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Crous-Bou M, Harrington LB, Kabrhel C. Environmental and Genetic Risk Factors Associated with Venous Thromboembolism. Semin Thromb Hemost. 2016;42(8):808-820doi: 10.1055/s-0036-1592333.
Crous-Bou, M., Harrington, L. B., & Kabrhel, C. (2016). Environmental and Genetic Risk Factors Associated with Venous Thromboembolism. Seminars in thrombosis and hemostasis, 42(8), 808-820. https://doi.org/10.1055/s-0036-1592333
Crous-Bou, Marta, et al. "Environmental and Genetic Risk Factors Associated with Venous Thromboembolism." Seminars in thrombosis and hemostasis vol. 42,8 (2016): 808-820. doi: https://doi.org/10.1055/s-0036-1592333
Crous-Bou M, Harrington LB, Kabrhel C. Environmental and Genetic Risk Factors Associated with Venous Thromboembolism. Semin Thromb Hemost. 2016 Nov;42(8):808-820. doi: 10.1055/s-0036-1592333. Epub 2016 Oct 20. PMID: 27764878; PMCID: PMC5146955.
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Semin Thromb Hemost. 2016 Nov;42(8):808-820. doi: 10.1055/s-0036-1592333. Epub 2016 Oct 20.

Environmental and Genetic Risk Factors Associated with Venous Thromboembolism.

Seminars in thrombosis and hemostasis

Marta Crous-Bou, Laura B Harrington, Christopher Kabrhel

Affiliations

  1. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  2. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  3. Department of Emergency Medicine, Center for Vascular Emergencies, Massachusetts General Hospital, Boston, Massachusetts.

PMID: 27764878 PMCID: PMC5146955 DOI: 10.1055/s-0036-1592333

Abstract

Venous thromboembolism (VTE) includes deep vein thrombosis and pulmonary embolism, and a combination of environmental and genetic risk factors contributes to VTE risk. Within environmental risk factors, some are provoking (e.g., cancer, surgery, trauma or fracture, immobilization, pregnancy and the postpartum period, long-distance travel, hospitalization, catheterization, and acute infection) and others are nonprovoking (e.g., age, sex, race/ethnicity, body mass index and obesity, oral contraceptive or hormone therapy use, corticosteroid use, statin use, diet, physical activity, sedentary time, and air pollution). Additionally, VTE has a strong genetic basis, with approximately 50 to 60% of the variance in VTE incidence attributed to genetic effects. Some genetic susceptibility variants that contribute to risk have been identified in candidate genes, mostly related to the clotting system and responsible for inherited hypercoagulable states (e.g., factor V Leiden, prothrombin, fibrinogen gamma, or blood group non-O). Other susceptibility single-nucleotide polymorphisms have been identified from genome-wide association studies, such as the two new loci in

