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Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans.

Clinical epigenetics

Ammous F, Zhao W, Ratliff SM, Mosley TH, Bielak LF, Zhou X, Peyser PA, Kardia SLR, Smith JA.
PMID: 33726838
Clin Epigenetics. 2021 Mar 16;13(1):55. doi: 10.1186/s13148-021-01035-3.

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality among US adults. African Americans have higher burden of CVD morbidity and mortality compared to any other racial group. Identifying biomarkers for clinical risk prediction of CVD offers an...

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Ammous F, Zhao W, Ratliff SM, et al. Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans. Clin Epigenetics. 2021;13(1):55doi: 10.1186/s13148-021-01035-3.
Ammous, F., Zhao, W., Ratliff, S. M., Mosley, T. H., Bielak, L. F., Zhou, X., Peyser, P. A., Kardia, S. L. R., & Smith, J. A. (2021). Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans. Clinical epigenetics, 13(1), 55. https://doi.org/10.1186/s13148-021-01035-3
Ammous, Farah, et al. "Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans." Clinical epigenetics vol. 13,1 (2021): 55. doi: https://doi.org/10.1186/s13148-021-01035-3
Ammous F, Zhao W, Ratliff SM, Mosley TH, Bielak LF, Zhou X, Peyser PA, Kardia SLR, Smith JA. Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans. Clin Epigenetics. 2021 Mar 16;13(1):55. doi: 10.1186/s13148-021-01035-3. PMID: 33726838; PMCID: PMC7962278.
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Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes.

Current epidemiology reports

Smith JA, Ware EB, Middha P, Beacher L, Kardia SL.
PMID: 26269782
Curr Epidemiol Rep. 2015;2(3):180-190. doi: 10.1007/s40471-015-0046-4.

Genetic risk scores are a useful tool for examining the cumulative predictive ability of genetic variation on cardiovascular disease. Important considerations for creating genetic risk scores include the choice of genetic variants, weighting, and comparability across ethnicities. Genetic risk...

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Smith JA, Ware EB, Middha P, et al. Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes. Curr Epidemiol Rep. 2015;2(3):180-190doi: 10.1007/s40471-015-0046-4.
Smith, J. A., Ware, E. B., Middha, P., Beacher, L., & Kardia, S. L. (2015). Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes. Current epidemiology reports, 2(3), 180-190. https://doi.org/10.1007/s40471-015-0046-4
Smith, Jennifer A, et al. "Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes." Current epidemiology reports vol. 2,3 (2015): 180-190. doi: https://doi.org/10.1007/s40471-015-0046-4
Smith JA, Ware EB, Middha P, Beacher L, Kardia SL. Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes. Curr Epidemiol Rep. 2015;2(3):180-190. doi: 10.1007/s40471-015-0046-4. PMID: 26269782; PMCID: PMC4527979.
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Genetics of Subclinical Coronary Atherosclerosis.

Current genetic medicine reports

Bielak LF, Peyser PA.
PMID: 30854262
Curr Genet Med Rep. 2018 Sep;6(3):116-123. doi: 10.1007/s40142-018-0145-x. Epub 2018 Jul 13.

PURPOSE OF REVIEW: This review highlights recent findings regarding genetics of coronary artery calcification (CAC), a marker of subclinical atherosclerosis burden, that is a precursor of clinical coronary artery disease.RECENT FINDINGS: CAC quantity is heritable. Genome wide association studies...

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Bielak LF, Peyser PA. Genetics of Subclinical Coronary Atherosclerosis. Curr Genet Med Rep. 2018;6(3):116-123doi: 10.1007/s40142-018-0145-x.
Bielak, L. F., & Peyser, P. A. (2018). Genetics of Subclinical Coronary Atherosclerosis. Current genetic medicine reports, 6(3), 116-123. https://doi.org/10.1007/s40142-018-0145-x
Bielak, Lawrence F, and Peyser, Patricia A. "Genetics of Subclinical Coronary Atherosclerosis." Current genetic medicine reports vol. 6,3 (2018): 116-123. doi: https://doi.org/10.1007/s40142-018-0145-x
Bielak LF, Peyser PA. Genetics of Subclinical Coronary Atherosclerosis. Curr Genet Med Rep. 2018 Sep;6(3):116-123. doi: 10.1007/s40142-018-0145-x. Epub 2018 Jul 13. PMID: 30854262; PMCID: PMC6405218.
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Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans.

