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A generalized least-squares framework for rare-variant analysis in family data.

BMC proceedings

Li D, Rotter JI, Guo X.
PMID: 25519378
BMC Proc. 2014 Jun 17;8:S28. doi: 10.1186/1753-6561-8-S1-S28. eCollection 2014.

Rare variants may, in part, explain some of the hereditability missing in current genome-wide association studies. Many gene-based rare-variant analysis approaches proposed in recent years are aimed at population-based samples, although analysis strategies for family-based samples are clearly warranted...

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Li D, Rotter JI, Guo X. A generalized least-squares framework for rare-variant analysis in family data. BMC Proc. 2014;8:S28doi: 10.1186/1753-6561-8-S1-S28.
Li, D., Rotter, J. I., & Guo, X. (2014). A generalized least-squares framework for rare-variant analysis in family data. BMC proceedings, 8S28. https://doi.org/10.1186/1753-6561-8-S1-S28
Li, Dalin, et al. "A generalized least-squares framework for rare-variant analysis in family data." BMC proceedings vol. 8 (2014): S28. doi: https://doi.org/10.1186/1753-6561-8-S1-S28
Li D, Rotter JI, Guo X. A generalized least-squares framework for rare-variant analysis in family data. BMC Proc. 2014 Jun 17;8:S28. doi: 10.1186/1753-6561-8-S1-S28. eCollection 2014. PMID: 25519378; PMCID: PMC4143681.
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Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy.

Journal of diabetes mellitus

Ogunyemi D, Xu J, Mahesan AM, Rad S, Kim E, Yano J, Alexander C, Rotter JI, Chen YD.
PMID: 26029481
J Diabetes Mellitus. 2013 May;3(2):86-95. doi: 10.4236/jdm.2013.32013.

OBJECTIVE: To profile the differential gene expression of the KEGG Adipocytokine Signaling pathway in omental compared to subcutaneous tissue in normal pregnancy.STUDY DESIGN: Subjects included 14 nonobese, normal glucose tolerant, healthy pregnant women. Matched omental and subcutaneous tissue were...

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Ogunyemi D, Xu J, Mahesan AM, et al. Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy. J Diabetes Mellitus. 2013;3(2):86-95doi: 10.4236/jdm.2013.32013.
Ogunyemi, D., Xu, J., Mahesan, A. M., Rad, S., Kim, E., Yano, J., Alexander, C., Rotter, J. I., & Chen, Y. D. (2013). Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy. Journal of diabetes mellitus, 3(2), 86-95. https://doi.org/10.4236/jdm.2013.32013
Ogunyemi, Dotun, et al. "Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy." Journal of diabetes mellitus vol. 3,2 (2013): 86-95. doi: https://doi.org/10.4236/jdm.2013.32013
Ogunyemi D, Xu J, Mahesan AM, Rad S, Kim E, Yano J, Alexander C, Rotter JI, Chen YD. Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy. J Diabetes Mellitus. 2013 May;3(2):86-95. doi: 10.4236/jdm.2013.32013. PMID: 26029481; PMCID: PMC4447103.
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Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.

Molecular metabolism

Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM.
PMID: 25973386
Mol Metab. 2015 Mar 05;4(5):378-91. doi: 10.1016/j.molmet.2015.02.007. eCollection 2015 May.

OBJECTIVE: Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcription factor peroxisome proliferator activated-receptor...

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Mayoral R, Osborn O, McNelis J, et al. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015;4(5):378-91doi: 10.1016/j.molmet.2015.02.007.
Mayoral, R., Osborn, O., McNelis, J., Johnson, A. M., Oh, D. Y., Izquierdo, C. L., Chung, H., Li, P., Traves, P. G., Bandyopadhyay, G., Pessentheiner, A. R., Ofrecio, J. M., Cook, J. R., Qiang, L., Accili, D., & Olefsky, J. M. (2015). Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Molecular metabolism, 4(5), 378-91. https://doi.org/10.1016/j.molmet.2015.02.007
Mayoral, Rafael, et al. "Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity." Molecular metabolism vol. 4,5 (2015): 378-91. doi: https://doi.org/10.1016/j.molmet.2015.02.007
Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015 Mar 05;4(5):378-91. doi: 10.1016/j.molmet.2015.02.007. eCollection 2015 May. PMID: 25973386; PMCID: PMC4421024.
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Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits.

