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The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.

Frontiers in cellular neuroscience

Albalawi F, Lu W, Beckel JM, Lim JC, McCaughey SA, Mitchell CH.
PMID: 28848393
Front Cell Neurosci. 2017 Aug 08;11:227. doi: 10.3389/fncel.2017.00227. eCollection 2017.

Inflammatory responses play a key role in many neural pathologies, with localized signaling from the non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to chronic inflammation....

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Albalawi F, Lu W, Beckel JM, et al. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci. 2017;11:227doi: 10.3389/fncel.2017.00227.
Albalawi, F., Lu, W., Beckel, J. M., Lim, J. C., McCaughey, S. A., & Mitchell, C. H. (2017). The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Frontiers in cellular neuroscience, 11227. https://doi.org/10.3389/fncel.2017.00227
Albalawi, Farraj, et al. "The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain." Frontiers in cellular neuroscience vol. 11 (2017): 227. doi: https://doi.org/10.3389/fncel.2017.00227
Albalawi F, Lu W, Beckel JM, Lim JC, McCaughey SA, Mitchell CH. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci. 2017 Aug 08;11:227. doi: 10.3389/fncel.2017.00227. eCollection 2017. PMID: 28848393; PMCID: PMC5550720.
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The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance.

Purinergic signalling

Mitchell CH, Lu W, Hu H, Zhang X, Reigada D, Zhang M.
PMID: 19241145
Purinergic Signal. 2009 Jun;5(2):241-9. doi: 10.1007/s11302-009-9142-6. Epub 2009 Feb 25.

Retinal ganglion cells process the visual signal and transmit it along their axons in the optic nerve to the brain. Molecular, immunohistochemical, and functional analyses indicate that the majority of retinal ganglion cells express the ionotropic P2X(7) receptor. Stimulation...

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Mitchell CH, Lu W, Hu H, et al. The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance. Purinergic Signal. 2009;5(2):241-9doi: 10.1007/s11302-009-9142-6.
Mitchell, C. H., Lu, W., Hu, H., Zhang, X., Reigada, D., & Zhang, M. (2009). The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance. Purinergic signalling, 5(2), 241-9. https://doi.org/10.1007/s11302-009-9142-6
Mitchell, Claire H, et al. "The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance." Purinergic signalling vol. 5,2 (2009): 241-9. doi: https://doi.org/10.1007/s11302-009-9142-6
Mitchell CH, Lu W, Hu H, Zhang X, Reigada D, Zhang M. The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance. Purinergic Signal. 2009 Jun;5(2):241-9. doi: 10.1007/s11302-009-9142-6. Epub 2009 Feb 25. PMID: 19241145; PMCID: PMC2686831.
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[No title available]

Pathogens (Basel, Switzerland)

Lally ET, Boesze-Battaglia K, Dhingra A, Gomez NM, Lora J, Mitchell CH, Giannakakis A, Fahim SA, Benz R, Balashova N.
PMID: 31973183
Pathogens. 2020 Jan 21;9(2). doi: 10.3390/pathogens9020074.

Leukotoxin (LtxA), from oral pathogen

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Lally ET, Boesze-Battaglia K, Dhingra A, et al. . Pathogens. 2020;9(2)doi: 10.3390/pathogens9020074.
Lally, E. T., Boesze-Battaglia, K., Dhingra, A., Gomez, N. M., Lora, J., Mitchell, C. H., Giannakakis, A., Fahim, S. A., Benz, R., & Balashova, N. (2020). . Pathogens (Basel, Switzerland), 9(2), . https://doi.org/10.3390/pathogens9020074
Lally, Edward T, et al. "." Pathogens (Basel, Switzerland) vol. 9,2 (2020). doi: https://doi.org/10.3390/pathogens9020074
Lally ET, Boesze-Battaglia K, Dhingra A, Gomez NM, Lora J, Mitchell CH, Giannakakis A, Fahim SA, Benz R, Balashova N. . Pathogens. 2020 Jan 21;9(2). doi: 10.3390/pathogens9020074. PMID: 31973183; PMCID: PMC7168647.
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The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance.

