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van Leeuwen EM, Huffman JE, Bis JC, et al. Fine mapping the . NPJ Aging Mech Dis. 2015;1:15011doi: 10.1038/npjamd.2015.11.
van Leeuwen, E. M., Huffman, J. E., Bis, J. C., Isaacs, A., Mulder, M., Sabo, A., Smith, A. V., Demissie, S., Manichaikul, A., Brody, J. A., Feitosa, M. F., Duan, Q., Schraut, K. E., Navarro, P., van Vliet-Ostaptchouk, J. V., Zhu, G., Mbarek, H., Trompet, S., Verweij, N., Lyytikäinen, L. P., Deelen, J., Nolte, I. M., van der Laan, S. W., Davies, G., Vermeij-Verdoold, A. J., van Oosterhout, A. A., Vergeer-Drop, J. M., Arking, D. E., Trochet, H., Medina-Gomez, C., Rivadeneira, F., Uitterlinden, A. G., Dehghan, A., Franco, O. H., Sijbrands, E. J., Hofman, A., White, C. C., Mychaleckyj, J. C., Peloso, G. M., Swertz, M. A., Willemsen, G., de Geus, E. J., Milaneschi, Y., Penninx, B. W., Ford, I., Buckley, B. M., de Craen, A. J., Starr, J. M., Deary, I. J., Pasterkamp, G., Oldehinkel, A. J., Snieder, H., Slagboom, P. E., Nikus, K., Kähönen, M., Lehtimäki, T., Viikari, J. S., Raitakari, O. T., van der Harst, P., Jukema, J. W., Hottenga, J. J., Boomsma, D. I., Whitfield, J. B., Montgomery, G., Martin, N. G., Polasek, O., Vitart, V., Hayward, C., Kolcic, I., Wright, A. F., Rudan, I., Joshi, P. K., Wilson, J. F., Lange, L. A., Wilson, J. G., Gudnason, V., Harris, T. B., Morrison, A. C., Borecki, I. B., Rich, S. S., Padmanabhan, S., Psaty, B. M., Rotter, J. I., Smith, B. H., Boerwinkle, E., Cupples, L. A., & van Duijn, C. (2015). Fine mapping the . NPJ aging and mechanisms of disease, 115011. https://doi.org/10.1038/npjamd.2015.11
van Leeuwen, Elisabeth M, et al. "Fine mapping the ." NPJ aging and mechanisms of disease vol. 1 (2015): 15011. doi: https://doi.org/10.1038/npjamd.2015.11
van Leeuwen EM, Huffman JE, Bis JC, Isaacs A, Mulder M, Sabo A, Smith AV, Demissie S, Manichaikul A, Brody JA, Feitosa MF, Duan Q, Schraut KE, Navarro P, van Vliet-Ostaptchouk JV, Zhu G, Mbarek H, Trompet S, Verweij N, Lyytikäinen LP, Deelen J, Nolte IM, van der Laan SW, Davies G, Vermeij-Verdoold AJ, van Oosterhout AA, Vergeer-Drop JM, Arking DE, Trochet H, Medina-Gomez C, Rivadeneira F, Uitterlinden AG, Dehghan A, Franco OH, Sijbrands EJ, Hofman A, White CC, Mychaleckyj JC, Peloso GM, Swertz MA, Willemsen G, de Geus EJ, Milaneschi Y, Penninx BW, Ford I, Buckley BM, de Craen AJ, Starr JM, Deary IJ, Pasterkamp G, Oldehinkel AJ, Snieder H, Slagboom PE, Nikus K, Kähönen M, Lehtimäki T, Viikari JS, Raitakari OT, van der Harst P, Jukema JW, Hottenga JJ, Boomsma DI, Whitfield JB, Montgomery G, Martin NG, Polasek O, Vitart V, Hayward C, Kolcic I, Wright AF, Rudan I, Joshi PK, Wilson JF, Lange LA, Wilson JG, Gudnason V, Harris TB, Morrison AC, Borecki IB, Rich SS, Padmanabhan S, Psaty BM, Rotter JI, Smith BH, Boerwinkle E, Cupples LA, van Duijn C. Fine mapping the . NPJ Aging Mech Dis. 2015 Nov 12;1:15011. doi: 10.1038/npjamd.2015.11. eCollection 2015. PMID: 28721259; PMCID: PMC5514988.
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NPJ Aging Mech Dis. 2015 Nov 12;1:15011. doi: 10.1038/npjamd.2015.11. eCollection 2015.