Psychosomatic medicine

Haljas K, Amare AT, Alizadeh BZ, Hsu YH, Mosley T, Newman A, Murabito J, Tiemeier H, Tanaka T, van Duijn C, Ding J, Llewellyn DJ, Bennett DA, Terracciano A, Launer L, Ladwig KH, Cornelis MC, Teumer A, Grabe H, Kardia SLR, Ware EB, Smith JA, Snieder H, Eriksson JG, Groop L, Räikkönen K, Lahti J.
PMID: 29280852
Psychosom Med. 2018 Apr;80(3):242-251. doi: 10.1097/PSY.0000000000000555.

OBJECTIVE: Shared genetic background may explain phenotypic associations between depression and Type 2 diabetes (T2D). We aimed to study, on a genome-wide level, if genetic correlation and pleiotropic loci exist between depressive symptoms and T2D or glycemic traits.METHODS: We...

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Haljas K, Amare AT, Alizadeh BZ, et al. Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits. Psychosom Med. 2018;80(3):242-251doi: 10.1097/PSY.0000000000000555.
Haljas, K., Amare, A. T., Alizadeh, B. Z., Hsu, Y. H., Mosley, T., Newman, A., Murabito, J., Tiemeier, H., Tanaka, T., van Duijn, C., Ding, J., Llewellyn, D. J., Bennett, D. A., Terracciano, A., Launer, L., Ladwig, K. H., Cornelis, M. C., Teumer, A., Grabe, H., Kardia, S. L. R., Ware, E. B., Smith, J. A., Snieder, H., Eriksson, J. G., Groop, L., Räikkönen, K., & Lahti, J. (2018). Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits. Psychosomatic medicine, 80(3), 242-251. https://doi.org/10.1097/PSY.0000000000000555
Haljas, Kadri, et al. "Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits." Psychosomatic medicine vol. 80,3 (2018): 242-251. doi: https://doi.org/10.1097/PSY.0000000000000555
Haljas K, Amare AT, Alizadeh BZ, Hsu YH, Mosley T, Newman A, Murabito J, Tiemeier H, Tanaka T, van Duijn C, Ding J, Llewellyn DJ, Bennett DA, Terracciano A, Launer L, Ladwig KH, Cornelis MC, Teumer A, Grabe H, Kardia SLR, Ware EB, Smith JA, Snieder H, Eriksson JG, Groop L, Räikkönen K, Lahti J. Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits. Psychosom Med. 2018 Apr;80(3):242-251. doi: 10.1097/PSY.0000000000000555. PMID: 29280852; PMCID: PMC6051528.
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Fine mapping the .

NPJ aging and mechanisms of disease

van Leeuwen EM, Huffman JE, Bis JC, Isaacs A, Mulder M, Sabo A, Smith AV, Demissie S, Manichaikul A, Brody JA, Feitosa MF, Duan Q, Schraut KE, Navarro P, van Vliet-Ostaptchouk JV, Zhu G, Mbarek H, Trompet S, Verweij N, Lyytikäinen LP, Deelen J, Nolte IM, van der Laan SW, Davies G, Vermeij-Verdoold AJ, van Oosterhout AA, Vergeer-Drop JM, Arking DE, Trochet H, Medina-Gomez C, Rivadeneira F, Uitterlinden AG, Dehghan A, Franco OH, Sijbrands EJ, Hofman A, White CC, Mychaleckyj JC, Peloso GM, Swertz MA, Willemsen G, de Geus EJ, Milaneschi Y, Penninx BW, Ford I, Buckley BM, de Craen AJ, Starr JM, Deary IJ, Pasterkamp G, Oldehinkel AJ, Snieder H, Slagboom PE, Nikus K, Kähönen M, Lehtimäki T, Viikari JS, Raitakari OT, van der Harst P, Jukema JW, Hottenga JJ, Boomsma DI, Whitfield JB, Montgomery G, Martin NG, Polasek O, Vitart V, Hayward C, Kolcic I, Wright AF, Rudan I, Joshi PK, Wilson JF, Lange LA, Wilson JG, Gudnason V, Harris TB, Morrison AC, Borecki IB, Rich SS, Padmanabhan S, Psaty BM, Rotter JI, Smith BH, Boerwinkle E, Cupples LA, van Duijn C.
PMID: 28721259
NPJ Aging Mech Dis. 2015 Nov 12;1:15011. doi: 10.1038/npjamd.2015.11. eCollection 2015.