Purinergic signalling

Mitchell CH, Lu W, Hu H, Zhang X, Reigada D, Zhang M.
PMID: 18923921
Purinergic Signal. 2008 Dec;4(4):313-21. doi: 10.1007/s11302-008-9125-z. Epub 2008 Oct 16.

Retinal ganglion cells process the visual signal and transmit it along their axons in the optic nerve to the brain. Molecular, immunohistochemical, and functional analyses indicate that the majority of retinal ganglion cells express the ionotropic P2X(7) receptor. Stimulation...

Cite
Mitchell CH, Lu W, Hu H, et al. The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance. Purinergic Signal. 2008;4(4):313-21doi: 10.1007/s11302-008-9125-z.
Mitchell, C. H., Lu, W., Hu, H., Zhang, X., Reigada, D., & Zhang, M. (2008). The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance. Purinergic signalling, 4(4), 313-21. https://doi.org/10.1007/s11302-008-9125-z
Mitchell, Claire H, et al. "The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance." Purinergic signalling vol. 4,4 (2008): 313-21. doi: https://doi.org/10.1007/s11302-008-9125-z
Mitchell CH, Lu W, Hu H, Zhang X, Reigada D, Zhang M. The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance. Purinergic Signal. 2008 Dec;4(4):313-21. doi: 10.1007/s11302-008-9125-z. Epub 2008 Oct 16. PMID: 18923921; PMCID: PMC2583208.
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Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE.

Purinergic signalling

Mitchell CH, Reigada D.
PMID: 18368526
Purinergic Signal. 2008 Jun;4(2):101-7. doi: 10.1007/s11302-007-9054-2. Epub 2007 Mar 14.

The retinal pigment epithelium (RPE) is separated from the photoreceptor outer segments by the subretinal space. While the actual volume of this space is minimal, the communication that occurs across this microenvironment is important to the visual process, and...

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Mitchell CH, Reigada D. Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE. Purinergic Signal. 2007;4(2):101-7doi: 10.1007/s11302-007-9054-2.
Mitchell, C. H., & Reigada, D. (2008). Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE. Purinergic signalling, 4(2), 101-7. https://doi.org/10.1007/s11302-007-9054-2
Mitchell, Claire H, and Reigada, David. "Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE." Purinergic signalling vol. 4,2 (2008): 101-7. doi: https://doi.org/10.1007/s11302-007-9054-2
Mitchell CH, Reigada D. Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE. Purinergic Signal. 2008 Jun;4(2):101-7. doi: 10.1007/s11302-007-9054-2. Epub 2007 Mar 14. PMID: 18368526; PMCID: PMC2377325.
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Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells.

Purinergic signalling

Reigada D, Zhang X, Crespo A, Nguyen J, Liu J, Pendrak K, Stone RA, Laties AM, Mitchell C.
PMID: 18404487
Purinergic Signal. 2006 Sep;2(3):499-507. doi: 10.1007/s11302-005-3980-7. Epub 2006 Aug 11.

The purines ATP and adenosine play an important role in the communication between the photoreceptors and the retinal pigment epithelium (RPE). While the RPE is known to release ATP into subretinal space, the source of extracellular adenosine is unclear....

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Reigada D, Zhang X, Crespo A, et al. Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells. Purinergic Signal. 2006;2(3):499-507doi: 10.1007/s11302-005-3980-7.
Reigada, D., Zhang, X., Crespo, A., Nguyen, J., Liu, J., Pendrak, K., Stone, R. A., Laties, A. M., & Mitchell, C. (2006). Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells. Purinergic signalling, 2(3), 499-507. https://doi.org/10.1007/s11302-005-3980-7
Reigada, David, et al. "Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells." Purinergic signalling vol. 2,3 (2006): 499-507. doi: https://doi.org/10.1007/s11302-005-3980-7
Reigada D, Zhang X, Crespo A, Nguyen J, Liu J, Pendrak K, Stone RA, Laties AM, Mitchell C. Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells. Purinergic Signal. 2006 Sep;2(3):499-507. doi: 10.1007/s11302-005-3980-7. Epub 2006 Aug 11. PMID: 18404487; PMCID: PMC2104005.
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The P2Y.

