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Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams.

Heterocycles

Zang Q, Javed S, Zhou A, Knudtson CA, Bi D, Basha FZ, Hanson PR.
PMID: 24385680
Heterocycles. 2012 Dec 31;86(2). doi: 10.3987/COM-12-S(N)122.

The synthesis of a library of bicyclic sultams incorporating the 1,5,2-dithiazepine 1,1-dioxide moiety is reported. Following scaffold synthesis via a one-pot sulfonylation/intramolecular thia-Michael protocol, several additional cyclization strategies have been realized enabling access to new bicyclic sultams.

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Zang Q, Javed S, Zhou A, et al. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Heterocycles. 2012;86(2)doi: 10.3987/COM-12-S(N)122.
Zang, Q., Javed, S., Zhou, A., Knudtson, C. A., Bi, D., Basha, F. Z., & Hanson, P. R. (2012). Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Heterocycles, 86(2), . https://doi.org/10.3987/COM-12-S(N)122
Zang, Qin, et al. "Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams." Heterocycles vol. 86,2 (2012). doi: https://doi.org/10.3987/COM-12-S(N)122
Zang Q, Javed S, Zhou A, Knudtson CA, Bi D, Basha FZ, Hanson PR. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Heterocycles. 2012 Dec 31;86(2). doi: 10.3987/COM-12-S(N)122. PMID: 24385680; PMCID: PMC3873775.
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Novel Algorithms for the Identification of Biologically Informative Chemical Diversity Metrics.

Current computer-aided drug design

Theertham B, Wang JL, Fang J, Lushington GH.
PMID: 19789655
Curr Comput Aided Drug Des. 2008 Mar 01;4(1):23-34. doi: 10.2174/157340908783769292.

Despite great advances in the efficiency of analytical and synthetic chemistry, time and available starting material still limit the number of unique compounds that can be practically synthesized and evaluated as prospective therapeutics. Chemical diversity analysis (the capacity to...

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Theertham B, Wang JL, Fang J, et al. Novel Algorithms for the Identification of Biologically Informative Chemical Diversity Metrics. Curr Comput Aided Drug Des. 2008;4(1):23-34doi: 10.2174/157340908783769292.
Theertham, B., Wang, J. L., Fang, J., & Lushington, G. H. (2008). Novel Algorithms for the Identification of Biologically Informative Chemical Diversity Metrics. Current computer-aided drug design, 4(1), 23-34. https://doi.org/10.2174/157340908783769292
Theertham, Bhargav, et al. "Novel Algorithms for the Identification of Biologically Informative Chemical Diversity Metrics." Current computer-aided drug design vol. 4,1 (2008): 23-34. doi: https://doi.org/10.2174/157340908783769292
Theertham B, Wang JL, Fang J, Lushington GH. Novel Algorithms for the Identification of Biologically Informative Chemical Diversity Metrics. Curr Comput Aided Drug Des. 2008 Mar 01;4(1):23-34. doi: 10.2174/157340908783769292. PMID: 19789655; PMCID: PMC2753527.
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GPM: A Graph Pattern Matching Kernel with Diffusion for Chemical Compound Classification.

Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering

Smalter A, Huan J, Lushington G.
PMID: 20428463
Proc IEEE Int Symp Bioinformatics Bioeng. 2008 Dec 08;2008:1-6. doi: 10.1109/BIBE.2008.4696654.

Classifying chemical compounds is an active topic in drug design and other cheminformatics applications. Graphs are general tools for organizing information from heterogenous sources and have been applied in modelling many kinds of biological data. With the fast accumulation...