BACKGROUND: Individuals with exceptional longevity and their offspring have significantly larger high-density lipoprotein concentrations (HDL-C) particle sizes due to the increased homozygosity for the I405V variant in the cholesteryl ester transfer protein (METHODS: We performed a meta-analysis of HDL-C...

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van Leeuwen EM, Huffman JE, Bis JC, et al. Fine mapping the . NPJ Aging Mech Dis. 2015;1:15011doi: 10.1038/npjamd.2015.11.
van Leeuwen, E. M., Huffman, J. E., Bis, J. C., Isaacs, A., Mulder, M., Sabo, A., Smith, A. V., Demissie, S., Manichaikul, A., Brody, J. A., Feitosa, M. F., Duan, Q., Schraut, K. E., Navarro, P., van Vliet-Ostaptchouk, J. V., Zhu, G., Mbarek, H., Trompet, S., Verweij, N., Lyytikäinen, L. P., Deelen, J., Nolte, I. M., van der Laan, S. W., Davies, G., Vermeij-Verdoold, A. J., van Oosterhout, A. A., Vergeer-Drop, J. M., Arking, D. E., Trochet, H., Medina-Gomez, C., Rivadeneira, F., Uitterlinden, A. G., Dehghan, A., Franco, O. H., Sijbrands, E. J., Hofman, A., White, C. C., Mychaleckyj, J. C., Peloso, G. M., Swertz, M. A., Willemsen, G., de Geus, E. J., Milaneschi, Y., Penninx, B. W., Ford, I., Buckley, B. M., de Craen, A. J., Starr, J. M., Deary, I. J., Pasterkamp, G., Oldehinkel, A. J., Snieder, H., Slagboom, P. E., Nikus, K., Kähönen, M., Lehtimäki, T., Viikari, J. S., Raitakari, O. T., van der Harst, P., Jukema, J. W., Hottenga, J. J., Boomsma, D. I., Whitfield, J. B., Montgomery, G., Martin, N. G., Polasek, O., Vitart, V., Hayward, C., Kolcic, I., Wright, A. F., Rudan, I., Joshi, P. K., Wilson, J. F., Lange, L. A., Wilson, J. G., Gudnason, V., Harris, T. B., Morrison, A. C., Borecki, I. B., Rich, S. S., Padmanabhan, S., Psaty, B. M., Rotter, J. I., Smith, B. H., Boerwinkle, E., Cupples, L. A., & van Duijn, C. (2015). Fine mapping the . NPJ aging and mechanisms of disease, 115011. https://doi.org/10.1038/npjamd.2015.11
van Leeuwen, Elisabeth M, et al. "Fine mapping the ." NPJ aging and mechanisms of disease vol. 1 (2015): 15011. doi: https://doi.org/10.1038/npjamd.2015.11
van Leeuwen EM, Huffman JE, Bis JC, Isaacs A, Mulder M, Sabo A, Smith AV, Demissie S, Manichaikul A, Brody JA, Feitosa MF, Duan Q, Schraut KE, Navarro P, van Vliet-Ostaptchouk JV, Zhu G, Mbarek H, Trompet S, Verweij N, Lyytikäinen LP, Deelen J, Nolte IM, van der Laan SW, Davies G, Vermeij-Verdoold AJ, van Oosterhout AA, Vergeer-Drop JM, Arking DE, Trochet H, Medina-Gomez C, Rivadeneira F, Uitterlinden AG, Dehghan A, Franco OH, Sijbrands EJ, Hofman A, White CC, Mychaleckyj JC, Peloso GM, Swertz MA, Willemsen G, de Geus EJ, Milaneschi Y, Penninx BW, Ford I, Buckley BM, de Craen AJ, Starr JM, Deary IJ, Pasterkamp G, Oldehinkel AJ, Snieder H, Slagboom PE, Nikus K, Kähönen M, Lehtimäki T, Viikari JS, Raitakari OT, van der Harst P, Jukema JW, Hottenga JJ, Boomsma DI, Whitfield JB, Montgomery G, Martin NG, Polasek O, Vitart V, Hayward C, Kolcic I, Wright AF, Rudan I, Joshi PK, Wilson JF, Lange LA, Wilson JG, Gudnason V, Harris TB, Morrison AC, Borecki IB, Rich SS, Padmanabhan S, Psaty BM, Rotter JI, Smith BH, Boerwinkle E, Cupples LA, van Duijn C. Fine mapping the . NPJ Aging Mech Dis. 2015 Nov 12;1:15011. doi: 10.1038/npjamd.2015.11. eCollection 2015. PMID: 28721259; PMCID: PMC5514988.
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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Hypertension (Dallas, Tex. : 1979)

