Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 808 entries
Sorted by: Best Match Show Resources per page
A Positive Selection for Nucleoside Kinases in E. coli.

PloS one

Shelat NY, Parhi S, Ostermeier M.
PMID: 27677184
PLoS One. 2016 Sep 27;11(9):e0162921. doi: 10.1371/journal.pone.0162921. eCollection 2016.

Engineering heterologous nucleoside kinases inside E. coli is a difficult process due to the integral role nucleosides play in cell division and transcription. Nucleoside analogs are used in many kinase screens that depend on cellular metabolization of the analogs....

Cite
Shelat NY, Parhi S, Ostermeier M. A Positive Selection for Nucleoside Kinases in E. coli. PLoS One. 2016;11(9):e0162921doi: 10.1371/journal.pone.0162921.
Shelat, N. Y., Parhi, S., & Ostermeier, M. (2016). A Positive Selection for Nucleoside Kinases in E. coli. PloS one, 11(9), e0162921. https://doi.org/10.1371/journal.pone.0162921
Shelat, Nirav Y, et al. "A Positive Selection for Nucleoside Kinases in E. coli." PloS one vol. 11,9 (2016): e0162921. doi: https://doi.org/10.1371/journal.pone.0162921
Shelat NY, Parhi S, Ostermeier M. A Positive Selection for Nucleoside Kinases in E. coli. PLoS One. 2016 Sep 27;11(9):e0162921. doi: 10.1371/journal.pone.0162921. eCollection 2016. PMID: 27677184; PMCID: PMC5038940.
Copy Download .nbib Format: NLM
Study on fluorouracil-chitosan nanoparticle preparation and its antitumor effect.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Chen G, Gong R.
PMID: 27275110
Saudi Pharm J. 2016 May;24(3):250-3. doi: 10.1016/j.jsps.2016.04.008. Epub 2016 Apr 23.

To successfully prepare fluorouracil-chitosan nanoparticles, and further analyze its anti-tumor activity mechanism, this paper makes a comprehensive study of existing preparation prescription and makes a detailed analysis of fluorouracil-chitosan in vitro release and pharmacodynamic behavior of animals. Two-step synthesis...

Cite
Chen G, Gong R. Study on fluorouracil-chitosan nanoparticle preparation and its antitumor effect. Saudi Pharm J. 2016;24(3):250-3doi: 10.1016/j.jsps.2016.04.008.
Chen, G., & Gong, R. (2016). Study on fluorouracil-chitosan nanoparticle preparation and its antitumor effect. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 24(3), 250-3. https://doi.org/10.1016/j.jsps.2016.04.008
Chen, Gaimin, and Gong, Rudong. "Study on fluorouracil-chitosan nanoparticle preparation and its antitumor effect." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 24,3 (2016): 250-3. doi: https://doi.org/10.1016/j.jsps.2016.04.008
Chen G, Gong R. Study on fluorouracil-chitosan nanoparticle preparation and its antitumor effect. Saudi Pharm J. 2016 May;24(3):250-3. doi: 10.1016/j.jsps.2016.04.008. Epub 2016 Apr 23. PMID: 27275110; PMCID: PMC4881156.
Copy Download .nbib Format: NLM
Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery.

Chemical science

Zheng YR, Suntharalingam K, Johnstone TC, Lippard SJ.
PMID: 25621144
Chem Sci. 2015 Feb 01;6(2):1189-1193. doi: 10.1039/C4SC01892C.

This report presents a novel strategy that facilitates delivery of multiple, specific payloads of Pt(IV) prodrugs using a well-defined supramolecular system. This delivery system comprises a hexanuclear Pt(II) cage that can host four Pt(IV) prodrug guest molecules. Relying on...

