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Showing 1 to 7 of 7 entries
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Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition.

Chemical communications (Cambridge, England)

Huisman M, White JK, Lewalski VG, Podgorski I, Turro C, Kodanko JJ.
PMID: 27711349
Chem Commun (Camb). 2016 Oct 18;52(85):12590-12593. doi: 10.1039/c6cc07083c.

Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy...

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Huisman M, White JK, Lewalski VG, et al. Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition. Chem Commun (Camb). 2016;52(85):12590-12593doi: 10.1039/c6cc07083c.
Huisman, M., White, J. K., Lewalski, V. G., Podgorski, I., Turro, C., & Kodanko, J. J. (2016). Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition. Chemical communications (Cambridge, England), 52(85), 12590-12593. https://doi.org/10.1039/c6cc07083c
Huisman, Matthew, et al. "Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition." Chemical communications (Cambridge, England) vol. 52,85 (2016): 12590-12593. doi: https://doi.org/10.1039/c6cc07083c
Huisman M, White JK, Lewalski VG, Podgorski I, Turro C, Kodanko JJ. Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition. Chem Commun (Camb). 2016 Oct 18;52(85):12590-12593. doi: 10.1039/c6cc07083c. PMID: 27711349; PMCID: PMC5076553.
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DFT Investigation of Ligand Photodissociation in [Ru.

Inorganic chemistry

Nisbett K, Tu YJ, Turro C, Kodanko JJ, Schlegel HB.
PMID: 29257679
Inorg Chem. 2018 Jan 02;57(1):231-240. doi: 10.1021/acs.inorgchem.7b02398. Epub 2017 Dec 19.

Photoinduced ligand dissociation of pyridine occurs much more readily in [Ru(tpy)(Me

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Nisbett K, Tu YJ, Turro C, et al. DFT Investigation of Ligand Photodissociation in [Ru. Inorg Chem. 2017;57(1):231-240doi: 10.1021/acs.inorgchem.7b02398.
Nisbett, K., Tu, Y. J., Turro, C., Kodanko, J. J., & Schlegel, H. B. (2018). DFT Investigation of Ligand Photodissociation in [Ru. Inorganic chemistry, 57(1), 231-240. https://doi.org/10.1021/acs.inorgchem.7b02398
Nisbett, Khalin, et al. "DFT Investigation of Ligand Photodissociation in [Ru." Inorganic chemistry vol. 57,1 (2018): 231-240. doi: https://doi.org/10.1021/acs.inorgchem.7b02398
Nisbett K, Tu YJ, Turro C, Kodanko JJ, Schlegel HB. DFT Investigation of Ligand Photodissociation in [Ru. Inorg Chem. 2018 Jan 02;57(1):231-240. doi: 10.1021/acs.inorgchem.7b02398. Epub 2017 Dec 19. PMID: 29257679; PMCID: PMC5901700.
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An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy.

Inorganica chimica acta

White JK, Schmehl RH, Turro C.
PMID: 28042171
Inorganica Chim Acta. 2017 Jan 01;454:7-20. doi: 10.1016/j.ica.2016.06.007. Epub 2016 Jun 18.

This article is a short review that presents a short review of photosubstitution reactions of Ru(II) imine complexes and illustrates their use in the development of therapeutic agents. The review begins with an overview of the photophysical behavior and...

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White JK, Schmehl RH, Turro C. An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy. Inorganica Chim Acta. 2016;454:7-20doi: 10.1016/j.ica.2016.06.007.
White, J. K., Schmehl, R. H., & Turro, C. (2017). An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy. Inorganica chimica acta, 4547-20. https://doi.org/10.1016/j.ica.2016.06.007
White, Jessica K, et al. "An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy." Inorganica chimica acta vol. 454 (2017): 7-20. doi: https://doi.org/10.1016/j.ica.2016.06.007
White JK, Schmehl RH, Turro C. An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy. Inorganica Chim Acta. 2017 Jan 01;454:7-20. doi: 10.1016/j.ica.2016.06.007. Epub 2016 Jun 18. PMID: 28042171; PMCID: PMC5193374.
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Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4.

Journal of the American Chemical Society

Toupin N, Steinke SJ, Nadella S, Li A, Rohrabaugh TN, Samuels ER, Turro C, Sevrioukova IF, Kodanko JJ.
PMID: 34110801
J Am Chem Soc. 2021 Jun 23;143(24):9191-9205. doi: 10.1021/jacs.1c04155. Epub 2021 Jun 10.

We report the synthesis and photochemical and biological characterization of the first selective and potent metal-based inhibitors of cytochrome P450 3A4 (CYP3A4), the major human drug metabolizing enzyme. Five Ru(II)-based derivatives were prepared from two analogs of the CYP3A4...

