Display options
Cite
Levian C, Ruiz E, Yang X. The pathogenesis of obesity from a genomic and systems biology perspective. Yale J Biol Med. 2014;87(2):113-26
Levian, C., Ruiz, E., & Yang, X. (2014). The pathogenesis of obesity from a genomic and systems biology perspective. The Yale journal of biology and medicine, 87(2), 113-26.
Levian, Candace, et al. "The pathogenesis of obesity from a genomic and systems biology perspective." The Yale journal of biology and medicine vol. 87,2 (2014): 113-26.
Levian C, Ruiz E, Yang X. The pathogenesis of obesity from a genomic and systems biology perspective. Yale J Biol Med. 2014 Jun 06;87(2):113-26. eCollection 2014 Jun. PMID: 24910557; PMCID: PMC4031785.
Copy Download .nbib Format: NLM
Share it on

Yale J Biol Med. 2014 Jun 06;87(2):113-26. eCollection 2014 Jun.

The pathogenesis of obesity from a genomic and systems biology perspective.

The Yale journal of biology and medicine

Candace Levian, Esmeralda Ruiz, Xia Yang

Affiliations

  1. Department of Integrative Biology and Physiology, University of California, Los Angeles.

PMID: 24910557 PMCID: PMC4031785

Abstract

The recent obesity epidemic has imposed significant health, economical, and societal concerns. However, effective preventive and therapeutic strategies are currently lacking, primarily due to a lack of comprehensive understanding of the underlying molecular mechanisms. Recent genome-wide scans of genetic variants, transcriptome, and epigenome have uncovered >50 genetic loci that predispose individuals to obesity and revealed hundreds of genes with altered transcriptional activity and/or epigenetic variations in obesity-related tissues upon various environmental challenges such as high caloric diets, lack of physical activity, and environmental chemicals. These discoveries highlight the importance of genes involved in the control of energy homeostasis and food intake by the central nervous system, as well as genes contributing to lipid metabolism, adipogenesis, fat cell differentiation, and immune response in peripheral tissues, in obesity development. Future studies that are directed to obtain a more comprehensive, systems-level understanding of disease mechanisms and that test novel therapeutic strategies aiming at systems-level normalization of the obesity-related molecular alterations are warranted.

Keywords: environmental risks; epigenome; exercise; genetic risks; genomics; high caloric diets; integrative genomics; obesity; obesogen; systems biology; transcriptome

References

  1. Cell Immunol. 2009;260(1):44-50 - PubMed
  2. QJM. 2006 Sep;99(9):565-79 - PubMed
  3. Endocr J. 2013;60(3):261-74 - PubMed
  4. Metabolism. 2012 Feb;61(2):146-52 - PubMed
  5. Am J Clin Nutr. 2008 Jun;87(6):1968 - PubMed
  6. PLoS Genet. 2013;9(1):e1003166 - PubMed
  7. Int J Obes (Lond). 2014 Feb;38(2):198-204 - PubMed
  8. Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E468-74 - PubMed
  9. Mol Cell Endocrinol. 2009 May 25;304(1-2):19-29 - PubMed
  10. Nature. 2009 Oct 8;461(7265):747-53 - PubMed
  11. Nature. 2008 Mar 27;452(7186):423-8 - PubMed
  12. Gene. 2004 Sep 29;340(1):99-109 - PubMed
  13. Metabolism. 2005 Dec;54(12):1571-81 - PubMed
  14. J Obes. 2011;2011:265417 - PubMed
  15. Nat Rev Microbiol. 2013 Sep;11(9):639-47 - PubMed
  16. Epidemiol Rev. 2007;29:1-5 - PubMed
  17. Nat Med. 2012 Mar 18;18(4):564-71 - PubMed
  18. Diabetes. 2012 Dec;61(12):3322-32 - PubMed
  19. J Nutr. 2001 Mar;131(3):871S-873S - PubMed
  20. PLoS Genet. 2006 May;2(5):e81 - PubMed
  21. Int J Androl. 2012 Jun;35(3):437-48 - PubMed
  22. Ann N Y Acad Sci. 2013 Apr;1281:178-90 - PubMed
  23. J Physiol Biochem. 2009 Mar;65(1):1-9 - PubMed
  24. J Neurosci. 2007 Dec 26;27(52):14265-74 - PubMed
  25. Mol Cell Endocrinol. 2013 May 6;370(1-2):52-64 - PubMed
  26. Prog Mol Biol Transl Sci. 2009;88:173-204 - PubMed
  27. Obesity (Silver Spring). 2006 Aug;14(8):1294-302 - PubMed
  28. Cell. 2012 Oct 26;151(3):658-70 - PubMed
  29. Nature. 2008 Mar 27;452(7186):429-35 - PubMed
  30. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7 - PubMed
  31. J Strength Cond Res. 2012 Dec;26(12):3469-72 - PubMed
  32. J Clin Invest. 2013 Aug;123(8):3539-51 - PubMed
  33. Life Sci. 2004 Nov 12;75(26):3117-28 - PubMed
  34. Exp Physiol. 2012 Jul;97(7):833-48 - PubMed
  35. Int J Obes (Lond). 2010 Jan;34(1):29-40 - PubMed
  36. Nutrition. 2010 Apr;26(4):411-22 - PubMed
  37. Am J Hum Genet. 2007 Dec;81(6):1278-83 - PubMed
  38. Biochem Biophys Res Commun. 2005 Oct 14;336(1):215-22 - PubMed
  39. Nat Med. 2012 Apr 05;18(4):496-7 - PubMed
  40. Endocrinology. 2006 Mar;147(3):1508-16 - PubMed
  41. Am J Hum Genet. 2010 Apr 9;86(4):581-91 - PubMed
  42. J Biol Chem. 2004 Dec 3;279(49):50743-53 - PubMed
  43. Sports Med. 2014 Feb;44(2):189-209 - PubMed
  44. Ann N Y Acad Sci. 2011 Mar;1220:162-71 - PubMed
  45. J Nutrigenet Nutrigenomics. 2009;2(6):280-91 - PubMed
  46. Nutrition. 2005 May;21(5):594-601 - PubMed
  47. J Physiol. 2009 Dec 15;587(Pt 24):5951-8 - PubMed
  48. JAMA. 2012 Feb 1;307(5):491-7 - PubMed
  49. PLoS Genet. 2013;9(1):e1003223 - PubMed
  50. Endocrinology. 2006 Jun;147(6 Suppl):S50-5 - PubMed
  51. BMC Genomics. 2010 Jun 23;11:398 - PubMed
  52. Obesity (Silver Spring). 2008 Oct;16(10):2323-30 - PubMed
  53. Eur Child Adolesc Psychiatry. 2010 Mar;19(3):297-310 - PubMed
  54. Nat Rev Genet. 2005 Mar;6(3):221-34 - PubMed
  55. Cell Metab. 2013 Jan 8;17(1):141-52 - PubMed
  56. Dig Dis Sci. 2013 Jan;58(1):72-6 - PubMed
  57. PLoS Genet. 2013 Jun;9(6):e1003572 - PubMed
  58. Diabetes. 2005 Jul;54(7):1926-33 - PubMed
  59. J Appl Physiol (1985). 2012 May;112(10):1625-36 - PubMed
  60. Epigenetics. 2012 Feb;7(2):183-90 - PubMed
  61. Curr Cardiovasc Risk Rep. 2013 Feb;7(1):73-83 - PubMed
  62. Nat Genet. 2009 Apr;41(4):415-23 - PubMed
  63. Nature. 2012 Oct 11;490(7419):267-72 - PubMed

MeSH terms

Publication Types

Grant support