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Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.

PLoS pathogens

Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN.
PMID: 28380070
PLoS Pathog. 2017 Apr 05;13(4):e1006317. doi: 10.1371/journal.ppat.1006317. eCollection 2017 Apr.

[This corrects the article DOI: 10.1371/journal.ppat.1006219.].

Clinical, genetic and environmental factors associated with congenital vertebral malformations.

Molecular syndromology

Giampietro PF, Raggio CL, Blank RD, McCarty C, Broeckel U, Pickart MA.
PMID: 23653580
Mol Syndromol. 2013 Feb;4(1):94-105. doi: 10.1159/000345329.

Congenital vertebral malformations (CVM) pose a significant health problem because they can be associated with spinal deformities, such as congenital scoliosis and kyphosis, in addition to various syndromes and other congenital malformations. Additional information remains to be learned regarding...

A mosaic hemagglutinin-based influenza virus vaccine candidate protects mice from challenge with divergent H3N2 strains.

NPJ vaccines

Broecker F, Liu STH, Suntronwong N, Sun W, Bailey MJ, Nachbagauer R, Krammer F, Palese P.
PMID: 31341648
NPJ Vaccines. 2019 Jul 19;4:31. doi: 10.1038/s41541-019-0126-4. eCollection 2019.

Current seasonal influenza virus vaccines only provide limited, short-lived protection, and antigenic drift in the hemagglutinin surface glycoprotein necessitates their annual re-formulation and re-administration. To overcome these limitations, universal vaccine strategies that aim at eliciting broadly protective antibodies to...

Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model).

Pathogens (Basel, Switzerland)

Broeckel R, Haese N, Messaoudi I, Streblow DN.
PMID: 26389957
Pathogens. 2015 Sep 16;4(3):662-81. doi: 10.3390/pathogens4030662.

Chikungunya virus (CHIKV) is a positive-sense RNA virus transmitted by Aedes mosquitoes. CHIKV is a reemerging Alphavirus that causes acute febrile illness and severe and debilitating polyarthralgia of the peripheral joints. Huge epidemics and the rapid spread of CHIKV...

Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits.

HGG advances

Sun D, Richard M, Musani SK, Sung YJ, Winkler TW, Schwander K, Chai JF, Guo X, Kilpeläinen TO, Vojinovic D, Aschard H, Bartz TM, Bielak LF, Brown MR, Chitrala K, Hartwig FP, Horimoto ARVR, Liu Y, Manning AK, Noordam R, Smith AV, Harris SE, Kühnel B, Lyytikäinen LP, Nolte IM, Rauramaa R, van der Most PJ, Wang R, Ware EB, Weiss S, Wen W, Yanek LR, Arking DE, Arnett DK, Barac A, Boerwinkle E, Broeckel U, Chakravarti A, Chen YI, Cupples LA, Davigulus ML, de Las Fuentes L, de Mutsert R, de Vries PS, Delaney JAC, Roux AVD, Dörr M, Faul JD, Fretts AM, Gallo LC, Grabe HJ, Gu CC, Harris TB, Hartman CCA, Heikkinen S, Ikram MA, Isasi C, Johnson WC, Jonas JB, Kaplan RC, Komulainen P, Krieger JE, Levy D, Liu J, Lohman K, Luik AI, Martin LW, Meitinger T, Milaneschi Y, O'Connell JR, Palmas WR, Peters A, Peyser PA, Pulkki-Råback L, Raffel LJ, Reiner AP, Rice K, Robinson JG, Rosendaal FR, Schmidt CO, Schreiner PJ, Schwettmann L, Shikany JM, Shu XO, Sidney S, Sims M, Smith JA, Sotoodehnia N, Strauch K, Tai ES, Taylor K, Uitterlinden AG, van Duijn CM, Waldenberger M, Wee HL, Wei WB, Wilson G, Xuan D, Yao J, Zeng D, Zhao W, Zhu X, Zonderman AB, Becker DM, Deary IJ, Gieger C, Lakka TA, Lehtimäki T, North KE, Oldehinkel AJ, Penninx BWJH, Snieder H, Wang YX, Weir DR, Zheng W, Evans MK, Gauderman WJ, Gudnason V, Horta BL, Liu CT, Mook-Kanamori DO, Morrison AC, Pereira AC, Psaty BM, Amin N, Fox ER, Kooperberg C, Sim X, Bierut L, Rotter JI, Kardia SLR, Franceschini N, Rao DC, Fornage M.
PMID: 34734193
HGG Adv. 2021 Jan 14;2(1). doi: 10.1016/j.xhgg.2020.100013. Epub 2020 Oct 31.

Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP taking...

Structural Study of Aavrh.10 Receptor and Antibody Interactions.

Journal of virology

Mietzsch M, Yu JC, Hsi J, Chipman P, Broecker F, Fuming Z, Linhardt RJ, Seeberger PH, Heilbronn R, McKenna R, Agbandje-McKenna M.
PMID: 34549984
J Virol. 2021 Nov 09;95(23):e0124921. doi: 10.1128/JVI.01249-21. Epub 2021 Sep 22.

Recombinant adeno-associated virus (rAAV) vectors are one of the leading tools for the delivery of therapeutic genes in human gene therapy applications. For a successful transfer of their payload, the AAV vectors have to circumvent potential preexisting neutralizing host...

Structural Study of Aavrh.10 Receptor and Antibody Interactions.

Journal of virology

Mietzsch M, Yu JC, Hsi J, Chipman P, Broecker F, Fuming Z, Linhardt RJ, Seeberger PH, Heilbronn R, McKenna R, Agbandje-McKenna M.
PMID: 34549984
J Virol. 2021 Nov 09;95(23):e0124921. doi: 10.1128/JVI.01249-21. Epub 2021 Sep 22.

Recombinant adeno-associated virus (rAAV) vectors are one of the leading tools for the delivery of therapeutic genes in human gene therapy applications. For a successful transfer of their payload, the AAV vectors have to circumvent potential preexisting neutralizing host...

Overestimate of committed warming.

Nature

Schmidt GA, Severinghaus J, Abe-Ouchi A, Alley RB, Broecker W, Brook E, Etheridge D, Kawamura K, Keeling RF, Leinen M, Marvel K, Stocker TF.
PMID: 28703191
Nature. 2017 Jul 12;547(7662):E16-E17. doi: 10.1038/nature22803.

No abstract available.

Numerical stabilization of entanglement computation in auxiliary-field quantum Monte Carlo simulations of interacting many-fermion systems.

Physical review. E

Broecker P, Trebst S.
PMID: 28085385
Phys Rev E. 2016 Dec;94(6):063306. doi: 10.1103/PhysRevE.94.063306. Epub 2016 Dec 19.

In the absence of a fermion sign problem, auxiliary-field (or determinantal) quantum Monte Carlo (DQMC) approaches have long been the numerical method of choice for unbiased, large-scale simulations of interacting many-fermion systems. More recently, the conceptual scope of this...

Genetics, genomics and the power of stem cells to identify novel treatment options in complex diseases.

Personalized medicine

Broeckel U, Maresso K.
PMID: 29776230
Per Med. 2012 Nov;9(8):821-828. doi: 10.2217/pme.12.92.

The advances in human genetics enabled through the implementation of the latest sequencing technologies have the potential to dramatically change the landscape of medicine. As we decipher the polymorphic structure of the genome, the next challenge will focus on...

The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation.

Mobile DNA

Broecker F, Horton R, Heinrich J, Franz A, Schweiger MR, Lehrach H, Moelling K.
PMID: 27980690
Mob DNA. 2016 Dec 07;7:25. doi: 10.1186/s13100-016-0081-9. eCollection 2016.

BACKGROUND: Human endogenous retroviruses (HERVs) constitute 8% of the human genome and contribute substantially to the transcriptome. HERVs have been shown to generate RNAs that modulate host gene expression. However, experimental evidence for an impact of these regulatory transcripts...

RNase H As Gene Modifier, Driver of Evolution and Antiviral Defense.

Frontiers in microbiology

Moelling K, Broecker F, Russo G, Sunagawa S.
PMID: 28959243
Front Microbiol. 2017 Sep 14;8:1745. doi: 10.3389/fmicb.2017.01745. eCollection 2017.

Retroviral infections are 'mini-symbiotic' events supplying recipient cells with sequences for viral replication, including the reverse transcriptase (RT) and ribonuclease H (RNase H). These proteins and other viral or cellular sequences can provide novel cellular functions including immune defense...

Showing 1 to 12 of 65 entries