Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 106 entries
Sorted by: Best Match Show Resources per page
Treatment of filariasis-diethylcarbamazine and its congeners.

Pharmaceutical research

Sharma S.
PMID: 24271464
Pharm Res. 1986 Apr;3(2):75-80. doi: 10.1023/A:1016385118265.

Structural modifications of diethylcarbamazine (DEC), a drug of choice for treating different forms of human filariasis, are analyzed in order to delineate structure-activity relationships among various piperazine and nonpiperazine DEC analogues. The acyclic congeners of DEC do not possess...

Cite
Sharma S. Treatment of filariasis-diethylcarbamazine and its congeners. Pharm Res. 1986;3(2):75-80doi: 10.1023/A:1016385118265.
Sharma, S. (1986). Treatment of filariasis-diethylcarbamazine and its congeners. Pharmaceutical research, 3(2), 75-80. https://doi.org/10.1023/A:1016385118265
Sharma, S. "Treatment of filariasis-diethylcarbamazine and its congeners." Pharmaceutical research vol. 3,2 (1986): 75-80. doi: https://doi.org/10.1023/A:1016385118265
Sharma S. Treatment of filariasis-diethylcarbamazine and its congeners. Pharm Res. 1986 Apr;3(2):75-80. doi: 10.1023/A:1016385118265. PMID: 24271464.
Copy Download .nbib Format: NLM
Tandem oxidation processes for the preparation of nitrogen-containing heteroaromatic and heterocyclic compounds.

Organic & biomolecular chemistry

Raw SA, Wilfred CD, Taylor RJ.
PMID: 14985820
Org Biomol Chem. 2004 Mar 07;2(5):788-96. doi: 10.1039/b315689c. Epub 2004 Feb 11.

alpha-hydroxy ketones undergo manganese dioxide-mediated oxidation followed by in situ trapping with aromatic or aliphatic 1,2-diamines to give quinoxalines or dihydropyrazines, respectively, in a one-pot procedure which avoids the need to isolate the highly reactive dicarbonyl intermediates. The scope...

Cite
Raw SA, Wilfred CD, Taylor RJ. Tandem oxidation processes for the preparation of nitrogen-containing heteroaromatic and heterocyclic compounds. Org Biomol Chem. 2004;2(5):788-96doi: 10.1039/b315689c.
Raw, S. A., Wilfred, C. D., & Taylor, R. J. (2004). Tandem oxidation processes for the preparation of nitrogen-containing heteroaromatic and heterocyclic compounds. Organic & biomolecular chemistry, 2(5), 788-96. https://doi.org/10.1039/b315689c
Raw, Steven A, et al. "Tandem oxidation processes for the preparation of nitrogen-containing heteroaromatic and heterocyclic compounds." Organic & biomolecular chemistry vol. 2,5 (2004): 788-96. doi: https://doi.org/10.1039/b315689c
Raw SA, Wilfred CD, Taylor RJ. Tandem oxidation processes for the preparation of nitrogen-containing heteroaromatic and heterocyclic compounds. Org Biomol Chem. 2004 Mar 07;2(5):788-96. doi: 10.1039/b315689c. Epub 2004 Feb 11. PMID: 14985820.
Copy Download .nbib Format: NLM
Stereoselective Synthesis of Saturated Heterocycles via Pd-Catalyzed Alkene Carboetherification and Carboamination Reactions.

Synlett : accounts and rapid communications in synthetic organic chemistry

Wolfe JP.
PMID: 19183704
Synlett. 2006 Nov 13;2007(4):571-582. doi: 10.1002/ejoc.200600767.

The development of Pd-catalyzed carboetherification and carboamination reactions between aryl/alkenyl halides and alkenes bearing pendant heteroatoms is described. These transformations effect the stereoselective construction of useful heterocycles such as tetrahydrofurans, pyrrolidines, imidazolidin-2-ones, isoxazolidines, and piperazines. The scope, limitations, and...

