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Showing 1 to 12 of 290 entries
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The Quest for Anti-inflammatory and Anti-infective Biomaterials in Clinical Translation.

Frontiers in bioengineering and biotechnology

Griffith M, Islam MM, Edin J, Papapavlou G, Buznyk O, Patra HK.
PMID: 27668213
Front Bioeng Biotechnol. 2016 Sep 09;4:71. doi: 10.3389/fbioe.2016.00071. eCollection 2016.

Biomaterials are now being used or evaluated clinically as implants to supplement the severe shortage of available human donor organs. To date, however, such implants have mainly been developed as scaffolds to promote the regeneration of failing organs due...

Phosphatidate phosphatase of dermatophytes.

Lipids

Kasinathan C, Chopra A, Khuller GK.
PMID: 27519433
Lipids. 1982 Dec;17(12):859-63. doi: 10.1007/BF02534579.

Phosphatidate phosphatase (EC 3.1.3.4) was detected in filamentous pathogenic fungi. In both dermatophytes,Microsporum gypseum andEpidermophyton floccosum, the enzyme was located in the mitochondrial and microsomal subcellular fractions with a pH optimum of 6.0. TheE. floccosum enzyme was more active...

IgM phosphorylcholine antibodies inhibit cell death and constitute a strong protection marker for atherosclerosis development, particularly in combination with other auto-antibodies against modified LDL.

Results in immunology

Fiskesund R, Su J, Bulatovic I, Vikström M, de Faire U, Frostegård J.
PMID: 24371562
Results Immunol. 2012 Jan 08;2:13-8. doi: 10.1016/j.rinim.2012.01.001. eCollection 2012.

BACKGROUND: We have reported that anti-phosphorylcholine (anti-PC) IgM is a protection marker for human cardiovascular disease (CVD) and atherosclerosis. We here investigate the anti-PC autoantibodies in a well-defined cohort with regard to idiotype, atherosclerosis progression and mechanisms for its...

Antimicrobial Silver Nanoclusters Bearing Biocompatible Phosphorylcholine-Based Zwitterionic Protection.

Bioconjugate chemistry

Sangsuwan A, Kawasaki H, Matsumura Y, Iwasaki Y.
PMID: 27689806
Bioconjug Chem. 2016 Oct 19;27(10):2527-2533. doi: 10.1021/acs.bioconjchem.6b00455. Epub 2016 Oct 07.

Infection is one of the most serious issues in medical treatments leading to the development of several antimicrobial agents. In particular, silver ions released from silver substrates is well-known as a reliable antimicrobial agent that either kills the microorganisms...

Corrigendum to "Epicutaneous immunization with phosphorylcholine conjugated to bovine serum albumin (PC-BSA) and TLR9 ligand CpG alleviates pneumococcal pneumonia in mice" [Pharmacol. Rep. 66 (2014) 570-575].

Pharmacological reports : PR

Majewska-Szczepanik M, Yamamoto N, Askenase PW, Szczepanik M.
PMID: 28365257
Pharmacol Rep. 2017 Jun;69(3):584. doi: 10.1016/j.pharep.2017.01.014. Epub 2017 Mar 29.

No abstract available.

Diffusion-Induced Hydrophilic Conversion of Polydimethylsiloxane/Block-Type Phospholipid Polymer Hybrid Substrate for Temporal Cell-Adhesive Surface.

ACS applied materials & interfaces

Seo JH, Ishihara K.
PMID: 27488537
ACS Appl Mater Interfaces. 2016 Aug 24;8(33):21839-46. doi: 10.1021/acsami.6b07414. Epub 2016 Aug 12.

In this study, diffusion-induced hydrophobic-hydrophilic conversion of the surface of the cross-linked polydimethylsiloxane (PDMS) substrate was realized by employing a simple swelling-deswelling process of PDMS substrate in a block-type polymer solution with the aim of development of a temporal...

Nonpolymeric Coatings of Iron Oxide Colloids for Biological Use as Magnetic Resonance Imaging Contrast Agents.

