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Showing 1 to 12 of 13 entries
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Epigenetic markers of renal function in african americans.

Nursing research and practice

Bomotti SM, Smith JA, Zagel AL, Taylor JY, Turner ST, Kardia SL.
PMID: 24396594
Nurs Res Pract. 2013;2013:687519. doi: 10.1155/2013/687519. Epub 2013 Dec 12.

Chronic kidney disease (CKD) is an increasing concern in the United States due to its rapidly rising prevalence, particularly among African Americans. Epigenetic DNA methylation markers are becoming important biomarkers of chronic diseases such as CKD. To better understand...

Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans.

Clinical epigenetics

Ammous F, Zhao W, Ratliff SM, Mosley TH, Bielak LF, Zhou X, Peyser PA, Kardia SLR, Smith JA.
PMID: 33726838
Clin Epigenetics. 2021 Mar 16;13(1):55. doi: 10.1186/s13148-021-01035-3.

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality among US adults. African Americans have higher burden of CVD morbidity and mortality compared to any other racial group. Identifying biomarkers for clinical risk prediction of CVD offers an...

Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans.

Epigenetics

Ammous F, Zhao W, Ratliff SM, Kho M, Shang L, Jones AC, Chaudhary NS, Tiwari HK, Irvin MR, Arnett DK, Mosley TH, Bielak LF, Kardia SLR, Zhou X, Smith J.
PMID: 33100131
Epigenetics. 2021 Aug;16(8):862-875. doi: 10.1080/15592294.2020.1827717. Epub 2020 Oct 26.

Target organ damage (TOD) manifests as vascular injuries in the body organ systems associated with long-standing hypertension. DNA methylation in peripheral blood leukocytes can capture inflammatory processes and gene expression changes underlying TOD. We investigated the association between epigenome-wide...

Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH.

Kidney international reports

Canales BK, Smith JA, Weiner ID, Ware EB, Zhao W, Kardia SLR, Curhan GC, Turner ST, Perinpam M, Lieske JC.
PMID: 29270519
Kidney Int Rep. 2017 Jun 21;2(6):1111-1121. doi: 10.1016/j.ekir.2017.06.009. eCollection 2017 Nov.

INTRODUCTION: Urine pH is critical for net acid and solute excretion, but the genetic factors that contribute to its regulation are incompletely understood.METHODS: We tested the association of single nucleotide polymorphisms (SNPs) from 16 genes related to ammonia (NHRESULTS:...

Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans.

Epigenetics

Ammous F, Zhao W, Ratliff SM, Kho M, Shang L, Jones AC, Chaudhary NS, Tiwari HK, Irvin MR, Arnett DK, Mosley TH, Bielak LF, Kardia SLR, Zhou X, Smith J.
PMID: 33100131
Epigenetics. 2021 Aug;16(8):862-875. doi: 10.1080/15592294.2020.1827717. Epub 2020 Oct 26.

Target organ damage (TOD) manifests as vascular injuries in the body organ systems associated with long-standing hypertension. DNA methylation in peripheral blood leukocytes can capture inflammatory processes and gene expression changes underlying TOD. We investigated the association between epigenome-wide...

An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program.

Nutrition & metabolism

Kraja AT, Rao DC, Weder AB, Mosley TH, Turner ST, Hsiung CA, Quertermous T, Cooper R, Curb JD, Province MA.
PMID: 16076393
Nutr Metab (Lond). 2005 Aug 02;2:17. doi: 10.1186/1743-7075-2-17.

BACKGROUND: The Family Blood Pressure Program is an ongoing, NHLBI-sponsored, multi-center program to study the genetic determinants of high blood pressure. The goal of this particular study was to study patterns of metabolic syndrome (MetS) in four ethnic groups:...

Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.