Cite
Wolfe JP. Stereoselective Synthesis of Saturated Heterocycles via Pd-Catalyzed Alkene Carboetherification and Carboamination Reactions. Synlett. 2006;2007(4):571-582doi: 10.1002/ejoc.200600767.
Wolfe, J. P. (2006). Stereoselective Synthesis of Saturated Heterocycles via Pd-Catalyzed Alkene Carboetherification and Carboamination Reactions. Synlett : accounts and rapid communications in synthetic organic chemistry, 2007(4), 571-582. https://doi.org/10.1002/ejoc.200600767
Wolfe, John P. "Stereoselective Synthesis of Saturated Heterocycles via Pd-Catalyzed Alkene Carboetherification and Carboamination Reactions." Synlett : accounts and rapid communications in synthetic organic chemistry vol. 2007,4 (2006): 571-582. doi: https://doi.org/10.1002/ejoc.200600767
Wolfe JP. Stereoselective Synthesis of Saturated Heterocycles via Pd-Catalyzed Alkene Carboetherification and Carboamination Reactions. Synlett. 2006 Nov 13;2007(4):571-582. doi: 10.1002/ejoc.200600767. PMID: 19183704; PMCID: PMC2633094.
Copy Download .nbib Format: NLM
Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production.

The Journal of organic chemistry

Reddy Guduru SK, Chamakuri S, Raji IO, MacKenzie KR, Santini C, Young DW.
PMID: 30180575
J Org Chem. 2018 Oct 05;83(19):11777-11793. doi: 10.1021/acs.joc.8b01708. Epub 2018 Sep 18.

The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring nitrogen substitutions, leaving the four carbon atoms underutilized. Using an efficient six-step synthesis, chiral amino acids were...

Cite
Reddy Guduru SK, Chamakuri S, Raji IO, et al. Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018;83(19):11777-11793doi: 10.1021/acs.joc.8b01708.
Reddy Guduru, S. K., Chamakuri, S., Raji, I. O., MacKenzie, K. R., Santini, C., & Young, D. W. (2018). Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production. The Journal of organic chemistry, 83(19), 11777-11793. https://doi.org/10.1021/acs.joc.8b01708
Reddy Guduru, Shiva Krishna, et al. "Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production." The Journal of organic chemistry vol. 83,19 (2018): 11777-11793. doi: https://doi.org/10.1021/acs.joc.8b01708
Reddy Guduru SK, Chamakuri S, Raji IO, MacKenzie KR, Santini C, Young DW. Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018 Oct 05;83(19):11777-11793. doi: 10.1021/acs.joc.8b01708. Epub 2018 Sep 18. PMID: 30180575.
Copy Download .nbib Format: NLM
A structural study of 2,4-di-methyl-aniline derivatives.

Acta crystallographica. Section E, Crystallographic communications

Penner SC, Kalvandi M, Ritch JS.
PMID: 30225116
Acta Crystallogr E Crystallogr Commun. 2018 Aug 21;74:1276-1280. doi: 10.1107/S2056989018011404. eCollection 2018 Sep 01.

Crystallographic studies of nitro-gen-containing small mol-ecules aid in the elucidation of their structure-activity relationships and modes of aggregation. In this study, two previously synthesized mol-ecules are crystallographically characterized for the first time. Reaction of 2,4-di-methyl-aniline with

Cite
Penner SC, Kalvandi M, Ritch JS. A structural study of 2,4-di-methyl-aniline derivatives. Acta Crystallogr E Crystallogr Commun. 2018;74:1276-1280doi: 10.1107/S2056989018011404.
Penner, S. C., Kalvandi, M., & Ritch, J. S. (2018). A structural study of 2,4-di-methyl-aniline derivatives. Acta crystallographica. Section E, Crystallographic communications, 741276-1280. https://doi.org/10.1107/S2056989018011404
Penner, Samuel C, et al. "A structural study of 2,4-di-methyl-aniline derivatives." Acta crystallographica. Section E, Crystallographic communications vol. 74 (2018): 1276-1280. doi: https://doi.org/10.1107/S2056989018011404
Penner SC, Kalvandi M, Ritch JS. A structural study of 2,4-di-methyl-aniline derivatives. Acta Crystallogr E Crystallogr Commun. 2018 Aug 21;74:1276-1280. doi: 10.1107/S2056989018011404. eCollection 2018 Sep 01. PMID: 30225116; PMCID: PMC6127724.
Copy Download .nbib Format: NLM
Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.

