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Hartmann P, Lang S, Zeng S, et al. Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder. Front Physiol. 2021;12:699253doi: 10.3389/fphys.2021.699253.
Hartmann, P., Lang, S., Zeng, S., Duan, Y., Zhang, X., Wang, Y., Bondareva, M., Kruglov, A., Fouts, D. E., Stärkel, P., & Schnabl, B. (2021). Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder. Frontiers in physiology, 12699253. https://doi.org/10.3389/fphys.2021.699253
Hartmann, Phillipp, et al. "Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder." Frontiers in physiology vol. 12 (2021): 699253. doi: https://doi.org/10.3389/fphys.2021.699253
Hartmann P, Lang S, Zeng S, Duan Y, Zhang X, Wang Y, Bondareva M, Kruglov A, Fouts DE, Stärkel P, Schnabl B. Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder. Front Physiol. 2021 Jul 19;12:699253. doi: 10.3389/fphys.2021.699253. eCollection 2021. PMID: 34349667; PMCID: PMC8327211.
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Front Physiol. 2021 Jul 19;12:699253. doi: 10.3389/fphys.2021.699253. eCollection 2021.

Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder.

Frontiers in physiology

Phillipp Hartmann, Sonja Lang, Suling Zeng, Yi Duan, Xinlian Zhang, Yanhan Wang, Marina Bondareva, Andrey Kruglov, Derrick E Fouts, Peter Stärkel, Bernd Schnabl

Affiliations

  1. Department of Pediatrics, University of California, San Diego, La Jolla, CA, United States.
  2. Department of Medicine, University of California, San Diego, La Jolla, CA, United States.
  3. Department of Medicine, VA San Diego Healthcare System, San Diego, CA, United States.
  4. Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, United States.
  5. Chronic Inflammation Lab, German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany.
  6. Belozerskiy Research Institute for Physical and Chemical Biology and Faculty of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, Moscow, Russia.
  7. Department of Genomic Medicine, J. Craig Venter Institute, Rockville, MD, United States.
  8. Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.

PMID: 34349667 PMCID: PMC8327211 DOI: 10.3389/fphys.2021.699253

Abstract

BACKGROUND: Alcohol-associated liver disease (ALD) is an important cause of morbidity and mortality worldwide. The intestinal microbiota is involved in the development and progression of ALD; however, little is known about commensal fungi therein.

METHODS: We studied the dynamic changes of the intestinal fungal microbiome, or mycobiome, in 66 patients with alcohol use disorder (AUD) and after 2 weeks of alcohol abstinence using internal transcribed spacer 2 (ITS2) amplicon sequencing of fecal samples.

RESULTS: Patients with AUD had significantly increased abundance of the genera

CONCLUSION: In conclusion, improved liver health in AUD patients after alcohol abstinence was associated with lower intestinal abundances of

Copyright © 2021 Hartmann, Lang, Zeng, Duan, Zhang, Wang, Bondareva, Kruglov, Fouts, Stärkel and Schnabl.

Keywords: abstinence; alcohol-associated liver disease; fungi; microbiome; mycobiome

Conflict of interest statement

BS has been consulting for Ferring Research Institute, HOST Therabiomics, Intercept Pharmaceuticals, Mabwell Therapeutics, Patara Pharmaceuticals and Takeda. BS’s institution UC San Diego has received

References

  1. Appl Environ Microbiol. 2016 Nov 21;82(24):7217-7226 - PubMed
  2. Microbiome. 2017 Nov 25;5(1):153 - PubMed
  3. Sci Rep. 2020 May 14;10(1):7954 - PubMed
  4. Gut. 2020 Jan;69(1):92-102 - PubMed
  5. Hepatology. 2020 Feb;71(2):522-538 - PubMed
  6. BMC Microbiol. 2020 Aug 17;20(1):257 - PubMed
  7. J Clin Invest. 2017 Jun 30;127(7):2829-2841 - PubMed
  8. Alcohol Clin Exp Res. 2015 May;39(5):763-75 - PubMed
  9. Genome Biol. 2011 Jun 24;12(6):R60 - PubMed
  10. Cell Host Microbe. 2019 Mar 13;25(3):377-388.e6 - PubMed
  11. Alcohol Alcohol. 2017 Jan;52(1):42-47 - PubMed
  12. Appl Environ Microbiol. 2007 Mar;73(5):1576-85 - PubMed
  13. Gut Microbes. 2020 Nov 9;12(1):1782157 - PubMed
  14. Gut. 2018 Jun;67(6):1146-1154 - PubMed
  15. J Hepatol. 2020 Mar;72(3):391-400 - PubMed
  16. J Gastroenterol. 2021 Jan;56(1):1-11 - PubMed
  17. Clin Gastroenterol Hepatol. 2018 Aug;16(8):1356-1358 - PubMed
  18. Appl Environ Microbiol. 2009 Dec;75(23):7537-41 - PubMed
  19. Lancet. 2007 Oct 20;370(9596):1453-7 - PubMed
  20. Hepatology. 2017 Jul;66(1):96-107 - PubMed
  21. Nat Methods. 2013 Oct;10(10):996-8 - PubMed
  22. Nucleic Acids Res. 2019 Jan 8;47(D1):D259-D264 - PubMed
  23. Front Cell Infect Microbiol. 2020 May 05;10:198 - PubMed
  24. Nature. 2014 Jan 23;505(7484):559-63 - PubMed
  25. Front Physiol. 2012 Oct 11;3:402 - PubMed
  26. Geroscience. 2019 Dec;41(6):907-921 - PubMed
  27. J Hepatol. 2013 Jul;59(1):160-8 - PubMed
  28. J Immunol Methods. 2015 Jun;421:112-121 - PubMed
  29. Intensive Care Med. 2017 Apr;43(4):509-518 - PubMed
  30. J Hepatol. 2014 Jul;61(1):51-8 - PubMed

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