Epigenetics

Ammous F, Zhao W, Ratliff SM, Kho M, Shang L, Jones AC, Chaudhary NS, Tiwari HK, Irvin MR, Arnett DK, Mosley TH, Bielak LF, Kardia SLR, Zhou X, Smith J.
PMID: 33100131
Epigenetics. 2021 Aug;16(8):862-875. doi: 10.1080/15592294.2020.1827717. Epub 2020 Oct 26.

Target organ damage (TOD) manifests as vascular injuries in the body organ systems associated with long-standing hypertension. DNA methylation in peripheral blood leukocytes can capture inflammatory processes and gene expression changes underlying TOD. We investigated the association between epigenome-wide...

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Ammous F, Zhao W, Ratliff SM, et al. Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans. Epigenetics. 2020;16(8):862-875doi: 10.1080/15592294.2020.1827717.
Ammous, F., Zhao, W., Ratliff, S. M., Kho, M., Shang, L., Jones, A. C., Chaudhary, N. S., Tiwari, H. K., Irvin, M. R., Arnett, D. K., Mosley, T. H., Bielak, L. F., Kardia, S. L. R., Zhou, X., & Smith, J. (2021). Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans. Epigenetics, 16(8), 862-875. https://doi.org/10.1080/15592294.2020.1827717
Ammous, Farah, et al. "Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans." Epigenetics vol. 16,8 (2021): 862-875. doi: https://doi.org/10.1080/15592294.2020.1827717
Ammous F, Zhao W, Ratliff SM, Kho M, Shang L, Jones AC, Chaudhary NS, Tiwari HK, Irvin MR, Arnett DK, Mosley TH, Bielak LF, Kardia SLR, Zhou X, Smith J. Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans. Epigenetics. 2021 Aug;16(8):862-875. doi: 10.1080/15592294.2020.1827717. Epub 2020 Oct 26. PMID: 33100131; PMCID: PMC8331005.
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Whole exome analyses to examine the impact of rare variants on left ventricular traits in African American participants from the HyperGEN and GENOA studies.

Journal of hypertension and management

Do AN, Zhao W, Srinivasasainagendra V, Aslibekyan S, Tiwari HK, Limdi N, Shah SJ, Zhi D, Broeckel U, Gu CC, Rao DC, Schwander K, Smith JA, Kardia SLR, Arnett DK, Irvin MR.
PMID: 29503979
J Hypertens Manag. 2017;3(1). doi: 10.23937/2474-3690/1510025. Epub 2017 Jul 20.

Left ventricular (LV) hypertrophy, highest in prevalence among African Americans, is an established risk factor heart failure. Several genome wide association studies have identified common variants associated with LV-related quantitative-traits in African Americans. To date, however, the effect of...

