Display options
Cite
Wen J, Xie M, Rowland B, et al. Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. Genes (Basel). 2021;12(7)doi: 10.3390/genes12071049.
Wen, J., Xie, M., Rowland, B., Rosen, J. D., Sun, Q., Chen, J., Tapia, A. L., Qian, H., Kowalski, M. H., Shan, Y., Young, K. L., Graff, M., Argos, M., Avery, C. L., Bien, S. A., Buyske, S., Yin, J., Choquet, H., Fornage, M., Hodonsky, C. J., Jorgenson, E., Kooperberg, C., Loos, R. J. F., Liu, Y., Moon, J. Y., North, K. E., Rich, S. S., Rotter, J. I., Smith, J. A., Zhao, W., Shang, L., Wang, T., Zhou, X., Reiner, A. P., Raffield, L. M., & Li, Y. (2021). Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. Genes, 12(7), . https://doi.org/10.3390/genes12071049
Wen, Jia, et al. "Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations." Genes vol. 12,7 (2021). doi: https://doi.org/10.3390/genes12071049
Wen J, Xie M, Rowland B, Rosen JD, Sun Q, Chen J, Tapia AL, Qian H, Kowalski MH, Shan Y, Young KL, Graff M, Argos M, Avery CL, Bien SA, Buyske S, Yin J, Choquet H, Fornage M, Hodonsky CJ, Jorgenson E, Kooperberg C, Loos RJF, Liu Y, Moon JY, North KE, Rich SS, Rotter JI, Smith JA, Zhao W, Shang L, Wang T, Zhou X, Reiner AP, Raffield LM, Li Y. Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. Genes (Basel). 2021 Jul 08;12(7). doi: 10.3390/genes12071049. PMID: 34356065; PMCID: PMC8307403.
Copy Download .nbib Format: NLM
Share it on

Genes (Basel). 2021 Jul 08;12(7). doi: 10.3390/genes12071049.

Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.

Genes

Jia Wen, Munan Xie, Bryce Rowland, Jonathan D Rosen, Quan Sun, Jiawen Chen, Amanda L Tapia, Huijun Qian, Madeline H Kowalski, Yue Shan, Kristin L Young, Marielisa Graff, Maria Argos, Christy L Avery, Stephanie A Bien, Steve Buyske, Jie Yin, Hélène Choquet, Myriam Fornage, Chani J Hodonsky, Eric Jorgenson, Charles Kooperberg, Ruth J F Loos, Yongmei Liu, Jee-Young Moon, Kari E North, Stephen S Rich, Jerome I Rotter, Jennifer A Smith, Wei Zhao, Lulu Shang, Tao Wang, Xiang Zhou, Alexander P Reiner, Laura M Raffield, Yun Li

Affiliations

  1. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
  2. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  3. Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  4. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
  5. Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60612, USA.
  6. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  7. Department of Statistics, Rutgers University, Piscataway, NJ 08854, USA.
  8. Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.
  9. Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
  10. Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
  11. Regeneron Genetics Center, Tarrytown, NY 10591, USA.
  12. The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  13. Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
  14. Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  15. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  16. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  17. Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  18. Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.

PMID: 34356065 PMCID: PMC8307403 DOI: 10.3390/genes12071049

Abstract

BACKGROUND: Thousands of genetic variants have been associated with hematological traits, though target genes remain unknown at most loci. Moreover, limited analyses have been conducted in African ancestry and Hispanic/Latino populations; hematological trait associated variants more common in these populations have likely been missed.

METHODS: To derive gene expression prediction models, we used ancestry-stratified datasets from the Multi-Ethnic Study of Atherosclerosis (MESA, including

RESULTS: Our results revealed 24 suggestive signals (

CONCLUSIONS: These analyses demonstrate the importance of performing TWAS and other genetic analyses across diverse populations and of balancing sample size and ancestry background matching when selecting a TWAS reference panel.

Keywords: TWAS (transcriptome-wide association study); ancestry; expression analysis; non-European populations

