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The pathogenesis of obesity from a genomic and systems biology perspective.

The Yale journal of biology and medicine

Levian C, Ruiz E, Yang X.
PMID: 24910557
Yale J Biol Med. 2014 Jun 06;87(2):113-26. eCollection 2014 Jun.

The recent obesity epidemic has imposed significant health, economical, and societal concerns. However, effective preventive and therapeutic strategies are currently lacking, primarily due to a lack of comprehensive understanding of the underlying molecular mechanisms. Recent genome-wide scans of genetic...

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Levian C, Ruiz E, Yang X. The pathogenesis of obesity from a genomic and systems biology perspective. Yale J Biol Med. 2014;87(2):113-26
Levian, C., Ruiz, E., & Yang, X. (2014). The pathogenesis of obesity from a genomic and systems biology perspective. The Yale journal of biology and medicine, 87(2), 113-26.
Levian, Candace, et al. "The pathogenesis of obesity from a genomic and systems biology perspective." The Yale journal of biology and medicine vol. 87,2 (2014): 113-26.
Levian C, Ruiz E, Yang X. The pathogenesis of obesity from a genomic and systems biology perspective. Yale J Biol Med. 2014 Jun 06;87(2):113-26. eCollection 2014 Jun. PMID: 24910557; PMCID: PMC4031785.
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Contemplative Practices: A Strategy to Improve Health and Reduce Disparities.

International journal of environmental research and public health

Bruce MA, Skrine Jeffers K, King Robinson J, Norris KC.
PMID: 30326604
Int J Environ Res Public Health. 2018 Oct 15;15(10). doi: 10.3390/ijerph15102253.

Health has many dimensions, and intolerance and lack of compassion may contribute to the poor health and disparities in our nation. Tolerance can convey an inherent paradox or dissonance that can be associated with stress. However, tolerance has a...

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Bruce MA, Skrine Jeffers K, King Robinson J, et al. Contemplative Practices: A Strategy to Improve Health and Reduce Disparities. Int J Environ Res Public Health. 2018;15(10)doi: 10.3390/ijerph15102253.
Bruce, M. A., Skrine Jeffers, K., King Robinson, J., & Norris, K. C. (2018). Contemplative Practices: A Strategy to Improve Health and Reduce Disparities. International journal of environmental research and public health, 15(10), . https://doi.org/10.3390/ijerph15102253
Bruce, Marino A, et al. "Contemplative Practices: A Strategy to Improve Health and Reduce Disparities." International journal of environmental research and public health vol. 15,10 (2018). doi: https://doi.org/10.3390/ijerph15102253
Bruce MA, Skrine Jeffers K, King Robinson J, Norris KC. Contemplative Practices: A Strategy to Improve Health and Reduce Disparities. Int J Environ Res Public Health. 2018 Oct 15;15(10). doi: 10.3390/ijerph15102253. PMID: 30326604; PMCID: PMC6210378.
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Directing Research Toward Health Equity: a Health Equity Research Impact Assessment.

Journal of general internal medicine

Castillo EG, Harris C.
PMID: 33948804
J Gen Intern Med. 2021 Sep;36(9):2803-2808. doi: 10.1007/s11606-021-06789-3. Epub 2021 May 04.

Despite medical research advancements, inequities persist, as research has enhanced the health of some while leaving many communities untouched. Reforms are needed to direct research toward health equity, both during this pandemic and beyond. All research must currently pass...

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Castillo EG, Harris C. Directing Research Toward Health Equity: a Health Equity Research Impact Assessment. J Gen Intern Med. 2021;36(9):2803-2808doi: 10.1007/s11606-021-06789-3.
Castillo, E. G., & Harris, C. (2021). Directing Research Toward Health Equity: a Health Equity Research Impact Assessment. Journal of general internal medicine, 36(9), 2803-2808. https://doi.org/10.1007/s11606-021-06789-3
Castillo, Enrico G, and Harris, Christina. "Directing Research Toward Health Equity: a Health Equity Research Impact Assessment." Journal of general internal medicine vol. 36,9 (2021): 2803-2808. doi: https://doi.org/10.1007/s11606-021-06789-3
Castillo EG, Harris C. Directing Research Toward Health Equity: a Health Equity Research Impact Assessment. J Gen Intern Med. 2021 Sep;36(9):2803-2808. doi: 10.1007/s11606-021-06789-3. Epub 2021 May 04. PMID: 33948804; PMCID: PMC8096150.
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Overwhelmed: a Dementia Caregiver Vital Sign.

