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Showing 1 to 12 of 95 entries
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The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression.

American journal of translational research

Cai N, Zhou W, Ye LL, Chen J, Liang QN, Chang G, Chen JJ.
PMID: 28861175
Am J Transl Res. 2017 Aug 15;9(8):3853-3866. eCollection 2017.

Currently, there is a considerable need to develop new treatments for osteosarcoma (OS), a very aggressive bone cancer. The activation of STAT3 signaling is positively associated with poor prognosis and aggressive progression in OS patients. Our previous study reported...

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Cai N, Zhou W, Ye LL, et al. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017;9(8):3853-3866
Cai, N., Zhou, W., Ye, L. L., Chen, J., Liang, Q. N., Chang, G., & Chen, J. J. (2017). The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. American journal of translational research, 9(8), 3853-3866.
Cai, Nan, et al. "The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression." American journal of translational research vol. 9,8 (2017): 3853-3866.
Cai N, Zhou W, Ye LL, Chen J, Liang QN, Chang G, Chen JJ. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017 Aug 15;9(8):3853-3866. eCollection 2017. PMID: 28861175; PMCID: PMC5575198.
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Effects of amphetamine and pimozide on reinforcement and motor parameters in variable-interval performance.

Journal of psychopharmacology (Oxford, England)

Willner P, Towell A, Muscat R.
PMID: 22158977
J Psychopharmacol. 1987 Jan;1(3):140-53. doi: 10.1177/026988118700100302.

The effects of amphetamine and pimozide were studied in rats performing on variable-interval (VI) schedules of reinforcement. In experiment 1, a five-component multiple VI schedule was used; in experiments 2 and 3, two VI schedules were presented on alternate...

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Willner P, Towell A, Muscat R. Effects of amphetamine and pimozide on reinforcement and motor parameters in variable-interval performance. J Psychopharmacol. 1987;1(3):140-53doi: 10.1177/026988118700100302.
Willner, P., Towell, A., & Muscat, R. (1987). Effects of amphetamine and pimozide on reinforcement and motor parameters in variable-interval performance. Journal of psychopharmacology (Oxford, England), 1(3), 140-53. https://doi.org/10.1177/026988118700100302
Willner, P, et al. "Effects of amphetamine and pimozide on reinforcement and motor parameters in variable-interval performance." Journal of psychopharmacology (Oxford, England) vol. 1,3 (1987): 140-53. doi: https://doi.org/10.1177/026988118700100302
Willner P, Towell A, Muscat R. Effects of amphetamine and pimozide on reinforcement and motor parameters in variable-interval performance. J Psychopharmacol. 1987 Jan;1(3):140-53. doi: 10.1177/026988118700100302. PMID: 22158977.
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A drug utilization study of psychotropic drugs prescribed in the psychiatry outpatient department of a tertiary care hospital.

Journal of clinical and diagnostic research : JCDR

Thakkar KB, Jain MM, Billa G, Joshi A, Khobragade AA.
PMID: 24551631
J Clin Diagn Res. 2013 Dec;7(12):2759-64. doi: 10.7860/JCDR/2013/6760.3885. Epub 2013 Dec 15.

BACKGROUND: Psychiatric disorders are one of the major causes of morbidity. Development of newer drugs like SSRIs and atypical antipsychotics has altered the treatment paradigms. Various factors like cost of drugs, local paradigms, etc. play a role in the...

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Thakkar KB, Jain MM, Billa G, et al. A drug utilization study of psychotropic drugs prescribed in the psychiatry outpatient department of a tertiary care hospital. J Clin Diagn Res. 2013;7(12):2759-64doi: 10.7860/JCDR/2013/6760.3885.
Thakkar, K. B., Jain, M. M., Billa, G., Joshi, A., & Khobragade, A. A. (2013). A drug utilization study of psychotropic drugs prescribed in the psychiatry outpatient department of a tertiary care hospital. Journal of clinical and diagnostic research : JCDR, 7(12), 2759-64. https://doi.org/10.7860/JCDR/2013/6760.3885
Thakkar, Karan B, et al. "A drug utilization study of psychotropic drugs prescribed in the psychiatry outpatient department of a tertiary care hospital." Journal of clinical and diagnostic research : JCDR vol. 7,12 (2013): 2759-64. doi: https://doi.org/10.7860/JCDR/2013/6760.3885
Thakkar KB, Jain MM, Billa G, Joshi A, Khobragade AA. A drug utilization study of psychotropic drugs prescribed in the psychiatry outpatient department of a tertiary care hospital. J Clin Diagn Res. 2013 Dec;7(12):2759-64. doi: 10.7860/JCDR/2013/6760.3885. Epub 2013 Dec 15. PMID: 24551631; PMCID: PMC3919294.
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Open study to determine appropriate maintenance dosage of pimozide in patients with chronic schizophrenia.