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Do AN, Zhao W, Srinivasasainagendra V, et al. Whole exome analyses to examine the impact of rare variants on left ventricular traits in African American participants from the HyperGEN and GENOA studies. J Hypertens Manag. 2017;3(1)doi: 10.23937/2474-3690/1510025.
Do, A. N., Zhao, W., Srinivasasainagendra, V., Aslibekyan, S., Tiwari, H. K., Limdi, N., Shah, S. J., Zhi, D., Broeckel, U., Gu, C. C., Rao, D. C., Schwander, K., Smith, J. A., Kardia, S. L. R., Arnett, D. K., & Irvin, M. R. (2017). Whole exome analyses to examine the impact of rare variants on left ventricular traits in African American participants from the HyperGEN and GENOA studies. Journal of hypertension and management, 3(1), . https://doi.org/10.23937/2474-3690/1510025
Do, Anh N, et al. "Whole exome analyses to examine the impact of rare variants on left ventricular traits in African American participants from the HyperGEN and GENOA studies." Journal of hypertension and management vol. 3,1 (2017). doi: https://doi.org/10.23937/2474-3690/1510025
Do AN, Zhao W, Srinivasasainagendra V, Aslibekyan S, Tiwari HK, Limdi N, Shah SJ, Zhi D, Broeckel U, Gu CC, Rao DC, Schwander K, Smith JA, Kardia SLR, Arnett DK, Irvin MR. Whole exome analyses to examine the impact of rare variants on left ventricular traits in African American participants from the HyperGEN and GENOA studies. J Hypertens Manag. 2017;3(1). doi: 10.23937/2474-3690/1510025. Epub 2017 Jul 20. PMID: 29503979; PMCID: PMC5831560.
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Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH.

Kidney international reports

Canales BK, Smith JA, Weiner ID, Ware EB, Zhao W, Kardia SLR, Curhan GC, Turner ST, Perinpam M, Lieske JC.
PMID: 29270519
Kidney Int Rep. 2017 Jun 21;2(6):1111-1121. doi: 10.1016/j.ekir.2017.06.009. eCollection 2017 Nov.

INTRODUCTION: Urine pH is critical for net acid and solute excretion, but the genetic factors that contribute to its regulation are incompletely understood.METHODS: We tested the association of single nucleotide polymorphisms (SNPs) from 16 genes related to ammonia (NHRESULTS:...

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Canales BK, Smith JA, Weiner ID, et al. Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH. Kidney Int Rep. 2017;2(6):1111-1121doi: 10.1016/j.ekir.2017.06.009.
Canales, B. K., Smith, J. A., Weiner, I. D., Ware, E. B., Zhao, W., Kardia, S. L. R., Curhan, G. C., Turner, S. T., Perinpam, M., & Lieske, J. C. (2017). Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH. Kidney international reports, 2(6), 1111-1121. https://doi.org/10.1016/j.ekir.2017.06.009
Canales, Benjamin K, et al. "Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH." Kidney international reports vol. 2,6 (2017): 1111-1121. doi: https://doi.org/10.1016/j.ekir.2017.06.009
Canales BK, Smith JA, Weiner ID, Ware EB, Zhao W, Kardia SLR, Curhan GC, Turner ST, Perinpam M, Lieske JC. Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH. Kidney Int Rep. 2017 Jun 21;2(6):1111-1121. doi: 10.1016/j.ekir.2017.06.009. eCollection 2017 Nov. PMID: 29270519; PMCID: PMC5733879.
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Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans.

Epigenetics

Ammous F, Zhao W, Ratliff SM, Kho M, Shang L, Jones AC, Chaudhary NS, Tiwari HK, Irvin MR, Arnett DK, Mosley TH, Bielak LF, Kardia SLR, Zhou X, Smith J.
PMID: 33100131
Epigenetics. 2021 Aug;16(8):862-875. doi: 10.1080/15592294.2020.1827717. Epub 2020 Oct 26.

Target organ damage (TOD) manifests as vascular injuries in the body organ systems associated with long-standing hypertension. DNA methylation in peripheral blood leukocytes can capture inflammatory processes and gene expression changes underlying TOD. We investigated the association between epigenome-wide...