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References

  1. JAMA Intern Med. 2014 Jan;174(1):25-31 - PubMed
  2. Circulation. 2010 Mar 30;121(12):1382-92 - PubMed
  3. Thromb Haemost. 2007 Feb;97(2):171-5 - PubMed
  4. Trans Ophthalmol Soc N Z. 1978;30:19-22 - PubMed
  5. J Biol Chem. 1992 May 5;267(13):8723-31 - PubMed
  6. Blood Coagul Fibrinolysis. 2009 Oct;20(7):503-10 - PubMed
  7. Haematologica. 2007 Aug;92(8):1107-14 - PubMed
  8. J Thromb Haemost. 2005 Jan;3(1):183-5 - PubMed
  9. J Thromb Haemost. 2004 May;2(5):731-6 - PubMed
  10. Lancet. 1999 Apr 3;353(9159):1167-73 - PubMed
  11. Circulation. 2008 Jan 1;117(1):93-102 - PubMed
  12. BMJ. 2012 May 10;344:e2990 - PubMed
  13. Haemostasis. 1999 Dec;29 Suppl S1:1-9 - PubMed
  14. Arch Intern Med. 2008 May 12;168(9):920-7 - PubMed
  15. Arch Intern Med. 2008 Jan 14;168(1):21-6 - PubMed
  16. J Thromb Haemost. 2005 Feb;3(2):300-4 - PubMed
  17. MMWR Surveill Summ. 2005 Nov 18;54(6):1-72 - PubMed
  18. Cochrane Database Syst Rev. 2014 Mar 03;(3):CD010813 - PubMed
  19. Thromb Haemost. 2012 Sep;108(3):554-60 - PubMed
  20. Thromb Haemost. 1998 Feb;79(2):444 - PubMed
  21. Lancet. 1971 Nov 27;2(7735):1209-10 - PubMed
  22. Thromb Haemost. 2016 Mar;115(3):682-4 - PubMed
  23. Thromb Res. 2009;123 Suppl 4:S22-4 - PubMed
  24. J Thromb Haemost. 2011 Jun;9(6):1133-42 - PubMed
  25. Arch Intern Med. 2002 May 27;162(10):1182-9 - PubMed
  26. Lancet. 1995 Oct 28;346(8983):1133-4 - PubMed
  27. Drug Saf. 2012 Mar 1;35(3):191-205 - PubMed
  28. Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):1012-7 - PubMed
  29. J Thromb Haemost. 2013 Jun;11 Suppl 1:111-21 - PubMed
  30. J Thromb Haemost. 2010 Apr;8(4):669-74 - PubMed
  31. Thromb Haemost. 2002 Apr;87(4):580-5 - PubMed
  32. J Thromb Haemost. 2010 May;8(5):1132-4 - PubMed
  33. J Thromb Haemost. 2007 Nov;5(11):2186-92 - PubMed
  34. Thromb Haemost. 1996 Nov;76(5):651-62 - PubMed
  35. Br Med J (Clin Res Ed). 1986 Feb 22;292(6519):526 - PubMed
  36. J Trauma Acute Care Surg. 2012 Jan;72(1):247-50 - PubMed
  37. PLoS One. 2012;7(9):e45458 - PubMed
  38. Thromb Haemost. 2005 Mar;93(3):468-74 - PubMed
  39. J Bone Joint Surg Am. 2002 Dec;84-A(12):2161-7 - PubMed
  40. Thromb Haemost. 1997 Sep;78(3):990-2 - PubMed
  41. Epidemiology. 2003 May;14(3):328-32 - PubMed
  42. J Thromb Haemost. 2007 Jul;5(7):1455-61 - PubMed
  43. N Engl J Med. 1985 Dec 19;313(25):1557-63 - PubMed
  44. Ann Intern Med. 1997 Apr 1;126(7):528-31 - PubMed
  45. Circulation. 2000 Apr 4;101(13):1546-51 - PubMed
  46. Br J Haematol. 2001 Oct;115(1):156-8 - PubMed
  47. Obes Surg. 2005 Apr;15(4):561-4 - PubMed
  48. J Thromb Haemost. 2005 Mar;3(3):459-64 - PubMed
  49. J Am Heart Assoc. 2014 Oct 23;3(5):e001060 - PubMed
  50. J Thromb Thrombolysis. 2016 Jan;41(1):3-14 - PubMed
