each type of co-prescription was also examined.PATIENTS AND METHODS: This cross-sectional study was conducted among opioid users receiving...

Differential Effects of Oxycodone, Hydrocodone, and Morphine on Activation Levels of Signaling Molecules.

Pain medicine (Malden, Mass.)

Emery MA, Bates ML, Wellman PJ, Eitan S.
PMID: 26349634
Pain Med. 2016 May 01;17(5):908-914. doi: 10.1111/pme.12918. Epub 2015 Sep 09.

BACKGROUND: Opioids alter the responses of D2-like dopamine receptors (D2DRs), known to be involved in the pathology of addiction and other mental illnesses. Importantly, our recent results demonstrated that various opioids differentially modulate the behavioral responses of D2DRs.OBJECTIVE: To...

Comparison of oxycodone and morphine on the proliferation, apoptosis and expression of related molecules in the A549 human lung adenocarcinoma cell line.

Experimental and therapeutic medicine

Tian M, Jin L, Li R, Zhu S, Ji M, Li W.
PMID: 27446244
Exp Ther Med. 2016 Aug;12(2):559-566. doi: 10.3892/etm.2016.3346. Epub 2016 May 17.

The present study aimed to compare the effects of oxycodone and morphine hydrochloride on the proliferation, apoptosis and migration of A549 lung cancer cells. A549 human lung cancer cells were cultured

Oxycodone IV?; Eliminate Teaspoonfuls; Avoid Vitamin D Products Dosed and Measured in Drops.

Hospital pharmacy

Cohen MR, Smetzer JL.
PMID: 26912913
Hosp Pharm. 2015 Oct;50(9):753-5. doi: 10.1310/hpj5009-753. Epub 2015 Oct 14.

These medication errors have occurred in health care facilities at least once. They will happen again-perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors...

Compartment syndrome of the deltoid: a case report of a common presentation in a rare location.

Hospital practice (1995)

Harrison A, Sumner M, Sobecki J, Christiansen G.
PMID: 27447677
Hosp Pract (1995). 2016 Oct;44(4):224-226. doi: 10.1080/21548331.2016.1216237. Epub 2016 Aug 16.

Compartment syndrome presents with a slow onset of pain. Anything that causes an increased intra-compartmental pressure can lead to surgical emergency. A 45-year-old male presents to the emergency department with prolonged syncope. The patient is unable to recall the...

Erratum to: Oxycodone/Naloxone PR: A Review in Severe Refractory Restless Legs Syndrome.

CNS drugs

Frampton JE.
PMID: 26293746
CNS Drugs. 2015 Aug;29(8):713. doi: 10.1007/s40263-015-0274-7.

No abstract available.

The role of cytochrome P450 pharmacogenomics in chronic non-cancer pain patients.

Expert opinion on drug metabolism & toxicology

Tverdohleb T, Dinc B, Knezevic I, Candido KD, Knezevic NN.
PMID: 27388970
Expert Opin Drug Metab Toxicol. 2016 Nov;12(11):1303-1311. doi: 10.1080/17425255.2016.1209482. Epub 2016 Jul 15.

INTRODUCTION: Pharmacogenomics is the field that studies an individualized treatment approach for patients' medication regimen that can impact drug safety, productivity, and personalized health care. Pharmacogenomics characterizes the genetic differences in metabolic pathways which can affect a patient's individual...

Showing 1 to 12 of 669 entries