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Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals.

BioData mining

Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, Riess H, Sivapalaratnam S, Tragante V, van Iperen EPA, Brautbar A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Larson EB, Rasmussen-Torvik LJ, Tromp G, Baumert J, Cruickshanks KJ, Farrall M, Hingorani AD, Hovingh GK, Kleber ME, Klein BE, Klein R, Koenig W, Lange LA, Mӓrz W, North KE, Charlotte Onland-Moret N, Reiner AP, Talmud PJ, van der Schouw YT, Wilson JG, Kivimaki M, Kumari M, Moore JH, Drenos F, Asselbergs FW, Keating BJ, Ritchie MD.
PMID: 28770004
BioData Min. 2017 Jul 24;10:25. doi: 10.1186/s13040-017-0145-5. eCollection 2017.

BACKGROUND: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol...

Cite
Holzinger ER, Verma SS, Moore CB, et al. Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min. 2017;10:25doi: 10.1186/s13040-017-0145-5.
Holzinger, E. R., Verma, S. S., Moore, C. B., Hall, M., De, R., Gilbert-Diamond, D., Lanktree, M. B., Pankratz, N., Amuzu, A., Burt, A., Dale, C., Dudek, S., Furlong, C. E., Gaunt, T. R., Kim, D. S., Riess, H., Sivapalaratnam, S., Tragante, V., van Iperen, E. P. A., Brautbar, A., Carrell, D. S., Crosslin, D. R., Jarvik, G. P., Kuivaniemi, H., Kullo, I. J., Larson, E. B., Rasmussen-Torvik, L. J., Tromp, G., Baumert, J., Cruickshanks, K. J., Farrall, M., Hingorani, A. D., Hovingh, G. K., Kleber, M. E., Klein, B. E., Klein, R., Koenig, W., Lange, L. A., Mӓrz, W., North, K. E., Charlotte Onland-Moret, N., Reiner, A. P., Talmud, P. J., van der Schouw, Y. T., Wilson, J. G., Kivimaki, M., Kumari, M., Moore, J. H., Drenos, F., Asselbergs, F. W., Keating, B. J., & Ritchie, M. D. (2017). Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData mining, 1025. https://doi.org/10.1186/s13040-017-0145-5
Holzinger, Emily R, et al. "Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals." BioData mining vol. 10 (2017): 25. doi: https://doi.org/10.1186/s13040-017-0145-5
Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, Riess H, Sivapalaratnam S, Tragante V, van Iperen EPA, Brautbar A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Larson EB, Rasmussen-Torvik LJ, Tromp G, Baumert J, Cruickshanks KJ, Farrall M, Hingorani AD, Hovingh GK, Kleber ME, Klein BE, Klein R, Koenig W, Lange LA, Mӓrz W, North KE, Charlotte Onland-Moret N, Reiner AP, Talmud PJ, van der Schouw YT, Wilson JG, Kivimaki M, Kumari M, Moore JH, Drenos F, Asselbergs FW, Keating BJ, Ritchie MD. Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min. 2017 Jul 24;10:25. doi: 10.1186/s13040-017-0145-5. eCollection 2017. PMID: 28770004; PMCID: PMC5525436.
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Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease.

Annals of clinical and translational neurology

Raghavan NS, Brickman AM, Andrews H, Manly JJ, Schupf N, Lantigua R, Wolock CJ, Kamalakaran S, Petrovski S, Tosto G, Vardarajan BN, Goldstein DB, Mayeux R.
PMID: 30009200
Ann Clin Transl Neurol. 2018 May 24;5(7):832-842. doi: 10.1002/acn3.582. eCollection 2018 Jul.

OBJECTIVE: The genetic bases of Alzheimer's disease remain uncertain. An international effort to fully articulate genetic risks and protective factors is underway with the hope of identifying potential therapeutic targets and preventive strategies. The goal here was to identify...

Cite
Raghavan NS, Brickman AM, Andrews H, et al. Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Ann Clin Transl Neurol. 2018;5(7):832-842doi: 10.1002/acn3.582.
Raghavan, N. S., Brickman, A. M., Andrews, H., Manly, J. J., Schupf, N., Lantigua, R., Wolock, C. J., Kamalakaran, S., Petrovski, S., Tosto, G., Vardarajan, B. N., Goldstein, D. B., Mayeux, R. (2018). Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Annals of clinical and translational neurology, 5(7), 832-842. https://doi.org/10.1002/acn3.582
Raghavan, Neha S, et al. "Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease." Annals of clinical and translational neurology vol. 5,7 (2018): 832-842. doi: https://doi.org/10.1002/acn3.582
Raghavan NS, Brickman AM, Andrews H, Manly JJ, Schupf N, Lantigua R, Wolock CJ, Kamalakaran S, Petrovski S, Tosto G, Vardarajan BN, Goldstein DB, Mayeux R. Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Ann Clin Transl Neurol. 2018 May 24;5(7):832-842. doi: 10.1002/acn3.582. eCollection 2018 Jul. PMID: 30009200; PMCID: PMC6043775.
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Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS.