  51. Am Heart J. 2000 Aug;140(2):189-95 - PubMed
  52. Diabete Metab. 1987 Jul;13(3 Pt 2):331-6 - PubMed
  53. BMJ. 2011 Jul 04;343:d3867 - PubMed
  54. Genet Epidemiol. 2013 Jul;37(5):512-21 - PubMed
  55. Blood. 2002 Apr 15;99(8):2720-5 - PubMed
  56. Cancer. 2004 Apr 15;100(8):1717-23 - PubMed
  57. N Engl J Med. 2009 Apr 30;360(18):1851-61 - PubMed
  58. Arteriosclerosis. 1990 Nov-Dec;10(6):1067-73 - PubMed
  59. Clin Orthop Relat Res. 2009 Jun;467(6):1507-15 - PubMed
  60. Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):700-3 - PubMed
  61. Thromb Haemost. 2008 Jan;99(1):246-8 - PubMed
  62. Clin Chem Lab Med. 2006;44(5):514-21 - PubMed
  63. Circulation. 2014 Apr 8;129(14):1502-9 - PubMed
  64. Thromb Haemost. 2009 Aug;102(2):360-70 - PubMed
  65. Lancet. 1994 Nov 26;344(8935):1453-7 - PubMed
  66. Thromb Haemost. 1996 Mar;75(3):417-21 - PubMed
  67. Blood. 2012 Aug 2;120(5):933-46 - PubMed
  68. Thromb Haemost. 2004 Apr;91(4):700-11 - PubMed
  69. Lancet. 2000 Sep 16;356(9234):1028-9 - PubMed
  70. Lancet. 1970 Jun 13;1(7659):1257-9 - PubMed
  71. Semin Thromb Hemost. 2011 Nov;37(8):885-96 - PubMed
  72. Lancet. 1972 May 27;1(7761):1152-4 - PubMed
  73. Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29;360(1460):1609-16 - PubMed
  74. J Thromb Haemost. 2003 Jan;1(1):80-7 - PubMed
  75. JAMA Intern Med. 2013 May 13;173(9):743-52 - PubMed
  76. Clin Appl Thromb Hemost. 2009 Jul-Aug;15(4):408-14 - PubMed
  77. Circulation. 2014 Apr 8;129(14):1463-5 - PubMed
  78. Arch Intern Med. 1978 Oct;138(10):1566-7 - PubMed
  79. JAMA. 2004 Apr 14;291(14):1701-12 - PubMed
  80. Circulation. 2014 Jan 7;129(1):51-6 - PubMed
  81. Am J Med. 2002 Dec 1;113(8):636-42 - PubMed
  82. Thromb Haemost. 2010 Nov;104(5):962-71 - PubMed
  83. JAMA. 2004 Oct 6;292(13):1573-80 - PubMed
  84. Ann Intern Med. 2005 Jun 21;142(12 Pt 1):1003-13 - PubMed
  85. N Engl J Med. 1987 Oct 15;317(16):991-6 - PubMed
  86. Clin Orthop Relat Res. 2011 Jan;469(1):131-7 - PubMed
  87. Environ Health Perspect. 2011 Mar;119(3):326-31 - PubMed
  88. Hum Hered. 2007;63(2):111-9 - PubMed
  89. J Thromb Haemost. 2005 Feb;3(2):305-11 - PubMed
  90. Lancet. 2000 Jul 15;356(9225):182-3 - PubMed
  91. Chest. 1997 Jun;111(6):1603-6 - PubMed
  92. Ir J Med Sci. 2007 Dec;176(4):273-7 - PubMed
  93. Circulation. 1998 Mar 24;97(11):1037-41 - PubMed
  94. Arch Intern Med. 2007 May 14;167(9):935-43 - PubMed
  95. J Thromb Haemost. 2004 Sep;2(9):1526-32 - PubMed
  96. Hematology Am Soc Hematol Educ Program. 2005;:1-12 - PubMed
  97. Thromb Haemost. 2006 Dec;96(6):744-9 - PubMed
  98. Thromb Haemost. 2005 Feb;93(2):388-9 - PubMed
  99. Lancet. 1971 Sep 18;2(7725):664 - PubMed
  100. J Clin Endocrinol Metab. 2015 Nov;100(11):4012-20 - PubMed