Frontiers in pharmacology

Lu W, Gómez NM, Lim JC, Guha S, O'Brien-Jenkins A, Coffey EE, Campagno KE, McCaughey SA, Laties AM, Carlsson LG, Mitchell CH.
PMID: 29725296
Front Pharmacol. 2018 Apr 19;9:242. doi: 10.3389/fphar.2018.00242. eCollection 2018.

The accumulation of partially degraded lipid waste in lysosomal-related organelles may contribute to pathology in many aging diseases. The presence of these lipofuscin granules is particularly evident in the autofluorescent lysosome-associated organelles of the retinal pigmented epithelial (RPE) cells,...

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Lu W, Gómez NM, Lim JC, et al. The P2Y. Front Pharmacol. 2018;9:242doi: 10.3389/fphar.2018.00242.
Lu, W., Gómez, N. M., Lim, J. C., Guha, S., O'Brien-Jenkins, A., Coffey, E. E., Campagno, K. E., McCaughey, S. A., Laties, A. M., Carlsson, L. G., & Mitchell, C. H. (2018). The P2Y. Frontiers in pharmacology, 9242. https://doi.org/10.3389/fphar.2018.00242
Lu, Wennan, et al. "The P2Y." Frontiers in pharmacology vol. 9 (2018): 242. doi: https://doi.org/10.3389/fphar.2018.00242
Lu W, Gómez NM, Lim JC, Guha S, O'Brien-Jenkins A, Coffey EE, Campagno KE, McCaughey SA, Laties AM, Carlsson LG, Mitchell CH. The P2Y. Front Pharmacol. 2018 Apr 19;9:242. doi: 10.3389/fphar.2018.00242. eCollection 2018. PMID: 29725296; PMCID: PMC5917064.
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The P2X.

Frontiers in cellular neuroscience

Campagno KE, Mitchell CH.
PMID: 33790743
Front Cell Neurosci. 2021 Mar 15;15:645244. doi: 10.3389/fncel.2021.645244. eCollection 2021.

Microglial cells regulate neural homeostasis by coordinating both immune responses and clearance of debris, and the P2X

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Campagno KE, Mitchell CH. The P2X. Front Cell Neurosci. 2021;15:645244doi: 10.3389/fncel.2021.645244.
Campagno, K. E., & Mitchell, C. H. (2021). The P2X. Frontiers in cellular neuroscience, 15645244. https://doi.org/10.3389/fncel.2021.645244
Campagno, Keith E, and Mitchell, Claire H. "The P2X." Frontiers in cellular neuroscience vol. 15 (2021): 645244. doi: https://doi.org/10.3389/fncel.2021.645244
Campagno KE, Mitchell CH. The P2X. Front Cell Neurosci. 2021 Mar 15;15:645244. doi: 10.3389/fncel.2021.645244. eCollection 2021. PMID: 33790743; PMCID: PMC8005553.
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Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure.

Journal of neuroinflammation

Campagno KE, Lu W, Jassim AH, Albalawi F, Cenaj A, Tso HY, Clark SP, Sripinun P, Gómez NM, Mitchell CH.
PMID: 34544431
J Neuroinflammation. 2021 Sep 20;18(1):217. doi: 10.1186/s12974-021-02251-7.

BACKGROUND: The identification of endogenous signals that lead to microglial activation is a key step in understanding neuroinflammatory cascades. As ATP release accompanies mechanical strain to neural tissue, and as the P2X7 receptor for ATP is expressed on microglial...

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Campagno KE, Lu W, Jassim AH, et al. Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure. J Neuroinflammation. 2021;18(1):217doi: 10.1186/s12974-021-02251-7.
Campagno, K. E., Lu, W., Jassim, A. H., Albalawi, F., Cenaj, A., Tso, H. Y., Clark, S. P., Sripinun, P., Gómez, N. M., & Mitchell, C. H. (2021). Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure. Journal of neuroinflammation, 18(1), 217. https://doi.org/10.1186/s12974-021-02251-7
Campagno, Keith E, et al. "Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure." Journal of neuroinflammation vol. 18,1 (2021): 217. doi: https://doi.org/10.1186/s12974-021-02251-7
Campagno KE, Lu W, Jassim AH, Albalawi F, Cenaj A, Tso HY, Clark SP, Sripinun P, Gómez NM, Mitchell CH. Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure. J Neuroinflammation. 2021 Sep 20;18(1):217. doi: 10.1186/s12974-021-02251-7. PMID: 34544431; PMCID: PMC8454080.
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Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration.

