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Sharifi MN, Mowers EE, Macleod KF. Autophagic degradation of focal adhesions underlies metastatic cancer dissemination. Mol Cell Oncol. 2016;4(2):e1198299doi: 10.1080/23723556.2016.1198299.
Sharifi, M. N., Mowers, E. E., & Macleod, K. F. (2017). Autophagic degradation of focal adhesions underlies metastatic cancer dissemination. Molecular & cellular oncology, 4(2), e1198299. https://doi.org/10.1080/23723556.2016.1198299
Sharifi, Marina N, et al. "Autophagic degradation of focal adhesions underlies metastatic cancer dissemination." Molecular & cellular oncology vol. 4,2 (2017): e1198299. doi: https://doi.org/10.1080/23723556.2016.1198299
Sharifi MN, Mowers EE, Macleod KF. Autophagic degradation of focal adhesions underlies metastatic cancer dissemination. Mol Cell Oncol. 2016 Jun 10;4(2):e1198299. doi: 10.1080/23723556.2016.1198299. eCollection 2017. PMID: 28401177; PMCID: PMC5383354.
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Mol Cell Oncol. 2016 Jun 10;4(2):e1198299. doi: 10.1080/23723556.2016.1198299. eCollection 2017.

Autophagic degradation of focal adhesions underlies metastatic cancer dissemination.

Molecular & cellular oncology

Marina N Sharifi, Erin E Mowers, Kay F Macleod

Affiliations

  1. The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA; Medical Scientist Training Program, The University of Chicago, Chicago, IL, USA; The Committee on Cancer Biology, The University of Chicago, Chicago, IL, USA.
  2. The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA; Medical Scientist Training Program, The University of Chicago, Chicago, IL, USA; Interdisciplinary Scientist Training Program, The University of Chicago, Chicago, IL, USA.
  3. The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA; The Committee on Cancer Biology, The University of Chicago, Chicago, IL, USA.

PMID: 28401177 PMCID: PMC5383354 DOI: 10.1080/23723556.2016.1198299

Abstract

Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein LC3B is required for focal adhesion disassembly, Src-stimulated tumor cell motility, and metastasis.

Keywords: Autophagy; Src; cell motility; metastasis; paxillin

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