Proceedings of the Royal Society of Medicine

Barnes TR, Roy DH, Gaind R.
PMID: 20919318
Proc R Soc Med. 1977;70:44-7.

No abstract available.

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Barnes TR, Roy DH, Gaind R. Open study to determine appropriate maintenance dosage of pimozide in patients with chronic schizophrenia. Proc R Soc Med. 1977;70:44-7
Barnes, T. R., Roy, D. H., & Gaind, R. (1977). Open study to determine appropriate maintenance dosage of pimozide in patients with chronic schizophrenia. Proceedings of the Royal Society of Medicine, 7044-7.
Barnes, T R, et al. "Open study to determine appropriate maintenance dosage of pimozide in patients with chronic schizophrenia." Proceedings of the Royal Society of Medicine vol. 70 (1977): 44-7.
Barnes TR, Roy DH, Gaind R. Open study to determine appropriate maintenance dosage of pimozide in patients with chronic schizophrenia. Proc R Soc Med. 1977;70:44-7. PMID: 20919318; PMCID: PMC1542818.
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Pimozide in withdrawn chronic schizophrenics: preliminary observations.

Proceedings of the Royal Society of Medicine

Freeman HL, Cheadle AJ.
PMID: 20919319
Proc R Soc Med. 1977;70:48-9.

No abstract available.

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Freeman HL, Cheadle AJ. Pimozide in withdrawn chronic schizophrenics: preliminary observations. Proc R Soc Med. 1977;70:48-9
Freeman, H. L., & Cheadle, A. J. (1977). Pimozide in withdrawn chronic schizophrenics: preliminary observations. Proceedings of the Royal Society of Medicine, 7048-9.
Freeman, H L, and Cheadle, A J. "Pimozide in withdrawn chronic schizophrenics: preliminary observations." Proceedings of the Royal Society of Medicine vol. 70 (1977): 48-9.
Freeman HL, Cheadle AJ. Pimozide in withdrawn chronic schizophrenics: preliminary observations. Proc R Soc Med. 1977;70:48-9. PMID: 20919319; PMCID: PMC1542814.
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In Vivo Effects of Dopamine and Dopaminergic Antagonists on Testicular Maturation in the Red Swamp Crayfish, Procambarus clarkii.

The Biological bulletin

Sarojini R, Nagabhushanam R, Fingerman M.
PMID: 29244575
Biol Bull. 1995 Dec;189(3):340-346. doi: 10.2307/1542151.

In vivo, dopamine (DA) inhibits testicular maturation in the red swamp crayfish, Procambarus clarkii. Crayfish given DA injections had a smaller testicular index, smaller testicular lobes, fewer mature sperm, and less-well-developed androgenic glands than did the control crayfish given...

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Sarojini R, Nagabhushanam R, Fingerman M. In Vivo Effects of Dopamine and Dopaminergic Antagonists on Testicular Maturation in the Red Swamp Crayfish, Procambarus clarkii. Biol Bull. 1995;189(3):340-346doi: 10.2307/1542151.
Sarojini, R., Nagabhushanam, R., & Fingerman, M. (1995). In Vivo Effects of Dopamine and Dopaminergic Antagonists on Testicular Maturation in the Red Swamp Crayfish, Procambarus clarkii. The Biological bulletin, 189(3), 340-346. https://doi.org/10.2307/1542151
Sarojini, R, et al. "In Vivo Effects of Dopamine and Dopaminergic Antagonists on Testicular Maturation in the Red Swamp Crayfish, Procambarus clarkii." The Biological bulletin vol. 189,3 (1995): 340-346. doi: https://doi.org/10.2307/1542151
Sarojini R, Nagabhushanam R, Fingerman M. In Vivo Effects of Dopamine and Dopaminergic Antagonists on Testicular Maturation in the Red Swamp Crayfish, Procambarus clarkii. Biol Bull. 1995 Dec;189(3):340-346. doi: 10.2307/1542151. PMID: 29244575.
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STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma.

Oncotarget

Simpson HM, Furusawa A, Sadashivaiah K, Civin CI, Banerjee A.
PMID: 29682185
Oncotarget. 2018 Mar 30;9(24):16792-16806. doi: 10.18632/oncotarget.24698. eCollection 2018 Mar 30.

Peripheral T-cell lymphoma (PTCL) is a rare, aggressive, heterogeneous, Non-Hodgkin's lymphoma with poor prognosis and inadequate response to current therapies. Recent sequencing studies indicate a prevalence of activating mutations in the JAK/STAT signaling pathway. Oncogenic mutations in STAT5B, observed...

