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Autophagic degradation of focal adhesions underlies metastatic cancer dissemination.

Molecular & cellular oncology

Sharifi MN, Mowers EE, Macleod KF.
PMID: 28401177
Mol Cell Oncol. 2016 Jun 10;4(2):e1198299. doi: 10.1080/23723556.2016.1198299. eCollection 2017.

Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein...

Mitophagy and cancer.

Cancer & metabolism

Chourasia AH, Boland ML, Macleod KF.
PMID: 25810907
Cancer Metab. 2015 Mar 26;3:4. doi: 10.1186/s40170-015-0130-8. eCollection 2015.

Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect of eliminating old and/or damaged mitochondria, thus maintaining the integrity of the mitochondrial pool. However, mitophagy...

Showing 1 to 2 of 2 entries