Fine mapping the .

NPJ aging and mechanisms of disease

Elisabeth M van Leeuwen, Jennifer E Huffman, Joshua C Bis, Aaron Isaacs, Monique Mulder, Aniko Sabo, Albert V Smith, Serkalem Demissie, Ani Manichaikul, Jennifer A Brody, Mary F Feitosa, Qing Duan, Katharina E Schraut, Pau Navarro, Jana V van Vliet-Ostaptchouk, Gu Zhu, Hamdi Mbarek, Stella Trompet, Niek Verweij, Leo-Pekka Lyytikäinen, Joris Deelen, Ilja M Nolte, Sander W van der Laan, Gail Davies, Andrea Jm Vermeij-Verdoold, Andy Alj van Oosterhout, Jeannette M Vergeer-Drop, Dan E Arking, Holly Trochet, Carolina Medina-Gomez, Fernando Rivadeneira, Andre G Uitterlinden, Abbas Dehghan, Oscar H Franco, Eric J Sijbrands, Albert Hofman, Charles C White, Josyf C Mychaleckyj, Gina M Peloso, Morris A Swertz, Gonneke Willemsen, Eco J de Geus, Yuri Milaneschi, Brenda Wjh Penninx, Ian Ford, Brendan M Buckley, Anton Jm de Craen, John M Starr, Ian J Deary, Gerard Pasterkamp, Albertine J Oldehinkel, Harold Snieder, P Eline Slagboom, Kjell Nikus, Mika Kähönen, Terho Lehtimäki, Jorma S Viikari, Olli T Raitakari, Pim van der Harst, J Wouter Jukema, Jouke-Jan Hottenga, Dorret I Boomsma, John B Whitfield, Grant Montgomery, Nicholas G Martin, Ozren Polasek, Veronique Vitart, Caroline Hayward, Ivana Kolcic, Alan F Wright, Igor Rudan, Peter K Joshi, James F Wilson, Leslie A Lange, James G Wilson, Vilmundur Gudnason, Tamar B Harris, Alanna C Morrison, Ingrid B Borecki, Stephen S Rich, Sandosh Padmanabhan, Bruce M Psaty, Jerome I Rotter, Blair H Smith, Eric Boerwinkle, L Adrienne Cupples, Cornelia van Duijn

Affiliations

  1. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  2. MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK.
  3. National Heart, Lung, and Blood Institute (NHLBI) Cardiovascular Epidemiology and Human Genomics Branch, Framingham Heart Study, Framingham, MA, USA.
  4. Department of Medicine, University of Washington, Seattle, WA, USA.
  5. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  6. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
  7. Icelandic Heart Association, Kopavogur, Iceland.
  8. Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  9. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  10. Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
  11. Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.
  12. Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
  13. Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland.
  14. Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  15. Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  16. Department of Biological Psychology, VU University Amsterdam and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
  17. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  18. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
  19. Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  20. Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
  21. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  22. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  23. Department of Experimental Cardiology, UMC Utrecht, Utrecht, The Netherlands.
  24. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  25. Department of Psychology, University of Edinburgh, Edinburgh, UK.
  26. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  27. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
  28. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  29. Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA.
  30. Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.
  31. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  32. Harvard Medical School, Boston, MA, USA.
  33. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  34. Department of Psychiatry, VU University Medical Center Amsterdam/GGZinGeest and EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
  35. Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
  36. Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
  37. Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
  38. Laboratory of Clinical Chemistry and Hematology, Division Laboratories & Pharmacy, UMC Utrecht, Utrecht, the Netherlands.
  39. Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  40. Department of Cardiology, Heart Centre, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
  41. Department of Clinical Physiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
  42. Division of Medicine, Turku University Hospital, and Department of Medicine, University of Turku, Turku, Finland.
  43. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
  44. Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  45. Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
  46. Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
  47. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
  48. National Institute on Aging, National Institute of Health, Bethesda, MD, USA.
  49. Human Genetics Center, The University of Texas School of Public Health, Houston, TX, USA.
  50. Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  51. Department of Medicine, Epidemiology & Health Services, University of Washington, Seattle, WA, USA.
  52. Group Health Research Institute, Group Health cooperative, Seattle, WA, USA.
  53. Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
  54. Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
  55. Departments of Pediatrics, Medicine, and Human Genetics, UCLA, Los Angeles, CA, USA.
  56. Medical Research Institute, University of Dundee, Dundee, UK.
  57. Framingham Heart Study, Framingham, MA, USA.