Journal of general internal medicine

Reuben DB, Romero T, Evertson LC, Jennings LA.
PMID: 34389938
J Gen Intern Med. 2021 Aug 13; doi: 10.1007/s11606-021-07054-3. Epub 2021 Aug 13.

BACKGROUND: The emotional stress of caring for someone with Alzheimer's disease and related dementias is high and results in adverse effects on caregivers and the persons living with disease. In preliminary work, caregiver reports of regularly feeling "completely overwhelmed"...

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Reuben DB, Romero T, Evertson LC, et al. Overwhelmed: a Dementia Caregiver Vital Sign. J Gen Intern Med. 2021;doi: 10.1007/s11606-021-07054-3.
Reuben, D. B., Romero, T., Evertson, L. C., & Jennings, L. A. (2021). Overwhelmed: a Dementia Caregiver Vital Sign. Journal of general internal medicine, . https://doi.org/10.1007/s11606-021-07054-3
Reuben, David B, et al. "Overwhelmed: a Dementia Caregiver Vital Sign." Journal of general internal medicine vol. (2021). doi: https://doi.org/10.1007/s11606-021-07054-3
Reuben DB, Romero T, Evertson LC, Jennings LA. Overwhelmed: a Dementia Caregiver Vital Sign. J Gen Intern Med. 2021 Aug 13; doi: 10.1007/s11606-021-07054-3. Epub 2021 Aug 13. PMID: 34389938.
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Lifetime Major Discrimination Experiences Moderate the Impact of Depressive Symptoms on Chronic Conditions among Black Americans.

Healthcare (Basel, Switzerland)

Skrine Jeffers K, Walton QL, Robinson MN, Thomas Tobin CS.
PMID: 34828574
Healthcare (Basel). 2021 Nov 09;9(11). doi: 10.3390/healthcare9111528.

To clarify the ways in which Black Americans' experiences of structural racism may influence their mental and physical health in distinct ways, the present study evaluated whether major discrimination moderates the association between depressive symptoms and chronic physical health...

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Skrine Jeffers K, Walton QL, Robinson MN, et al. Lifetime Major Discrimination Experiences Moderate the Impact of Depressive Symptoms on Chronic Conditions among Black Americans. Healthcare (Basel). 2021;9(11)doi: 10.3390/healthcare9111528.
Skrine Jeffers, K., Walton, Q. L., Robinson, M. N., & Thomas Tobin, C. S. (2021). Lifetime Major Discrimination Experiences Moderate the Impact of Depressive Symptoms on Chronic Conditions among Black Americans. Healthcare (Basel, Switzerland), 9(11), . https://doi.org/10.3390/healthcare9111528
Skrine Jeffers, Kia, et al. "Lifetime Major Discrimination Experiences Moderate the Impact of Depressive Symptoms on Chronic Conditions among Black Americans." Healthcare (Basel, Switzerland) vol. 9,11 (2021). doi: https://doi.org/10.3390/healthcare9111528
Skrine Jeffers K, Walton QL, Robinson MN, Thomas Tobin CS. Lifetime Major Discrimination Experiences Moderate the Impact of Depressive Symptoms on Chronic Conditions among Black Americans. Healthcare (Basel). 2021 Nov 09;9(11). doi: 10.3390/healthcare9111528. PMID: 34828574; PMCID: PMC8620289.
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Live vs electronically delivered weight-loss interventions: paying for feasible interventions.

JAMA internal medicine

Moin T, Mangione CM.
PMID: 24861172
JAMA Intern Med. 2014 Jul;174(7):1157-9. doi: 10.1001/jamainternmed.2014.414.

No abstract available.