ACS medicinal chemistry letters

Zhou Y, Manka JT, Rodriguez AL, Weaver CD, Days EL, Vinson PN, Jadhav S, Hermann EJ, Jones CK, Conn PJ, Lindsley CW, Stauffer SR.
PMID: 23308336
ACS Med Chem Lett. 2010 Nov 11;1(8):433-438. doi: 10.1021/ml100181a. Epub 2010 Aug 13.

This Letter describes the discovery, SAR and in vitro and in vivo pharmacological profile of a novel non-MPEP derived mGlu(5) positive allosteric modulator (PAM) based upon an N-aryl piperazine chemotype. This mGlu(5) chemotype exhibits the ability to act as...

Cite
Zhou Y, Manka JT, Rodriguez AL, et al. Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity. ACS Med Chem Lett. 2010;1(8):433-438doi: 10.1021/ml100181a.
Zhou, Y., Manka, J. T., Rodriguez, A. L., Weaver, C. D., Days, E. L., Vinson, P. N., Jadhav, S., Hermann, E. J., Jones, C. K., Conn, P. J., Lindsley, C. W., & Stauffer, S. R. (2010). Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity. ACS medicinal chemistry letters, 1(8), 433-438. https://doi.org/10.1021/ml100181a
Zhou, Ya, et al. "Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity." ACS medicinal chemistry letters vol. 1,8 (2010): 433-438. doi: https://doi.org/10.1021/ml100181a
Zhou Y, Manka JT, Rodriguez AL, Weaver CD, Days EL, Vinson PN, Jadhav S, Hermann EJ, Jones CK, Conn PJ, Lindsley CW, Stauffer SR. Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity. ACS Med Chem Lett. 2010 Nov 11;1(8):433-438. doi: 10.1021/ml100181a. Epub 2010 Aug 13. PMID: 23308336; PMCID: PMC3539763.
Copy Download .nbib Format: NLM
Twelve 4-(4-meth-oxy-phen-yl)piperazin-1-ium salts containing organic anions: supra-molecular assembly in one, two and three dimensions.

Acta crystallographica. Section E, Crystallographic communications

Kiran Kumar H, Yathirajan HS, Foro S, Glidewell C.
PMID: 31636982
Acta Crystallogr E Crystallogr Commun. 2019 Sep 20;75:1494-1506. doi: 10.1107/S2056989019012702. eCollection 2019 Oct 01.

Twelve 4-(4-meth-oxy-phen-yl)piperazin-1-ium salts containing organic anions have been prepared and structurally characterized. The monohydrated benzoate, 4-fluoro-benzoate, 4-chloro-benzoate and 4-bromo-benzoate salts, C

Cite
Kiran Kumar H, Yathirajan HS, Foro S, et al. Twelve 4-(4-meth-oxy-phen-yl)piperazin-1-ium salts containing organic anions: supra-molecular assembly in one, two and three dimensions. Acta Crystallogr E Crystallogr Commun. 2019;75:1494-1506doi: 10.1107/S2056989019012702.
Kiran Kumar, H., Yathirajan, H. S., Foro, S., & Glidewell, C. (2019). Twelve 4-(4-meth-oxy-phen-yl)piperazin-1-ium salts containing organic anions: supra-molecular assembly in one, two and three dimensions. Acta crystallographica. Section E, Crystallographic communications, 751494-1506. https://doi.org/10.1107/S2056989019012702
Kiran Kumar, Haruvegowda, et al. "Twelve 4-(4-meth-oxy-phen-yl)piperazin-1-ium salts containing organic anions: supra-molecular assembly in one, two and three dimensions." Acta crystallographica. Section E, Crystallographic communications vol. 75 (2019): 1494-1506. doi: https://doi.org/10.1107/S2056989019012702
Kiran Kumar H, Yathirajan HS, Foro S, Glidewell C. Twelve 4-(4-meth-oxy-phen-yl)piperazin-1-ium salts containing organic anions: supra-molecular assembly in one, two and three dimensions. Acta Crystallogr E Crystallogr Commun. 2019 Sep 20;75:1494-1506. doi: 10.1107/S2056989019012702. eCollection 2019 Oct 01. PMID: 31636982; PMCID: PMC6775724.
Copy Download .nbib Format: NLM
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity.