Journal of Alzheimer's disease : JAD

Briceño EM, Gross AL, Giordani BJ, Manly JJ, Gottesman RF, Elkind MSV, Sidney S, Hingtgen S, Sacco RL, Wright CB, Fitzpatrick A, Fohner AE, Mosley TH, Yaffe K, Levine DA.
PMID: 34459397
J Alzheimers Dis. 2021;83(4):1803-1813. doi: 10.3233/JAD-210459.

BACKGROUND: Meta-analyses of individuals' cognitive data are increasing to investigate the biomedical, lifestyle, and sociocultural factors that influence cognitive decline and dementia risk. Pre-statistical harmonization of cognitive instruments is a critical methodological step for accurate cognitive data harmonization, yet...

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Briceño EM, Gross AL, Giordani BJ, et al. Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS. J Alzheimers Dis. 2021;83(4):1803-1813doi: 10.3233/JAD-210459.
Briceño, E. M., Gross, A. L., Giordani, B. J., Manly, J. J., Gottesman, R. F., Elkind, M. S. V., Sidney, S., Hingtgen, S., Sacco, R. L., Wright, C. B., Fitzpatrick, A., Fohner, A. E., Mosley, T. H., Yaffe, K., & Levine, D. A. (2021). Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS. Journal of Alzheimer's disease : JAD, 83(4), 1803-1813. https://doi.org/10.3233/JAD-210459
Briceño, Emily M, et al. "Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS." Journal of Alzheimer's disease : JAD vol. 83,4 (2021): 1803-1813. doi: https://doi.org/10.3233/JAD-210459
Briceño EM, Gross AL, Giordani BJ, Manly JJ, Gottesman RF, Elkind MSV, Sidney S, Hingtgen S, Sacco RL, Wright CB, Fitzpatrick A, Fohner AE, Mosley TH, Yaffe K, Levine DA. Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS. J Alzheimers Dis. 2021;83(4):1803-1813. doi: 10.3233/JAD-210459. PMID: 34459397.
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Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals.

BioData mining

Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, Riess H, Sivapalaratnam S, Tragante V, van Iperen EPA, Brautbar A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Larson EB, Rasmussen-Torvik LJ, Tromp G, Baumert J, Cruickshanks KJ, Farrall M, Hingorani AD, Hovingh GK, Kleber ME, Klein BE, Klein R, Koenig W, Lange LA, Mӓrz W, North KE, Charlotte Onland-Moret N, Reiner AP, Talmud PJ, van der Schouw YT, Wilson JG, Kivimaki M, Kumari M, Moore JH, Drenos F, Asselbergs FW, Keating BJ, Ritchie MD.
PMID: 28770004
BioData Min. 2017 Jul 24;10:25. doi: 10.1186/s13040-017-0145-5. eCollection 2017.

BACKGROUND: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol...

