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Showing 1 to 12 of 193 entries
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Sodium-Glucose Cotransporter 2 Inhibitors and Diabetic Ketoacidosis: A Case Series From Three Academic Institutions.

Diabetes care

Misaghian-Xanthos N, Shariff AI, Mekala K, Fearrington LR, Setji TL, Aloi JA, Buse JB.
PMID: 28351898
Diabetes Care. 2017 Jun;40(6):e65-e66. doi: 10.2337/dc16-2591. Epub 2017 Mar 28.

No abstract available.

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis.

Alzheimer's & dementia (Amsterdam, Netherlands)

Hughes TM, Craft S, Baker LD, Espeland MA, Rapp SR, Sink KM, Bertoni AG, Burke GL, Gottesman RF, Michos ED, Luchsinger JA, Fitzpatrick AL, Hayden KM.
PMID: 28435852
Alzheimers Dement (Amst). 2017 Mar 31;8:18-25. doi: 10.1016/j.dadm.2017.03.003. eCollection 2017.

BACKGROUND: We examined whether changes in metabolic factors over 10 years were associated with cognitive performance.METHODS: Participants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000-2002) with five clinical examinations. At exam 5 (2010-2012), they received a...

Physical activity, sedentary behaviors and the incidence of type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA).

BMJ open diabetes research & care

Joseph JJ, Echouffo-Tcheugui JB, Golden SH, Chen H, Jenny NS, Carnethon MR, Jacobs D, Burke GL, Vaidya D, Ouyang P, Bertoni AG.
PMID: 27403323
BMJ Open Diabetes Res Care. 2016 Jun 23;4(1):e000185. doi: 10.1136/bmjdrc-2015-000185. eCollection 2016.

BACKGROUND: The association between physical activity (PA), sedentary behavior, and incident diabetes has been assessed in whites but is less well investigated in multiethnic populations.OBJECTIVE: To assess the association between PA, sedentary behavior, and incident diabetes in the Multi-Ethnic...

A survey of practices for the use of electronic health records to support research recruitment.

Journal of clinical and translational science

Obeid JS, Beskow LM, Rape M, Gouripeddi R, Black RA, Cimino JJ, Embi PJ, Weng C, Marnocha R, Buse JB.
PMID: 29657859
J Clin Transl Sci. 2017 Aug;1(4):246-252. doi: 10.1017/cts.2017.301.

Electronic health records (EHRs) provide great promise for identifying cohorts and enhancing research recruitment. Such approaches are sorely needed, but there are few descriptions in the literature of prevailing practices to guide their use. A multidisciplinary workgroup was formed...

Delivery of the research participant perception survey through the patient portal.

Journal of clinical and translational science

Kelly-Pumarol IJ, Henderson PQ, Rushing JT, Andrews JE, Kost RG, Wagenknecht LE.
PMID: 30370068
J Clin Transl Sci. 2018 Jun;2(3):163-168. doi: 10.1017/cts.2018.32. Epub 2018 Sep 21.

INTRODUCTION: The patient portal may be an effective method for administering surveys regarding participant research experiences but has not been systematically studied.METHODS: We evaluated 4 methods of delivering a research participant perception survey: mailing, phone, email, and patient portal....

Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits.

Psychosomatic medicine

Haljas K, Amare AT, Alizadeh BZ, Hsu YH, Mosley T, Newman A, Murabito J, Tiemeier H, Tanaka T, van Duijn C, Ding J, Llewellyn DJ, Bennett DA, Terracciano A, Launer L, Ladwig KH, Cornelis MC, Teumer A, Grabe H, Kardia SLR, Ware EB, Smith JA, Snieder H, Eriksson JG, Groop L, Räikkönen K, Lahti J.
PMID: 29280852
Psychosom Med. 2018 Apr;80(3):242-251. doi: 10.1097/PSY.0000000000000555.

OBJECTIVE: Shared genetic background may explain phenotypic associations between depression and Type 2 diabetes (T2D). We aimed to study, on a genome-wide level, if genetic correlation and pleiotropic loci exist between depressive symptoms and T2D or glycemic traits.METHODS: We...