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D, Luan J, Del Greco M F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Marten J, Gandin I, Harris SE, Zemunik T, Lu Y, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR, Batini C, Beilby J, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M, Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Dörr M, Farrall M, Ferreira T, Frånberg M, Gao H, Giedraitis V, Gieger C, Giulianini F, Gow AJ, Hamsten A, Harris TB, Hofman A, Holliday EG, Hui J, Jarvelin MR, Johansson Å, Johnson AD, Jousilahti P, Jula A, Kähönen M, Kathiresan S, Khaw KT, Kolcic I, Koskinen S, Langenberg C, Larson M, Launer LJ, Lehne B, Liewald DCM, Lin L, Lind L, Mach F, Mamasoula C, Menni C, Mifsud B, Milaneschi Y, Morgan A, Morris AD, Morrison AC, Munson PJ, Nandakumar P, Nguyen QT, Nutile T, Oldehinkel AJ, Oostra BA, Org E, Padmanabhan S, Palotie A, Paré G, Pattie A, Penninx BWJH, Poulter N, Pramstaller PP, Raitakari OT, Ren M, Rice K, Ridker PM, Riese H, Ripatti S, Robino A, Rotter JI, Rudan I, Saba Y, Saint Pierre A, Sala CF, Sarin AP, Schmidt R, Scott R, Seelen MA, Shields DC, Siscovick D, Sorice R, Stanton A, Stott DJ, Sundström J, Swertz M, Taylor KD, Thom S, Tzoulaki I, Tzourio C, Uitterlinden AG, Völker U, Vollenweider P, Wild S, Willemsen G, Wright AF, Yao J, Thériault S, Conen D, Attia J, Sever P, Debette S, Mook-Kanamori DO, Zeggini E, Spector TD, van der Harst P, Palmer CNA, Vergnaud AC, Loos RJF, Polasek O, Starr JM, Girotto G, Hayward C, Kooner JS, Lindgren CM, Vitart V, Samani NJ, Tuomilehto J, Gyllensten U, Knekt P, Deary IJ, Ciullo M, Elosua R, Keavney BD, Hicks AA, Scott RA, Gasparini P, Laan M, Liu Y, Watkins H, Hartman CA, Salomaa V, Toniolo D, Perola M, Wilson JF, Schmidt H, Zhao JH, Lehtimäki T, van Duijn CM, Gudnason V, Psaty BM, Peters A, Rettig R, James A, Jukema JW, Strachan DP, Palmas W, Metspalu A, Ingelsson E, Boomsma DI, Franco OH, Bochud M, Newton-Cheh C, Munroe PB, Elliott P, Chasman DI, Chakravarti A, Knight J, Morris AP, Levy D, Tobin MD, Snieder H, Caulfield MJ, Ehret GB.
PMID: 28739976
Hypertension. 2017 Jul 24; doi: 10.1161/HYPERTENSIONAHA.117.09438. Epub 2017 Jul 24.