PMID: 28721259 PMCID: PMC5514988 DOI: 10.1038/npjamd.2015.11

Abstract

BACKGROUND: Individuals with exceptional longevity and their offspring have significantly larger high-density lipoprotein concentrations (HDL-C) particle sizes due to the increased homozygosity for the I405V variant in the cholesteryl ester transfer protein (

METHODS: We performed a meta-analysis of HDL-C within the

RESULTS: The meta-analysis of HDL-C within the

CONCLUSIONS: The causal variants in

Conflict of interest statement

PSM serves on the DSMB of a clinical trial of a device funded by the manufacturer (Zoll LifeCor) and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. SWvL is

References

  1. Nat Commun. 2014 Jun 02;5:3983 - PubMed
  2. Arch Gerontol Geriatr. 2006 Sep-Oct;43(2):213-21 - PubMed
  3. Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):884-90 - PubMed
  4. J Lipid Res. 2010 Dec;51(12):3524-32 - PubMed
  5. Diabetologia. 2011 Nov;54(11):2811-9 - PubMed
  6. Am J Hum Genet. 2014 Feb 6;94(2):223-32 - PubMed
  7. PLoS Genet. 2011 Jul;7(7):e1002198 - PubMed
  8. Nutrients. 2013 Jul 16;5(7):2708-33 - PubMed
  9. PLoS Genet. 2013 Mar;9(3):e1003379 - PubMed
  10. J Clin Invest. 1996 Jun 15;97(12):2917-23 - PubMed
  11. J Clin Endocrinol Metab. 2010 Oct;95(10):4493-500 - PubMed
  12. N Engl J Med. 2007 Nov 22;357(21):2109-22 - PubMed
  13. Nat Genet. 2012 Jul 22;44(8):955-9 - PubMed
  14. Hum Hered. 1986;36(3):143-53 - PubMed
  15. Diabetes. 2012 Jun;61(6):1315-22 - PubMed
  16. Nature. 2010 Aug 5;466(7307):707-13 - PubMed
  17. PLoS Genet. 2013;9(2):e1003264 - PubMed
  18. Heredity (Edinb). 2005 Sep;95(3):221-7 - PubMed
  19. Bioinformatics. 2010 Sep 1;26(17):2190-1 - PubMed
  20. Circulation. 2005 Jan 25;111(3):278-87 - PubMed
  21. J Clin Endocrinol Metab. 2009 Dec;94(12):4946-52 - PubMed
  22. J Clin Invest. 1995 Oct;96(4):2071-4 - PubMed
  23. Front Genet. 2014 Jun 03;5:159 - PubMed
  24. Nat Genet. 2013 Aug;45(8):899-901 - PubMed
  25. Diabetologia. 2007 Oct;50(10):2107-16 - PubMed
  26. Br J Pharmacol. 2008 Aug;154(7):1379-81 - PubMed
  27. Nat Genet. 2002 Jan;30(1):97-101 - PubMed
  28. PLoS Genet. 2012;8(3):e1002637 - PubMed
  29. Hum Genet. 2013 Feb;132(2):129-38 - PubMed
  30. J Lipid Res. 2014 Aug;55(8):1693-701 - PubMed
  31. Am J Hum Genet. 2007 Sep;81(3):559-75 - PubMed
  32. PLoS One. 2014 Jul 03;9(7):e101688 - PubMed
  33. Cardiovasc Res. 2014 Aug 1;103(3):423-8 - PubMed
  34. Circ Res. 2013 Jul 5;113(2):167-75 - PubMed
  35. Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2826-34 - PubMed
  36. Nat Genet. 2013 Nov;45(11):1274-1283 - PubMed
  37. Am J Hum Genet. 2011 Jan 7;88(1):76-82 - PubMed
  38. Exp Gerontol. 2014 Jul;55:129-33 - PubMed
  39. JAMA. 2003 Oct 15;290(15):2030-40 - PubMed
  40. Atherosclerosis. 2002 Apr;161(2):269-79 - PubMed
  41. PLoS Genet. 2009 Jun;5(6):e1000529 - PubMed
  42. Eur J Pharmacol. 2014 Oct 5;740:135-43 - PubMed

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