European journal of medicinal chemistry

Chiaramonte N, Angeli A, Sgambellone S, Bonardi A, Nocentini A, Bartolucci G, Braconi L, Dei S, Lucarini L, Teodori E, Gratteri P, Wünsch B, Supuran CT, Romanelli MN.
PMID: 34920169
Eur J Med Chem. 2022 Jan 15;228:114026. doi: 10.1016/j.ejmech.2021.114026. Epub 2021 Dec 04.

Targeting Carbonic Anhydrases (CAs) represents a strategy to treat several diseases, from glaucoma to cancer. To widen the structure-activity relationships (SARs) of our series of piperazines endowed with potent human carbonic anhydrase (hCA) inhibition, a new series of chiral...

Cite
Chiaramonte N, Angeli A, Sgambellone S, et al. 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2021;228:114026doi: 10.1016/j.ejmech.2021.114026.
Chiaramonte, N., Angeli, A., Sgambellone, S., Bonardi, A., Nocentini, A., Bartolucci, G., Braconi, L., Dei, S., Lucarini, L., Teodori, E., Gratteri, P., Wünsch, B., Supuran, C. T., & Romanelli, M. N. (2022). 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. European journal of medicinal chemistry, 228114026. https://doi.org/10.1016/j.ejmech.2021.114026
Chiaramonte, Niccolò, et al. "2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity." European journal of medicinal chemistry vol. 228 (2022): 114026. doi: https://doi.org/10.1016/j.ejmech.2021.114026
Chiaramonte N, Angeli A, Sgambellone S, Bonardi A, Nocentini A, Bartolucci G, Braconi L, Dei S, Lucarini L, Teodori E, Gratteri P, Wünsch B, Supuran CT, Romanelli MN. 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2022 Jan 15;228:114026. doi: 10.1016/j.ejmech.2021.114026. Epub 2021 Dec 04. PMID: 34920169.
Copy Download .nbib Format: NLM
Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library.

Bioorganic & medicinal chemistry

Chamakuri S, Chung MK, Samuel ELG, Tran KA, Chen YC, Nyshadham P, Santini C, Matzuk MM, Young DW.
PMID: 34571488
Bioorg Med Chem. 2021 Oct 15;48:116387. doi: 10.1016/j.bmc.2021.116387. Epub 2021 Sep 13.

Here we report the successful construction of a novel, stereochemically diverse DNA-Encoded Chemical Library (DECL) by utilizing 24 enantiomerically pure trifunctional 2, 6- di-substituted piperazines as central cores. We introduce the concept of positional diversity by placing the DNA...

Cite
Chamakuri S, Chung MK, Samuel ELG, et al. Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library. Bioorg Med Chem. 2021;48:116387doi: 10.1016/j.bmc.2021.116387.
Chamakuri, S., Chung, M. K., Samuel, E. L. G., Tran, K. A., Chen, Y. C., Nyshadham, P., Santini, C., Matzuk, M. M., & Young, D. W. (2021). Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library. Bioorganic & medicinal chemistry, 48116387. https://doi.org/10.1016/j.bmc.2021.116387
Chamakuri, Srinivas, et al. "Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library." Bioorganic & medicinal chemistry vol. 48 (2021): 116387. doi: https://doi.org/10.1016/j.bmc.2021.116387
Chamakuri S, Chung MK, Samuel ELG, Tran KA, Chen YC, Nyshadham P, Santini C, Matzuk MM, Young DW. Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library. Bioorg Med Chem. 2021 Oct 15;48:116387. doi: 10.1016/j.bmc.2021.116387. Epub 2021 Sep 13. PMID: 34571488.
Copy Download .nbib Format: NLM
Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs.