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Moin T, Mangione CM. Live vs electronically delivered weight-loss interventions: paying for feasible interventions. JAMA Intern Med. 2014;174(7):1157-9doi: 10.1001/jamainternmed.2014.414.
Moin, T., & Mangione, C. M. (2014). Live vs electronically delivered weight-loss interventions: paying for feasible interventions. JAMA internal medicine, 174(7), 1157-9. https://doi.org/10.1001/jamainternmed.2014.414
Moin, Tannaz, and Mangione, Carol M. "Live vs electronically delivered weight-loss interventions: paying for feasible interventions." JAMA internal medicine vol. 174,7 (2014): 1157-9. doi: https://doi.org/10.1001/jamainternmed.2014.414
Moin T, Mangione CM. Live vs electronically delivered weight-loss interventions: paying for feasible interventions. JAMA Intern Med. 2014 Jul;174(7):1157-9. doi: 10.1001/jamainternmed.2014.414. PMID: 24861172; PMCID: PMC4220444.
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Genome-wide association of body fat distribution in African ancestry populations suggests new loci.

PLoS genetics

Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS.
PMID: 23966867
PLoS Genet. 2013;9(8):e1003681. doi: 10.1371/journal.pgen.1003681. Epub 2013 Aug 15.

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly...

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Liu CT, Monda KL, Taylor KC, et al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681doi: 10.1371/journal.pgen.1003681.
Liu, C. T., Monda, K. L., Taylor, K. C., Lange, L., Demerath, E. W., Palmas, W., Wojczynski, M. K., Ellis, J. C., Vitolins, M. Z., Liu, S., Papanicolaou, G. J., Irvin, M. R., Xue, L., Griffin, P. J., Nalls, M. A., Adeyemo, A., Liu, J., Li, G., Ruiz-Narvaez, E. A., Chen, W. M., Chen, F., Henderson, B. E., Millikan, R. C., Ambrosone, C. B., Strom, S. S., Guo, X., Andrews, J. S., Sun, Y. V., Mosley, T. H., Yanek, L. R., Shriner, D., Haritunians, T., Rotter, J. I., Speliotes, E. K., Smith, M., Rosenberg, L., Mychaleckyj, J., Nayak, U., Spruill, I., Garvey, W. T., Pettaway, C., Nyante, S., Bandera, E. V., Britton, A. F., Zonderman, A. B., Rasmussen-Torvik, L. J., Chen, Y. D., Ding, J., Lohman, K., Kritchevsky, S. B., Zhao, W., Peyser, P. A., Kardia, S. L., Kabagambe, E., Broeckel, U., Chen, G., Zhou, J., Wassertheil-Smoller, S., Neuhouser, M. L., Rampersaud, E., Psaty, B., Kooperberg, C., Manson, J. E., Kuller, L. H., Ochs-Balcom, H. M., Johnson, K. C., Sucheston, L., Ordovas, J. M., Palmer, J. R., Haiman, C. A., McKnight, B., Howard, B. V., Becker, D. M., Bielak, L. F., Liu, Y., Allison, M. A., Grant, S. F., Burke, G. L., Patel, S. R., Schreiner, P. J., Borecki, I. B., Evans, M. K., Taylor, H., Sale, M. M., Howard, V., Carlson, C. S., Rotimi, C. N., Cushman, M., Harris, T. B., Reiner, A. P., Cupples, L. A., North, K. E., & Fox, C. S. (2013). Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS genetics, 9(8), e1003681. https://doi.org/10.1371/journal.pgen.1003681
Liu, Ching-Ti, et al. "Genome-wide association of body fat distribution in African ancestry populations suggests new loci." PLoS genetics vol. 9,8 (2013): e1003681. doi: https://doi.org/10.1371/journal.pgen.1003681
Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681. doi: 10.1371/journal.pgen.1003681. Epub 2013 Aug 15. PMID: 23966867; PMCID: PMC3744443.
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Case Study of an Unsustainable Community-Academic Partnership: Toward Core Standards for the Structure of Emerging Participatory Research.

Ethnicity & disease

Calderón JL, Norris KC, Hardigan PC, Calderón LA, Hays RD.
PMID: 26673638
Ethn Dis. 2015 Aug 07;25(3):363-72. doi: 10.18865/ed.25.3.363.