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Simpson HM, Furusawa A, Sadashivaiah K, et al. STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma. Oncotarget. 2018;9(24):16792-16806doi: 10.18632/oncotarget.24698.
Simpson, H. M., Furusawa, A., Sadashivaiah, K., Civin, C. I., & Banerjee, A. (2018). STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma. Oncotarget, 9(24), 16792-16806. https://doi.org/10.18632/oncotarget.24698
Simpson, Haley M, et al. "STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma." Oncotarget vol. 9,24 (2018): 16792-16806. doi: https://doi.org/10.18632/oncotarget.24698
Simpson HM, Furusawa A, Sadashivaiah K, Civin CI, Banerjee A. STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma. Oncotarget. 2018 Mar 30;9(24):16792-16806. doi: 10.18632/oncotarget.24698. eCollection 2018 Mar 30. PMID: 29682185; PMCID: PMC5908286.
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[No title available]

Frontiers in microbiology

Mellini M, Di Muzio E, D'Angelo F, Baldelli V, Ferrillo S, Visca P, Leoni L, Polticelli F, Rampioni G.
PMID: 31649658
Front Microbiol. 2019 Oct 10;10:2355. doi: 10.3389/fmicb.2019.02355. eCollection 2019.

The emergence of antibiotic resistant bacterial pathogens is increasing at an unprecedented pace, calling for the development of new therapeutic options. Small molecules interfering with virulence processes rather than growth hold promise as an alternative to conventional antibiotics. Anti-virulence...

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Mellini M, Di Muzio E, D'Angelo F, et al. . Front Microbiol. 2019;10:2355doi: 10.3389/fmicb.2019.02355.
Mellini, M., Di Muzio, E., D'Angelo, F., Baldelli, V., Ferrillo, S., Visca, P., Leoni, L., Polticelli, F., & Rampioni, G. (2019). . Frontiers in microbiology, 102355. https://doi.org/10.3389/fmicb.2019.02355
Mellini, Marta, et al. "." Frontiers in microbiology vol. 10 (2019): 2355. doi: https://doi.org/10.3389/fmicb.2019.02355
Mellini M, Di Muzio E, D'Angelo F, Baldelli V, Ferrillo S, Visca P, Leoni L, Polticelli F, Rampioni G. . Front Microbiol. 2019 Oct 10;10:2355. doi: 10.3389/fmicb.2019.02355. eCollection 2019. PMID: 31649658; PMCID: PMC6796623.
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Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia.

Antioxidants (Basel, Switzerland)

Wang Z, Mi T, Bradley HL, Metts J, Sabnis H, Zhu W, Arbiser J, Bunting KD.
PMID: 34203664
Antioxidants (Basel). 2021 Jun 15;10(6). doi: 10.3390/antiox10060956.

Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathways has been difficult. Recent success in the development...

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Wang Z, Mi T, Bradley HL, et al. Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia. Antioxidants (Basel). 2021;10(6)doi: 10.3390/antiox10060956.
Wang, Z., Mi, T., Bradley, H. L., Metts, J., Sabnis, H., Zhu, W., Arbiser, J., & Bunting, K. D. (2021). Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia. Antioxidants (Basel, Switzerland), 10(6), . https://doi.org/10.3390/antiox10060956
Wang, Zhengqi, et al. "Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia." Antioxidants (Basel, Switzerland) vol. 10,6 (2021). doi: https://doi.org/10.3390/antiox10060956
Wang Z, Mi T, Bradley HL, Metts J, Sabnis H, Zhu W, Arbiser J, Bunting KD. Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia. Antioxidants (Basel). 2021 Jun 15;10(6). doi: 10.3390/antiox10060956. PMID: 34203664; PMCID: PMC8232307.
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STAT5 inhibitor Pimozide as a probable therapeutic option in overcoming Ponatinib resistance in K562 leukemic cells.

Journal of biomolecular structure & dynamics

Gumus N, Gunduz C, Tezcanli Kaymaz B.
PMID: 34842047
J Biomol Struct Dyn. 2021 Nov 28;1-14. doi: 10.1080/07391102.2021.2004924. Epub 2021 Nov 28.

Signal Transducer and Activator of Transcription 5 (STAT5) is a transcription factor that plays a key role in neoplasia, triggered by the fusion oncogene BCR-ABL1; it is not only an essential protein for the pathogenesis of chronic myeloid leukemia...

