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Hughes TM, Craft S, Baker LD, et al. Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis. Alzheimers Dement (Amst). 2017;8:18-25doi: 10.1016/j.dadm.2017.03.003.
Hughes, T. M., Craft, S., Baker, L. D., Espeland, M. A., Rapp, S. R., Sink, K. M., Bertoni, A. G., Burke, G. L., Gottesman, R. F., Michos, E. D., Luchsinger, J. A., Fitzpatrick, A. L., & Hayden, K. M. (2017). Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis. Alzheimer's & dementia (Amsterdam, Netherlands), 818-25. https://doi.org/10.1016/j.dadm.2017.03.003
Hughes, Timothy M, et al. "Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 8 (2017): 18-25. doi: https://doi.org/10.1016/j.dadm.2017.03.003
Hughes TM, Craft S, Baker LD, Espeland MA, Rapp SR, Sink KM, Bertoni AG, Burke GL, Gottesman RF, Michos ED, Luchsinger JA, Fitzpatrick AL, Hayden KM. Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis. Alzheimers Dement (Amst). 2017 Mar 31;8:18-25. doi: 10.1016/j.dadm.2017.03.003. eCollection 2017. PMID: 28435852; PMCID: PMC5390661.
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Alzheimers Dement (Amst). 2017 Mar 31;8:18-25. doi: 10.1016/j.dadm.2017.03.003. eCollection 2017.

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis.

Alzheimer's & dementia (Amsterdam, Netherlands)

Timothy M Hughes, Suzanne Craft, Laura D Baker, Mark A Espeland, Stephen R Rapp, Kaycee M Sink, Alain G Bertoni, Gregory L Burke, Rebecca F Gottesman, Erin D Michos, José A Luchsinger, Annette L Fitzpatrick, Kathleen M Hayden

Affiliations

  1. Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  2. Department of Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  3. Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  4. Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  5. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  6. The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  7. Department of Medicine, Columbia University Medical Center, New York, NY, USA.
  8. Department of Epidemiology, Columbia University Medical Center, New York, NY, USA.
  9. Department of Family Medicine, University of Washington, Seattle, WA, USA.
  10. Department of Epidemiology, University of Washington, Seattle, WA, USA.
  11. Department of Global Health, University of Washington, Seattle, WA, USA.
  12. Department of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.

PMID: 28435852 PMCID: PMC5390661 DOI: 10.1016/j.dadm.2017.03.003

Abstract

BACKGROUND: We examined whether changes in metabolic factors over 10 years were associated with cognitive performance.

METHODS: Participants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000-2002) with five clinical examinations. At exam 5 (2010-2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and their changes over time before cognitive testing.

RESULTS: Among 4392 participants, baseline metabolic disorders (fasting glucose, systolic and diastolic blood pressures) were significantly associated with poorer CASI, DSC, and DS scores measured 10 years later. Increases in blood pressure were associated with lower cognitive performance. Results did not differ by race/ethnicity and were stronger among those without the

CONCLUSIONS: Cognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases. Findings appeared stronger among

Keywords: Brain; Cognitive function; Metabolic disorders; Metabolism

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