This report retrospectively examines the structure of an emerging community-academic participatory research (PR) partnership that was not sustainable, despite attempts to adhere to PR principles and demonstrable success in research outcomes. The influence of community and academic parent organizations...

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Calderón JL, Norris KC, Hardigan PC, et al. Case Study of an Unsustainable Community-Academic Partnership: Toward Core Standards for the Structure of Emerging Participatory Research. Ethn Dis. 2015;25(3):363-72doi: 10.18865/ed.25.3.363.
Calderón, J. L., Norris, K. C., Hardigan, P. C., Calderón, L. A., & Hays, R. D. (2015). Case Study of an Unsustainable Community-Academic Partnership: Toward Core Standards for the Structure of Emerging Participatory Research. Ethnicity & disease, 25(3), 363-72. https://doi.org/10.18865/ed.25.3.363
Calderón, José L, et al. "Case Study of an Unsustainable Community-Academic Partnership: Toward Core Standards for the Structure of Emerging Participatory Research." Ethnicity & disease vol. 25,3 (2015): 363-72. doi: https://doi.org/10.18865/ed.25.3.363
Calderón JL, Norris KC, Hardigan PC, Calderón LA, Hays RD. Case Study of an Unsustainable Community-Academic Partnership: Toward Core Standards for the Structure of Emerging Participatory Research. Ethn Dis. 2015 Aug 07;25(3):363-72. doi: 10.18865/ed.25.3.363. PMID: 26673638; PMCID: PMC4671418.
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Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos.

American journal of human genetics

Conomos MP, Laurie CA, Stilp AM, Gogarten SM, McHugh CP, Nelson SC, Sofer T, Fernández-Rhodes L, Justice AE, Graff M, Young KL, Seyerle AA, Avery CL, Taylor KD, Rotter JI, Talavera GA, Daviglus ML, Wassertheil-Smoller S, Schneiderman N, Heiss G, Kaplan RC, Franceschini N, Reiner AP, Shaffer JR, Barr RG, Kerr KF, Browning SR, Browning BL, Weir BS, Avilés-Santa ML, Papanicolaou GJ, Lumley T, Szpiro AA, North KE, Rice K, Thornton TA, Laurie CC.
PMID: 26748518
Am J Hum Genet. 2016 Jan 07;98(1):165-84. doi: 10.1016/j.ajhg.2015.12.001.

US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental exposures. Here, we characterized and controlled for this diversity in genome-wide association studies (GWASs) for the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We simultaneously estimated population-structure principal...

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Conomos MP, Laurie CA, Stilp AM, et al. Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. Am J Hum Genet. 2016;98(1):165-84doi: 10.1016/j.ajhg.2015.12.001.
Conomos, M. P., Laurie, C. A., Stilp, A. M., Gogarten, S. M., McHugh, C. P., Nelson, S. C., Sofer, T., Fernández-Rhodes, L., Justice, A. E., Graff, M., Young, K. L., Seyerle, A. A., Avery, C. L., Taylor, K. D., Rotter, J. I., Talavera, G. A., Daviglus, M. L., Wassertheil-Smoller, S., Schneiderman, N., Heiss, G., Kaplan, R. C., Franceschini, N., Reiner, A. P., Shaffer, J. R., Barr, R. G., Kerr, K. F., Browning, S. R., Browning, B. L., Weir, B. S., Avilés-Santa, M. L., Papanicolaou, G. J., Lumley, T., Szpiro, A. A., North, K. E., Rice, K., Thornton, T. A., & Laurie, C. C. (2016). Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. American journal of human genetics, 98(1), 165-84. https://doi.org/10.1016/j.ajhg.2015.12.001
Conomos, Matthew P, et al. "Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos." American journal of human genetics vol. 98,1 (2016): 165-84. doi: https://doi.org/10.1016/j.ajhg.2015.12.001
Conomos MP, Laurie CA, Stilp AM, Gogarten SM, McHugh CP, Nelson SC, Sofer T, Fernández-Rhodes L, Justice AE, Graff M, Young KL, Seyerle AA, Avery CL, Taylor KD, Rotter JI, Talavera GA, Daviglus ML, Wassertheil-Smoller S, Schneiderman N, Heiss G, Kaplan RC, Franceschini N, Reiner AP, Shaffer JR, Barr RG, Kerr KF, Browning SR, Browning BL, Weir BS, Avilés-Santa ML, Papanicolaou GJ, Lumley T, Szpiro AA, North KE, Rice K, Thornton TA, Laurie CC. Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. Am J Hum Genet. 2016 Jan 07;98(1):165-84. doi: 10.1016/j.ajhg.2015.12.001. PMID: 26748518; PMCID: PMC4716704.
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Evaluation of the diabetes health plan to improve diabetes care and prevention.

