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Showing 1 to 12 of 116 entries
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Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder.

Frontiers in physiology

Hartmann P, Lang S, Zeng S, Duan Y, Zhang X, Wang Y, Bondareva M, Kruglov A, Fouts DE, Stärkel P, Schnabl B.
PMID: 34349667
Front Physiol. 2021 Jul 19;12:699253. doi: 10.3389/fphys.2021.699253. eCollection 2021.

BACKGROUND: Alcohol-associated liver disease (ALD) is an important cause of morbidity and mortality worldwide. The intestinal microbiota is involved in the development and progression of ALD; however, little is known about commensal fungi therein.METHODS: We studied the dynamic changes...

Disease Activity Indices for Pouchitis: A Systematic Review.

Inflammatory bowel diseases

Sedano R, Nguyen TM, Almradi A, Rieder F, Parker CE, Shackelton LM, D'Haens G, Sandborn WJ, Feagan BG, Ma C, Jairath V.
PMID: 34180986
Inflamm Bowel Dis. 2021 Jun 28; doi: 10.1093/ibd/izab124. Epub 2021 Jun 28.

BACKGROUND: Several indices exist to measure pouchitis disease activity; however, none are fully validated. As an initial step toward creating a validated instrument, we identified pouchitis disease activity indices, examined their operating properties, and assessed their value as outcome...

Vitamin D Levels May Predict Response to Vedolizumab.

Journal of Crohn's & colitis

Bamias G, Rivera-Nieves J.
PMID: 34185075
J Crohns Colitis. 2021 Jun 29; doi: 10.1093/ecco-jcc/jjab105. Epub 2021 Jun 29.

No abstract available.

Emerging Role of Genomic Analysis in Clinical Evaluation of Lean Individuals With NAFLD.

Hepatology (Baltimore, Md.)

Vilarinho S, Ajmera V, Zheng M, Loomba R.
PMID: 34233030
Hepatology. 2021 Oct;74(4):2241-2250. doi: 10.1002/hep.32047.

No abstract available.

Links between gut microbiome composition and fatty liver disease in a large population sample.

Gut microbes

Ruuskanen MO, Åberg F, Männistö V, Havulinna AS, Méric G, Liu Y, Loomba R, Vázquez-Baeza Y, Tripathi A, Valsta LM, Inouye M, Jousilahti P, Salomaa V, Jain M, Knight R, Lahti L, Niiranen TJ.
PMID: 33651661
Gut Microbes. 2021 Jan-Dec;13(1):1-22. doi: 10.1080/19490976.2021.1888673.

Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 y, but this association remains mostly unstudied in the general population because of underdiagnosis...

Class Ib MHC-Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine.

ImmunoHorizons

Dasgupta S, Maricic I, Tang J, Wandro S, Weldon K, Carpenter CS, Eckmann L, Rivera-Nieves J, Sandborn W, Knight R, Dorrestein P, Swafford AD, Kumar V.
PMID: 34911745
Immunohorizons. 2021 Dec 15;5(12):953-971. doi: 10.4049/immunohorizons.2100090.

Lymphocytes within the intestinal epithelial layer (IEL) in mammals have unique composition compared with their counterparts in the lamina propria. Little is known about the role of some of the key colonic IEL subsets, such as TCRαβ

Heterogeneity of HSCs in a Mouse Model of NASH.

Hepatology (Baltimore, Md.)

Rosenthal SB, Liu X, Ganguly S, Dhar D, Pasillas MP, Ricciardelli E, Li RZ, Troutman TD, Kisseleva T, Glass CK, Brenner DA.
PMID: 33550587
Hepatology. 2021 Aug;74(2):667-685. doi: 10.1002/hep.31743. Epub 2021 Aug 10.

BACKGROUND AND AIMS: In clinical and experimental NASH, the origin of the scar-forming myofibroblast is the HSC. We used foz/foz mice on a Western diet to characterize in detail the phenotypic changes of HSCs in a NASH model.APPROACH AND...

Vitamin D Levels May Predict Response to Vedolizumab.

Journal of Crohn's & colitis

Bamias G, Rivera-Nieves J.
PMID: 34185075
J Crohns Colitis. 2021 Dec 18;15(12):1978-1979. doi: 10.1093/ecco-jcc/jjab105.

No abstract available.

Comprehensive characterization of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter.

Molecular microbiology

Natto MJ, Miyamoto Y, Munday JC, AlSiari TA, Al-Salabi MI, Quashie NB, Eze AA, Eckmann L, De Koning HP.
PMID: 34738285
Mol Microbiol. 2021 Dec;116(6):1489-1511. doi: 10.1111/mmi.14840. Epub 2021 Nov 20.

Trichomoniasis is a common and widespread sexually-transmitted infection, caused by the protozoan parasite Trichomonas vaginalis. T. vaginalis lacks the biosynthetic pathways for purines and pyrimidines, making nucleoside metabolism a drug target. Here we report the first comprehensive investigation into...

Aryl Hydrocarbon Receptor Deficiency in Intestinal Epithelial Cells Aggravates Alcohol-Related Liver Disease.

Cellular and molecular gastroenterology and hepatology

Qian M, Liu J, Zhao D, Cai P, Pan C, Jia W, Gao Y, Zhang Y, Zhang N, Zhang Y, Zhang Q, Wu D, Shan C, Zhang M, Schnabl B, Yang S, Shen X, Wang L.
PMID: 34454169
Cell Mol Gastroenterol Hepatol. 2022;13(1):233-256. doi: 10.1016/j.jcmgh.2021.08.014. Epub 2021 Aug 25.

BACKGROUND & AIMS: The ligand-activated transcription factor, aryl hydrocarbon receptor (AHR) can sense xenobiotics, dietary, microbial, and metabolic cues. Roles of Ahr in intestinal epithelial cells (IECs) have been much less elucidated compared with those in intestinal innate immune...

Multicenter Analysis of Liver Injury Patterns and Mortality in COVID-19.

Frontiers in medicine

Chu H, Bai T, Chen L, Hu L, Xiao L, Yao L, Zhu R, Niu X, Li Z, Zhang L, Han C, Song S, He Q, Zhao Y, Zhu Q, Chen H, Schnabl B, Yang L, Hou X.
PMID: 33195339
Front Med (Lausanne). 2020 Oct 20;7:584342. doi: 10.3389/fmed.2020.584342. eCollection 2020.

No abstract available.

Influence of Intermittent Hypoxia/Hypercapnia on Atherosclerosis, Gut Microbiome, and Metabolome.

Frontiers in physiology

Xue J, Allaband C, Zhou D, Poulsen O, Martino C, Jiang L, Tripathi A, Elijah E, Dorrestein PC, Knight R, Zarrinpar A, Haddad GG.
PMID: 33897472
Front Physiol. 2021 Apr 08;12:663950. doi: 10.3389/fphys.2021.663950. eCollection 2021.

Obstructive sleep apnea (OSA), a common sleep disorder characterized by intermittent hypoxia and hypercapnia (IHC), increases atherosclerosis risk. However, the contribution of intermittent hypoxia (IH) or intermittent hypercapnia (IC) in promoting atherosclerosis remains unclear. Since gut microbiota and metabolites...

Showing 1 to 12 of 116 entries