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Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks.

Cancers

Jones NR, Ashmore JH, Lee SY, Richie JP, Lazarus P, Muscat JE.
PMID: 26690219
Cancers (Basel). 2015 Dec 09;7(4):2386-96. doi: 10.3390/cancers7040898.

BACKGROUND: Polymorphisms in the hemochromatosis (HFE) gene are associated with excessive iron absorption from the diet, and pro-oxidant effects of iron accumulation are thought to be a risk factor for several types of cancer.METHODS: The C282Y (rs1800562) and H63D...

Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.

Frontiers in oncology

Chuang SC, Agudo A, Ahrens W, Anantharaman D, Benhamou S, Boccia S, Chen C, Conway DI, Fabianova E, Hayes RB, Healy CM, Holcatova I, Kjaerheim K, Lagiou P, Lazarus P, Macfarlane TV, Mahimkar MB, Mates D, Matsuo K, Merletti F, Metspalu A, Morgenstern H, Muscat J, Cadoni G, Olshan AF, Purdue M, Ramroth H, Rudnai P, Schwartz SM, Simonato L, Smith EM, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Thomson P, Wei Q, Zaridze D, Zhang ZF, Znaor A, Brennan P, Boffetta P, Hashibe M.
PMID: 22655231
Front Oncol. 2011 Jul 12;1:13. doi: 10.3389/fonc.2011.00013. eCollection 2011.

Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in...

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