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Prostaglandin Pathways: Opportunities for Cancer Prevention and Therapy.

Cancer research

Wang Q, Morris RJ, Bode AM, Zhang T.
PMID: 34949672
Cancer Res. 2021 Dec 23; doi: 10.1158/0008-5472.CAN-21-2297. Epub 2021 Dec 23.

Because of profound effects observed in carcinogenesis, prostaglandins (PGs), prostaglandin-endoperoxide synthases, and PG receptors are implicated in cancer development and progression. Understanding the molecular mechanisms of PG actions has potential clinical relevance for cancer prevention and therapy. This review...

Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both .

Frontiers in neurology

Calvello R, Lofrumento DD, Perrone MG, Cianciulli A, Salvatore R, Vitale P, De Nuccio F, Giannotti L, Nicolardi G, Panaro MA, Scilimati A.
PMID: 28649222
Front Neurol. 2017 Jun 09;8:251. doi: 10.3389/fneur.2017.00251. eCollection 2017.

Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the inflammation, are the pharmacological targets of non-steroidal...

Showing 1 to 2 of 2 entries