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Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.

Genes

Wen J, Xie M, Rowland B, Rosen JD, Sun Q, Chen J, Tapia AL, Qian H, Kowalski MH, Shan Y, Young KL, Graff M, Argos M, Avery CL, Bien SA, Buyske S, Yin J, Choquet H, Fornage M, Hodonsky CJ, Jorgenson E, Kooperberg C, Loos RJF, Liu Y, Moon JY, North KE, Rich SS, Rotter JI, Smith JA, Zhao W, Shang L, Wang T, Zhou X, Reiner AP, Raffield LM, Li Y.
PMID: 34356065
Genes (Basel). 2021 Jul 08;12(7). doi: 10.3390/genes12071049.

BACKGROUND: Thousands of genetic variants have been associated with hematological traits, though target genes remain unknown at most loci. Moreover, limited analyses have been conducted in African ancestry and Hispanic/Latino populations; hematological trait associated variants more common in these...

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Wen J, Xie M, Rowland B, et al. Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. Genes (Basel). 2021;12(7)doi: 10.3390/genes12071049.
Wen, J., Xie, M., Rowland, B., Rosen, J. D., Sun, Q., Chen, J., Tapia, A. L., Qian, H., Kowalski, M. H., Shan, Y., Young, K. L., Graff, M., Argos, M., Avery, C. L., Bien, S. A., Buyske, S., Yin, J., Choquet, H., Fornage, M., Hodonsky, C. J., Jorgenson, E., Kooperberg, C., Loos, R. J. F., Liu, Y., Moon, J. Y., North, K. E., Rich, S. S., Rotter, J. I., Smith, J. A., Zhao, W., Shang, L., Wang, T., Zhou, X., Reiner, A. P., Raffield, L. M., & Li, Y. (2021). Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. Genes, 12(7), . https://doi.org/10.3390/genes12071049
Wen, Jia, et al. "Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations." Genes vol. 12,7 (2021). doi: https://doi.org/10.3390/genes12071049
Wen J, Xie M, Rowland B, Rosen JD, Sun Q, Chen J, Tapia AL, Qian H, Kowalski MH, Shan Y, Young KL, Graff M, Argos M, Avery CL, Bien SA, Buyske S, Yin J, Choquet H, Fornage M, Hodonsky CJ, Jorgenson E, Kooperberg C, Loos RJF, Liu Y, Moon JY, North KE, Rich SS, Rotter JI, Smith JA, Zhao W, Shang L, Wang T, Zhou X, Reiner AP, Raffield LM, Li Y. Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. Genes (Basel). 2021 Jul 08;12(7). doi: 10.3390/genes12071049. PMID: 34356065; PMCID: PMC8307403.
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Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos.

American journal of human genetics

Conomos MP, Laurie CA, Stilp AM, Gogarten SM, McHugh CP, Nelson SC, Sofer T, Fernández-Rhodes L, Justice AE, Graff M, Young KL, Seyerle AA, Avery CL, Taylor KD, Rotter JI, Talavera GA, Daviglus ML, Wassertheil-Smoller S, Schneiderman N, Heiss G, Kaplan RC, Franceschini N, Reiner AP, Shaffer JR, Barr RG, Kerr KF, Browning SR, Browning BL, Weir BS, Avilés-Santa ML, Papanicolaou GJ, Lumley T, Szpiro AA, North KE, Rice K, Thornton TA, Laurie CC.
PMID: 26748518
Am J Hum Genet. 2016 Jan 07;98(1):165-84. doi: 10.1016/j.ajhg.2015.12.001.

US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental exposures. Here, we characterized and controlled for this diversity in genome-wide association studies (GWASs) for the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We simultaneously estimated population-structure principal...

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Conomos MP, Laurie CA, Stilp AM, et al. Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. Am J Hum Genet. 2016;98(1):165-84doi: 10.1016/j.ajhg.2015.12.001.
Conomos, M. P., Laurie, C. A., Stilp, A. M., Gogarten, S. M., McHugh, C. P., Nelson, S. C., Sofer, T., Fernández-Rhodes, L., Justice, A. E., Graff, M., Young, K. L., Seyerle, A. A., Avery, C. L., Taylor, K. D., Rotter, J. I., Talavera, G. A., Daviglus, M. L., Wassertheil-Smoller, S., Schneiderman, N., Heiss, G., Kaplan, R. C., Franceschini, N., Reiner, A. P., Shaffer, J. R., Barr, R. G., Kerr, K. F., Browning, S. R., Browning, B. L., Weir, B. S., Avilés-Santa, M. L., Papanicolaou, G. J., Lumley, T., Szpiro, A. A., North, K. E., Rice, K., Thornton, T. A., & Laurie, C. C. (2016). Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. American journal of human genetics, 98(1), 165-84. https://doi.org/10.1016/j.ajhg.2015.12.001
Conomos, Matthew P, et al. "Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos." American journal of human genetics vol. 98,1 (2016): 165-84. doi: https://doi.org/10.1016/j.ajhg.2015.12.001
Conomos MP, Laurie CA, Stilp AM, Gogarten SM, McHugh CP, Nelson SC, Sofer T, Fernández-Rhodes L, Justice AE, Graff M, Young KL, Seyerle AA, Avery CL, Taylor KD, Rotter JI, Talavera GA, Daviglus ML, Wassertheil-Smoller S, Schneiderman N, Heiss G, Kaplan RC, Franceschini N, Reiner AP, Shaffer JR, Barr RG, Kerr KF, Browning SR, Browning BL, Weir BS, Avilés-Santa ML, Papanicolaou GJ, Lumley T, Szpiro AA, North KE, Rice K, Thornton TA, Laurie CC. Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos. Am J Hum Genet. 2016 Jan 07;98(1):165-84. doi: 10.1016/j.ajhg.2015.12.001. PMID: 26748518; PMCID: PMC4716704.
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Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos.

