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Showing 1 to 12 of 225 entries
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Legal highs: staying on top of the flood of novel psychoactive substances.

Therapeutic advances in psychopharmacology

Baumeister D, Tojo LM, Tracy DK.
PMID: 26240749
Ther Adv Psychopharmacol. 2015 Apr;5(2):97-132. doi: 10.1177/2045125314559539.

There has been growing clinical, public, and media awareness and concern about the availability and potential harmfulness of so-called 'legal highs', which are more appropriately called new or novel psychoactive substances (NPS). A cat-and-mouse process has emerged wherein unknown...

Attempts to establish phencyclidine and cocaine discrimination without error.

Behavioural pharmacology

McMillan DE, Hardwick WC.
PMID: 11224081
Behav Pharmacol. 1991 Nov;2(4):379-389.

An attempt was made to train pigeons to discriminate phencyclidine (PCP) from saline using a three-key color-tracking procedure under which birds were trained under a second order schedule [FR10 (FR5)] "without errors." Training without errors was done by not...

Effects of phencyclidine and dizocilpine on NMDA-, kainate-, and water deprivation-induced drinking in pigeons.

Behavioural pharmacology

Baron SP, Woods JH.
PMID: 11224193
Behav Pharmacol. 1993 Jun;4(3):257-261.

The excitatory amino acid (EAA) agonists, N-methyl-D-aspartate (NMDA) and kainate, elicit a copious drinking response in pigeons. NMDA-induced drinking, as compared with kainate- and water deprivation-induced drinking, is selectively antagonized by the competitive, NMDA receptor antagonist CGS 19755, and...

N-Methyl-D-aspartate (NMDA) receptor-based treatment approaches in schizophrenia: the first decade.

The international journal of neuropsychopharmacology

Heresco-Levy U.
PMID: 11343602
Int J Neuropsychopharmacol. 2000 Sep;3(3):243-258. doi: 10.1017/S1461145700001978.

The study of excitatory amino acids (EAA) [e.g. glutamate (Glu), aspartate] as neurotransmitters has resulted in many new and fundamental concepts in neuroscience. Much of this progress centres upon the role of N-methyl-D-aspartate (NMDA) subtype of Glu receptors in...

Role of serotonergic 5-HT2A receptors in the psychotomimetic actions of phencyclidine.

The international journal of neuropsychopharmacology

Rabin RA, Doat M, Winter JC.
PMID: 11343613
Int J Neuropsychopharmacol. 2000 Dec;3(4):333-338. doi: 10.1017/S1461145700002091.

The psychotomimetic phencyclidine (PCP) alters various behavioural responses involving the serotonergic system including potentiating the discriminative stimulus effects of the phenethylamine hallucinogen, 2,5-dimethoxy-4-methylamphetamine (DOM). The present study was undertaken to test the hypothesis that PCP directly interacts with the...

Effects of excitatory amino acid antagonists on social recognition of male rats.

Behavioural pharmacology

Hlinák Z, Krejcí I.
PMID: 11224273
Behav Pharmacol. 1994 Jun;5(3):239-244. doi: 10.1097/00008877-199406000-00002.

The effects of NMDA and non-NMDA glutamate receptor antagonists were evaluated on social recognition of adult male rats. Adult animals were injected (s.c.) with drug or saline immediately after the initial exposure to a juvenile male, 21-24 days old,...

Pentobarbital discrimination and generalization to other drugs under multiple fixed-ratio fixed-interval schedules.

Behavioural pharmacology

McMillan DE, Hardwick WC.
PMID: 11224420
Behav Pharmacol. 1996 May;7(3):285-293.

Pigeons were trained to discriminate 5mg/kg pentobarbital from saline under several multiple fixed-ratio fixed-interval schedules of food presentation. The following schedules were studied: multiple fixed-ratio 40 fixed-interval 18s (mult FR40 FI18), mult FR10 FI18s, mult FR10 FI180s and mult...

Effects of phencyclidine-like drugs on responding under multiple fixed ratio, fixed interval schedules.

Behavioural pharmacology

McMillan DE, Wright DW, Wenger GR.
PMID: 11224112
Behav Pharmacol. 1992 Apr;3(2):143-147.

The effects of phencyclidine and a series of related drugs were studied on rates and patterns of responding by rats under a multiple fixed-interval 300s, fixed-ratio 30-response schedule of food presentation. Dizocilipine produced large increases in the rate of...

Genetic differences in the locomotor response to single and daily doses of phencyclidine in inbred mouse strains.

Behavioural pharmacology

Xu X, Domino EF.
PMID: 11224242
Behav Pharmacol. 1994 Oct;5(6):623-629. doi: 10.1097/00008877-199410000-00008.

Genetic differences in the locomotor stimulant effects of both single and daily administration of phencyclidine were investigated in four inbred strains of male mice A/J, C57BL/6J, C57BL/6ByJ and BALB/cByJ. Each mouse was injected i.p. once in Experiment 1, or...

The anti-ischaemic drug, eliprodil, blocks hyperactivity induced by intra-accumbens injection of spermine.

Behavioural pharmacology

Sanger DJ, Perrault G, Audi E.
PMID: 11224359
Behav Pharmacol. 1995 Aug;6(5):520-526.

NMDA receptor mechanisms in the nucleus accumbens play an important role in the control of locomotor activity. Among the several binding sites associated with these receptors, the polyamine-sensitive sites have received relatively little attention. It has recently been shown,...

Examination of phencyclidine hydrochloride via cryogenic terahertz spectroscopy, solid-state density functional theory, and X-ray diffraction.

The journal of physical chemistry. A

Hakey PM, Hudson MR, Allis DG, Ouellette W, Korter TM.
PMID: 19817468
J Phys Chem A. 2009 Nov 19;113(46):13013-22. doi: 10.1021/jp907083u.

The terahertz (THz) spectrum of phencyclidine hydrochloride from 7.0 to 100.0 cm(-1) has been measured at cryogenic (78.4 K) temperature. The complete structural analysis and vibrational assignment of the compound have been performed employing solid-state density functional theory utilizing...

Involvement of glutamate receptor subtypes in l-[(3)H]noradrenaline release from cerebral cortical and hippocampal slices of mice.

Neurochemistry international

Zhao XH, Kitamura Y, Nomura Y.
PMID: 20504535
Neurochem Int. 1990;16(1):11-6. doi: 10.1016/0197-0186(90)90118-d.

The effects of glutamate receptor agonists and antagonists on l-[(3)H]noradrenaline (NA) release were examined in cerebral cortical and hippocampal slices of mice by superfusion methods. N- Methyl- d -aspartate (NMDA) at 100 ?M significantly stimulated l-[(3)H]NA release. The NMDA-induced...

Showing 1 to 12 of 225 entries