  101. J Thromb Haemost. 2016 Jan;14 (1):83-8 - PubMed
  102. Circulation. 2007 Jan 16;115(2):188-95 - PubMed
  103. J Mal Vasc. 1986;11(2):125-7 - PubMed
  104. Lancet. 1969 Mar 15;1(7594):539-42 - PubMed
  105. Am Heart J. 2009 Jun;157(6):1081-7 - PubMed
  106. Am J Hum Genet. 2000 Dec;67(6):1452-9 - PubMed
  107. PLoS One. 2011;6(9):e25581 - PubMed
  108. J Thromb Haemost. 2011 Apr;9(4):672-8 - PubMed
  109. Am J Med. 2016 Mar;129(3):339.e19-26 - PubMed
  110. Circulation. 2004 Jun 1;109(21):2655-71 - PubMed
  111. J Thromb Haemost. 2011 Oct;9(10):1877-82 - PubMed
  112. Blood. 1996 Nov 15;88(10):3698-703 - PubMed
  113. Lancet. 1971 Jan 30;1(7692):239 - PubMed
  114. BMJ. 2014 Jul 17;349:g3743 - PubMed
  115. Circulation. 1997 Apr 1;95(7):1777-82 - PubMed
  116. Blood. 2012 Jul 19;120(3):656-63 - PubMed
  117. Lancet. 1969 Apr 26;1(7600):887 - PubMed
  118. Haematologica. 2010 Dec;95(12):2088-94 - PubMed
  119. Circulation. 2009 Jun 23;119(24):3118-24 - PubMed
  120. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1872-7 - PubMed
  121. J Thromb Haemost. 2012 Aug;10(8):1521-31 - PubMed
  122. Thromb Haemost. 2016 Sep 27;116(4):705-13 - PubMed
  123. Br J Haematol. 2011 Aug;154(4):486-91 - PubMed
  124. J Thromb Haemost. 2016 Apr;14(4):716-23 - PubMed
  125. Circulation. 2012 Feb 14;125(6):837-9 - PubMed
  126. Eur J Intern Med. 2010 Aug;21(4):268-72 - PubMed
  127. Blood Coagul Fibrinolysis. 2009 Oct;20(7):524-34 - PubMed
  128. Thromb Haemost. 2007 Apr;97(4):534-41 - PubMed
  129. Blood. 1998 May 15;91(10):3562-5 - PubMed
  130. Arteriosclerosis. 1989 May-Jun;9(3):362-7 - PubMed
  131. Haematologica. 2008 May;93(5):729-34 - PubMed
  132. Lancet. 1970 Feb 7;1(7641):303 - PubMed
  133. J Thromb Haemost. 2012 Feb;10(2):189-98 - PubMed
  134. Environ Health Perspect. 2015 Dec;123(12):1265-70 - PubMed
  135. Am J Epidemiol. 2012 Jan 15;175(2):114-26 - PubMed
  136. Arch Intern Med. 1998 Mar 23;158(6):585-93 - PubMed
  137. Am J Hum Genet. 2015 Apr 2;96(4):532-42 - PubMed
  138. Eur J Intern Med. 2016 Jan;27:10-3 - PubMed
  139. J Nutr. 2014 Jun;144(6):861-7 - PubMed
  140. J Thromb Haemost. 2011 Jun;9(6):1249-51 - PubMed
  141. Hematology Am Soc Hematol Educ Program. 2005;:452-7 - PubMed
  142. Blood. 2009 May 21;113(21):5298-303 - PubMed
  143. J Thromb Haemost. 2008 Jan;6(1):62-9 - PubMed
  144. Atherosclerosis. 1976 Jan-Feb;23(1):141-2 - PubMed
  145. Blood. 1999 Oct 15;94(8):2590-4 - PubMed
  146. Thromb Haemost. 2000 Nov;84(5):918 - PubMed
  147. J Thromb Haemost. 2009 Jul;7 Suppl 1:301-4 - PubMed
  148. Circulation. 1995 Nov 15;92(10):2800-2 - PubMed
  149. Lancet. 1969 Mar 22;1(7595):623 - PubMed
  150. J Am Geriatr Soc. 2008 Mar;56(3):517-22 - PubMed
  151. Hum Genet. 1980;55(1):129-31 - PubMed

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