BMC obesity

Fernández-Rhodes L, Howard AG, Graff M, Isasi CR, Highland HM, Young KL, Parra E, Below JE, Qi Q, Kaplan RC, Justice AE, Papanicolaou G, Laurie CC, Grant SFA, Haiman C, Loos RJF, North KE.
PMID: 30305909
BMC Obes. 2018 Oct 02;5:26. doi: 10.1186/s40608-018-0200-x. eCollection 2018.

BACKGROUND: Genome-wide association studies have implicated the METHODS: Using 9031 Hispanic/Latino adults (21-76 years) with complete weight history and genetic data from the community-based Hispanic Community Health Study/Study of Latinos (HCHS/SOL, Baseline 2008-2011), we estimated the multivariable association between...

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Fernández-Rhodes L, Howard AG, Graff M, et al. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC Obes. 2018;5:26doi: 10.1186/s40608-018-0200-x.
Fernández-Rhodes, L., Howard, A. G., Graff, M., Isasi, C. R., Highland, H. M., Young, K. L., Parra, E., Below, J. E., Qi, Q., Kaplan, R. C., Justice, A. E., Papanicolaou, G., Laurie, C. C., Grant, S. F. A., Haiman, C., Loos, R. J. F., & North, K. E. (2018). Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC obesity, 526. https://doi.org/10.1186/s40608-018-0200-x
Fernández-Rhodes, Lindsay, et al. "Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos." BMC obesity vol. 5 (2018): 26. doi: https://doi.org/10.1186/s40608-018-0200-x
Fernández-Rhodes L, Howard AG, Graff M, Isasi CR, Highland HM, Young KL, Parra E, Below JE, Qi Q, Kaplan RC, Justice AE, Papanicolaou G, Laurie CC, Grant SFA, Haiman C, Loos RJF, North KE. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC Obes. 2018 Oct 02;5:26. doi: 10.1186/s40608-018-0200-x. eCollection 2018. PMID: 30305909; PMCID: PMC6167893.
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Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents.

Pediatric research

Kim D, Justice AE, Chittoor G, Blanco E, Burrows R, Graff M, Howard AG, Wang Y, Rohde R, Buchanan VL, Voruganti VS, Almeida M, Peralta J, Lehman DM, Curran JE, Comuzzie AG, Duggirala R, Blangero J, Albala C, Santos JL, Angel B, Lozoff B, Gahagan S, North KE.
PMID: 34645953
Pediatr Res. 2021 Oct 13; doi: 10.1038/s41390-021-01729-7. Epub 2021 Oct 13.

BACKGROUND: Metabolic regulation plays a significant role in energy homeostasis, and adolescence is a crucial life stage for the development of cardiometabolic disease (CMD). This study aims to investigate the genetic determinants of metabolic biomarkers-adiponectin, leptin, ghrelin, and orexin-and...

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Kim D, Justice AE, Chittoor G, et al. Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents. Pediatr Res. 2021;doi: 10.1038/s41390-021-01729-7.
Kim, D., Justice, A. E., Chittoor, G., Blanco, E., Burrows, R., Graff, M., Howard, A. G., Wang, Y., Rohde, R., Buchanan, V. L., Voruganti, V. S., Almeida, M., Peralta, J., Lehman, D. M., Curran, J. E., Comuzzie, A. G., Duggirala, R., Blangero, J., Albala, C., Santos, J. L., Angel, B., Lozoff, B., Gahagan, S., & North, K. E. (2021). Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents. Pediatric research, . https://doi.org/10.1038/s41390-021-01729-7
Kim, Daeeun, et al. "Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents." Pediatric research vol. (2021). doi: https://doi.org/10.1038/s41390-021-01729-7
Kim D, Justice AE, Chittoor G, Blanco E, Burrows R, Graff M, Howard AG, Wang Y, Rohde R, Buchanan VL, Voruganti VS, Almeida M, Peralta J, Lehman DM, Curran JE, Comuzzie AG, Duggirala R, Blangero J, Albala C, Santos JL, Angel B, Lozoff B, Gahagan S, North KE. Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents. Pediatr Res. 2021 Oct 13; doi: 10.1038/s41390-021-01729-7. Epub 2021 Oct 13. PMID: 34645953.
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Showing 1 to 4 of 4 entries