Cite
Holzinger ER, Verma SS, Moore CB, et al. Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min. 2017;10:25doi: 10.1186/s13040-017-0145-5.
Holzinger, E. R., Verma, S. S., Moore, C. B., Hall, M., De, R., Gilbert-Diamond, D., Lanktree, M. B., Pankratz, N., Amuzu, A., Burt, A., Dale, C., Dudek, S., Furlong, C. E., Gaunt, T. R., Kim, D. S., Riess, H., Sivapalaratnam, S., Tragante, V., van Iperen, E. P. A., Brautbar, A., Carrell, D. S., Crosslin, D. R., Jarvik, G. P., Kuivaniemi, H., Kullo, I. J., Larson, E. B., Rasmussen-Torvik, L. J., Tromp, G., Baumert, J., Cruickshanks, K. J., Farrall, M., Hingorani, A. D., Hovingh, G. K., Kleber, M. E., Klein, B. E., Klein, R., Koenig, W., Lange, L. A., Mӓrz, W., North, K. E., Charlotte Onland-Moret, N., Reiner, A. P., Talmud, P. J., van der Schouw, Y. T., Wilson, J. G., Kivimaki, M., Kumari, M., Moore, J. H., Drenos, F., Asselbergs, F. W., Keating, B. J., & Ritchie, M. D. (2017). Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData mining, 1025. https://doi.org/10.1186/s13040-017-0145-5
Holzinger, Emily R, et al. "Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals." BioData mining vol. 10 (2017): 25. doi: https://doi.org/10.1186/s13040-017-0145-5
Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, Riess H, Sivapalaratnam S, Tragante V, van Iperen EPA, Brautbar A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Larson EB, Rasmussen-Torvik LJ, Tromp G, Baumert J, Cruickshanks KJ, Farrall M, Hingorani AD, Hovingh GK, Kleber ME, Klein BE, Klein R, Koenig W, Lange LA, Mӓrz W, North KE, Charlotte Onland-Moret N, Reiner AP, Talmud PJ, van der Schouw YT, Wilson JG, Kivimaki M, Kumari M, Moore JH, Drenos F, Asselbergs FW, Keating BJ, Ritchie MD. Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min. 2017 Jul 24;10:25. doi: 10.1186/s13040-017-0145-5. eCollection 2017. PMID: 28770004; PMCID: PMC5525436.
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Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals.

BioData mining

Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, Riess H, Sivapalaratnam S, Tragante V, van Iperen EPA, Brautbar A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Larson EB, Rasmussen-Torvik LJ, Tromp G, Baumert J, Cruickshanks KJ, Farrall M, Hingorani AD, Hovingh GK, Kleber ME, Klein BE, Klein R, Koenig W, Lange LA, Mӓrz W, North KE, Charlotte Onland-Moret N, Reiner AP, Talmud PJ, van der Schouw YT, Wilson JG, Kivimaki M, Kumari M, Moore JH, Drenos F, Asselbergs FW, Keating BJ, Ritchie MD.
PMID: 28770004
BioData Min. 2017 Jul 24;10:25. doi: 10.1186/s13040-017-0145-5. eCollection 2017.

BACKGROUND: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol...

Cite
Holzinger ER, Verma SS, Moore CB, et al. Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min. 2017;10:25doi: 10.1186/s13040-017-0145-5.
Holzinger, E. R., Verma, S. S., Moore, C. B., Hall, M., De, R., Gilbert-Diamond, D., Lanktree, M. B., Pankratz, N., Amuzu, A., Burt, A., Dale, C., Dudek, S., Furlong, C. E., Gaunt, T. R., Kim, D. S., Riess, H., Sivapalaratnam, S., Tragante, V., van Iperen, E. P. A., Brautbar, A., Carrell, D. S., Crosslin, D. R., Jarvik, G. P., Kuivaniemi, H., Kullo, I. J., Larson, E. B., Rasmussen-Torvik, L. J., Tromp, G., Baumert, J., Cruickshanks, K. J., Farrall, M., Hingorani, A. D., Hovingh, G. K., Kleber, M. E., Klein, B. E., Klein, R., Koenig, W., Lange, L. A., Mӓrz, W., North, K. E., Charlotte Onland-Moret, N., Reiner, A. P., Talmud, P. J., van der Schouw, Y. T., Wilson, J. G., Kivimaki, M., Kumari, M., Moore, J. H., Drenos, F., Asselbergs, F. W., Keating, B. J., & Ritchie, M. D. (2017). Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData mining, 1025. https://doi.org/10.1186/s13040-017-0145-5
Holzinger, Emily R, et al. "Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals." BioData mining vol. 10 (2017): 25. doi: https://doi.org/10.1186/s13040-017-0145-5
Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, Riess H, Sivapalaratnam S, Tragante V, van Iperen EPA, Brautbar A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Larson EB, Rasmussen-Torvik LJ, Tromp G, Baumert J, Cruickshanks KJ, Farrall M, Hingorani AD, Hovingh GK, Kleber ME, Klein BE, Klein R, Koenig W, Lange LA, Mӓrz W, North KE, Charlotte Onland-Moret N, Reiner AP, Talmud PJ, van der Schouw YT, Wilson JG, Kivimaki M, Kumari M, Moore JH, Drenos F, Asselbergs FW, Keating BJ, Ritchie MD. Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min. 2017 Jul 24;10:25. doi: 10.1186/s13040-017-0145-5. eCollection 2017. PMID: 28770004; PMCID: PMC5525436.
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Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment.