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel...

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Wain LV, Vaez A, Jansen R, et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017;doi: 10.1161/HYPERTENSIONAHA.117.09438.
Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P. J., Erzurumluoglu, A. M., O'Reilly, P. F., Cabrera, C. P., Warren, H. R., Rose, L. M., Verwoert, G. C., Hottenga, J. J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S. J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N., Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, J., Del Greco M, F., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Marten, J., Gandin, I., Harris, S. E., Zemunik, T., Lu, Y., Evangelou, E., Shah, N., de Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Barnes, M. R., Batini, C., Beilby, J., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brown, M., Brumat, M., Campbell, H., Chambers, J. C., Cocca, M., Collins, F., Connell, J., Cordell, H. J., Damman, J. J., Davies, G., de Geus, E. J., de Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Farrall, M., Ferreira, T., Frånberg, M., Gao, H., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Hui, J., Jarvelin, M. R., Johansson, �. �., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Mifsud, B., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Padmanabhan, S., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Poulter, N., Pramstaller, P. P., Raitakari, O. T., Ren, M., Rice, K., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Shields, D. C., Siscovick, D., Sorice, R., Stanton, A., Stott, D. J., Sundström, J., Swertz, M., Taylor, K. D., Thom, S., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., Attia, J., Sever, P., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., van der Harst, P., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Hayward, C., Kooner, J. S., Lindgren, C. M., Vitart, V., Samani, N. J., Tuomilehto, J., Gyllensten, U., Knekt, P., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Jukema, J. W., Strachan, D. P., Palmas, W., Metspalu, A., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M., Newton-Cheh, C., Munroe, P. B., Elliott, P., Chasman, D. I., Chakravarti, A., Knight, J., Morris, A. P., Levy, D., Tobin, M. D., Snieder, H., Caulfield, M. J., & Ehret, G. B. (2017). Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension (Dallas, Tex. : 1979), . https://doi.org/10.1161/HYPERTENSIONAHA.117.09438
Wain, Louise V, et al. "Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney." Hypertension (Dallas, Tex. : 1979) vol. (2017). doi: https://doi.org/10.1161/HYPERTENSIONAHA.117.09438
Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D, Luan J, Del Greco M F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Marten J, Gandin I, Harris SE, Zemunik T, Lu Y, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR, Batini C, Beilby J, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M, Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Dörr M, Farrall M, Ferreira T, Frånberg M, Gao H, Giedraitis V, Gieger C, Giulianini F, Gow AJ, Hamsten A, Harris TB, Hofman A, Holliday EG, Hui J, Jarvelin MR, Johansson Å, Johnson AD, Jousilahti P, Jula A, Kähönen M, Kathiresan S, Khaw KT, Kolcic I, Koskinen S, Langenberg C, Larson M, Launer LJ, Lehne B, Liewald DCM, Lin L, Lind L, Mach F, Mamasoula C, Menni C, Mifsud B, Milaneschi Y, Morgan A, Morris AD, Morrison AC, Munson PJ, Nandakumar P, Nguyen QT, Nutile T, Oldehinkel AJ, Oostra BA, Org E, Padmanabhan S, Palotie A, Paré G, Pattie A, Penninx BWJH, Poulter N, Pramstaller PP, Raitakari OT, Ren M, Rice K, Ridker PM, Riese H, Ripatti S, Robino A, Rotter JI, Rudan I, Saba Y, Saint Pierre A, Sala CF, Sarin AP, Schmidt R, Scott R, Seelen MA, Shields DC, Siscovick D, Sorice R, Stanton A, Stott DJ, Sundström J, Swertz M, Taylor KD, Thom S, Tzoulaki I, Tzourio C, Uitterlinden AG, Völker U, Vollenweider P, Wild S, Willemsen G, Wright AF, Yao J, Thériault S, Conen D, Attia J, Sever P, Debette S, Mook-Kanamori DO, Zeggini E, Spector TD, van der Harst P, Palmer CNA, Vergnaud AC, Loos RJF, Polasek O, Starr JM, Girotto G, Hayward C, Kooner JS, Lindgren CM, Vitart V, Samani NJ, Tuomilehto J, Gyllensten U, Knekt P, Deary IJ, Ciullo M, Elosua R, Keavney BD, Hicks AA, Scott RA, Gasparini P, Laan M, Liu Y, Watkins H, Hartman CA, Salomaa V, Toniolo D, Perola M, Wilson JF, Schmidt H, Zhao JH, Lehtimäki T, van Duijn CM, Gudnason V, Psaty BM, Peters A, Rettig R, James A, Jukema JW, Strachan DP, Palmas W, Metspalu A, Ingelsson E, Boomsma DI, Franco OH, Bochud M, Newton-Cheh C, Munroe PB, Elliott P, Chasman DI, Chakravarti A, Knight J, Morris AP, Levy D, Tobin MD, Snieder H, Caulfield MJ, Ehret GB. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017 Jul 24; doi: 10.1161/HYPERTENSIONAHA.117.09438. Epub 2017 Jul 24. PMID: 28739976; PMCID: PMC5783787.
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E47 Governs the MYC-CDKN1B/p27.