A comprehensively revised strategy that improves the specific activity and long-term stability of clinically relevant .

Dalton transactions (Cambridge, England : 2003)

Bhatt NB, Pandya DN, Rideout-Danner S, Gage HD, Marini FC, Wadas TJ.
PMID: 30178793
Dalton Trans. 2018 Oct 07;47(37):13214-13221. doi: 10.1039/c8dt01841c. Epub 2018 Sep 04.

Zirconium-89 is currently being used in numerous clinical trials involving monoclonal antibodies and positron emission tomography. This report describes a revised strategy that reduces preparation time while increasing the specific activity of clinically relevant immuno-PET agents. Additionally, it demonstrates...

Natural killer cell-mediated inflammation resolution is disabled in severe asthma.

Science immunology

Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD.
PMID: 28783702
Sci Immunol. 2017 Mar 10;2(9). doi: 10.1126/sciimmunol.aam5446.

Severe asthma is typically characterized by chronic airway inflammation that is refractory to corticosteroids and associated with excess morbidity. Patients were recruited into the National Heart, Lung, and Blood Institute-sponsored Severe Asthma Research Program and comprehensively phenotyped by bronchoscopy....

Immunogenicity in African Green Monkeys of M Protein Mutant Vesicular Stomatitis Virus Vectors and Contribution of Vector-Encoded Flagellin.

Vaccines

Westcott MM, Smedberg J, Jorgensen MJ, Puckett S, Lyles DS.
PMID: 29562688
Vaccines (Basel). 2018 Mar 19;6(1). doi: 10.3390/vaccines6010016.

Recombinant vesicular stomatitis virus (VSV) is a promising platform for vaccine development. M51R VSV, an attenuated, M protein mutant strain, is an effective inducer of Type I interferon and dendritic cell (DC) maturation, which are desirable properties to exploit...

Methods guiding stakeholder engagement in planning a pragmatic study on changing stroke systems of care.

Journal of clinical and translational science

Gesell SB, Klein KP, Halladay J, Bettger JP, Freburger J, Cummings DM, Lutz BJ, Coleman S, Bushnell C, Rosamond W, Duncan PW.
PMID: 28649454
J Clin Transl Sci. 2017 Apr;1(2):121-128. doi: 10.1017/cts.2016.26. Epub 2017 Feb 27.

BACKGROUND: The Comprehensive Post-Acute Stroke Services (COMPASS) Study is one of the first large pragmatic randomized-controlled clinical trials using comparative effectiveness research methods, funded by the Patient-Centered Outcomes Research Institute. In the COMPASS Study, we compare the effectiveness of...

Discrimination against Mixed-Status Families and its Health Impact on Latino Children.

The journal of applied research on children : informing policy for children at risk

Singer MA, Velez MG, Rhodes SD, Linton JM.
PMID: 31528499
J Appl Res Child. 2018;10(1).

BACKGROUND AND OBJECTIVE: Restrictive immigration policies and discrimination are associated with negative health outcomes for immigrant and Latino families. Mixed-status families represent a unique subpopulation of Latinos affected by restrictive immigration policies. This qualitative study explored discrimination against mixed-status...

Selling the product: Strategies to increase recruitment and retention of Spanish-speaking Latinos in biomedical research.

Journal of clinical and translational science

Rhodes SD, Alonzo J, Mann-Jackson L, Tanner AE, Vissman AT, Martinez O, Rodriguez-Celedon R, Garcia JM, Arellano JE, Song EY, Eng E, Reboussin BA.
PMID: 30510779
J Clin Transl Sci. 2018 Jun;2(3):147-155. doi: 10.1017/cts.2018.314. Epub 2018 Oct 21.

INTRODUCTION: The Latino population in the US is rapidly growing and faces profound health disparities; however, engagement of Latinos in biomedical research remains low. Our community-based participatory research (CBPR) partnership has recruited 2,083 Spanish-speaking Latinos into 21 studies over...

Showing 1 to 12 of 193 entries