Preventing chronic disease

Duru OK, Mangione CM, Chan C, Keckhafer A, Kimbro L, Kirvan KA, Turk N, Luchs R, Li J, Ettner S.
PMID: 23369769
Prev Chronic Dis. 2013;10:E16. doi: 10.5888/pcd10.120150.

Investigators from the University of California, Los Angeles (UCLA), and members of the leadership and data analysis teams at UnitedHealthcare (UHC) are partnering to evaluate the Diabetes Health Plan (DHP), an innovative disease-specific insurance product designed by UHC specifically...

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Duru OK, Mangione CM, Chan C, et al. Evaluation of the diabetes health plan to improve diabetes care and prevention. Prev Chronic Dis. 2013;10:E16doi: 10.5888/pcd10.120150.
Duru, O. K., Mangione, C. M., Chan, C., Keckhafer, A., Kimbro, L., Kirvan, K. A., Turk, N., Luchs, R., Li, J., & Ettner, S. (2013). Evaluation of the diabetes health plan to improve diabetes care and prevention. Preventing chronic disease, 10E16. https://doi.org/10.5888/pcd10.120150
Duru, O Kenrik, et al. "Evaluation of the diabetes health plan to improve diabetes care and prevention." Preventing chronic disease vol. 10 (2013): E16. doi: https://doi.org/10.5888/pcd10.120150
Duru OK, Mangione CM, Chan C, Keckhafer A, Kimbro L, Kirvan KA, Turk N, Luchs R, Li J, Ettner S. Evaluation of the diabetes health plan to improve diabetes care and prevention. Prev Chronic Dis. 2013;10:E16. doi: 10.5888/pcd10.120150. PMID: 23369769; PMCID: PMC3562175.
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Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics.

Hepatology communications

Shaheen M, Pan D, Schrode KM, Kermah D, Puri V, Zarrinpar A, Elisha D, Najjar SM, Friedman TC.
PMID: 34558824
Hepatol Commun. 2021 Dec;5(12):2068-2079. doi: 10.1002/hep4.1775. Epub 2021 Jul 16.

Hepatic steatosis (HS) is a growing problem in adults worldwide, with racial/ethnic disparity in the prevalence of the disease. The purpose of this study was to characterize the racial/ethnic prevalence of the stages (normal/mild [S0/S1], moderate [S2], and severe...

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Shaheen M, Pan D, Schrode KM, et al. Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics. Hepatol Commun. 2021;5(12):2068-2079doi: 10.1002/hep4.1775.
Shaheen, M., Pan, D., Schrode, K. M., Kermah, D., Puri, V., Zarrinpar, A., Elisha, D., Najjar, S. M., & Friedman, T. C. (2021). Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics. Hepatology communications, 5(12), 2068-2079. https://doi.org/10.1002/hep4.1775
Shaheen, Magda, et al. "Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics." Hepatology communications vol. 5,12 (2021): 2068-2079. doi: https://doi.org/10.1002/hep4.1775
Shaheen M, Pan D, Schrode KM, Kermah D, Puri V, Zarrinpar A, Elisha D, Najjar SM, Friedman TC. Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics. Hepatol Commun. 2021 Dec;5(12):2068-2079. doi: 10.1002/hep4.1775. Epub 2021 Jul 16. PMID: 34558824; PMCID: PMC8631095.
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