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Showing 1 to 12 of 532 entries
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Precocious markers of cardiovascular risk and vascular damage in apparently healthy women with previous gestational diabetes.

Diabetology & metabolic syndrome

Zajdenverg L, Rodacki M, Faria JP, Pires ML, Oliveira JE, Halfoun VL.
PMID: 24955136
Diabetol Metab Syndr. 2014 May 26;6:63. doi: 10.1186/1758-5996-6-63. eCollection 2014.

UNLABELLED: Previous gestational diabetes mellitus (pGDM) indicates future risk for type 2 diabetes (T2DM). Insulin resistance (IR) may precede T2DM in many years and is associated with an increased risk for cardiovascular diseases.AIM: This study aims to identify endothelial...

Comparison of the Effects of Subcutaneous Versus Continuous Infusion of Heparin on Key Inflammatory Parameters Following Sepsis.

Anesthesiology and pain medicine

Nouri M, Ahmadi A, Etezadi F, Barzegar E, Mojtahedzadeh M.
PMID: 27252904
Anesth Pain Med. 2016 Apr 02;6(2):e33780. doi: 10.5812/aapm.33780. eCollection 2016 Apr.

BACKGROUND: Sepsis is the result of the interaction between inflammatory mediators and coagulation pathway. Unfractionated heparin may play a role as an anti-inflammatory agent beyond its anticoagulatory effect in sepsis. As a result, it may cause reduction in organ...

Circulating Levels of PAI-1 and SERPINE1 4G/4G Polymorphism Are Predictive of Poor Prognosis in HCC Patients Undergoing TACE.

Translational oncology

Divella R, Daniele A, Abbate I, Savino E, Casamassima P, Sciortino G, Simone G, Gadaleta-Caldarola G, Fazio V, Gadaleta CD, Sabbà C, Mazzocca A.
PMID: 26310373
Transl Oncol. 2015 Aug;8(4):273-8. doi: 10.1016/j.tranon.2015.05.002.

Although several molecular markers have been proposed as prognostic of disease progression in Hepatocellular carcinoma (HCC), predictive markers of response to treatment are still unsatisfactory. Here, we propose a genetic polymorphism as a potential predictive factor of poor prognosis...

The coagulopathy of trauma.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

Maegele M.
PMID: 26815891
Eur J Trauma Emerg Surg. 2014 Apr;40(2):113-26. doi: 10.1007/s00068-014-0389-4. Epub 2014 Mar 18.

Trauma is a leading cause of death, with uncontrolled hemorrhage and exsanguination being the primary causes of preventable deaths during the first 24 h following trauma. Death usually occurs quickly, typically within the first 6 h after injury. One...

Role of flow cytometry in multiple myeloma and the prognostic significance of CD87 (uPAR) expression.

Turkish journal of haematology : official journal of Turkish Society of Haematology

Albayrak M, Şahin Balçık Ö, Dağdaş S, Yılmaz M, Ceran F, Yokuş O, Özet G.
PMID: 27263603
Turk J Haematol. 2010 Sep 05;27(3):182-9. doi: 10.5152/tjh.2010.26.

OBJECTIVE: The plasminogen activator system consists of the serine protease urokinase plasminogen activator (uPA), two endogenous inhibitors of PAI-1 (plasminogen activator inhibitor-1) as well as the PAI-2 and uPA receptor (uPAR or CD87). The aim of this study was...

Involvement of hypoxia-inducing factor-1α-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion.

The Journal of biological chemistry

Lin MT, Kuo IH, Chang CC, Chu CY, Chen HY, Lin BR, Sureshbabu M, Shih HJ, Kuo ML.
PMID: 28039333
J Biol Chem. 2016 Dec 30;291(53):27433. doi: 10.1074/jbc.A116.708933.

No abstract available.

Circulating interleukin-8 and plasminogen activator inhibitor-1 are increased in women with ovarian carcinoma.

