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Showing 1 to 4 of 4 entries
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Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic Fatty liver disease.

Journal of lipids

de Bari O, Neuschwander-Tetri BA, Liu M, Portincasa P, Wang DQ.
PMID: 22132342
J Lipids. 2012;2012:302847. doi: 10.1155/2012/302847. Epub 2011 Nov 03.

The cholesterol absorption inhibitor ezetimibe can significantly reduce plasma cholesterol concentrations by inhibiting the Niemann-Pick C1-like 1 protein (NPC1L1), an intestinal sterol influx transporter that can actively facilitate the uptake of cholesterol for intestinal absorption. Unexpectedly, ezetimibe treatment also...

Therapy of gallstone disease: What it was, what it is, what it will be.

World journal of gastrointestinal pharmacology and therapeutics

Portincasa P, Ciaula AD, Bonfrate L, Wang DQ.
PMID: 22577615
World J Gastrointest Pharmacol Ther. 2012 Apr 06;3(2):7-20. doi: 10.4292/wjgpt.v3.i2.7.

Cholesterol gallstone disease is a common clinical condition influenced by genetic factors, increasing age, female gender, and metabolic factors. Although laparoscopic cholecystectomy is currently considered the gold standard in treating patients with symptomatic gallstones, new perspectives regarding medical therapy...

A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways.

Journal of lipids

Garruti G, Wang HH, Bonfrate L, de Bari O, Wang DQ, Portincasa P.
PMID: 22577560
J Lipids. 2012;2012:304292. doi: 10.1155/2012/304292. Epub 2012 Apr 22.

Nuclear receptors (NRs) comprise one of the most abundant classes of transcriptional regulators of metabolic diseases and have emerged as promising pharmaceutical targets. Small heterodimer partner (SHP; NR0B2) is a unique orphan NR lacking a DNA-binding domain but contains...

The deletion of the estrogen receptor α gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice.

Biochimica et biophysica acta

de Bari O, Wang HH, Portincasa P, Liu M, Wang DQ.
PMID: 26232687
Biochim Biophys Acta. 2015 Oct;1852(10):2161-9. doi: 10.1016/j.bbadis.2015.07.020. Epub 2015 Jul 30.

Compelling evidence has demonstrated that estrogen is a critical risk factor for gallstone formation and enhances cholesterol cholelithogenesis through the hepatic estrogen receptor α (ERα), but not ERβ. To study the lithogenic mechanisms of estrogen through ERα, we investigated...

Showing 1 to 4 of 4 entries