Genes

Wen J, Xie M, Rowland B, Rosen JD, Sun Q, Chen J, Tapia AL, Qian H, Kowalski MH, Shan Y, Young KL, Graff M, Argos M, Avery CL, Bien SA, Buyske S, Yin J, Choquet H, Fornage M, Hodonsky CJ, Jorgenson E, Kooperberg C, Loos RJF, Liu Y, Moon JY, North KE, Rich SS, Rotter JI, Smith JA, Zhao W, Shang L, Wang T, Zhou X, Reiner AP, Raffield LM, Li Y.
PMID: 34356065
Genes (Basel). 2021 Jul 08;12(7). doi: 10.3390/genes12071049.

BACKGROUND: Thousands of genetic variants have been associated with hematological traits, though target genes remain unknown at most loci. Moreover, limited analyses have been conducted in African ancestry and Hispanic/Latino populations; hematological trait associated variants more common in these...

Epigenomic Indicators of Age in African Americans.

Hereditary genetics : current research

Smith JA, Zagel AL, Sun YV, Dolinoy DC, Bielak LF, Peyser PA, Turner ST, Mosley TH, Kardia SL.
PMID: 26807331
Hereditary Genet. 2014 Dec;3(3). doi: 10.4172/2161-1041.1000137. Epub 2014 Oct 01.

Age is a well-established risk factor for chronic diseases. However, the cellular and molecular changes associated with aging processes that are related to chronic disease initiation and progression are not well-understood. Thus, there is an increased need to identify...

Investigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites.

BMC medical genomics

Kardia SL, Greene MT, Boerwinkle E, Turner ST, Kullo IJ.
PMID: 18482449
BMC Med Genomics. 2008 May 15;1:16. doi: 10.1186/1755-8794-1-16.

BACKGROUND: Atherosclerotic peripheral arterial disease (PAD) affects 8-10 million people in the United States and is associated with a marked impairment in quality of life and an increased risk of cardiovascular events. Noninvasive assessment of PAD is performed by...

C-reactive Protein among Community-Dwelling Hypertensives on Single-agent Antihypertensive Treatment.

Journal of the American Society of Hypertension : JASH

Fulop T, Rule AD, Schmidt DW, Wiste HJ, Bailey KR, Kullo IJ, Schwartz GL, Mosley TH, Boerwinkle E, Turner ST.
PMID: 20161163
J Am Soc Hypertens. 2009 Jul-Aug;3(4):260-6. doi: 10.1016/j.jash.2009.03.003.

BACKGROUND: C-reactive protein is a predictor of adverse cardiovascular outcomes. The effect of antihypertensive therapy on C-reactive protein levels is largely unknown.METHOD: We undertook a cross-sectional study of CRP levels among participants with primary hypertension on single-agent anti-hypertensive therapy...

Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid.

Mayo Clinic proceedings. Innovations, quality & outcomes

Ware EB, Smith JA, Zhao W, Ganesvoort RT, Curhan GC, Pollak M, Mount DB, Turner ST, Chen G, Shah RJ, Kardia SLR, Lieske JC.
PMID: 31993563
Mayo Clin Proc Innov Qual Outcomes. 2019 Nov 22;3(4):448-460. doi: 10.1016/j.mayocpiqo.2019.08.007. eCollection 2019 Dec.

OBJECTIVES: The urinary excretion of organic and inorganic substances and their concentrations have attracted extensive attention for their role in the pathogenesis of urinary stone disease. The urinary excretion of specific factors associates with sex and age and seems...

Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA).

Clinical epigenetics

Ammous F, Zhao W, Lin L, Ratliff SM, Mosley TH, Bielak LF, Zhou X, Peyser PA, Kardia SLR, Smith JA.
PMID: 35039093
Clin Epigenetics. 2022 Jan 17;14(1):10. doi: 10.1186/s13148-022-01229-3.

BACKGROUND: DNA methylation, an epigenetic mechanism modulated by lifestyle and environmental factors, may be an important biomarker of complex diseases including cardiovascular diseases (CVD) and subclinical atherosclerosis.METHODS: DNA methylation in peripheral blood samples from 391 African-Americans from the Genetic...

Showing 1 to 12 of 13 entries