Cite
Zheng YR, Suntharalingam K, Johnstone TC, et al. Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery. Chem Sci. 2015;6(2):1189-1193doi: 10.1039/C4SC01892C.
Zheng, Y. R., Suntharalingam, K., Johnstone, T. C., & Lippard, S. J. (2015). Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery. Chemical science, 6(2), 1189-1193. https://doi.org/10.1039/C4SC01892C
Zheng, Yao-Rong, et al. "Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery." Chemical science vol. 6,2 (2015): 1189-1193. doi: https://doi.org/10.1039/C4SC01892C
Zheng YR, Suntharalingam K, Johnstone TC, Lippard SJ. Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery. Chem Sci. 2015 Feb 01;6(2):1189-1193. doi: 10.1039/C4SC01892C. PMID: 25621144; PMCID: PMC4303084.
Copy Download .nbib Format: NLM
Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria.

Chemical communications (Cambridge, England)

Bio M, Rajaputra P, Lim I, Thapa P, Tienabeso B, Hurst RE, You Y.
PMID: 28111669
Chem Commun (Camb). 2017 Feb 07;53(11):1884-1887. doi: 10.1039/c6cc09994g. Epub 2017 Jan 23.

Photo-unclick chemistry mediates visible and near IR-controlled drug release via a singlet oxygen (SO)-cleavable linker. Due to the limited diffusion distance of SO in biological systems, a photosensitizer and the SO-cleavable linker have been conjugated in one molecule or...

Cite
Bio M, Rajaputra P, Lim I, et al. Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria. Chem Commun (Camb). 2017;53(11):1884-1887doi: 10.1039/c6cc09994g.
Bio, M., Rajaputra, P., Lim, I., Thapa, P., Tienabeso, B., Hurst, R. E., & You, Y. (2017). Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria. Chemical communications (Cambridge, England), 53(11), 1884-1887. https://doi.org/10.1039/c6cc09994g
Bio, Moses, et al. "Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria." Chemical communications (Cambridge, England) vol. 53,11 (2017): 1884-1887. doi: https://doi.org/10.1039/c6cc09994g
Bio M, Rajaputra P, Lim I, Thapa P, Tienabeso B, Hurst RE, You Y. Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria. Chem Commun (Camb). 2017 Feb 07;53(11):1884-1887. doi: 10.1039/c6cc09994g. Epub 2017 Jan 23. PMID: 28111669.
Copy Download .nbib Format: NLM
Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV.

Chemical science

Smith AAA, Zuwala K, Kryger MBL, Wohl BM, Guerrero-Sanchez C, Tolstrup M, Postma A, Zelikin AN.
PMID: 28580095
Chem Sci. 2015 Jan 01;6(1):264-269. doi: 10.1039/c4sc02754j. Epub 2014 Sep 16.

Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) represent tremendous healthcare burdens with a large proportion of patients hosting the two viruses at the same time. An altered hepatic function and immunity as well as cross-interference of drugs...

Cite
Smith AAA, Zuwala K, Kryger MBL, et al. Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV. Chem Sci. 2014;6(1):264-269doi: 10.1039/c4sc02754j.
Smith, A. A. A., Zuwala, K., Kryger, M. B. L., Wohl, B. M., Guerrero-Sanchez, C., Tolstrup, M., Postma, A., & Zelikin, A. N. (2015). Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV. Chemical science, 6(1), 264-269. https://doi.org/10.1039/c4sc02754j
Smith, Anton A A, et al. "Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV." Chemical science vol. 6,1 (2015): 264-269. doi: https://doi.org/10.1039/c4sc02754j
Smith AAA, Zuwala K, Kryger MBL, Wohl BM, Guerrero-Sanchez C, Tolstrup M, Postma A, Zelikin AN. Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV. Chem Sci. 2015 Jan 01;6(1):264-269. doi: 10.1039/c4sc02754j. Epub 2014 Sep 16. PMID: 28580095; PMCID: PMC5435870.
Copy Download .nbib Format: NLM
Glutathione Transferase (GST)-Activated Prodrugs.

Pharmaceutics

Ruzza P, Calderan A.
PMID: 24300447
Pharmaceutics. 2013 Apr 02;5(2):220-31. doi: 10.3390/pharmaceutics5020220.