Cite
Ammous F, Zhao W, Ratliff SM, et al. Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans. Epigenetics. 2020;16(8):862-875doi: 10.1080/15592294.2020.1827717.
Ammous, F., Zhao, W., Ratliff, S. M., Kho, M., Shang, L., Jones, A. C., Chaudhary, N. S., Tiwari, H. K., Irvin, M. R., Arnett, D. K., Mosley, T. H., Bielak, L. F., Kardia, S. L. R., Zhou, X., & Smith, J. (2021). Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans. Epigenetics, 16(8), 862-875. https://doi.org/10.1080/15592294.2020.1827717
Ammous, Farah, et al. "Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans." Epigenetics vol. 16,8 (2021): 862-875. doi: https://doi.org/10.1080/15592294.2020.1827717
Ammous F, Zhao W, Ratliff SM, Kho M, Shang L, Jones AC, Chaudhary NS, Tiwari HK, Irvin MR, Arnett DK, Mosley TH, Bielak LF, Kardia SLR, Zhou X, Smith J. Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans. Epigenetics. 2021 Aug;16(8):862-875. doi: 10.1080/15592294.2020.1827717. Epub 2020 Oct 26. PMID: 33100131; PMCID: PMC8331005.
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Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.

Genes

Wen J, Xie M, Rowland B, Rosen JD, Sun Q, Chen J, Tapia AL, Qian H, Kowalski MH, Shan Y, Young KL, Graff M, Argos M, Avery CL, Bien SA, Buyske S, Yin J, Choquet H, Fornage M, Hodonsky CJ, Jorgenson E, Kooperberg C, Loos RJF, Liu Y, Moon JY, North KE, Rich SS, Rotter JI, Smith JA, Zhao W, Shang L, Wang T, Zhou X, Reiner AP, Raffield LM, Li Y.
PMID: 34356065
Genes (Basel). 2021 Jul 08;12(7). doi: 10.3390/genes12071049.

BACKGROUND: Thousands of genetic variants have been associated with hematological traits, though target genes remain unknown at most loci. Moreover, limited analyses have been conducted in African ancestry and Hispanic/Latino populations; hematological trait associated variants more common in these...

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Wen J, Xie M, Rowland B, et al. Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. Genes (Basel). 2021;12(7)doi: 10.3390/genes12071049.
Wen, J., Xie, M., Rowland, B., Rosen, J. D., Sun, Q., Chen, J., Tapia, A. L., Qian, H., Kowalski, M. H., Shan, Y., Young, K. L., Graff, M., Argos, M., Avery, C. L., Bien, S. A., Buyske, S., Yin, J., Choquet, H., Fornage, M., Hodonsky, C. J., Jorgenson, E., Kooperberg, C., Loos, R. J. F., Liu, Y., Moon, J. Y., North, K. E., Rich, S. S., Rotter, J. I., Smith, J. A., Zhao, W., Shang, L., Wang, T., Zhou, X., Reiner, A. P., Raffield, L. M., & Li, Y. (2021). Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. Genes, 12(7), . https://doi.org/10.3390/genes12071049
Wen, Jia, et al. "Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations." Genes vol. 12,7 (2021). doi: https://doi.org/10.3390/genes12071049
Wen J, Xie M, Rowland B, Rosen JD, Sun Q, Chen J, Tapia AL, Qian H, Kowalski MH, Shan Y, Young KL, Graff M, Argos M, Avery CL, Bien SA, Buyske S, Yin J, Choquet H, Fornage M, Hodonsky CJ, Jorgenson E, Kooperberg C, Loos RJF, Liu Y, Moon JY, North KE, Rich SS, Rotter JI, Smith JA, Zhao W, Shang L, Wang T, Zhou X, Reiner AP, Raffield LM, Li Y. Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. Genes (Basel). 2021 Jul 08;12(7). doi: 10.3390/genes12071049. PMID: 34356065; PMCID: PMC8307403.
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Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid.

Mayo Clinic proceedings. Innovations, quality & outcomes

Ware EB, Smith JA, Zhao W, Ganesvoort RT, Curhan GC, Pollak M, Mount DB, Turner ST, Chen G, Shah RJ, Kardia SLR, Lieske JC.
PMID: 31993563
Mayo Clin Proc Innov Qual Outcomes. 2019 Nov 22;3(4):448-460. doi: 10.1016/j.mayocpiqo.2019.08.007. eCollection 2019 Dec.

