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Showing 1 to 12 of 96 entries
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Prepregnancy Nutrition and Early Pregnancy Outcomes.

Current nutrition reports

Gaskins AJ, Toth TL, Chavarro JE.
PMID: 26457232
Curr Nutr Rep. 2015 Sep;4(3):265-272. doi: 10.1007/s13668-015-0127-5. Epub 2015 Jun 25.

Implantation failure and pregnancy loss are estimated to affect up to 75% of fertilized ova; however as of yet there is limited empirical evidence, particularly at the population level, for understanding the environmental determinants of these losses. The purpose...

Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes.

Molecular metabolism

Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF.
PMID: 26629401
Mol Metab. 2015 Sep 18;4(11):758-70. doi: 10.1016/j.molmet.2015.09.002. eCollection 2015 Nov.

OBJECTIVE: Adipocytes are robust protein secretors, most notably of adipokines, hormone-like polypeptides, which act in an endocrine and paracrine fashion to affect numerous physiological processes such as energy balance and insulin sensitivity. To understand how such proteins are assembled...

Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research.

Current nutrition reports

Cornelis MC, Hu FB.
PMID: 24278790
Curr Nutr Rep. 2013 Dec;2(4). doi: 10.1007/s13668-013-0052-4.

Systems epidemiology applied to the field of nutrition has potential to provide new insight into underlying mechanisms and ways to study the health effects of specific foods more comprehensively. Human intervention and population-based studies have identified i) common genetic...

Commentary on "A meta-analysis but not a systematic review: an evaluation of the Global BMI Mortality Collaboration".

Journal of clinical epidemiology

Bhupathiraju SN, Di Angelantonio E, Danesh J, Hu FB.
PMID: 28411079
J Clin Epidemiol. 2017 Aug;88:30-32. doi: 10.1016/j.jclinepi.2017.04.006. Epub 2017 Apr 12.

No abstract available.

Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction.

Journal of the Endocrine Society

Thomas DD, Corkey BE, Istfan NW, Apovian CM.
PMID: 31528832
J Endocr Soc. 2019 Jul 24;3(9):1727-1747. doi: 10.1210/js.2019-00065. eCollection 2019 Sep 01.

Hyperinsulinemia is strongly associated with type 2 diabetes. Racial and ethnic minority populations are disproportionately affected by diabetes and obesity-related complications. This mini-review provides an overview of the genetic and environmental factors associated with hyperinsulinemia with a focus on...

Injury Risk Associated With Sports Specialization and Activity Volume in Youth.

Orthopaedic journal of sports medicine

Field AE, Tepolt FA, Yang DS, Kocher MS.
PMID: 31555716
Orthop J Sports Med. 2019 Sep 18;7(9):2325967119870124. doi: 10.1177/2325967119870124. eCollection 2019 Sep.

BACKGROUND: Sports specialization has become increasingly common among youth.PURPOSE/HYPOTHESIS: To investigate the relative importance of specialization vs volume of activity in increasing risk of injury. Hypotheses were that specialization increases the risk of injury and that risk varies by...

Food cue regulation of AGRP hunger neurons guides learning.

Nature

Berrios J, Li C, Madara JC, Garfield AS, Steger JS, Krashes MJ, Lowell BB.
PMID: 34262177
Nature. 2021 Jul;595(7869):695-700. doi: 10.1038/s41586-021-03729-3. Epub 2021 Jul 14.

Agouti-related peptide (AGRP)-expressing neurons are activated by fasting-this causes hunger

Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits.

Nature human behaviour

Merino J, Dashti HS, Sarnowski C, Lane JM, Todorov PV, Udler MS, Song Y, Wang H, Kim J, Tucker C, Campbell J, Tanaka T, Chu AY, Tsai L, Pers TH, Chasman DI, Rutter MK, Dupuis J, Florez JC, Saxena R.
PMID: 34426670
Nat Hum Behav. 2021 Aug 23; doi: 10.1038/s41562-021-01182-w. Epub 2021 Aug 23.

Dietary intake is a major contributor to the global obesity epidemic and represents a complex behavioural phenotype that is partially affected by innate biological differences. Here, we present a multivariate genome-wide association analysis of overall variation in dietary intake...

Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study.

Clinical nutrition (Edinburgh, Scotland)

Heianza Y, Zhou T, Sun D, Hu FB, Qi L.
PMID: 34237696
Clin Nutr. 2021 Jul;40(7):4694-4701. doi: 10.1016/j.clnu.2021.06.018. Epub 2021 Jun 24.

BACKGROUND & AIMS: People with a higher genetic risk for obesity are more likely to develop cardiovascular disease (CVD), and healthy plant-based dietary patterns may be associated with decreased risks of obesity and cardiovascular events. We investigated whether adherence...

Pesticide residue intake from fruits and vegetables and alterations in the serum metabolome of women undergoing infertility treatment.

Environment international

Hood RB, Liang D, Chiu YH, Sandoval-Insausti H, Chavarro JE, Jones D, Hauser R, Gaskins AJ.
PMID: 34959198
Environ Int. 2021 Dec 24;160:107061. doi: 10.1016/j.envint.2021.107061. Epub 2021 Dec 24.

BACKGROUND: Pesticide exposure is linked to a myriad of negative health effects; however, the mechanisms underlying these associations are less clear. We utilized metabolomics to describe the alterations in the serum metabolome associated with high and low pesticide residue...

The Sulfur Microbial Diet and Risk of Colorectal Cancer by Molecular Subtypes and Intratumoral Microbial Species in Adult Men.

Clinical and translational gastroenterology

Sikavi DR, Nguyen LH, Haruki K, Ugai T, Ma W, Wang DD, Thompson KN, Yan Y, Branck T, Wilkinson JE, Akimoto N, Zhong R, Lau MC, Mima K, Kosumi K, Morikawa T, Rimm EB, Garrett WS, Izard J, Cao Y, Song M, Huttenhower C, Ogino S, Chan AT.
PMID: 34333506
Clin Transl Gastroenterol. 2021 Aug 01;12(8):e00338. doi: 10.14309/ctg.0000000000000338.

INTRODUCTION: We recently described the sulfur microbial diet, a pattern of intake associated with increased gut sulfur-metabolizing bacteria and incidence of distal colorectal cancer (CRC). We assessed whether this risk differed by CRC molecular subtypes or presence of intratumoral...

Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.

Cell metabolism

Li J, Li E, Czepielewski RS, Chi J, Guo X, Han YH, Wang D, Wang L, Hu B, Dawes B, Jacobs C, Tenen D, Lin SJ, Lee B, Morris D, Tobias A, Randolph GJ, Cohen P, Tsai L, Rosen ED.
PMID: 34038712
Cell Metab. 2021 Jul 06;33(7):1449-1465.e6. doi: 10.1016/j.cmet.2021.04.019. Epub 2021 May 25.

The lymphatic vasculature plays important roles in the physiology of the organs in which it resides, though a clear mechanistic understanding of how this crosstalk is mediated is lacking. Here, we performed single-cell transcriptional profiling of human and mouse...

Showing 1 to 12 of 96 entries