Journal of colloid and interface science

Portet D, Denizot B, Rump E, Lejeune JJ, Jallet P.
PMID: 11350133
J Colloid Interface Sci. 2001 Jun 01;238(1):37-42. doi: 10.1006/jcis.2001.7500.

Iron oxide nanoparticles are used in vivo as contrast agents in magnetic resonance imaging. Their widely used polymer coatings are directly involved in their biocompatibility and avoid magnetic aggregation. As these polymer brushes also limit their tissular diffusion due...

Multicenter evaluation of the phosphorylcholine-coated biodivYsio stent in short de novo coronary lesions: The SOPHOS study.

International journal of cardiovascular interventions

Boland JL, Corbeij HA, Van Der Giessen W, Seabra-Gomes R, Suryapranata H, Wijns W, Hanet C, Suttorp MJ, Buller C, Bonnier JJ, Colombo A, Van Birgelen C, Pieper M, Mangioni JA, Londero H, Carere RG, Hamm CW, Bonan R, Bartorelli A, Kyriakides ZS, Chauhan A, Rothman M, Grinfeld L, Oosterwijk C, Serruys PW, Cumberland DC.
PMID: 12431346
Int J Cardiovasc Intervent. 2000 Dec;3(4):215-225. doi: 10.1080/14628840050515966.

AIMS: The BiodivYsio trade mark stent (Biocompatibles Ltd, Farnham, UK) is coated with a phosphorylcholine (PC)-containing copolymer to confer biocompatibility. The SOPHOS (Study Of PHosphorylcholine coating On Stents) study was designed to assess the safety and efficacy of this...

Effects of phospholipids on sphingomyelin hydrolysis induced by intestinal alkaline sphingomyelinase: an in vitro study.

The Journal of nutritional biochemistry

Liu JJ, Nilsson A, Duan RD.
PMID: 10827341
J Nutr Biochem. 2000 Apr;11(4):192-7. doi: 10.1016/s0955-2863(00)00064-4.

Digestion of dietary sphingomyelin (SM) is catalyzed by intestinal alkaline sphingomyelinase (SMase) and may have important implications in colonic tumorigenesis. Previous studies demonstrated that the digestion and absorption of dietary SM was slow and incomplete and that the colon...

Phosphorylcholine-based polymer coatings for stent drug delivery.

Journal of materials science. Materials in medicine

Lewis AL, Vick TA, Collias AC, Hughes LG, Palmer RR, Leppard SW, Furze JD, Taylor AS, Stratford PW.
PMID: 15348331
J Mater Sci Mater Med. 2001 Oct-Dec;12(10):865-70. doi: 10.1023/a:1012803503667.

Phosphorylcholine-based polymers have been used commercially to improve the biocompatibility of coronary stents. In this study, one particular polymer is assessed for its suitability as a drug delivery vehicle. Membranes of the material are characterized in terms of water...

Effect of gibberellin a(3) on the endoplasmic reticulum and on the formation of glyoxysomes in the endosperm of germinating castor bean.

Plant physiology

González E.
PMID: 16660535
Plant Physiol. 1978 Sep;62(3):449-53. doi: 10.1104/pp.62.3.449.

Seedlings of castor bean (Ricinus communis cv. Hale) were exposed to a range of concentrations of gibberellin A(3) (GA(3)). Treatments for 20 hours with GA(3) concentrations of 0.5 muM or higher resulted in increased levels of NADH-cytochrome c reductase,...

The development of in vitro biocompatibility tests for the evaluation of intraocular biomaterials.

Journal of materials science. Materials in medicine

Lloyd AW, Dropcova S, Faragher RG, Gard PR, Hanlon GW, Mikhalovsky SV, Olliff CJ, Denyer SP, Letko E, Filipec M.
PMID: 15347976
J Mater Sci Mater Med. 1999 Oct-Nov;10(10):621-7. doi: 10.1023/a:1008935707910.

Recent developments in ocular implant technology require the in vitro evaluation of ocular compatibility in early stage development programs. This requires an understanding and appreciation of the biological interactions which occur in the ocular environment and their relevance with...

Showing 1 to 12 of 290 entries