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Showing 1 to 12 of 56 entries
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Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography.

Alzheimer's research & therapy

Sha SJ, Ghosh PM, Lee SE, Corbetta-Rastelli C, Jagust WJ, Kornak J, Rankin KP, Grinberg LT, Vinters HV, Mendez MF, Dickson DW, Seeley WW, Gorno-Tempini M, Kramer J, Miller BL, Boxer AL, Rabinovici GD.
PMID: 25733984
Alzheimers Res Ther. 2015 Mar 02;7(1):8. doi: 10.1186/s13195-014-0093-y. eCollection 2015.

INTRODUCTION: Group comparisons demonstrate greater visuospatial and memory deficits and temporoparietal-predominant degeneration on neuroimaging in patients with corticobasal syndrome (CBS) found to have Alzheimer's disease (AD) pathology versus those with underlying frontotemporal lobar degeneration (FTLD). The value of these...

Neural Correlates of Verbal Episodic Memory and Lexical Retrieval in Logopenic Variant Primary Progressive Aphasia.

Frontiers in neuroscience

Win KT, Pluta J, Yushkevich P, Irwin DJ, McMillan CT, Rascovsky K, Wolk D, Grossman M.
PMID: 28659753
Front Neurosci. 2017 Jun 14;11:330. doi: 10.3389/fnins.2017.00330. eCollection 2017.

No abstract available.

Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice.

Acta neuropathologica communications

Spiller KJ, Restrepo CR, Khan T, Stieber AM, Kwong LK, Trojanowski JQ, Lee VM.
PMID: 27687289
Acta Neuropathol Commun. 2016 Sep 29;4(1):105. doi: 10.1186/s40478-016-0377-5.

In order to treat progressive paralysis in ALS patients, it is critical to develop a mouse that closely models human ALS in both pathology and also in the timing of these events. We have recently generated new TDP-43 bigenic...

If so many are "few," how few are "many"?.

Frontiers in psychology

Heim S, McMillan CT, Clark R, Golob S, Min NE, Olm C, Powers J, Grossman M.
PMID: 25941502
Front Psychol. 2015 Apr 17;6:441. doi: 10.3389/fpsyg.2015.00441. eCollection 2015.

The scope of reference of a word's meaning can be highly variable. We present a novel paradigm to investigate the flexible interpretation of word meaning. We focus on quantifiers such as "many" or "few," a class of words that...

Is the glass half empty or half full? Genetically determined disease in frontotemporal dementia.

Neurology

Grossman M.
PMID: 18703461
Neurology. 2008 Oct 14;71(16):1216-7. doi: 10.1212/01.wnl.0000326061.82037.62. Epub 2008 Aug 13.

No abstract available.

Executive resources.

Continuum (Minneapolis, Minn.)

Gross RG, Grossman M.
PMID: 22810519
Continuum (Minneap Minn). 2010 Aug;16(4):140-52. doi: 10.1212/01.CON.0000368266.46038.0e.

Executive resources allow for flexible, adaptive, goal-directed responses to environmental circumstances in essentially all facets of daily living. Executive function is composed of related, but separable, components. This article will highlight three essential aspects of executive function: (1) working...

Where is the anterior temporal lobe and what does it do?.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Bonner MF, Price AR.
PMID: 23467339
J Neurosci. 2013 Mar 06;33(10):4213-5. doi: 10.1523/JNEUROSCI.0041-13.2013.

No abstract available.

Age-related vulnerability in the neural systems supporting semantic processing.

Frontiers in aging neuroscience

Peelle JE, Chandrasekaran K, Powers J, Smith EE, Grossman M.
PMID: 24062684
Front Aging Neurosci. 2013 Sep 12;5:46. doi: 10.3389/fnagi.2013.00046. eCollection 2013.

Our ability to form abstract representations of objects in semantic memory is crucial to language and thought. The utility of this information relies both on the representations of sensory-motor feature knowledge stored in long-term memory and the executive processes...

The Kaplan-Meier Method for Estimating and Comparing Proportions in a Randomized Controlled Trial with Dropouts.

Biostatistics & epidemiology

Zee J, Xie SX.
PMID: 30234179
Biostat Epidemiol. 2018;2(1):23-33. doi: 10.1080/24709360.2017.1407866. Epub 2017 Nov 30.

We propose a method for estimating and comparing proportions of study participants who reached an event of interest during a randomized controlled trial. Standard methods for estimating this proportion include the intent-to-treat method, which counts the number who reached...

Processing ambiguity in a linguistic context: decision-making difficulties in non-aphasic patients with behavioral variant frontotemporal degeneration.

Frontiers in human neuroscience

Spotorno N, Healey M, McMillan CT, Rascovsky K, Irwin DJ, Clark R, Grossman M.
PMID: 26578928
Front Hum Neurosci. 2015 Oct 27;9:583. doi: 10.3389/fnhum.2015.00583. eCollection 2015.

Some extent of ambiguity is ubiquitous in everyday conversations. For example, words have multiple meaning and very common pronouns, like "he" and "she" (anaphoric pronouns), have little meaning on their own and refer to a noun that has been...

Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology.

NeuroImage. Clinical

Tisdall MD, Ohm DT, Lobrovich R, Das SR, Mizsei G, Prabhakaran K, Ittyerah R, Lim S, McMillan CT, Wolk DA, Gee J, Trojanowski JQ, Lee EB, Detre JA, Yushkevich P, Grossman M, Irwin DJ.
PMID: 34952351
Neuroimage Clin. 2021 Dec 14;33:102913. doi: 10.1016/j.nicl.2021.102913. Epub 2021 Dec 14.

Frontotemporal lobar degeneration (FTLD) is a heterogeneous spectrum of age-associated neurodegenerative diseases that include two main pathologic categories of tau (FTLD-Tau) and TDP-43 (FTLD-TDP) proteinopathies. These distinct proteinopathies are often clinically indistinguishable during life, posing a major obstacle for...

Cognitive and Affective Perspective-Taking: Evidence for Shared and Dissociable Anatomical Substrates.

Frontiers in neurology

Healey ML, Grossman M.
PMID: 29988515
Front Neurol. 2018 Jun 25;9:491. doi: 10.3389/fneur.2018.00491. eCollection 2018.

Perspective-taking refers to the ability to recognize another person's point of view. Crucial to the development of interpersonal relationships and prosocial behavior, perspective-taking is closely linked to human empathy, and like empathy, perspective-taking is commonly subdivided into cognitive and...

Showing 1 to 12 of 56 entries