Glutathione transferase (formerly GST) catalyzes the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione. Moreover, several data link the overexpression of some GSTs, in particular GSTP1-1, to both natural and acquired resistance to various structurally...

Cite
Ruzza P, Calderan A. Glutathione Transferase (GST)-Activated Prodrugs. Pharmaceutics. 2013;5(2):220-31doi: 10.3390/pharmaceutics5020220.
Ruzza, P., & Calderan, A. (2013). Glutathione Transferase (GST)-Activated Prodrugs. Pharmaceutics, 5(2), 220-31. https://doi.org/10.3390/pharmaceutics5020220
Ruzza, Paolo, and Calderan, Andrea. "Glutathione Transferase (GST)-Activated Prodrugs." Pharmaceutics vol. 5,2 (2013): 220-31. doi: https://doi.org/10.3390/pharmaceutics5020220
Ruzza P, Calderan A. Glutathione Transferase (GST)-Activated Prodrugs. Pharmaceutics. 2013 Apr 02;5(2):220-31. doi: 10.3390/pharmaceutics5020220. PMID: 24300447; PMCID: PMC3834953.
Copy Download .nbib Format: NLM
Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs.

Beilstein journal of organic chemistry

Chiodo F, Marradi M, Calvo J, Yuste E, Penadés S.
PMID: 24991287
Beilstein J Org Chem. 2014 Jun 12;10:1339-46. doi: 10.3762/bjoc.10.136. eCollection 2014.

The therapeutic approach for the treatment of HIV infection is based on the highly active antiretroviral therapy (HAART), a cocktail of antiretroviral drugs. Notwithstanding HAART has shown different drawbacks like toxic side effects and the emergence of viral multidrug...

Cite
Chiodo F, Marradi M, Calvo J, et al. Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs. Beilstein J Org Chem. 2014;10:1339-46doi: 10.3762/bjoc.10.136.
Chiodo, F., Marradi, M., Calvo, J., Yuste, E., & Penadés, S. (2014). Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs. Beilstein journal of organic chemistry, 101339-46. https://doi.org/10.3762/bjoc.10.136
Chiodo, Fabrizio, et al. "Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs." Beilstein journal of organic chemistry vol. 10 (2014): 1339-46. doi: https://doi.org/10.3762/bjoc.10.136
Chiodo F, Marradi M, Calvo J, Yuste E, Penadés S. Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs. Beilstein J Org Chem. 2014 Jun 12;10:1339-46. doi: 10.3762/bjoc.10.136. eCollection 2014. PMID: 24991287; PMCID: PMC4077455.
Copy Download .nbib Format: NLM
Synthesis of phenylazonaphtol-β-D-O-glycosides, evaluation as substrates for beta-glycosidase activity and molecular studies.

Organic and medicinal chemistry letters

Brito-Arias M, Aguilar-Lemus C, Hurtado-Ponce PB, Martínez-Barrón G, Ibañez-Hernandez M.
PMID: 24995152
Org Med Chem Lett. 2014 May 17;4:2. doi: 10.1186/2191-2858-4-2. eCollection 2014.

BACKGROUND: Phenylazonaphtol-β-D-O-glycosides are alternative substrates for the detection of enzymatic activity of β-glycosidases which are involved in various important processes. These azoic compounds are currently exploited as prodrugs for colonic disease due the presence of β-glycosidase activity in the...

