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Jones NR, Ashmore JH, Lee SY, et al. Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks. Cancers (Basel). 2015;7(4):2386-96doi: 10.3390/cancers7040898.
Jones, N. R., Ashmore, J. H., Lee, S. Y., Richie, J. P., Lazarus, P., & Muscat, J. E. (2015). Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks. Cancers, 7(4), 2386-96. https://doi.org/10.3390/cancers7040898
Jones, Nathan R, et al. "Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks." Cancers vol. 7,4 (2015): 2386-96. doi: https://doi.org/10.3390/cancers7040898
Jones NR, Ashmore JH, Lee SY, Richie JP, Lazarus P, Muscat JE. Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks. Cancers (Basel). 2015 Dec 09;7(4):2386-96. doi: 10.3390/cancers7040898. PMID: 26690219; PMCID: PMC4695898.
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Cancers (Basel). 2015 Dec 09;7(4):2386-96. doi: 10.3390/cancers7040898.

Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks.

Cancers

Nathan R Jones, Joseph H Ashmore, Sang Y Lee, John P Richie, Philip Lazarus, Joshua E Muscat

Affiliations

  1. Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA. [email protected].
  2. Department of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA. [email protected].
  3. Department of Neurosurgery, Penn State University College of Medicine, Hershey, PA 17033, USA. [email protected].
  4. Department of Public Health Sciences, Penn State University College of Medicine, 500 University Drive, CH69, Hershey, PA 17033, USA. [email protected].
  5. Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA. [email protected].
  6. Department of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA. [email protected].
  7. Department of Public Health Sciences, Penn State University College of Medicine, 500 University Drive, CH69, Hershey, PA 17033, USA. [email protected].

PMID: 26690219 PMCID: PMC4695898 DOI: 10.3390/cancers7040898

Abstract

BACKGROUND: Polymorphisms in the hemochromatosis (HFE) gene are associated with excessive iron absorption from the diet, and pro-oxidant effects of iron accumulation are thought to be a risk factor for several types of cancer.

METHODS: The C282Y (rs1800562) and H63D (rs1799945) polymorphisms were genotyped in 301 oral cancer cases and 437 controls and analyzed in relation to oral cancer risk, and serum iron biomarker levels from a subset of 130 subjects.

RESULTS: Individuals with the C282Y allele had lower total iron binding capacity (TIBC) (321.2 ± 37.2 µg/dL vs. 397.7 ± 89.0 µg/dL, p = 0.007) and higher percent transferrin saturation (22.0 ± 8.7 vs. 35.6 ± 22.9, p = 0.023) than wild type individuals. Iron and ferritin levels approached significantly higher levels for the C282Y allele (p = 0.0632 and p = 0.0588, respectively).

CONCLUSIONS: Iron biomarker levels were elevated by the C282Y allele, but neither (rs1800562) nor (rs1799945) was associated with oral cancer risk in blacks and whites.

Keywords: Black; HFE; SNP; White; genotyping; iron homeostasis; oral cancer

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