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Huisman M, White JK, Lewalski VG, et al. Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition. Chem Commun (Camb). 2016;52(85):12590-12593doi: 10.1039/c6cc07083c.
Huisman, M., White, J. K., Lewalski, V. G., Podgorski, I., Turro, C., & Kodanko, J. J. (2016). Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition. Chemical communications (Cambridge, England), 52(85), 12590-12593. https://doi.org/10.1039/c6cc07083c
Huisman, Matthew, et al. "Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition." Chemical communications (Cambridge, England) vol. 52,85 (2016): 12590-12593. doi: https://doi.org/10.1039/c6cc07083c
Huisman M, White JK, Lewalski VG, Podgorski I, Turro C, Kodanko JJ. Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition. Chem Commun (Camb). 2016 Oct 18;52(85):12590-12593. doi: 10.1039/c6cc07083c. PMID: 27711349; PMCID: PMC5076553.
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Chem Commun (Camb). 2016 Oct 18;52(85):12590-12593. doi: 10.1039/c6cc07083c.

Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition.

Chemical communications (Cambridge, England)

Matthew Huisman, Jessica K White, Veronica G Lewalski, Izabela Podgorski, Claudia Turro, Jeremy J Kodanko

Affiliations

  1. Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. [email protected].
  2. Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA. [email protected].
  3. Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
  4. Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. [email protected] and Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.

PMID: 27711349 PMCID: PMC5076553 DOI: 10.1039/c6cc07083c

Abstract

Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy for photoreleasing Ru(ii) fragments from inhibitor-enzyme conjugates is also reported.

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