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Smalter A, Huan J, Lushington G. GPM: A Graph Pattern Matching Kernel with Diffusion for Chemical Compound Classification. Proc IEEE Int Symp Bioinformatics Bioeng. 2008;2008:1-6doi: 10.1109/BIBE.2008.4696654.
Smalter, A., Huan, J., & Lushington, G. (2008). GPM: A Graph Pattern Matching Kernel with Diffusion for Chemical Compound Classification. Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering, 20081-6. https://doi.org/10.1109/BIBE.2008.4696654
Smalter, Aaron, et al. "GPM: A Graph Pattern Matching Kernel with Diffusion for Chemical Compound Classification." Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering vol. 2008 (2008): 1-6. doi: https://doi.org/10.1109/BIBE.2008.4696654
Smalter A, Huan J, Lushington G. GPM: A Graph Pattern Matching Kernel with Diffusion for Chemical Compound Classification. Proc IEEE Int Symp Bioinformatics Bioeng. 2008 Dec 08;2008:1-6. doi: 10.1109/BIBE.2008.4696654. PMID: 20428463; PMCID: PMC2860184.
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Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegans.

Small GTPases

Dyer JO, Demarco RS, Lundquist EA.
PMID: 21686119
Small GTPases. 2010 Jul;1(1):44-61. doi: 10.4161/sgtp.1.1.12991.

The Rac and Cdc42 GTPases as well as the multiple GTP exchange factors that regulate their activity have been implicated in the pathways that drive actin cytoskeleton reorganization, but the individual contributions of these molecules to cell migration remain...

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Dyer JO, Demarco RS, Lundquist EA. Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegans. Small GTPases. 2010;1(1):44-61doi: 10.4161/sgtp.1.1.12991.
Dyer, J. O., Demarco, R. S., & Lundquist, E. A. (2010). Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegans. Small GTPases, 1(1), 44-61. https://doi.org/10.4161/sgtp.1.1.12991
Dyer, Jamie O, et al. "Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegans." Small GTPases vol. 1,1 (2010): 44-61. doi: https://doi.org/10.4161/sgtp.1.1.12991
Dyer JO, Demarco RS, Lundquist EA. Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegans. Small GTPases. 2010 Jul;1(1):44-61. doi: 10.4161/sgtp.1.1.12991. PMID: 21686119; PMCID: PMC3109480.
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Increasing Phosphatidylinositol (4,5)-Bisphosphate Biosynthesis Affects Basal Signaling and Chloroplast Metabolism in Arabidopsis thaliana.

Plants (Basel, Switzerland)

Im YJ, Smith CM, Phillippy BQ, Strand D, Kramer DM, Grunden AM, Boss WF.
PMID: 27135490
Plants (Basel). 2014 Jan 03;3(1):27-57. doi: 10.3390/plants3010027.

One challenge in studying the second messenger inositol(1,4,5)-trisphosphate (InsP₃) is that it is present in very low amounts and increases only transiently in response to stimuli. To identify events downstream of InsP₃, we generated transgenic plants constitutively expressing the...

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Im YJ, Smith CM, Phillippy BQ, et al. Increasing Phosphatidylinositol (4,5)-Bisphosphate Biosynthesis Affects Basal Signaling and Chloroplast Metabolism in Arabidopsis thaliana. Plants (Basel). 2014;3(1):27-57doi: 10.3390/plants3010027.
Im, Y. J., Smith, C. M., Phillippy, B. Q., Strand, D., Kramer, D. M., Grunden, A. M., & Boss, W. F. (2014). Increasing Phosphatidylinositol (4,5)-Bisphosphate Biosynthesis Affects Basal Signaling and Chloroplast Metabolism in Arabidopsis thaliana. Plants (Basel, Switzerland), 3(1), 27-57. https://doi.org/10.3390/plants3010027
Im, Yang Ju, et al. "Increasing Phosphatidylinositol (4,5)-Bisphosphate Biosynthesis Affects Basal Signaling and Chloroplast Metabolism in Arabidopsis thaliana." Plants (Basel, Switzerland) vol. 3,1 (2014): 27-57. doi: https://doi.org/10.3390/plants3010027
Im YJ, Smith CM, Phillippy BQ, Strand D, Kramer DM, Grunden AM, Boss WF. Increasing Phosphatidylinositol (4,5)-Bisphosphate Biosynthesis Affects Basal Signaling and Chloroplast Metabolism in Arabidopsis thaliana. Plants (Basel). 2014 Jan 03;3(1):27-57. doi: 10.3390/plants3010027. PMID: 27135490; PMCID: PMC4844314.
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Dorsal Root Ganglia Mitochondrial Biochemical Changes in Non-diabetic and Streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet.