Forensic science international

Niebel A, Pragst F, Krumbiegel F, Hartwig S.
PMID: 34923263
Forensic Sci Int. 2021 Dec 10;331:111148. doi: 10.1016/j.forsciint.2021.111148. Epub 2021 Dec 10.

BACKGROUND: Hair analysis of parents and their children was regularly used since 2011 as a diagnostic tool in a social support project for families with known or suspected abuse of conventional illegal drugs and revealed a high incidence of...

Cite
Niebel A, Pragst F, Krumbiegel F, et al. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic Sci Int. 2021;331:111148doi: 10.1016/j.forsciint.2021.111148.
Niebel, A., Pragst, F., Krumbiegel, F., & Hartwig, S. (2021). Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic science international, 331111148. https://doi.org/10.1016/j.forsciint.2021.111148
Niebel, André, et al. "Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs." Forensic science international vol. 331 (2021): 111148. doi: https://doi.org/10.1016/j.forsciint.2021.111148
Niebel A, Pragst F, Krumbiegel F, Hartwig S. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic Sci Int. 2021 Dec 10;331:111148. doi: 10.1016/j.forsciint.2021.111148. Epub 2021 Dec 10. PMID: 34923263.
Copy Download .nbib Format: NLM
Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs.

Forensic science international

Niebel A, Pragst F, Krumbiegel F, Hartwig S.
PMID: 34923263
Forensic Sci Int. 2021 Dec 10;331:111148. doi: 10.1016/j.forsciint.2021.111148. Epub 2021 Dec 10.

BACKGROUND: Hair analysis of parents and their children was regularly used since 2011 as a diagnostic tool in a social support project for families with known or suspected abuse of conventional illegal drugs and revealed a high incidence of...

Cite
Niebel A, Pragst F, Krumbiegel F, et al. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic Sci Int. 2021;331:111148doi: 10.1016/j.forsciint.2021.111148.
Niebel, A., Pragst, F., Krumbiegel, F., & Hartwig, S. (2021). Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic science international, 331111148. https://doi.org/10.1016/j.forsciint.2021.111148
Niebel, André, et al. "Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs." Forensic science international vol. 331 (2021): 111148. doi: https://doi.org/10.1016/j.forsciint.2021.111148
Niebel A, Pragst F, Krumbiegel F, Hartwig S. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic Sci Int. 2021 Dec 10;331:111148. doi: 10.1016/j.forsciint.2021.111148. Epub 2021 Dec 10. PMID: 34923263.
Copy Download .nbib Format: NLM
Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs.

Forensic science international

Niebel A, Pragst F, Krumbiegel F, Hartwig S.
PMID: 34923263
Forensic Sci Int. 2021 Dec 10;331:111148. doi: 10.1016/j.forsciint.2021.111148. Epub 2021 Dec 10.

BACKGROUND: Hair analysis of parents and their children was regularly used since 2011 as a diagnostic tool in a social support project for families with known or suspected abuse of conventional illegal drugs and revealed a high incidence of...

Cite
Niebel A, Pragst F, Krumbiegel F, et al. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic Sci Int. 2021;331:111148doi: 10.1016/j.forsciint.2021.111148.
Niebel, A., Pragst, F., Krumbiegel, F., & Hartwig, S. (2021). Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic science international, 331111148. https://doi.org/10.1016/j.forsciint.2021.111148
Niebel, André, et al. "Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs." Forensic science international vol. 331 (2021): 111148. doi: https://doi.org/10.1016/j.forsciint.2021.111148
Niebel A, Pragst F, Krumbiegel F, Hartwig S. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic Sci Int. 2021 Dec 10;331:111148. doi: 10.1016/j.forsciint.2021.111148. Epub 2021 Dec 10. PMID: 34923263.
Copy Download .nbib Format: NLM
Showing 1 to 12 of 106 entries