NeuroImage. Clinical

Rajagopalan P, Jahanshad N, Stein JL, Hua X, Madsen SK, Kohannim O, Hibar DP, Toga AW, Jack CR, Saykin AJ, Green RC, Weiner MW, Bis JC, Kuller LH, Riverol M, Becker JT, Lopez OL, Thompson PM.
PMID: 24179750
Neuroimage Clin. 2012 Oct 04;1(1):179-87. doi: 10.1016/j.nicl.2012.09.012. eCollection 2012.

A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether people carrying the...

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Rajagopalan P, Jahanshad N, Stein JL, et al. Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment. Neuroimage Clin. 2012;1(1):179-87doi: 10.1016/j.nicl.2012.09.012.
Rajagopalan, P., Jahanshad, N., Stein, J. L., Hua, X., Madsen, S. K., Kohannim, O., Hibar, D. P., Toga, A. W., Jack, C. R., Saykin, A. J., Green, R. C., Weiner, M. W., Bis, J. C., Kuller, L. H., Riverol, M., Becker, J. T., Lopez, O. L., Thompson, P. M. (2012). Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment. NeuroImage. Clinical, 1(1), 179-87. https://doi.org/10.1016/j.nicl.2012.09.012
Rajagopalan, Priya, et al. "Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment." NeuroImage. Clinical vol. 1,1 (2012): 179-87. doi: https://doi.org/10.1016/j.nicl.2012.09.012
Rajagopalan P, Jahanshad N, Stein JL, Hua X, Madsen SK, Kohannim O, Hibar DP, Toga AW, Jack CR, Saykin AJ, Green RC, Weiner MW, Bis JC, Kuller LH, Riverol M, Becker JT, Lopez OL, Thompson PM. Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment. Neuroimage Clin. 2012 Oct 04;1(1):179-87. doi: 10.1016/j.nicl.2012.09.012. eCollection 2012. PMID: 24179750; PMCID: PMC3757723.
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Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences.

PLoS genetics

Zhan L, Li J, Jew B, Sul JH.
PMID: 34516545
PLoS Genet. 2021 Sep 13;17(9):e1009772. doi: 10.1371/journal.pgen.1009772. eCollection 2021 Sep.

Late-onset Alzheimer's disease (LOAD) is the most common type of dementia causing irreversible brain damage to the elderly and presents a major public health challenge. Clinical research and genome-wide association studies have suggested a potential contribution of the endocytic...

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Zhan L, Li J, Jew B, et al. Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. PLoS Genet. 2021;17(9):e1009772doi: 10.1371/journal.pgen.1009772.
Zhan, L., Li, J., Jew, B., & Sul, J. H. (2021). Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. PLoS genetics, 17(9), e1009772. https://doi.org/10.1371/journal.pgen.1009772
Zhan, Lingyu, et al. "Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences." PLoS genetics vol. 17,9 (2021): e1009772. doi: https://doi.org/10.1371/journal.pgen.1009772
Zhan L, Li J, Jew B, Sul JH. Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. PLoS Genet. 2021 Sep 13;17(9):e1009772. doi: 10.1371/journal.pgen.1009772. eCollection 2021 Sep. PMID: 34516545; PMCID: PMC8460036.
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Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Hwang PH, Longstreth WT, Thielke SM, Francis CE, Carone M, Kuller LH, Fitzpatrick AL.
PMID: 33788406
Alzheimers Dement. 2021 Sep;17(9):1442-1451. doi: 10.1002/alz.12313. Epub 2021 Mar 31.

INTRODUCTION: Ophthalmic conditions and dementia appear to overlap and may share common pathways, but research has not differentiated dementia subtypes.METHODS: Diagnoses of cataracts, age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma were based on medical histories and International...

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Hwang PH, Longstreth WT, Thielke SM, et al. Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study. Alzheimers Dement. 2021;17(9):1442-1451doi: 10.1002/alz.12313.
Hwang, P. H., Longstreth, W. T., Thielke, S. M., Francis, C. E., Carone, M., Kuller, L. H., & Fitzpatrick, A. L. (2021). Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(9), 1442-1451. https://doi.org/10.1002/alz.12313
Hwang, Phillip H, et al. "Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17,9 (2021): 1442-1451. doi: https://doi.org/10.1002/alz.12313
Hwang PH, Longstreth WT, Thielke SM, Francis CE, Carone M, Kuller LH, Fitzpatrick AL. Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study. Alzheimers Dement. 2021 Sep;17(9):1442-1451. doi: 10.1002/alz.12313. Epub 2021 Mar 31. PMID: 33788406; PMCID: PMC8527838.
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Comparing years of healthy life, measured in 16 ways, for normal weight and overweight older adults.