Cite
Brito-Arias M, Aguilar-Lemus C, Hurtado-Ponce PB, et al. Synthesis of phenylazonaphtol-β-D-O-glycosides, evaluation as substrates for beta-glycosidase activity and molecular studies. Org Med Chem Lett. 2014;4:2doi: 10.1186/2191-2858-4-2.
Brito-Arias, M., Aguilar-Lemus, C., Hurtado-Ponce, P. B., Martínez-Barrón, G., & Ibañez-Hernandez, M. (2014). Synthesis of phenylazonaphtol-β-D-O-glycosides, evaluation as substrates for beta-glycosidase activity and molecular studies. Organic and medicinal chemistry letters, 42. https://doi.org/10.1186/2191-2858-4-2
Brito-Arias, Marco, et al. "Synthesis of phenylazonaphtol-β-D-O-glycosides, evaluation as substrates for beta-glycosidase activity and molecular studies." Organic and medicinal chemistry letters vol. 4 (2014): 2. doi: https://doi.org/10.1186/2191-2858-4-2
Brito-Arias M, Aguilar-Lemus C, Hurtado-Ponce PB, Martínez-Barrón G, Ibañez-Hernandez M. Synthesis of phenylazonaphtol-β-D-O-glycosides, evaluation as substrates for beta-glycosidase activity and molecular studies. Org Med Chem Lett. 2014 May 17;4:2. doi: 10.1186/2191-2858-4-2. eCollection 2014. PMID: 24995152; PMCID: PMC4074863.
Copy Download .nbib Format: NLM
Maintenance of glutathione levels and its importance in epigenetic regulation.

Frontiers in pharmacology

García-Giménez JL, Pallardó FV.
PMID: 24847264
Front Pharmacol. 2014 May 05;5:88. doi: 10.3389/fphar.2014.00088. eCollection 2014.

No abstract available.

Cite
García-Giménez JL, Pallardó FV. Maintenance of glutathione levels and its importance in epigenetic regulation. Front Pharmacol. 2014;5:88doi: 10.3389/fphar.2014.00088.
García-Giménez, J. L., & Pallardó, F. V. (2014). Maintenance of glutathione levels and its importance in epigenetic regulation. Frontiers in pharmacology, 588. https://doi.org/10.3389/fphar.2014.00088
García-Giménez, José L, and Pallardó, Federico V. "Maintenance of glutathione levels and its importance in epigenetic regulation." Frontiers in pharmacology vol. 5 (2014): 88. doi: https://doi.org/10.3389/fphar.2014.00088
García-Giménez JL, Pallardó FV. Maintenance of glutathione levels and its importance in epigenetic regulation. Front Pharmacol. 2014 May 05;5:88. doi: 10.3389/fphar.2014.00088. eCollection 2014. PMID: 24847264; PMCID: PMC4017153.
Copy Download .nbib Format: NLM
Intramolecular Rearrangement of α-Amino Acid Amide Derivatives of 2-Aminobenzothiazoles.

Tetrahedron letters

Pelletier JC, Velvadapu V, McDonnell ME, Wrobel JE, Reitz AB.
PMID: 25018567
Tetrahedron Lett. 2014 Jul 23;55(30):4193-4195. doi: 10.1016/j.tetlet.2014.05.046.

We have found that α-amino acid amide derivatives of 2-aminobenzothiazoles undergo a time-dependent, thermal rearrangement in which the amine group attacks the 2-position carbon of the thiazole ring to form a 5,5-spiro ring system. This is followed by sulfur...

Cite
Pelletier JC, Velvadapu V, McDonnell ME, et al. Intramolecular Rearrangement of α-Amino Acid Amide Derivatives of 2-Aminobenzothiazoles. Tetrahedron Lett. 2014;55(30):4193-4195doi: 10.1016/j.tetlet.2014.05.046.
Pelletier, J. C., Velvadapu, V., McDonnell, M. E., Wrobel, J. E., & Reitz, A. B. (2014). Intramolecular Rearrangement of α-Amino Acid Amide Derivatives of 2-Aminobenzothiazoles. Tetrahedron letters, 55(30), 4193-4195. https://doi.org/10.1016/j.tetlet.2014.05.046
Pelletier, Jeffrey C, et al. "Intramolecular Rearrangement of α-Amino Acid Amide Derivatives of 2-Aminobenzothiazoles." Tetrahedron letters vol. 55,30 (2014): 4193-4195. doi: https://doi.org/10.1016/j.tetlet.2014.05.046
Pelletier JC, Velvadapu V, McDonnell ME, Wrobel JE, Reitz AB. Intramolecular Rearrangement of α-Amino Acid Amide Derivatives of 2-Aminobenzothiazoles. Tetrahedron Lett. 2014 Jul 23;55(30):4193-4195. doi: 10.1016/j.tetlet.2014.05.046. PMID: 25018567; PMCID: PMC4090782.
Copy Download .nbib Format: NLM
An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species.