Cellular and molecular gastroenterology and hepatology

Scully KM, Lahmy R, Signaevskaia L, Sasik R, Medal R, Kim H, French R, James B, Wu Y, Lowy AM, Itkin-Ansari P.
PMID: 30003124
Cell Mol Gastroenterol Hepatol. 2018 May 16;6(2):181-198. doi: 10.1016/j.jcmgh.2018.05.002. eCollection 2018.

BACKGROUND & AIMS: Oncogenic mutations in KRAS, coupled with inactivation of p53, CDKN2A/p16METHODS: RNA sequencing was used to profile E47-dependent transcriptomes in 5 PDA cell lines. Gene Ontology analysis identified cell-cycle control as the most altered pathway. Small interfering...

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Scully KM, Lahmy R, Signaevskaia L, et al. E47 Governs the MYC-CDKN1B/p27. Cell Mol Gastroenterol Hepatol. 2018;6(2):181-198doi: 10.1016/j.jcmgh.2018.05.002.
Scully, K. M., Lahmy, R., Signaevskaia, L., Sasik, R., Medal, R., Kim, H., French, R., James, B., Wu, Y., Lowy, A. M., & Itkin-Ansari, P. (2018). E47 Governs the MYC-CDKN1B/p27. Cellular and molecular gastroenterology and hepatology, 6(2), 181-198. https://doi.org/10.1016/j.jcmgh.2018.05.002
Scully, Kathleen M, et al. "E47 Governs the MYC-CDKN1B/p27." Cellular and molecular gastroenterology and hepatology vol. 6,2 (2018): 181-198. doi: https://doi.org/10.1016/j.jcmgh.2018.05.002
Scully KM, Lahmy R, Signaevskaia L, Sasik R, Medal R, Kim H, French R, James B, Wu Y, Lowy AM, Itkin-Ansari P. E47 Governs the MYC-CDKN1B/p27. Cell Mol Gastroenterol Hepatol. 2018 May 16;6(2):181-198. doi: 10.1016/j.jcmgh.2018.05.002. eCollection 2018. PMID: 30003124; PMCID: PMC6039985.
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Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction.

Journal of the Endocrine Society

Rickert E, Fernandez MO, Choi I, Gorman M, Olefsky JM, Webster NJG.
PMID: 30746504
J Endocr Soc. 2018 Dec 24;3(2):427-445. doi: 10.1210/js.2018-00318. eCollection 2019 Feb 01.

Sirt1 is an NAD-dependent, class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neuronal Sirt1 activity plays a role in the central regulation of energy...

