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Heianza Y, Zhou T, Sun D, et al. Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study. Clin Nutr. 2021;40(7):4694-4701doi: 10.1016/j.clnu.2021.06.018.
Heianza, Y., Zhou, T., Sun, D., Hu, F. B., & Qi, L. (2021). Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study. Clinical nutrition (Edinburgh, Scotland), 40(7), 4694-4701. https://doi.org/10.1016/j.clnu.2021.06.018
Heianza, Yoriko, et al. "Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study." Clinical nutrition (Edinburgh, Scotland) vol. 40,7 (2021): 4694-4701. doi: https://doi.org/10.1016/j.clnu.2021.06.018
Heianza Y, Zhou T, Sun D, Hu FB, Qi L. Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study. Clin Nutr. 2021 Jul;40(7):4694-4701. doi: 10.1016/j.clnu.2021.06.018. Epub 2021 Jun 24. PMID: 34237696; PMCID: PMC8338907.
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Clin Nutr. 2021 Jul;40(7):4694-4701. doi: 10.1016/j.clnu.2021.06.018. Epub 2021 Jun 24.

Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study.

Clinical nutrition (Edinburgh, Scotland)

Yoriko Heianza, Tao Zhou, Dianjianyi Sun, Frank B Hu, Lu Qi

Affiliations

  1. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
  2. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  3. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: [email protected].

PMID: 34237696 PMCID: PMC8338907 DOI: 10.1016/j.clnu.2021.06.018

Abstract

BACKGROUND & AIMS: People with a higher genetic risk for obesity are more likely to develop cardiovascular disease (CVD), and healthy plant-based dietary patterns may be associated with decreased risks of obesity and cardiovascular events. We investigated whether adherence to healthy plant-foods-rich dietary patterns might attenuate risks of obesity and related cardiovascular abnormalities for people at genetically higher risk of obesity.

METHODS: This study included 121,799 middle-aged adults in UK Biobank who were initially free of metabolic diseases and cancer. We calculated a healthful plant-based diet index (hPDI) based on 17 major food groups as well as a genetic risk score (GRS) for obesity consisting of body mass index (BMI)-associated variants. The incidence of cardiovascular events (myocardial infarction, MI, or stroke) was prospectively followed during a mean (SD) 5.1 (0.9) years.

RESULTS: We found significant interactions between GRS and hPDI on adiposity (P

CONCLUSIONS: Adherence to healthy plant-based dietary patterns significantly attenuated risks of cardiovascular abnormalities for people at genetically higher risk of obesity. Our results support the precision medicine strategies considering genetics and dietary habits to modify cardiovascular health for people at higher risk of genetically determined obesity.

Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Keywords: Cardiovascular events; Genetic predisposition; Obesity; Plant-based nutrition; Risk factors

Conflict of interest statement

Conflict of interest The authors declare no conflict of interest associated with this publication.

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