Chemistry (Weinheim an der Bergstrasse, Germany)

Seixas JD, Chaves-Ferreira M, Montes-Grajales D, Gonçalves AM, Marques AR, Saraiva LM, Olivero-Verbel J, Romão CC, Bernardes GJ.
PMID: 26316066
Chemistry. 2015 Oct 12;21(42):14708-12. doi: 10.1002/chem.201502474. Epub 2015 Aug 28.

We have designed and synthesised a [Ru(CO)3 Cl2 (NAC)] pro-drug that features an N-acetyl cysteine (NAC) ligand. This NAC carbon monoxide releasing molecule (CORM) conjugate is able to simultaneously release biologically active CO and to ablate the concurrent formation...

Cite
Seixas JD, Chaves-Ferreira M, Montes-Grajales D, et al. An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species. Chemistry. 2015;21(42):14708-12doi: 10.1002/chem.201502474.
Seixas, J. D., Chaves-Ferreira, M., Montes-Grajales, D., Gonçalves, A. M., Marques, A. R., Saraiva, L. M., Olivero-Verbel, J., Romão, C. C., & Bernardes, G. J. (2015). An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species. Chemistry (Weinheim an der Bergstrasse, Germany), 21(42), 14708-12. https://doi.org/10.1002/chem.201502474
Seixas, João D, et al. "An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 21,42 (2015): 14708-12. doi: https://doi.org/10.1002/chem.201502474
Seixas JD, Chaves-Ferreira M, Montes-Grajales D, Gonçalves AM, Marques AR, Saraiva LM, Olivero-Verbel J, Romão CC, Bernardes GJ. An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species. Chemistry. 2015 Oct 12;21(42):14708-12. doi: 10.1002/chem.201502474. Epub 2015 Aug 28. PMID: 26316066; PMCID: PMC4641457.
Copy Download .nbib Format: NLM
Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers.

Molecular therapy. Nucleic acids

Prodeus A, Abdul-Wahid A, Fischer NW, Huang EH, Cydzik M, Gariépy J.
PMID: 25919090
Mol Ther Nucleic Acids. 2015 Apr 28;4:e237. doi: 10.1038/mtna.2015.11.

Blocking the immunoinhibitory PD-1:PD-L1 pathway using monoclonal antibodies has led to dramatic clinical responses by reversing tumor immune evasion and provoking robust and durable antitumor responses. Anti-PD-1 antibodies have now been approved for the treatment of melanoma, and are...

Cite
Prodeus A, Abdul-Wahid A, Fischer NW, et al. Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers. Mol Ther Nucleic Acids. 2015;4:e237doi: 10.1038/mtna.2015.11.
Prodeus, A., Abdul-Wahid, A., Fischer, N. W., Huang, E. H., Cydzik, M., & Gariépy, J. (2015). Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers. Molecular therapy. Nucleic acids, 4e237. https://doi.org/10.1038/mtna.2015.11
Prodeus, Aaron, et al. "Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers." Molecular therapy. Nucleic acids vol. 4 (2015): e237. doi: https://doi.org/10.1038/mtna.2015.11
Prodeus A, Abdul-Wahid A, Fischer NW, Huang EH, Cydzik M, Gariépy J. Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers. Mol Ther Nucleic Acids. 2015 Apr 28;4:e237. doi: 10.1038/mtna.2015.11. PMID: 25919090; PMCID: PMC4417124.
Copy Download .nbib Format: NLM
Showing 1 to 12 of 808 entries