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Rickert E, Fernandez MO, Choi I, et al. Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction. J Endocr Soc. 2018;3(2):427-445doi: 10.1210/js.2018-00318.
Rickert, E., Fernandez, M. O., Choi, I., Gorman, M., Olefsky, J. M., & Webster, N. J. G. (2019). Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction. Journal of the Endocrine Society, 3(2), 427-445. https://doi.org/10.1210/js.2018-00318
Rickert, Emily, et al. "Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction." Journal of the Endocrine Society vol. 3,2 (2019): 427-445. doi: https://doi.org/10.1210/js.2018-00318
Rickert E, Fernandez MO, Choi I, Gorman M, Olefsky JM, Webster NJG. Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction. J Endocr Soc. 2018 Dec 24;3(2):427-445. doi: 10.1210/js.2018-00318. eCollection 2019 Feb 01. PMID: 30746504; PMCID: PMC6364627.
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Can Monoclonal Antibodies against CGRP Offer New Treatment Options for Type 2 Diabetes?.

Journal of diabetes and clinical research

Riera CE.
PMID: 33604590
J Diabetes Clin Res. 2020;2(4):114-118. doi: 10.33696/diabetes.1.028.

No abstract available.

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Riera CE. Can Monoclonal Antibodies against CGRP Offer New Treatment Options for Type 2 Diabetes?. J Diabetes Clin Res. 2020;2(4):114-118doi: 10.33696/diabetes.1.028.
Riera, C. E. (2020). Can Monoclonal Antibodies against CGRP Offer New Treatment Options for Type 2 Diabetes?. Journal of diabetes and clinical research, 2(4), 114-118. https://doi.org/10.33696/diabetes.1.028
Riera, Celine E. "Can Monoclonal Antibodies against CGRP Offer New Treatment Options for Type 2 Diabetes?." Journal of diabetes and clinical research vol. 2,4 (2020): 114-118. doi: https://doi.org/10.33696/diabetes.1.028
Riera CE. Can Monoclonal Antibodies against CGRP Offer New Treatment Options for Type 2 Diabetes?. J Diabetes Clin Res. 2020;2(4):114-118. doi: 10.33696/diabetes.1.028. PMID: 33604590; PMCID: PMC7889048.
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Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome.

EBioMedicine

Zeng Y, Amador C, Gao C, Walker RM, Morris SW, Campbell A, Frkatović A, Madden RA, Adams MJ, He S, Bretherick AD, Hayward C, Porteous DJ, Wilson JF, Evans KL, McIntosh AM, Navarro P, Haley CS.
PMID: 34883445
EBioMedicine. 2021 Dec 05;74:103730. doi: 10.1016/j.ebiom.2021.103730. Epub 2021 Dec 05.

BACKGROUND: parent-of-origin effects (POE) play important roles in complex disease and thus understanding their regulation and associated molecular and phenotypic variation are warranted. Previous studies mainly focused on the detection of genomic regions or phenotypes regulated by POE. Understanding...

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Zeng Y, Amador C, Gao C, et al. Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome. EBioMedicine. 2021;74:103730doi: 10.1016/j.ebiom.2021.103730.
Zeng, Y., Amador, C., Gao, C., Walker, R. M., Morris, S. W., Campbell, A., Frkatović, A., Madden, R. A., Adams, M. J., He, S., Bretherick, A. D., Hayward, C., Porteous, D. J., Wilson, J. F., Evans, K. L., McIntosh, A. M., Navarro, P., & Haley, C. S. (2021). Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome. EBioMedicine, 74103730. https://doi.org/10.1016/j.ebiom.2021.103730
Zeng, Yanni, et al. "Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome." EBioMedicine vol. 74 (2021): 103730. doi: https://doi.org/10.1016/j.ebiom.2021.103730
Zeng Y, Amador C, Gao C, Walker RM, Morris SW, Campbell A, Frkatović A, Madden RA, Adams MJ, He S, Bretherick AD, Hayward C, Porteous DJ, Wilson JF, Evans KL, McIntosh AM, Navarro P, Haley CS. Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome. EBioMedicine. 2021 Dec 05;74:103730. doi: 10.1016/j.ebiom.2021.103730. Epub 2021 Dec 05. PMID: 34883445; PMCID: PMC8654798.
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Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation.