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Gumus N, Gunduz C, Tezcanli Kaymaz B. STAT5 inhibitor Pimozide as a probable therapeutic option in overcoming Ponatinib resistance in K562 leukemic cells. J Biomol Struct Dyn. 2021;1-14doi: 10.1080/07391102.2021.2004924.
Gumus, N., Gunduz, C., & Tezcanli Kaymaz, B. (2021). STAT5 inhibitor Pimozide as a probable therapeutic option in overcoming Ponatinib resistance in K562 leukemic cells. Journal of biomolecular structure & dynamics, 1-14. https://doi.org/10.1080/07391102.2021.2004924
Gumus, Nurcan, et al. "STAT5 inhibitor Pimozide as a probable therapeutic option in overcoming Ponatinib resistance in K562 leukemic cells." Journal of biomolecular structure & dynamics vol. (2021): 1-14. doi: https://doi.org/10.1080/07391102.2021.2004924
Gumus N, Gunduz C, Tezcanli Kaymaz B. STAT5 inhibitor Pimozide as a probable therapeutic option in overcoming Ponatinib resistance in K562 leukemic cells. J Biomol Struct Dyn. 2021 Nov 28;1-14. doi: 10.1080/07391102.2021.2004924. Epub 2021 Nov 28. PMID: 34842047.
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Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles.

Biological & pharmaceutical bulletin

Obara K, Matsuoka Y, Iwata N, Abe Y, Ikegami Y, Shioda N, Hattori Y, Hamamatsu S, Yoshioka K, Yamaki F, Matsuo K, Yoshio T, Tanaka Y.
PMID: 34334499
Biol Pharm Bull. 2021;44(8):1140-1150. doi: 10.1248/bpb.b21-00363.

The clinical applications of antipsychotics for symptoms unrelated to schizophrenia, such as behavioral and psychological symptoms, in patients with Alzheimer's disease, and the likelihood of doctors prescribing antipsychotics for elderly people are increasing. In elderly people, drug-induced and aging-associated...

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Obara K, Matsuoka Y, Iwata N, et al. Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles. Biol Pharm Bull. 2021;44(8):1140-1150doi: 10.1248/bpb.b21-00363.
Obara, K., Matsuoka, Y., Iwata, N., Abe, Y., Ikegami, Y., Shioda, N., Hattori, Y., Hamamatsu, S., Yoshioka, K., Yamaki, F., Matsuo, K., Yoshio, T., & Tanaka, Y. (2021). Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles. Biological & pharmaceutical bulletin, 44(8), 1140-1150. https://doi.org/10.1248/bpb.b21-00363
Obara, Keisuke, et al. "Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles." Biological & pharmaceutical bulletin vol. 44,8 (2021): 1140-1150. doi: https://doi.org/10.1248/bpb.b21-00363
Obara K, Matsuoka Y, Iwata N, Abe Y, Ikegami Y, Shioda N, Hattori Y, Hamamatsu S, Yoshioka K, Yamaki F, Matsuo K, Yoshio T, Tanaka Y. Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles. Biol Pharm Bull. 2021;44(8):1140-1150. doi: 10.1248/bpb.b21-00363. PMID: 34334499.
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The antipsychotic drug pimozide is effective against human T-cell leukemia virus type 1-infected T cells.

European journal of pharmacology

Ishikawa C, Mori N.
PMID: 34303663
Eur J Pharmacol. 2021 Oct 05;908:174373. doi: 10.1016/j.ejphar.2021.174373. Epub 2021 Jul 22.

Patients with adult T-cell leukemia (ATL), caused by the human T-cell leukemia virus type 1 (HTLV-1), exhibit poor prognosis owing to drug resistance. Pimozide is a dopamine D2 receptor antagonist and antipsychotic shown to exhibit anticancer activity. Herein, we...

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Ishikawa C, Mori N. The antipsychotic drug pimozide is effective against human T-cell leukemia virus type 1-infected T cells. Eur J Pharmacol. 2021;908:174373doi: 10.1016/j.ejphar.2021.174373.
Ishikawa, C., & Mori, N. (2021). The antipsychotic drug pimozide is effective against human T-cell leukemia virus type 1-infected T cells. European journal of pharmacology, 908174373. https://doi.org/10.1016/j.ejphar.2021.174373
Ishikawa, Chie, and Mori, Naoki. "The antipsychotic drug pimozide is effective against human T-cell leukemia virus type 1-infected T cells." European journal of pharmacology vol. 908 (2021): 174373. doi: https://doi.org/10.1016/j.ejphar.2021.174373
Ishikawa C, Mori N. The antipsychotic drug pimozide is effective against human T-cell leukemia virus type 1-infected T cells. Eur J Pharmacol. 2021 Oct 05;908:174373. doi: 10.1016/j.ejphar.2021.174373. Epub 2021 Jul 22. PMID: 34303663.
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Showing 1 to 12 of 95 entries