Journal of neurology and neuroscience

Guilford BL, Ryals JM, Lezi E, Swerdlow RH, Wright DE.
PMID: 28775932
J Neurol Neurosci. 2017;8(2). doi: 10.21767/2171-6625.1000180. Epub 2017 Mar 27.

BACKGROUND: Mitochondrial dysfunction is purported as a contributory mechanism underlying diabetic neuropathy, but a defined role for damaged mitochondria in diabetic nerves remains unclear, particularly in standard diabetes models. Experiments here used a high-fat diet in attempt to exacerbate...

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Guilford BL, Ryals JM, Lezi E, et al. Dorsal Root Ganglia Mitochondrial Biochemical Changes in Non-diabetic and Streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet. J Neurol Neurosci. 2017;8(2)doi: 10.21767/2171-6625.1000180.
Guilford, B. L., Ryals, J. M., Lezi, E., Swerdlow, R. H., & Wright, D. E. (2017). Dorsal Root Ganglia Mitochondrial Biochemical Changes in Non-diabetic and Streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet. Journal of neurology and neuroscience, 8(2), . https://doi.org/10.21767/2171-6625.1000180
Guilford, B L, et al. "Dorsal Root Ganglia Mitochondrial Biochemical Changes in Non-diabetic and Streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet." Journal of neurology and neuroscience vol. 8,2 (2017). doi: https://doi.org/10.21767/2171-6625.1000180
Guilford BL, Ryals JM, Lezi E, Swerdlow RH, Wright DE. Dorsal Root Ganglia Mitochondrial Biochemical Changes in Non-diabetic and Streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet. J Neurol Neurosci. 2017;8(2). doi: 10.21767/2171-6625.1000180. Epub 2017 Mar 27. PMID: 28775932; PMCID: PMC5538136.
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Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.

BMC chemical biology

Fang J, Koen YM, Hanzlik RP.
PMID: 19523227
BMC Chem Biol. 2009 Jun 12;9:5. doi: 10.1186/1472-6769-9-5.

BACKGROUND: Protein covalent binding by reactive metabolites of drugs, chemicals and natural products can lead to acute cytotoxicity. Recent rapid progress in reactive metabolite target protein identification has shown that adduction is surprisingly selective and inspired the hope that...

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Fang J, Koen YM, Hanzlik RP. Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners. BMC Chem Biol. 2009;9:5doi: 10.1186/1472-6769-9-5.
Fang, J., Koen, Y. M., & Hanzlik, R. P. (2009). Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners. BMC chemical biology, 95. https://doi.org/10.1186/1472-6769-9-5
Fang, Jianwen, et al. "Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners." BMC chemical biology vol. 9 (2009): 5. doi: https://doi.org/10.1186/1472-6769-9-5
Fang J, Koen YM, Hanzlik RP. Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners. BMC Chem Biol. 2009 Jun 12;9:5. doi: 10.1186/1472-6769-9-5. PMID: 19523227; PMCID: PMC2711050.
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CHEMICAL COMPOUND CLASSIFICATION WITH AUTOMATICALLY MINED STRUCTURE PATTERNS.

Proceedings of the ... Asia-Pacific bioinformatics conference

Smalter AM, Huan J, Lushington GH.
PMID: 20448828
Proc Asia Pac Bioinform Conf. 2008;6:39-48. doi: 10.1901/jaba.2008.6-39.

In this paper we propose new methods of chemical structure classification based on the integration of graph database mining from data mining and graph kernel functions from machine learning. In our method, we first identify a set of general...

