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Showing 1 to 12 of 141 entries
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Getting to the "Heart" of the Matter on Diabetic Cardiovascular Disease: "Thanks for the Memory".

Diabetes care

Cefalu WT, Rosenstock J, LeRoith D, Blonde L, Riddle MC.
PMID: 27208373
Diabetes Care. 2016 May;39(5):664-7. doi: 10.2337/dc16-0405.

No abstract available.

Obesity and Structural Brain Integrity in Older Women: The Women's Health Initiative Magnetic Resonance Imaging Study.

The journals of gerontology. Series A, Biological sciences and medical sciences

Driscoll I, Gaussoin SA, Wassertheil-Smoller S, Limacher M, Casanova R, Yaffe K, Resnick SM, Espeland MA.
PMID: 26961581
J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1216-1222. doi: 10.1093/gerona/glw023. Epub 2016 Mar 09.

BACKGROUND: Midlife obesity has been linked to age-related brain atrophy and risk of dementia, but the relationships are less clear for older individuals. These associations may be explained by changes in appetite or metabolism in the dementia prodrome; thus,...

New melanocortin-like peptide of .

NPJ biofilms and microbiomes

Qiang X, Liotta AS, Shiloach J, Gutierrez JC, Wang H, Ochani M, Ochani K, Yang H, Rabin A, LeRoith D, Lesniak MA, Böhm M, Maaser C, Kannengiesser K, Donowitz M, Rabizadeh S, Czura CJ, Tracey KJ, Westlake M, Zarfeshani A, Mehdi SF, Danoff A, Ge X, Sanyal S, Schwartz GJ, Roth J.
PMID: 29152323
NPJ Biofilms Microbiomes. 2017 Nov 13;3:31. doi: 10.1038/s41522-017-0039-9. eCollection 2017.

No abstract available.

Nativity differences in allostatic load by age, sex, and Hispanic background from the Hispanic Community Health Study/Study of Latinos.

SSM - population health

Salazar CR, Strizich G, Seeman TE, Isasi CR, Gallo LC, Avilés-Santa ML, Cai J, Penedo FJ, Arguelles W, Sanders AE, Lipton RB, Kaplan RC.
PMID: 27540567
SSM Popul Health. 2016 Dec;2:416-424. doi: 10.1016/j.ssmph.2016.05.003. Epub 2016 May 09.

Allostatic load (AL), an index of biological "wear and tear" on the body from cumulative exposure to stress, has been little studied in US Hispanics/Latinos. We investigated AL accumulation patterns by age, sex, and nativity in the Hispanic Community...

Abdominal obesity is a risk factor for dysexecutive function in chronic kidney disease.

Preventive medicine reports

Zammit AR, Katz MJ, Derby C, Bitzer M, Lipton RB.
PMID: 27413673
Prev Med Rep. 2016 Jun 07;4:128-33. doi: 10.1016/j.pmedr.2016.06.007. eCollection 2016 Dec.

The aim of this study was to assess the influence of the metabolic syndrome and its components on dysexecutive function (DF) in individuals with and without CKD. Among 588 participants aged over 70 from the Einstein Aging Study (EAS),...

Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.

Frontiers in genetics

Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M.
PMID: 26257774
Front Genet. 2015 Jul 22;6:247. doi: 10.3389/fgene.2015.00247. eCollection 2015.

Rapamycin extends lifespan and attenuates age-related pathologies in mice when administered through diet at 14 parts per million (PPM). Recently, we reported that daily intraperitoneal injection of rapamycin at 8 mg/kg attenuates mitochondrial disease symptoms and progression in the...

Cost effectiveness of a telephone intervention to promote dilated fundus examination in adults with diabetes mellitus.

Clinical ophthalmology (Auckland, N.Z.)

Schechter CB, Basch CE, Caban A, Walker EA.
PMID: 19668428
Clin Ophthalmol. 2008 Dec;2(4):763-8. doi: 10.2147/opth.s3232.

In a clinical trial, we have previously shown that a telephone intervention can significantly increase participation in dilated fundus examination (DFE) screening among low-income adults with diabetes. Here the costs and cost-effectiveness ratio of this intervention are calculated. Intervention...

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism.

Molecular metabolism

Marcelin G, Jo YH, Li X, Schwartz GJ, Zhang Y, Dun NJ, Lyu RM, Blouet C, Chang JK, Chua S.
PMID: 24567901
Mol Metab. 2013 Oct 23;3(1):19-28. doi: 10.1016/j.molmet.2013.10.002. eCollection 2014 Feb.

Tight control of glucose excursions has been a long-standing goal of treatment for patients with type 2 diabetes mellitus in order to ameliorate the morbidity and mortality associated with hyperglycemia. Fibroblast growth factor (FGF) 19 is a hormone-like enterokine...

The Impact of Dopamine on Insulin Secretion in Healthy Controls.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Underland LJ, Mark ER, Katikaneni R, Heptulla R.
PMID: 29743758
Indian J Crit Care Med. 2018 Apr;22(4):209-213. doi: 10.4103/ijccm.IJCCM_175_17.

OBJECTIVE: Dopamine is very commonly used in the critical care setting and impacts glucose homeostasis. In some studies, it is noted to increase insulin resistance or decrease insulin secretion. The role of insulin secretion in response to dopamine is...

Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants.

Oncotarget

Miller EM, Patterson NE, Zechmeister JM, Bejerano-Sagie M, Delio M, Patel K, Ravi N, Quispe-Tintaya W, Maslov A, Simmons N, Castaldi M, Vijg J, Karabakhtsian RG, Greally JM, Kuo DYS, Montagna C.
PMID: 29254223
Oncotarget. 2017 Oct 26;8(60):102033-102045. doi: 10.18632/oncotarget.22116. eCollection 2017 Nov 24.

Next generation sequencing (NGS) technologies have revolutionized our approach to genomic research. The use of whole genome sequencing (WGS), whole exome sequencing (WES), transcriptome profiling, and targeted DNA sequencing has exponentially improved our understanding of the human genome and...

Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing.

Mutation research

Ryu S, Han J, Norden-Krichmar TM, Schork NJ, Suh Y.
PMID: 29677560
Mutat Res. 2018 May;809:24-31. doi: 10.1016/j.mrfmmm.2018.03.007. Epub 2018 Mar 30.

Identification of all genetic variants associated with complex traits is one of the most important goals in modern human genetics. Genome-wide association studies (GWAS) have been successfully applied to identify common variants, which thus far explain only small portion...

Cell biological mechanisms in regulation of the post-infarction inflammatory response.

Current opinion in physiology

Frangogiannis NG.
PMID: 29552674
Curr Opin Physiol. 2018 Feb;1:7-13. doi: 10.1016/j.cophys.2017.09.001. Epub 2017 Dec 13.

Inflammation plays a crucial role in cardiac repair, but may also extend ischemic injury and contribute to post-infarction remodeling. This review manuscript discusses recent advances in our understanding of the cell biology of the post-infarction inflammatory response. Recently published...

Showing 1 to 12 of 141 entries