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Zang Q, Javed S, Zhou A, et al. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Heterocycles. 2012;86(2)doi: 10.3987/COM-12-S(N)122.
Zang, Q., Javed, S., Zhou, A., Knudtson, C. A., Bi, D., Basha, F. Z., & Hanson, P. R. (2012). Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Heterocycles, 86(2), . https://doi.org/10.3987/COM-12-S(N)122
Zang, Qin, et al. "Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams." Heterocycles vol. 86,2 (2012). doi: https://doi.org/10.3987/COM-12-S(N)122
Zang Q, Javed S, Zhou A, Knudtson CA, Bi D, Basha FZ, Hanson PR. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Heterocycles. 2012 Dec 31;86(2). doi: 10.3987/COM-12-S(N)122. PMID: 24385680; PMCID: PMC3873775.
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Heterocycles. 2012 Dec 31;86(2). doi: 10.3987/COM-12-S(N)122.

Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams.

Heterocycles

Qin Zang, Salim Javed, Aihua Zhou, Chris A Knudtson, Danse Bi, Fatima Z Basha, Paul R Hanson

Affiliations

  1. Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582 and the University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD), 2034 Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047-3761.
  2. Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582 and the University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD), 2034 Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047-3761 ; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
  3. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.

PMID: 24385680 PMCID: PMC3873775 DOI: 10.3987/COM-12-S(N)122

Abstract

The synthesis of a library of bicyclic sultams incorporating the 1,5,2-dithiazepine 1,1-dioxide moiety is reported. Following scaffold synthesis via a one-pot sulfonylation/intramolecular thia-Michael protocol, several additional cyclization strategies have been realized enabling access to new bicyclic sultams.

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