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Smalter AM, Huan J, Lushington GH. CHEMICAL COMPOUND CLASSIFICATION WITH AUTOMATICALLY MINED STRUCTURE PATTERNS. Proc Asia Pac Bioinform Conf. 2008;6:39-48doi: 10.1901/jaba.2008.6-39.
Smalter, A. M., Huan, J., & Lushington, G. H. (2008). CHEMICAL COMPOUND CLASSIFICATION WITH AUTOMATICALLY MINED STRUCTURE PATTERNS. Proceedings of the ... Asia-Pacific bioinformatics conference, 639-48. https://doi.org/10.1901/jaba.2008.6-39
Smalter, A M, et al. "CHEMICAL COMPOUND CLASSIFICATION WITH AUTOMATICALLY MINED STRUCTURE PATTERNS." Proceedings of the ... Asia-Pacific bioinformatics conference vol. 6 (2008): 39-48. doi: https://doi.org/10.1901/jaba.2008.6-39
Smalter AM, Huan J, Lushington GH. CHEMICAL COMPOUND CLASSIFICATION WITH AUTOMATICALLY MINED STRUCTURE PATTERNS. Proc Asia Pac Bioinform Conf. 2008;6:39-48. doi: 10.1901/jaba.2008.6-39. PMID: 20448828; PMCID: PMC2864492.
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Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow.

Synthesis

Zang Q, Javed S, Ullah F, Zhou A, Knudtson CA, Bi D, Basha FZ, Organ MG, Hanson PR.
PMID: 21927510
Synthesis (Stuttg). 2011 Sep 01;2011(17):2743-2750. doi: 10.1055/s-0030-1260112.

The development of a 'click, click, cy-click' process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the inter-/intramolecular double aza-Michael addition has also been realized using a...

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Zang Q, Javed S, Ullah F, et al. Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow. Synthesis (Stuttg). 2011;2011(17):2743-2750doi: 10.1055/s-0030-1260112.
Zang, Q., Javed, S., Ullah, F., Zhou, A., Knudtson, C. A., Bi, D., Basha, F. Z., Organ, M. G., & Hanson, P. R. (2011). Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow. Synthesis, 2011(17), 2743-2750. https://doi.org/10.1055/s-0030-1260112
Zang, Qin, et al. "Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow." Synthesis vol. 2011,17 (2011): 2743-2750. doi: https://doi.org/10.1055/s-0030-1260112
Zang Q, Javed S, Ullah F, Zhou A, Knudtson CA, Bi D, Basha FZ, Organ MG, Hanson PR. Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow. Synthesis (Stuttg). 2011 Sep 01;2011(17):2743-2750. doi: 10.1055/s-0030-1260112. PMID: 21927510; PMCID: PMC3171749.
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TLR9 is dispensable for intestinal ischemia/reperfusion-induced tissue damage.

American journal of clinical and experimental immunology

Slone EA, Pope MR, Roth M, Welti R, Fleming SD.
PMID: 23205322
Am J Clin Exp Immunol. 2012;1(2):124-135.

The mortality rate due to intestinal ischemia/reperfusion (IR) remains at 60-80%. As toll-like receptor (TLR) 4 has been shown to be critical for IR injury in several organs, including the intestine, and TLR9 is necessary for IR-induced damage of...

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Slone EA, Pope MR, Roth M, et al. TLR9 is dispensable for intestinal ischemia/reperfusion-induced tissue damage. Am J Clin Exp Immunol. 2012;1(2):124-135
Slone, E. A., Pope, M. R., Roth, M., Welti, R., & Fleming, S. D. (2012). TLR9 is dispensable for intestinal ischemia/reperfusion-induced tissue damage. American journal of clinical and experimental immunology, 1(2), 124-135.
Slone, Emily Archer, et al. "TLR9 is dispensable for intestinal ischemia/reperfusion-induced tissue damage." American journal of clinical and experimental immunology vol. 1,2 (2012): 124-135.
Slone EA, Pope MR, Roth M, Welti R, Fleming SD. TLR9 is dispensable for intestinal ischemia/reperfusion-induced tissue damage. Am J Clin Exp Immunol. 2012;1(2):124-135. PMID: 23205322; PMCID: PMC3509382.
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Domino Heck-Aza-Michael Reactions: A One-Pot, Sequential Three-Component Approach to 1,1-Dioxido-1,2-benzisothiazoline-3-acetic Acid.

