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Showing 1 to 12 of 74 entries
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Frontiers in physiology

Quarto N, Shailendra S, Meyer NP, Menon S, Renda A, Longaker MT.
PMID: 30374308
Front Physiol. 2018 Oct 15;9:1426. doi: 10.3389/fphys.2018.01426. eCollection 2018.

Craniofacial development is a program exquisitely orchestrated by tissue contributions and regulation of genes expression. The basic helix-loop-helix (bHLH) transcription factor Twist1 expressed in the skeletal mesenchyme is a key regulator of craniofacial development playing an important role during...

CGM Initiation Soon After Type 1 Diabetes Diagnosis Results in Sustained CGM Use and Wear Time.

Diabetes care

Prahalad P, Addala A, Scheinker D, Hood KK, Maahs DM.
PMID: 31558548
Diabetes Care. 2020 Jan;43(1):e3-e4. doi: 10.2337/dc19-1205. Epub 2019 Sep 26.

No abstract available.

Utility of ALT Concentration in Men and Women with Nonalcoholic Fatty Liver Disease: Cohort Study.

Journal of clinical medicine

Sung KC, Lee MY, Lee JY, Lee SH, Kim SH, Kim SH.
PMID: 30987010
J Clin Med. 2019 Apr 02;8(4). doi: 10.3390/jcm8040445.

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated alanine aminotransferase (ALT), but the clinical utility of ALT in detecting and following individuals with NAFLD remains unclear. We conducted a retrospective analysis of 30,988 men and...

Predictors of Time-in-Range (70-180 mg/dL) Achieved Using a Closed-Loop Control System.

Diabetes technology & therapeutics

Schoelwer MJ, Kanapka LG, Wadwa RP, Breton MD, Ruedy KJ, Ekhlaspour L, Forlenza GP, Cobry EC, Messer LH, Cengiz E, Jost E, Carria L, Emory E, Hsu LJ, Weinzimer SA, Buckingham BA, Lal RA, Oliveri MC, Kollman CC, Dokken BB, Cherñavvsky DR, Beck RW, DeBoer MD.
PMID: 33689454
Diabetes Technol Ther. 2021 Jul;23(7):475-481. doi: 10.1089/dia.2020.0646. Epub 2021 Mar 09.

No abstract available.

Relationship Between Coronary Atheroma, Epicardial Adipose Tissue Inflammation, and Adipocyte Differentiation Across the Human Myocardial Bridge.

Journal of the American Heart Association

McLaughlin T, Schnittger I, Nagy A, Zanley E, Xu Y, Song Y, Nieman K, Tremmel JA, Dey D, Boyd J, Sacks H.
PMID: 34726081
J Am Heart Assoc. 2021 Nov 16;10(22):e021003. doi: 10.1161/JAHA.121.021003. Epub 2021 Nov 02.

Background Inflammation in epicardial adipose tissue (EAT) may contribute to coronary atherosclerosis. Myocardial bridge is a congenital anomaly in which the left anterior descending coronary artery takes a "tunneled" course under a bridge of myocardium: while atherosclerosis develops in...

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion.

Genes & development

Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK.
PMID: 34385262
Genes Dev. 2021 Sep 01;35(17):1243-1255. doi: 10.1101/gad.348261.121. Epub 2021 Aug 12.

Multiple G protein-coupled receptors (GPCRs) are expressed in pancreatic islet cells, but the majority have unknown functions. We observed specific GPCRs localized to primary cilia, a prominent signaling organelle, in pancreatic α and β cells. Loss of cilia disrupts...

SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior.

Biochimica et biophysica acta. Molecular basis of disease

Hao X, Zhu B, Yang P, Dong D, Sahbaie P, Oliver PL, Shen WJ, Azhar S, Kraemer FB.
PMID: 34826585
Biochim Biophys Acta Mol Basis Dis. 2022 Feb 01;1868(2):166304. doi: 10.1016/j.bbadis.2021.166304. Epub 2021 Nov 24.

OBJECTIVE: SNAP-25 is one of the key proteins involved in formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes that are at the core of hormonal secretion and synaptic transmission. Altered expression or function of SNAP-25 can contribute...

ONBOARD: A Feasibility Study of a Telehealth-Based Continuous Glucose Monitoring Adoption Intervention for Adults with Type 1 Diabetes.

Diabetes technology & therapeutics

Tanenbaum ML, Ngo J, Hanes SJ, Basina M, Buckingham BA, Hessler D, Maahs DM, Mulvaney S, Hood KK.
PMID: 34270351
Diabetes Technol Ther. 2021 Dec;23(12):818-827. doi: 10.1089/dia.2021.0198.

No abstract available.

Enhancing islet transplantation using a biocompatible collagen-PDMS bioscaffold enriched with dexamethasone-microplates.

Biofabrication

Primavera R, Razavi M, Kevadiya BD, Wang J, Vykunta A, Di Mascolo D, Decuzzi P, Thakor AS.
PMID: 33455953
Biofabrication. 2021 Jan 18; doi: 10.1088/1758-5090/abdcac. Epub 2021 Jan 18.

Islet transplantation is a promising approach to enable type 1 diabetic patients to attain glycemic control independent of insulin injections. However, up to 60% of islets are lost immediately following transplantation. To improve this outcome, islets can be transplanted...

A Real-World Prospective Study of the Safety and Effectiveness of the Loop Open Source Automated Insulin Delivery System.

Diabetes technology & therapeutics

Lum JW, Bailey RJ, Barnes-Lomen V, Naranjo D, Hood KK, Lal RA, Arbiter B, Brown AS, DeSalvo DJ, Pettus J, Calhoun P, Beck RW.
PMID: 33226840
Diabetes Technol Ther. 2021 May;23(5):367-375. doi: 10.1089/dia.2020.0535. Epub 2021 Apr 12.

No abstract available.

Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.

medRxiv : the preprint server for health sciences

Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schürch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK.
PMID: 32511516
medRxiv. 2020 May 12; doi: 10.1101/2020.05.08.20092866.

We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated...

Discontinued Use of the Loop Insulin Dosing System: A Mixed-Methods Investigation.

Diabetes technology & therapeutics

Wong J, Suttiratana S, Lal RA, Lum J, Lanning MS, Dunlap A, Arbiter B, Hanes S, Bailey R, Hood K, Naranjo D.
PMID: 34780283
Diabetes Technol Ther. 2021 Nov 15; doi: 10.1089/dia.2021.0362. Epub 2021 Nov 15.

BACKGROUND: Loop is an open-source automated insulin dosing system that allows users unrivaled control over system settings that effect future glucose prediction. Thousands use Loop, but little is known about those who discontinue.METHODS: In a large observational study, 874...

Showing 1 to 12 of 74 entries