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Liu CT, Monda KL, Taylor KC, et al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681doi: 10.1371/journal.pgen.1003681.
Liu, C. T., Monda, K. L., Taylor, K. C., Lange, L., Demerath, E. W., Palmas, W., Wojczynski, M. K., Ellis, J. C., Vitolins, M. Z., Liu, S., Papanicolaou, G. J., Irvin, M. R., Xue, L., Griffin, P. J., Nalls, M. A., Adeyemo, A., Liu, J., Li, G., Ruiz-Narvaez, E. A., Chen, W. M., Chen, F., Henderson, B. E., Millikan, R. C., Ambrosone, C. B., Strom, S. S., Guo, X., Andrews, J. S., Sun, Y. V., Mosley, T. H., Yanek, L. R., Shriner, D., Haritunians, T., Rotter, J. I., Speliotes, E. K., Smith, M., Rosenberg, L., Mychaleckyj, J., Nayak, U., Spruill, I., Garvey, W. T., Pettaway, C., Nyante, S., Bandera, E. V., Britton, A. F., Zonderman, A. B., Rasmussen-Torvik, L. J., Chen, Y. D., Ding, J., Lohman, K., Kritchevsky, S. B., Zhao, W., Peyser, P. A., Kardia, S. L., Kabagambe, E., Broeckel, U., Chen, G., Zhou, J., Wassertheil-Smoller, S., Neuhouser, M. L., Rampersaud, E., Psaty, B., Kooperberg, C., Manson, J. E., Kuller, L. H., Ochs-Balcom, H. M., Johnson, K. C., Sucheston, L., Ordovas, J. M., Palmer, J. R., Haiman, C. A., McKnight, B., Howard, B. V., Becker, D. M., Bielak, L. F., Liu, Y., Allison, M. A., Grant, S. F., Burke, G. L., Patel, S. R., Schreiner, P. J., Borecki, I. B., Evans, M. K., Taylor, H., Sale, M. M., Howard, V., Carlson, C. S., Rotimi, C. N., Cushman, M., Harris, T. B., Reiner, A. P., Cupples, L. A., North, K. E., & Fox, C. S. (2013). Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS genetics, 9(8), e1003681. https://doi.org/10.1371/journal.pgen.1003681
Liu, Ching-Ti, et al. "Genome-wide association of body fat distribution in African ancestry populations suggests new loci." PLoS genetics vol. 9,8 (2013): e1003681. doi: https://doi.org/10.1371/journal.pgen.1003681
Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681. doi: 10.1371/journal.pgen.1003681. Epub 2013 Aug 15. PMID: 23966867; PMCID: PMC3744443.
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PLoS Genet. 2013;9(8):e1003681. doi: 10.1371/journal.pgen.1003681. Epub 2013 Aug 15.

Genome-wide association of body fat distribution in African ancestry populations suggests new loci.

PLoS genetics

Ching-Ti Liu, Keri L Monda, Kira C Taylor, Leslie Lange, Ellen W Demerath, Walter Palmas, Mary K Wojczynski, Jaclyn C Ellis, Mara Z Vitolins, Simin Liu, George J Papanicolaou, Marguerite R Irvin, Luting Xue, Paula J Griffin, Michael A Nalls, Adebowale Adeyemo, Jiankang Liu, Guo Li, Edward A Ruiz-Narvaez, Wei-Min Chen, Fang Chen, Brian E Henderson, Robert C Millikan, Christine B Ambrosone, Sara S Strom, Xiuqing Guo, Jeanette S Andrews, Yan V Sun, Thomas H Mosley, Lisa R Yanek, Daniel Shriner, Talin Haritunians, Jerome I Rotter, Elizabeth K Speliotes, Megan Smith, Lynn Rosenberg, Josyf Mychaleckyj, Uma Nayak, Ida Spruill, W Timothy Garvey, Curtis Pettaway, Sarah Nyante, Elisa V Bandera, Angela F Britton, Alan B Zonderman, Laura J Rasmussen-Torvik, Yii-Der Ida Chen, Jingzhong Ding, Kurt Lohman, Stephen B Kritchevsky, Wei Zhao, Patricia A Peyser, Sharon L R Kardia, Edmond Kabagambe, Ulrich Broeckel, Guanjie Chen, Jie Zhou, Sylvia Wassertheil-Smoller, Marian L Neuhouser, Evadnie Rampersaud, Bruce Psaty, Charles Kooperberg, Joann E Manson, Lewis H Kuller, Heather M Ochs-Balcom, Karen C Johnson, Lara Sucheston, Jose M Ordovas, Julie R Palmer, Christopher A Haiman, Barbara McKnight, Barbara V Howard, Diane M Becker, Lawrence F Bielak, Yongmei Liu, Matthew A Allison, Struan F A Grant, Gregory L Burke, Sanjay R Patel, Pamela J Schreiner, Ingrid B Borecki, Michele K Evans, Herman Taylor, Michele M Sale, Virginia Howard, Christopher S Carlson, Charles N Rotimi, Mary Cushman, Tamara B Harris, Alexander P Reiner, L Adrienne Cupples, Kari E North, Caroline S Fox

Affiliations

  1. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.

PMID: 23966867 PMCID: PMC3744443 DOI: 10.1371/journal.pgen.1003681

Abstract

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly African ancestry (AA). We performed GWAS of WC and WHR, adjusted and unadjusted for BMI, in up to 33,591 and 27,350 AA individuals, respectively. We identified loci associated with fat distribution in AA individuals using meta-analyses of GWA results for WC and WHR (stage 1). Overall, 25 SNPs with single genomic control (GC)-corrected p-values<5.0 × 10(-6) were followed-up (stage 2) in AA with WC and with WHR. Additionally, we interrogated genomic regions of previously identified European ancestry (EA) WHR loci among AA. In joint analysis of association results including both Stage 1 and 2 cohorts, 2 SNPs demonstrated association, rs2075064 at LHX2, p = 2.24×10(-8) for WC-adjusted-for-BMI, and rs6931262 at RREB1, p = 2.48×10(-8) for WHR-adjusted-for-BMI. However, neither signal was genome-wide significant after double GC-correction (LHX2: p = 6.5 × 10(-8); RREB1: p = 5.7 × 10(-8)). Six of fourteen previously reported loci for waist in EA populations were significant (p<0.05 divided by the number of independent SNPs within the region) in AA studied here (TBX15-WARS2, GRB14, ADAMTS9, LY86, RSPO3, ITPR2-SSPN). Further, we observed associations with metabolic traits: rs13389219 at GRB14 associated with HDL-cholesterol, triglycerides, and fasting insulin, and rs13060013 at ADAMTS9 with HDL-cholesterol and fasting insulin. Finally, we observed nominal evidence for sexual dimorphism, with stronger results in AA women at the GRB14 locus (p for interaction = 0.02). In conclusion, we identified two suggestive loci associated with fat distribution in AA populations in addition to confirming 6 loci previously identified in populations of EA. These findings reinforce the concept that there are fat distribution loci that are independent of generalized adiposity.

Conflict of interest statement

The authors have declared that no competing interests exist.

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