Results in immunology

Aune G, Stunes AK, Lian AM, Reseland JE, Tingulstad S, Torp SH, Syversen U.
PMID: 24371583
Results Immunol. 2012 Nov 02;2:190-5. doi: 10.1016/j.rinim.2012.10.003. eCollection 2012.

Elevated serum levels of several cytokines have been reported in ovarian cancer. We have previously found a diagnostic and prognostic value of hepatocyte growth factor (HGF). The aims of this study were to evaluate the diagnostic and prognostic value...

Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency.

Clinical and translational medicine

Tucker TA, Jeffers A, Boren J, Quaid B, Owens S, Koenig KB, Tsukasaki Y, Florova G, Komissarov AA, Ikebe M, Idell S.
PMID: 27271877
Clin Transl Med. 2016 Dec;5(1):17. doi: 10.1186/s40169-016-0097-2. Epub 2016 May 13.

BACKGROUND: Pleural infection affects about 65,000 patients annually in the US and UK. In this and other forms of pleural injury, mesothelial cells (PMCs) undergo a process called mesothelial (Meso) mesenchymal transition (MT), by which PMCs acquire a profibrogenic...

Short-term efficacy of recombinant human GH therapy in cured acromegaly patients with GH deficiency: a single-center experience.

Endocrine connections

Dutta P, Mahendran B, Reddy KS, Ahluwalia J, Vaiphei K, Kochhar RK, Gupta P, Srinivasan A, Prakash M, Mukherjee KK, Shah VN, Parthan G, Bhansali A.
PMID: 25600246
Endocr Connect. 2015 Mar;4(1):65-75. doi: 10.1530/EC-14-0132. Epub 2015 Jan 19.

The effectiveness and short-term safety of recombinant human GH (r-hGH) in acromegaly patients with GH deficiency (GHD) after treatment are not well established. The study includes ten subjects with acromegaly who had GHD treated with r-hGH for 6 months....

Crosstalk of Various Biomarkers That Might Provide Prompt Identification of Acute or Chronic Cardiorenal Syndromes.

Cardiorenal medicine

Tasić D, Radenkovic S, Stojanovic D, Milojkovic M, Stojanovic M, Ilic MD, Kocic G.
PMID: 26989395
Cardiorenal Med. 2016 Feb;6(2):99-107. doi: 10.1159/000437309. Epub 2015 Nov 11.

INTRODUCTION: Pathophysiological interaction between the heart and kidneys represents the basis for clinical entities called cardiorenal syndromes. The purpose of the study was to assess the relations between acute and chronic cardiorenal syndromes and biomarkers [advanced oxidation protein products,...

Effect of Fagonia arabica on thrombin induced release of t-PA and complex of PAI-1 tPA in cultured HUVE cells.

Journal of traditional and complementary medicine

Aloni PD, Nayak AR, Chaurasia SR, Deopujari JY, Chourasia C, Purohit HJ, Taori GM, Daginawala HF, Kashyap RS.
PMID: 27419084
J Tradit Complement Med. 2015 Apr 03;6(3):219-23. doi: 10.1016/j.jtcme.2015.03.002. eCollection 2016 Jul.

Fagonia arabica (FA) possesses a thrombolytic property which has been earlier reported in our laboratory. Current study was undertaken to investigate the effect of aqueous extract of FA on thrombin-induced tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1)...

Relation between osteonecrosis of the femoral head and PAI-1 4G/5G gene polymorphism: a meta-analysis.

International journal of clinical and experimental medicine

Zeng Z, Wang B, Pan H.
PMID: 26884949
Int J Clin Exp Med. 2015 Nov 15;8(11):20337-42. eCollection 2015.

OBJECTIVE: The aim of this study was to investigate the association of plasminogen activator inhibitor-1 (PAI-1) 4G/5G gene polymorphism and osteonecrosis of the femoral head (ONFH).METHODS: The pooled relative risk ratio (RR) and 95% confidence intervals (95% CI) were...

Showing 1 to 12 of 532 entries