Journal of obesity

Diehr P, Thielke S, O'Meara E, Fitzpatrick AL, Newman A.
PMID: 22778920
J Obes. 2012;2012:894894. doi: 10.1155/2012/894894. Epub 2012 Jun 20.

Introduction. The traditional definitions of overweight and obesity are not age specific, even though the relationship of weight to mortality is different for older adults. Effects of adiposity on aspects of health beside mortality have not been well investigated....

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Diehr P, Thielke S, O'Meara E, et al. Comparing years of healthy life, measured in 16 ways, for normal weight and overweight older adults. J Obes. 2012;2012:894894doi: 10.1155/2012/894894.
Diehr, P., Thielke, S., O'Meara, E., Fitzpatrick, A. L., & Newman, A. (2012). Comparing years of healthy life, measured in 16 ways, for normal weight and overweight older adults. Journal of obesity, 2012894894. https://doi.org/10.1155/2012/894894
Diehr, Paula, et al. "Comparing years of healthy life, measured in 16 ways, for normal weight and overweight older adults." Journal of obesity vol. 2012 (2012): 894894. doi: https://doi.org/10.1155/2012/894894
Diehr P, Thielke S, O'Meara E, Fitzpatrick AL, Newman A. Comparing years of healthy life, measured in 16 ways, for normal weight and overweight older adults. J Obes. 2012;2012:894894. doi: 10.1155/2012/894894. Epub 2012 Jun 20. PMID: 22778920; PMCID: PMC3388309.
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Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease.

Annals of clinical and translational neurology

Vardarajan BN, Barral S, Jaworski J, Beecham GW, Blue E, Tosto G, Reyes-Dumeyer D, Medrano M, Lantigua R, Naj A, Thornton T, DeStefano A, Martin E, Wang LS, Brown L, Bush W, van Duijn C, Goate A, Farrer L, Haines JL, Boerwinkle E, Schellenberg G, Wijsman E, Pericak-Vance MA, Mayeux R, Wang LS.
PMID: 29688227
Ann Clin Transl Neurol. 2018 Mar 13;5(4):406-417. doi: 10.1002/acn3.537. eCollection 2018 Apr.

OBJECTIVE: To identify rare causal variants underlying known loci that segregate with late-onset Alzheimer's disease (LOAD) in multiplex families.METHODS: We analyzed whole genome sequences (WGS) from 351 members of 67 Caribbean Hispanic (CH) families from Dominican Republic and New...

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Vardarajan BN, Barral S, Jaworski J, et al. Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease. Ann Clin Transl Neurol. 2018;5(4):406-417doi: 10.1002/acn3.537.
Vardarajan, B. N., Barral, S., Jaworski, J., Beecham, G. W., Blue, E., Tosto, G., Reyes-Dumeyer, D., Medrano, M., Lantigua, R., Naj, A., Thornton, T., DeStefano, A., Martin, E., Wang, L. S., Brown, L., Bush, W., van Duijn, C., Goate, A., Farrer, L., Haines, J. L., Boerwinkle, E., Schellenberg, G., Wijsman, E., Pericak-Vance, M. A., Mayeux, R., & Wang, L. S. (2018). Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease. Annals of clinical and translational neurology, 5(4), 406-417. https://doi.org/10.1002/acn3.537
Vardarajan, Badri N, et al. "Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease." Annals of clinical and translational neurology vol. 5,4 (2018): 406-417. doi: https://doi.org/10.1002/acn3.537
Vardarajan BN, Barral S, Jaworski J, Beecham GW, Blue E, Tosto G, Reyes-Dumeyer D, Medrano M, Lantigua R, Naj A, Thornton T, DeStefano A, Martin E, Wang LS, Brown L, Bush W, van Duijn C, Goate A, Farrer L, Haines JL, Boerwinkle E, Schellenberg G, Wijsman E, Pericak-Vance MA, Mayeux R, Wang LS. Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease. Ann Clin Transl Neurol. 2018 Mar 13;5(4):406-417. doi: 10.1002/acn3.537. eCollection 2018 Apr. PMID: 29688227; PMCID: PMC5899906.
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Effect of dementia on the use of drugs for secondary prevention of ischemic heart disease.