Frontiers in pharmacology

Jassim AH, Inman DM, Mitchell CH.
PMID: 34366851
Front Pharmacol. 2021 Jul 21;12:699623. doi: 10.3389/fphar.2021.699623. eCollection 2021.

Mitochondrial dysfunction and excessive inflammatory responses are both sufficient to induce pathology in age-dependent neurodegenerations. However, emerging evidence indicates crosstalk between damaged mitochondrial and inflammatory signaling can exacerbate issues in chronic neurodegenerations. This review discusses evidence for the interaction...

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Jassim AH, Inman DM, Mitchell CH. Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration. Front Pharmacol. 2021;12:699623doi: 10.3389/fphar.2021.699623.
Jassim, A. H., Inman, D. M., & Mitchell, C. H. (2021). Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration. Frontiers in pharmacology, 12699623. https://doi.org/10.3389/fphar.2021.699623
Jassim, Assraa Hassan, et al. "Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration." Frontiers in pharmacology vol. 12 (2021): 699623. doi: https://doi.org/10.3389/fphar.2021.699623
Jassim AH, Inman DM, Mitchell CH. Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration. Front Pharmacol. 2021 Jul 21;12:699623. doi: 10.3389/fphar.2021.699623. eCollection 2021. PMID: 34366851; PMCID: PMC8334009.
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Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification.

Glia

Lööv C, Mitchell CH, Simonsson M, Erlandsson A.
PMID: 26095880
Glia. 2015 Nov;63(11):1997-2009. doi: 10.1002/glia.22873. Epub 2015 Jun 12.

Inefficient lysosomal degradation is central in the development of various brain disorders, but the underlying mechanisms and the involvement of different cell types remains elusive. We have previously shown that astrocytes effectively engulf dead cells, but then store, rather...

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Lööv C, Mitchell CH, Simonsson M, et al. Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification. Glia. 2015;63(11):1997-2009doi: 10.1002/glia.22873.
Lööv, C., Mitchell, C. H., Simonsson, M., & Erlandsson, A. (2015). Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification. Glia, 63(11), 1997-2009. https://doi.org/10.1002/glia.22873
Lööv, Camilla, et al. "Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification." Glia vol. 63,11 (2015): 1997-2009. doi: https://doi.org/10.1002/glia.22873
Lööv C, Mitchell CH, Simonsson M, Erlandsson A. Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification. Glia. 2015 Nov;63(11):1997-2009. doi: 10.1002/glia.22873. Epub 2015 Jun 12. PMID: 26095880; PMCID: PMC6728804.
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Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective.

Frontiers in cellular neuroscience

Lim JC, Lu W, Beckel JM, Mitchell CH.
PMID: 27932954
Front Cell Neurosci. 2016 Nov 23;10:270. doi: 10.3389/fncel.2016.00270. eCollection 2016.

Mechanical strain due to increased pressure or swelling activates inflammatory responses in many neural systems. As cytokines and chemokine messengers lead to both pro-inflammatory and neuroprotective actions, understanding the signaling patterns triggered by mechanical stress may help improve overall...

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Lim JC, Lu W, Beckel JM, et al. Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective. Front Cell Neurosci. 2016;10:270doi: 10.3389/fncel.2016.00270.
Lim, J. C., Lu, W., Beckel, J. M., & Mitchell, C. H. (2016). Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective. Frontiers in cellular neuroscience, 10270. https://doi.org/10.3389/fncel.2016.00270
Lim, Jason C, et al. "Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective." Frontiers in cellular neuroscience vol. 10 (2016): 270. doi: https://doi.org/10.3389/fncel.2016.00270
Lim JC, Lu W, Beckel JM, Mitchell CH. Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective. Front Cell Neurosci. 2016 Nov 23;10:270. doi: 10.3389/fncel.2016.00270. eCollection 2016. PMID: 27932954; PMCID: PMC5120082.
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