European journal of organic chemistry

Rolfe A, Young K, Hanson PR.
PMID: 19603087
European J Org Chem. 2008;(31):5254-5262. doi: 10.1002/ejoc.200800651.

The development of a new method for the synthesis of 1,1-dioxido-1,2-benzisothiazoline-3-acetic acid by a domino process is reported whereby a classical Heck reaction is coupled to an intramolecular aza-Michael reaction. Ultimately, this method has been expanded to a one-pot,...

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Rolfe A, Young K, Hanson PR. Domino Heck-Aza-Michael Reactions: A One-Pot, Sequential Three-Component Approach to 1,1-Dioxido-1,2-benzisothiazoline-3-acetic Acid. European J Org Chem. 2008;(31):5254-5262doi: 10.1002/ejoc.200800651.
Rolfe, A., Young, K., & Hanson, P. R. (2008). Domino Heck-Aza-Michael Reactions: A One-Pot, Sequential Three-Component Approach to 1,1-Dioxido-1,2-benzisothiazoline-3-acetic Acid. European journal of organic chemistry, (31), 5254-5262. https://doi.org/10.1002/ejoc.200800651
Rolfe, Alan, et al. "Domino Heck-Aza-Michael Reactions: A One-Pot, Sequential Three-Component Approach to 1,1-Dioxido-1,2-benzisothiazoline-3-acetic Acid." European journal of organic chemistry vol. ,31 (2008): 5254-5262. doi: https://doi.org/10.1002/ejoc.200800651
Rolfe A, Young K, Hanson PR. Domino Heck-Aza-Michael Reactions: A One-Pot, Sequential Three-Component Approach to 1,1-Dioxido-1,2-benzisothiazoline-3-acetic Acid. European J Org Chem. 2008;(31):5254-5262. doi: 10.1002/ejoc.200800651. PMID: 19603087; PMCID: PMC2709420.
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Macro- and Micro-heterogeneity in Pituitary and Urinary Follicle-Stimulating Hormone Glycosylation.

Journal of glycomics & lipidomics

Bousfield GR, Butnev VY, Rueda-Santos MA, Brown A, Hall AS, Harvey DJ.
PMID: 25722940
J Glycomics Lipidomics. 2014;4. doi: 10.4172/2153-0637.1000125.

FSH glycosylation macroheterogeneity in pituitary and urinary hFSH samples was evaluated by Western blotting. Microheterogeneity in two highly purified urinary and pituitary hFSH preparations was evaluated by nano-electrospray mass spectrometry of peptide-N-glycanase-released oligosaccharides. An age-related loss of hypo-glycosylated hFSH...

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Bousfield GR, Butnev VY, Rueda-Santos MA, et al. Macro- and Micro-heterogeneity in Pituitary and Urinary Follicle-Stimulating Hormone Glycosylation. J Glycomics Lipidomics. 2014;4doi: 10.4172/2153-0637.1000125.
Bousfield, G. R., Butnev, V. Y., Rueda-Santos, M. A., Brown, A., Hall, A. S., & Harvey, D. J. (2014). Macro- and Micro-heterogeneity in Pituitary and Urinary Follicle-Stimulating Hormone Glycosylation. Journal of glycomics & lipidomics, 4. https://doi.org/10.4172/2153-0637.1000125
Bousfield, George R, et al. "Macro- and Micro-heterogeneity in Pituitary and Urinary Follicle-Stimulating Hormone Glycosylation." Journal of glycomics & lipidomics vol. 4 (2014). doi: https://doi.org/10.4172/2153-0637.1000125
Bousfield GR, Butnev VY, Rueda-Santos MA, Brown A, Hall AS, Harvey DJ. Macro- and Micro-heterogeneity in Pituitary and Urinary Follicle-Stimulating Hormone Glycosylation. J Glycomics Lipidomics. 2014;4. doi: 10.4172/2153-0637.1000125. PMID: 25722940; PMCID: PMC4338580.
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Showing 1 to 12 of 42 entries