Journal of aging research

Fowler NR, Barnato AE, Degenholtz HB, Curcio AM, Becker JT, Kuller LH, Lopez OL.
PMID: 24719764
J Aging Res. 2014;2014:897671. doi: 10.1155/2014/897671. Epub 2014 Feb 25.

Background. Dementia and cardiovascular disease (CVD) are frequently comorbid. The presence of dementia may have an effect on how CVD is treated. Objective. To examine the effect of dementia on the use of four medications recommended for secondary prevention...

Cite
Fowler NR, Barnato AE, Degenholtz HB, et al. Effect of dementia on the use of drugs for secondary prevention of ischemic heart disease. J Aging Res. 2014;2014:897671doi: 10.1155/2014/897671.
Fowler, N. R., Barnato, A. E., Degenholtz, H. B., Curcio, A. M., Becker, J. T., Kuller, L. H., & Lopez, O. L. (2014). Effect of dementia on the use of drugs for secondary prevention of ischemic heart disease. Journal of aging research, 2014897671. https://doi.org/10.1155/2014/897671
Fowler, Nicole R, et al. "Effect of dementia on the use of drugs for secondary prevention of ischemic heart disease." Journal of aging research vol. 2014 (2014): 897671. doi: https://doi.org/10.1155/2014/897671
Fowler NR, Barnato AE, Degenholtz HB, Curcio AM, Becker JT, Kuller LH, Lopez OL. Effect of dementia on the use of drugs for secondary prevention of ischemic heart disease. J Aging Res. 2014;2014:897671. doi: 10.1155/2014/897671. Epub 2014 Feb 25. PMID: 24719764; PMCID: PMC3955600.
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Genome-wide association of body fat distribution in African ancestry populations suggests new loci.

PLoS genetics

Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS.
PMID: 23966867
PLoS Genet. 2013;9(8):e1003681. doi: 10.1371/journal.pgen.1003681. Epub 2013 Aug 15.

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly...

Cite
Liu CT, Monda KL, Taylor KC, et al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681doi: 10.1371/journal.pgen.1003681.
Liu, C. T., Monda, K. L., Taylor, K. C., Lange, L., Demerath, E. W., Palmas, W., Wojczynski, M. K., Ellis, J. C., Vitolins, M. Z., Liu, S., Papanicolaou, G. J., Irvin, M. R., Xue, L., Griffin, P. J., Nalls, M. A., Adeyemo, A., Liu, J., Li, G., Ruiz-Narvaez, E. A., Chen, W. M., Chen, F., Henderson, B. E., Millikan, R. C., Ambrosone, C. B., Strom, S. S., Guo, X., Andrews, J. S., Sun, Y. V., Mosley, T. H., Yanek, L. R., Shriner, D., Haritunians, T., Rotter, J. I., Speliotes, E. K., Smith, M., Rosenberg, L., Mychaleckyj, J., Nayak, U., Spruill, I., Garvey, W. T., Pettaway, C., Nyante, S., Bandera, E. V., Britton, A. F., Zonderman, A. B., Rasmussen-Torvik, L. J., Chen, Y. D., Ding, J., Lohman, K., Kritchevsky, S. B., Zhao, W., Peyser, P. A., Kardia, S. L., Kabagambe, E., Broeckel, U., Chen, G., Zhou, J., Wassertheil-Smoller, S., Neuhouser, M. L., Rampersaud, E., Psaty, B., Kooperberg, C., Manson, J. E., Kuller, L. H., Ochs-Balcom, H. M., Johnson, K. C., Sucheston, L., Ordovas, J. M., Palmer, J. R., Haiman, C. A., McKnight, B., Howard, B. V., Becker, D. M., Bielak, L. F., Liu, Y., Allison, M. A., Grant, S. F., Burke, G. L., Patel, S. R., Schreiner, P. J., Borecki, I. B., Evans, M. K., Taylor, H., Sale, M. M., Howard, V., Carlson, C. S., Rotimi, C. N., Cushman, M., Harris, T. B., Reiner, A. P., Cupples, L. A., North, K. E., & Fox, C. S. (2013). Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS genetics, 9(8), e1003681. https://doi.org/10.1371/journal.pgen.1003681
Liu, Ching-Ti, et al. "Genome-wide association of body fat distribution in African ancestry populations suggests new loci." PLoS genetics vol. 9,8 (2013): e1003681. doi: https://doi.org/10.1371/journal.pgen.1003681
Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681. doi: 10.1371/journal.pgen.1003681. Epub 2013 Aug 15. PMID: 23966867; PMCID: PMC3744443.
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