Blood

Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, van Hylckama Vlieg A, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, Daian D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison AC, Mook-Kanamori DO, Deleuze JF, Johnson A, de Vries PS, Sabater-Lleal M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Trégouët DA, Morange PE.
PMID: 33512453
Blood. 2021 Apr 29;137(17):2394-2402. doi: 10.1182/blood.2020008997.

Genetic risk score (GRS) analysis is a popular approach to derive individual risk prediction models for complex diseases. In venous thrombosis (VT), such type of analysis shall integrate information at the ABO blood group locus, which is one of...

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Goumidi L, Thibord F, Wiggins KL, et al. Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. Blood. 2021;137(17):2394-2402doi: 10.1182/blood.2020008997.
Goumidi, L., Thibord, F., Wiggins, K. L., Li-Gao, R., Brown, M. R., van Hylckama Vlieg, A., Souto, J. C., Soria, J. M., Ibrahim-Kosta, M., Saut, N., Daian, D., Olaso, R., Amouyel, P., Debette, S., Boland, A., Bailly, P., Morrison, A. C., Mook-Kanamori, D. O., Deleuze, J. F., Johnson, A., de Vries, P. S., Sabater-Lleal, M., Chiaroni, J., Smith, N. L., Rosendaal, F. R., Chasman, D. I., Trégouët, D. A., & Morange, P. E. (2021). Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. Blood, 137(17), 2394-2402. https://doi.org/10.1182/blood.2020008997
Goumidi, Louisa, et al. "Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation." Blood vol. 137,17 (2021): 2394-2402. doi: https://doi.org/10.1182/blood.2020008997
Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, van Hylckama Vlieg A, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, Daian D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison AC, Mook-Kanamori DO, Deleuze JF, Johnson A, de Vries PS, Sabater-Lleal M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Trégouët DA, Morange PE. Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. Blood. 2021 Apr 29;137(17):2394-2402. doi: 10.1182/blood.2020008997. PMID: 33512453; PMCID: PMC8085481.
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Heterogeneity of HSCs in a Mouse Model of NASH.

Hepatology (Baltimore, Md.)

Rosenthal SB, Liu X, Ganguly S, Dhar D, Pasillas MP, Ricciardelli E, Li RZ, Troutman TD, Kisseleva T, Glass CK, Brenner DA.
PMID: 33550587
Hepatology. 2021 Aug;74(2):667-685. doi: 10.1002/hep.31743. Epub 2021 Aug 10.

BACKGROUND AND AIMS: In clinical and experimental NASH, the origin of the scar-forming myofibroblast is the HSC. We used foz/foz mice on a Western diet to characterize in detail the phenotypic changes of HSCs in a NASH model.APPROACH AND...

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Rosenthal SB, Liu X, Ganguly S, et al. Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology. 2021;74(2):667-685doi: 10.1002/hep.31743.
Rosenthal, S. B., Liu, X., Ganguly, S., Dhar, D., Pasillas, M. P., Ricciardelli, E., Li, R. Z., Troutman, T. D., Kisseleva, T., Glass, C. K., & Brenner, D. A. (2021). Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology (Baltimore, Md.), 74(2), 667-685. https://doi.org/10.1002/hep.31743
Rosenthal, Sara Brin, et al. "Heterogeneity of HSCs in a Mouse Model of NASH." Hepatology (Baltimore, Md.) vol. 74,2 (2021): 667-685. doi: https://doi.org/10.1002/hep.31743
Rosenthal SB, Liu X, Ganguly S, Dhar D, Pasillas MP, Ricciardelli E, Li RZ, Troutman TD, Kisseleva T, Glass CK, Brenner DA. Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology. 2021 Aug;74(2):667-685. doi: 10.1002/hep.31743. Epub 2021 Aug 10. PMID: 33550587; PMCID: PMC8346581.
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