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Showing 1 to 12 of 501 entries
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Gene × environment interactions in type 2 diabetes.

Current diabetes reports

Franks PW.
PMID: 21887612
Curr Diab Rep. 2011 Dec;11(6):552-61. doi: 10.1007/s11892-011-0224-9.

People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome...

Recent genomic advances in schizophrenia.

Clinical genetics

Doherty JL, O'Donovan MC, Owen MJ.
PMID: 21895634
Clin Genet. 2012 Feb;81(2):103-9. doi: 10.1111/j.1399-0004.2011.01773.x. Epub 2011 Oct 05.

Recent studies have supported the hypothesis based upon expectations from population genetics that the high heritability of schizophrenia reflects a combination of relatively common alleles of small effect and rare alleles some with relatively large effects. Genome-wide association studies...

From Locus Association to Mechanism of Gene Causality: The Devil Is in the Details.

Arteriosclerosis, thrombosis, and vascular biology

Miller CL, Pjanic M, Quertermous T.
PMID: 26399919
Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2079-2080. doi: 10.1161/ATVBAHA.115.306366.

No abstract available.

Genome-wide association studies in pediatric chronic kidney disease.

Pediatric nephrology (Berlin, Germany)

Gupta J, Kanetsky PA, Wuttke M, Köttgen A, Schaefer F, Wong CS.
PMID: 26490952
Pediatr Nephrol. 2016 Aug;31(8):1241-52. doi: 10.1007/s00467-015-3235-y. Epub 2015 Oct 21.

The genome-wide association study (GWAS) has become an established scientific method that provides an unbiased screen for genetic loci potentially associated with phenotypes of clinical interest, such as chronic kidney disease (CKD). Thus, GWAS provides opportunities to gain new...

Environmental and Genetic Risk Factors Associated with Venous Thromboembolism.

Seminars in thrombosis and hemostasis

Crous-Bou M, Harrington LB, Kabrhel C.
PMID: 27764878
Semin Thromb Hemost. 2016 Nov;42(8):808-820. doi: 10.1055/s-0036-1592333. Epub 2016 Oct 20.

Venous thromboembolism (VTE) includes deep vein thrombosis and pulmonary embolism, and a combination of environmental and genetic risk factors contributes to VTE risk. Within environmental risk factors, some are provoking (e.g., cancer, surgery, trauma or fracture, immobilization, pregnancy and...

Family or SNPs: what counts for hereditary risk of coronary artery disease?.

European heart journal

Schunkert H.
PMID: 26475834
Eur Heart J. 2016 Feb 07;37(6):568-71. doi: 10.1093/eurheartj/ehv545. Epub 2015 Oct 15.

No abstract available.

[Is it our genes or our lifestyle that determines the risk for diabetes? Results from diabetes cohort study have no relevance in clinical practice].

Deutsche medizinische Wochenschrift (1946)

Nawroth PP.
PMID: 24983191
Dtsch Med Wochenschr. 2014 Jul;139(28):1452. doi: 10.1055/s-0033-1353911. Epub 2014 Jul 01.

No abstract available.

Traditional risk factors and a Genetic Risk Score are associated with age of first acute coronary syndrome.

Heart (British Cardiac Society)

Labos C, Wang RH, Pilote L, Bogaty P, Brophy JM, Engert JC, Thanassoulis G.
PMID: 24842871
Heart. 2014 Oct;100(20):1620-4. doi: 10.1136/heartjnl-2013-305416.

OBJECTIVE: To examine the association between traditional risk factors (TRF) and a Genetic Risk Score (GRS) with age of first acute coronary syndrome (ACS). Early onset ACS may occur due to a high burden of TRFs or to genetic...

Understanding pediatric chronic pancreatitis: inspiration and hard work required.

The Journal of pediatrics

Pant C, Sferra TJ.
PMID: 25661402
J Pediatr. 2015 Apr;166(4):798-800. doi: 10.1016/j.jpeds.2014.12.052. Epub 2015 Feb 04.

No abstract available.

When to suspect occupational asthma.

Canadian respiratory journal

Lemière C.
PMID: 24324981
Can Respir J. 2013 Nov-Dec;20(6):442-4. doi: 10.1155/2013/893150.

Occupational asthma (OA) is a difficult diagnosis to make. The present review describes the work environments in which workers are at risk for developing OA, the characteristics of the individuals in whom OA should be suspected and the investigation...

[Fine mapping of complex disease susceptibility loci].

Yi chuan = Hereditas

Song Q, Zhang H, Ma Y, Zhou G.
PMID: 24846913
Yi Chuan. 2014 Jan;36(1):2-10. doi: 10.3724/sp.j.1005.2014.00002.

Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers have identified more than 3800 susceptibility loci for more than 660 diseases or traits. However, the most significantly associated variants or causative variants in these loci and their biological...

[Strategies for elucidating functional significance of complex disease related loci].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

Jin G, Du J, Hu Z, Shen H.
PMID: 26081530
Zhonghua Yu Fang Yi Xue Za Zhi. 2015 Apr;49(4):299-302.

Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with complex diseases or traits. However, the exact biological functions of these loci are largely unknown. Recent functional annotation indicates that the majority of disease/trait associated loci are...

Showing 1 to 12 of 501 entries