OBJECTIVES: The urinary excretion of organic and inorganic substances and their concentrations have attracted extensive attention for their role in the pathogenesis of urinary stone disease. The urinary excretion of specific factors associates with sex and age and seems...

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Ware EB, Smith JA, Zhao W, et al. Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid. Mayo Clin Proc Innov Qual Outcomes. 2019;3(4):448-460doi: 10.1016/j.mayocpiqo.2019.08.007.
Ware, E. B., Smith, J. A., Zhao, W., Ganesvoort, R. T., Curhan, G. C., Pollak, M., Mount, D. B., Turner, S. T., Chen, G., Shah, R. J., Kardia, S. L. R., & Lieske, J. C. (2019). Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid. Mayo Clinic proceedings. Innovations, quality & outcomes, 3(4), 448-460. https://doi.org/10.1016/j.mayocpiqo.2019.08.007
Ware, Erin B, et al. "Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid." Mayo Clinic proceedings. Innovations, quality & outcomes vol. 3,4 (2019): 448-460. doi: https://doi.org/10.1016/j.mayocpiqo.2019.08.007
Ware EB, Smith JA, Zhao W, Ganesvoort RT, Curhan GC, Pollak M, Mount DB, Turner ST, Chen G, Shah RJ, Kardia SLR, Lieske JC. Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid. Mayo Clin Proc Innov Qual Outcomes. 2019 Nov 22;3(4):448-460. doi: 10.1016/j.mayocpiqo.2019.08.007. eCollection 2019 Dec. PMID: 31993563; PMCID: PMC6978610.
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Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects.

Clinical epigenetics

Christiansen C, Castillo-Fernandez JE, Domingo-Relloso A, Zhao W, El-Sayed Moustafa JS, Tsai PC, Maddock J, Haack K, Cole SA, Kardia SLR, Molokhia M, Suderman M, Power C, Relton C, Wong A, Kuh D, Goodman A, Small KS, Smith JA, Tellez-Plaza M, Navas-Acien A, Ploubidis GB, Hardy R, Bell JT.
PMID: 33593402
Clin Epigenetics. 2021 Feb 16;13(1):36. doi: 10.1186/s13148-021-01018-4.

BACKGROUND: Smoking remains one of the leading preventable causes of death. Smoking leaves a strong signature on the blood methylome as shown in multiple studies using the Infinium HumanMethylation450 BeadChip. Here, we explore novel blood methylation smoking signals on...

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Christiansen C, Castillo-Fernandez JE, Domingo-Relloso A, et al. Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects. Clin Epigenetics. 2021;13(1):36doi: 10.1186/s13148-021-01018-4.
Christiansen, C., Castillo-Fernandez, J. E., Domingo-Relloso, A., Zhao, W., El-Sayed Moustafa, J. S., Tsai, P. C., Maddock, J., Haack, K., Cole, S. A., Kardia, S. L. R., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Small, K. S., Smith, J. A., Tellez-Plaza, M., Navas-Acien, A., Ploubidis, G. B., Hardy, R., & Bell, J. T. (2021). Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects. Clinical epigenetics, 13(1), 36. https://doi.org/10.1186/s13148-021-01018-4
Christiansen, C, et al. "Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects." Clinical epigenetics vol. 13,1 (2021): 36. doi: https://doi.org/10.1186/s13148-021-01018-4
Christiansen C, Castillo-Fernandez JE, Domingo-Relloso A, Zhao W, El-Sayed Moustafa JS, Tsai PC, Maddock J, Haack K, Cole SA, Kardia SLR, Molokhia M, Suderman M, Power C, Relton C, Wong A, Kuh D, Goodman A, Small KS, Smith JA, Tellez-Plaza M, Navas-Acien A, Ploubidis GB, Hardy R, Bell JT. Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects. Clin Epigenetics. 2021 Feb 16;13(1):36. doi: 10.1186/s13148-021-01018-4. PMID: 33593402; PMCID: PMC7888173.
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