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Toupin N, Steinke SJ, Nadella S, et al. Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4. J Am Chem Soc. 2021;143(24):9191-9205doi: 10.1021/jacs.1c04155.
Toupin, N., Steinke, S. J., Nadella, S., Li, A., Rohrabaugh, T. N., Samuels, E. R., Turro, C., Sevrioukova, I. F., & Kodanko, J. J. (2021). Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4. Journal of the American Chemical Society, 143(24), 9191-9205. https://doi.org/10.1021/jacs.1c04155
Toupin, Nicholas, et al. "Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4." Journal of the American Chemical Society vol. 143,24 (2021): 9191-9205. doi: https://doi.org/10.1021/jacs.1c04155
Toupin N, Steinke SJ, Nadella S, Li A, Rohrabaugh TN, Samuels ER, Turro C, Sevrioukova IF, Kodanko JJ. Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4. J Am Chem Soc. 2021 Jun 23;143(24):9191-9205. doi: 10.1021/jacs.1c04155. Epub 2021 Jun 10. PMID: 34110801; PMCID: PMC8265689.
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Effects of Methyl Substitution in Ruthenium Tris(2-pyridylmethyl)amine Photocaging Groups for Nitriles.

Inorganic chemistry

Arora K, White JK, Sharma R, Mazumder S, Martin PD, Schlegel HB, Turro C, Kodanko JJ.
PMID: 27355786
Inorg Chem. 2016 Jul 18;55(14):6968-79. doi: 10.1021/acs.inorgchem.6b00650. Epub 2016 Jun 29.

Four complexes of the general formula [Ru(L)(CH3CN)2](PF6)2, [L = TPA (5), MeTPA (6), Me2TPA (7), and Me3TPA (8)] [TPA = tris[(pyridin-2-yl)methyl]amine, where methyl groups were introduced consecutively onto the 6-position of py donors of TPA, were prepared and characterized...

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Arora K, White JK, Sharma R, et al. Effects of Methyl Substitution in Ruthenium Tris(2-pyridylmethyl)amine Photocaging Groups for Nitriles. Inorg Chem. 2016;55(14):6968-79doi: 10.1021/acs.inorgchem.6b00650.
Arora, K., White, J. K., Sharma, R., Mazumder, S., Martin, P. D., Schlegel, H. B., Turro, C., & Kodanko, J. J. (2016). Effects of Methyl Substitution in Ruthenium Tris(2-pyridylmethyl)amine Photocaging Groups for Nitriles. Inorganic chemistry, 55(14), 6968-79. https://doi.org/10.1021/acs.inorgchem.6b00650
Arora, Karan, et al. "Effects of Methyl Substitution in Ruthenium Tris(2-pyridylmethyl)amine Photocaging Groups for Nitriles." Inorganic chemistry vol. 55,14 (2016): 6968-79. doi: https://doi.org/10.1021/acs.inorgchem.6b00650
Arora K, White JK, Sharma R, Mazumder S, Martin PD, Schlegel HB, Turro C, Kodanko JJ. Effects of Methyl Substitution in Ruthenium Tris(2-pyridylmethyl)amine Photocaging Groups for Nitriles. Inorg Chem. 2016 Jul 18;55(14):6968-79. doi: 10.1021/acs.inorgchem.6b00650. Epub 2016 Jun 29. PMID: 27355786; PMCID: PMC4966558.
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Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy.

Coordination chemistry reviews

Knoll JD, Turro C, Yonezawa A, Horta H.
PMID: 25729089
Coord Chem Rev. 2015 Jan 01;282:110-126. doi: 10.1016/j.ccr.2014.05.018.

The use of visible light to produce highly selective and potent drugs through photodynamic therapy (PDT) holds much potential in the treatment of cancer. PDT agents can be designed to follow an O

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Knoll JD, Turro C, Yonezawa A, et al. Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy. Coord Chem Rev. 2015;282:110-126doi: 10.1016/j.ccr.2014.05.018.
Knoll, J. D., Turro, C., Yonezawa, A., & Horta, H. (2015). Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy. Coordination chemistry reviews, 282110-126. https://doi.org/10.1016/j.ccr.2014.05.018
Knoll, Jessica D, et al. "Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy." Coordination chemistry reviews vol. 282 (2015): 110-126. doi: https://doi.org/10.1016/j.ccr.2014.05.018
Knoll JD, Turro C, Yonezawa A, Horta H. Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy. Coord Chem Rev. 2015 Jan 01;282:110-126. doi: 10.1016/j.ccr.2014.05.018. PMID: 25729089; PMCID: PMC4343038.
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Dual Photoreactivity of a New Rh.

Inorganica chimica acta

Akhimie RN, White JK, Turro C.
PMID: 30026633
Inorganica Chim Acta. 2017 Jan 01;454:149-154. doi: 10.1016/j.ica.2016.04.001. Epub 2016 Apr 18.

A new Rh

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Akhimie RN, White JK, Turro C. Dual Photoreactivity of a New Rh. Inorganica Chim Acta. 2016;454:149-154doi: 10.1016/j.ica.2016.04.001.
Akhimie, R. N., White, J. K., & Turro, C. (2017). Dual Photoreactivity of a New Rh. Inorganica chimica acta, 454149-154. https://doi.org/10.1016/j.ica.2016.04.001
Akhimie, Regina N, et al. "Dual Photoreactivity of a New Rh." Inorganica chimica acta vol. 454 (2017): 149-154. doi: https://doi.org/10.1016/j.ica.2016.04.001
Akhimie RN, White JK, Turro C. Dual Photoreactivity of a New Rh. Inorganica Chim Acta. 2017 Jan 01;454:149-154. doi: 10.1016/j.ica.2016.04.001. Epub 2016 Apr 18. PMID: 30026633; PMCID: PMC6049087.
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Showing 1 to 7 of 7 entries