References

  1. Science. 2015 Jan 23;347(6220):1260419 - PubMed
  2. Am J Hum Genet. 2019 Jan 3;104(1):65-75 - PubMed
  3. J Immunol. 1992 May 15;148(10):3302-12 - PubMed
  4. Elife. 2017 Jan 09;6: - PubMed
  5. Nat Rev Genet. 2009 Feb;10(2):83-93 - PubMed
  6. Cancer Res. 2000 Apr 1;60(7):1824-9 - PubMed
  7. Am J Hum Genet. 2013 Aug 8;93(2):278-88 - PubMed
  8. Bioinformatics. 2016 May 15;32(10):1493-501 - PubMed
  9. PLoS One. 2013 Jul 18;8(7):e68141 - PubMed
  10. Nat Genet. 2016 Mar;48(3):245-52 - PubMed
  11. Kidney Int Rep. 2019 Dec 13;5(3):278-288 - PubMed
  12. Science. 2010 Aug 13;329(5993):841-5 - PubMed
  13. Eur J Hum Genet. 2016 Aug;24(8):1097-8 - PubMed
  14. Genome Biol. 2020 Feb 20;21(1):42 - PubMed
  15. Nat Commun. 2018 May 8;9(1):1825 - PubMed
  16. Nature. 2011 Nov 30;480(7376):201-8 - PubMed
  17. Hum Mol Genet. 2013 Dec 15;22(24):5065-74 - PubMed
  18. Am J Hum Genet. 2008 Jan;82(1):81-7 - PubMed
  19. Am J Hum Genet. 2021 May 6;108(5):874-893 - PubMed
  20. Nat Genet. 2018 Jul;50(7):968-978 - PubMed
  21. Nat Genet. 2016 Oct;48(10):1284-1287 - PubMed
  22. J Biol Chem. 1994 Feb 4;269(5):3633-40 - PubMed
  23. Am J Epidemiol. 2009 Feb 1;169(3):355-64 - PubMed
  24. PLoS One. 2020 Sep 28;15(9):e0236209 - PubMed
  25. Nat Commun. 2018 Oct 4;9(1):4079 - PubMed
  26. Genome Res. 2014 Jan;24(1):14-24 - PubMed
  27. Nat Genet. 2019 Apr;51(4):683-693 - PubMed
  28. Carcinogenesis. 2011 Nov;32(11):1668-74 - PubMed
  29. PLoS Genet. 2009 Jan;5(1):e1000360 - PubMed
  30. Cell. 2016 Nov 17;167(5):1415-1429.e19 - PubMed
  31. PLoS Genet. 2020 Aug 14;16(8):e1008927 - PubMed
  32. iScience. 2020 Nov 23;23(12):101850 - PubMed
  33. Nature. 2017 Oct 11;550(7675):204-213 - PubMed
  34. Cell. 2016 Nov 17;167(5):1369-1384.e19 - PubMed
  35. Nat Genet. 2019 Apr;51(4):592-599 - PubMed
  36. J Exp Clin Cancer Res. 2015 Mar 26;34:27 - PubMed
  37. Nat Genet. 2009 Nov;41(11):1191-8 - PubMed
  38. Ann Epidemiol. 2006 Feb;16(2):123-30 - PubMed
  39. Am J Hum Genet. 2019 Mar 7;104(3):410-421 - PubMed
  40. Nat Protoc. 2012 Feb 16;7(3):500-7 - PubMed
  41. Nat Commun. 2017 Aug 30;8(1):393 - PubMed
  42. Nat Genet. 2021 Jul;53(7):1097-1103 - PubMed
  43. Bioinformatics. 2010 Sep 1;26(17):2190-1 - PubMed
  44. Cell. 2020 Sep 3;182(5):1198-1213.e14 - PubMed
  45. Nature. 2019 Jun;570(7762):514-518 - PubMed
  46. Nat Commun. 2019 Dec 16;10(1):5732 - PubMed
  47. Blood. 2010 Dec 9;116(24):5316-26 - PubMed
  48. Nature. 2015 Oct 1;526(7571):68-74 - PubMed
  49. Int J Lab Hematol. 2010 Dec;32(6 Pt 2):590-7 - PubMed
  50. Nature. 2016 Oct 12;538(7624):161-164 - PubMed
  51. Am J Hum Genet. 2020 Apr 2;106(4):496-512 - PubMed
  52. Cell. 2020 Sep 3;182(5):1214-1231.e11 - PubMed
  53. BMC Genomics. 2020 Mar 14;21(1):228 - PubMed
  54. Glob Heart. 2017 Jun;12(2):67-68 - PubMed
  55. PLoS Genet. 2018 Aug 10;14(8):e1007586 - PubMed
  56. Blood. 2005 Jul 15;106(2):740-5 - PubMed
  57. Neuroreport. 2018 May 23;29(8):655-660 - PubMed
  58. Nat Genet. 2015 Sep;47(9):1091-8 - PubMed
  59. PLoS Genet. 2019 Dec 23;15(12):e1008500 - PubMed
  60. Arch Pharm Res. 2019 Nov;42(11):1021-1029 - PubMed
  61. Am J Med Sci. 2016 Apr;351(4):366-73 - PubMed
  62. Ethn Health. 2021 Feb 8;:1-13 - PubMed
  63. PLoS One. 2019 Aug 8;14(8):e0220827 - PubMed

Publication Types

Grant support