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Showing 1 to 12 of 140 entries
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Common, germline genetic variations in the novel tumor suppressor .

Oncotarget

Lin M, Zhang L, Hildebrandt MAT, Huang M, Wu X, Ye Y.
PMID: 29088836
Oncotarget. 2017 Aug 24;8(43):74936-74946. doi: 10.18632/oncotarget.20465. eCollection 2017 Sep 26.

BRCA1 associated protein-1 (BAP1) is a novel tumor suppressor that has recently been shown to be somatically mutated in several cancers. The

A Multi-Camera System for Bioluminescence Tomography in Preclinical Oncology Research.

Diagnostics (Basel, Switzerland)

Lewis MA, Richer E, Slavine NV, Kodibagkar VD, Soesbe TC, Antich PP, Mason RP.
PMID: 26824926
Diagnostics (Basel). 2013 Jul 09;3(3):325-43. doi: 10.3390/diagnostics3030325.

Bioluminescent imaging (BLI) of cells expressing luciferase is a valuable noninvasive technique for investigating molecular events and tumor dynamics in the living animal. Current usage is often limited to planar imaging, but tomographic imaging can enhance the usefulness of...

Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes.

Journal of biomedicine & biotechnology

Wren JD, Garner HR.
PMID: 16046815
J Biomed Biotechnol. 2005 Jun 30;2005(2):104-12. doi: 10.1155/JBB.2005.104.

The etiological origin of type 2 diabetes mellitus (T2DM) has long been controversial. The body of literature related to T2DM is vast and varied in focus, making a broad epidemiological perspective difficult, if not impossible. A data-mining approach was...

Nonparametric Sample Size Estimation for Sensitivity and Specificity with Multiple Observations per Subject.

Drug information journal

Hu F, Schucany WR, Ahn C.
PMID: 22114363
Drug Inf J. 2010;44(5):609-616. doi: 10.1177/009286151004400508.

We propose a sample size calculation approach for the estimation of sensitivity and specificity of diagnostic tests with multiple observations per subjects. Many diagnostic tests such as diagnostic imaging or periodontal tests are characterized by the presence of multiple...

Tumor oncogenotypes and lung cancer stem cell identity.

Cell stem cell

Sullivan JP, Minna JD.
PMID: 20621039
Cell Stem Cell. 2010 Jul 02;7(1):2-4. doi: 10.1016/j.stem.2010.06.005.

In this issue of Cell Stem Cell, Curtis et. al. (2010) reveal that the identities of lung cancer stem cell populations differ depending on the specific tumor oncogenotype in three murine lung adenocarcinoma models. These findings highlight the importance...

Molecular biology of lung cancer.

Journal of thoracic disease

Cooper WA, Lam DC, O'Toole SA, Minna JD.
PMID: 24163741
J Thorac Dis. 2013 Oct;5:S479-90. doi: 10.3978/j.issn.2072-1439.2013.08.03.

Lung cancers are characterised by abundant genetic diversity with relatively few recurrent mutations occurring at high frequency. However, the genetic alterations often affect a common group of oncogenic signalling pathways. There have been vast improvements in our understanding of...

Relative Efficiency of Unequal Versus Equal Cluster Sizes for the Nonparametric Weighted Sign Test Estimators in Clustered Binary Data.

Drug information journal

Ahn C, Hu F, Lee SC.
PMID: 23486929
Drug Inf J. 2012 Jul 02;46(4):428-433. doi: 10.1177/0092861512449818.

We consider analysis of clustered binary data from multiple observations for each subject in which any two observations from a subject are assumed to have a common correlation coefficient. In the weighted sign test on proportion in clustered binary...

Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study.

Journal of clinical bioinformatics

Nomura M, Fukuda T, Fujii K, Kawamura T, Tojo H, Kihara M, Bando Y, Gazdar AF, Tsuboi M, Oshiro H, Nagao T, Ohira T, Ikeda N, Gotoh N, Kato H, Marko-Varga G, Nishimura T.
PMID: 21888658
J Clin Bioinforma. 2011 Sep 03;1(1):23. doi: 10.1186/2043-9113-1-23.

BACKGROUND: Large cell neuroendocrine carcinoma (LCNEC) of the lung, a subtype of large cell carcinoma (LCC), is characterized by neuroendocrine differentiation that small cell lung carcinoma (SCLC) shares. Pre-therapeutic histological distinction between LCNEC and SCLC has so far been...

Integrative proteomic and transcriptomic analysis provides evidence for TrkB (NTRK2) as a therapeutic target in combination with tyrosine kinase inhibitors for non-small cell lung cancer.

Oncotarget

Gomez DR, Byers LA, Nilsson M, Diao L, Wang J, Li L, Tong P, Hofstad M, Saigal B, Wistuba I, Kalhor N, Swisher S, Fan Y, Hong WK, Suraokar M, Behrens C, Moran C, Heymach JV.
PMID: 29581842
Oncotarget. 2018 Jan 30;9(18):14268-14284. doi: 10.18632/oncotarget.24361. eCollection 2018 Mar 06.

While several molecular targets have been identified for adenocarcinoma (ACA) of the lung, similar drivers with squamous cell carcinoma (SCC) are sparse. We compared signaling pathways and potential therapeutic targets in lung SCC and ACA tumors using reverse phase...

Probe mapping across multiple microarray platforms.

Briefings in bioinformatics

Allen JD, Wang S, Chen M, Girard L, Minna JD, Xie Y, Xiao G.
PMID: 22199380
Brief Bioinform. 2012 Sep;13(5):547-54. doi: 10.1093/bib/bbr076. Epub 2011 Dec 23.

Access to gene expression data has become increasingly common in recent years; however, analysis has become more difficult as it is often desirable to integrate data from different platforms. Probe mapping across microarray platforms is the first and most...

New targets for controlling Ebola virus disease.

National science review

Qin FX, Jiang CY, Jiang T, Cheng G.
PMID: 26550528
Natl Sci Rev. 2015 Sep;2(3):266-267. doi: 10.1093/nsr/nwv043. Epub 2015 Jul 17.

No abstract available.

Development and Validation of a Nomogram Prognostic Model for Patients With Advanced Non-Small-Cell Lung Cancer.

Cancer informatics

Wang T, Lu R, Lai S, Schiller JH, Zhou FL, Ci B, Wang S, Gao X, Yao B, Gerber DE, Johnson DH, Xiao G, Xie Y.
PMID: 31057324
Cancer Inform. 2019 Apr 05;18:1176935119837547. doi: 10.1177/1176935119837547. eCollection 2019.

IMPORTANCE: Nomogram prognostic models can facilitate cancer patient treatment plans and patient enrollment in clinical trials.OBJECTIVE: The primary objective is to provide an updated and accurate prognostic model for predicting the survival of advanced non-small-cell lung cancer (NSCLC) patients,...

Showing 1 to 12 of 140 entries