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Albalawi F, Lu W, Beckel JM, et al. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci. 2017;11:227doi: 10.3389/fncel.2017.00227.
Albalawi, F., Lu, W., Beckel, J. M., Lim, J. C., McCaughey, S. A., & Mitchell, C. H. (2017). The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Frontiers in cellular neuroscience, 11227. https://doi.org/10.3389/fncel.2017.00227
Albalawi, Farraj, et al. "The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain." Frontiers in cellular neuroscience vol. 11 (2017): 227. doi: https://doi.org/10.3389/fncel.2017.00227
Albalawi F, Lu W, Beckel JM, Lim JC, McCaughey SA, Mitchell CH. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci. 2017 Aug 08;11:227. doi: 10.3389/fncel.2017.00227. eCollection 2017. PMID: 28848393; PMCID: PMC5550720.
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Front Cell Neurosci. 2017 Aug 08;11:227. doi: 10.3389/fncel.2017.00227. eCollection 2017.

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.

Frontiers in cellular neuroscience

Farraj Albalawi, Wennan Lu, Jonathan M Beckel, Jason C Lim, Stuart A McCaughey, Claire H Mitchell

Affiliations

  1. Department of Anatomy and Cell Biology, University of Pennsylvania, PhiladelphiaPA, United States.
  2. Department of Orthodontics, University of Pennsylvania, PhiladelphiaPA, United States.
  3. Department of Pharmacology and Chemical Biology, Pittsburgh University, PittsburghPA, United States.
  4. Department of Ophthalmology, University of Pennsylvania, PhiladelphiaPA, United States.
  5. Department of Physiology, University of Pennsylvania, PhiladelphiaPA, United States.

PMID: 28848393 PMCID: PMC5550720 DOI: 10.3389/fncel.2017.00227

Abstract

Inflammatory responses play a key role in many neural pathologies, with localized signaling from the non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to chronic inflammation. The NLRP3 inflammasome requires two stages to contribute: priming and activation. The priming stage involves upregulation of inflammasome components while the activation stage results in the assembly and activation of the inflammasome complex. The priming step can be rate limiting and can connect insult to chronic inflammation, but our knowledge of the signals that regulate NLRP3 inflammasome priming in sterile inflammation is limited. This study examined the link between mechanical strain and inflammasome priming in neural systems. Transient non-ischemic elevation of intraocular pressure increased mRNA for inflammasome components

Keywords: ATP release; IL-1β; NFκB; NLRP3; astrocytes; caspase 1; glaucoma; pannexin

References

  1. PLoS One. 2012;7(7):e41229 - PubMed
  2. J Neurochem. 2017 May;141(3):436-448 - PubMed
  3. Exp Eye Res. 2011 Oct;93(4):528-33 - PubMed
  4. Neuroscience. 2014 Mar 28;263:111-24 - PubMed
  5. Nat Rev Neurosci. 2015 Jun;16(6):358-72 - PubMed
  6. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11181-6 - PubMed
  7. Trends Pharmacol Sci. 2014 Oct;35(10):537-47 - PubMed
  8. Nature. 1992 Apr 30;356(6372):768-74 - PubMed
  9. J Physiol. 2012 May 15;590(10):2285-304 - PubMed
  10. Immunity. 2013 Jun 27;38(6):1142-53 - PubMed
  11. J Pharmacol Exp Ther. 2006 Dec;319(3):1376-85 - PubMed
  12. Br J Pharmacol. 2009 Aug;157(7):1203-14 - PubMed
  13. Mol Vis. 2015 Jul 14;21:749-66 - PubMed
  14. J Neurochem. 2012 Aug;122(4):823-33 - PubMed
  15. Purinergic Signal. 2009 Jun;5(2):241-9 - PubMed
  16. Biochem Biophys Res Commun. 2015 Mar 13;458(3):700-6 - PubMed
  17. Periodontol 2000. 2015 Oct;69(1):83-95 - PubMed
  18. PLoS One. 2016 Nov 28;11(11):e0167364 - PubMed
  19. Eye (Lond). 2000 Jun;14 ( Pt 3B):437-44 - PubMed
  20. J Neurochem. 2016 Jan;136 Suppl 1:29-38 - PubMed
  21. Comput Struct Biotechnol J. 2015 Mar 11;13:176-81 - PubMed
  22. Mol Reprod Dev. 2015 Jul-Aug;82(7-8):518-29 - PubMed
  23. Am J Physiol Cell Physiol. 2005 Sep;289(3):C617-24 - PubMed
  24. Invest Ophthalmol Vis Sci. 2015 May;56(5):3075-83 - PubMed
  25. Nat Immunol. 2012 Mar 19;13(4):333-42 - PubMed
  26. Glia. 2014 Sep;62(9):1486-501 - PubMed
  27. J Biol Chem. 1994 May 27;269(21):15195-203 - PubMed
  28. Am J Physiol Cell Physiol. 2009 Jul;297(1):C111-20 - PubMed
  29. Nat Commun. 2016 Feb 15;7:10555 - PubMed
  30. Cytokine. 2011 Aug;55(2):229-36 - PubMed
  31. Nat Rev Neurosci. 2014 Feb;15(2):84-97 - PubMed
  32. J Glaucoma. 2009 Jun-Jul;18(5):341-53 - PubMed
  33. Exp Eye Res. 2007 Nov;85(5):637-43 - PubMed
  34. Exp Eye Res. 2015 Dec;141:3-8 - PubMed
  35. Immunity. 1995 Sep;3(3):263-72 - PubMed
  36. Neuroscience. 2008 Nov 19;157(2):396-404 - PubMed
  37. J Clin Invest. 2011 Sep;121(9):3542-53 - PubMed
  38. PLoS One. 2012;7(2):e32270 - PubMed
  39. J Gen Physiol. 2012 Nov;140(5):571-5 - PubMed
  40. J Immunol. 2015 Apr 15;194(8):3937-52 - PubMed
  41. Eur J Immunol. 2007 Nov;37 Suppl 1:S34-45 - PubMed
  42. Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651 - PubMed
  43. Optom Vis Sci. 2008 Jun;85(6):425-35 - PubMed
  44. Prog Retin Eye Res. 2005 Jan;24(1):39-73 - PubMed
  45. Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2183-91 - PubMed
  46. Exp Eye Res. 2010 Sep;91(3):425-32 - PubMed
  47. Nature. 2006 Mar 9;440(7081):228-32 - PubMed
  48. Cell Death Differ. 2007 Sep;14 (9):1583-9 - PubMed
  49. Behav Brain Res. 2009 Dec 1;204(1):77-81 - PubMed
  50. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3860-9 - PubMed
  51. Trends Mol Med. 2017 Feb;23 (2):165-180 - PubMed
  52. JAMA Neurol. 2015 Mar;72(3):355-62 - PubMed
  53. J Neuroinflammation. 2015 Jul 30;12 :137 - PubMed
  54. Sci Rep. 2016 Dec 08;6:38499 - PubMed
  55. Front Cell Neurosci. 2016 Nov 23;10 :270 - PubMed
  56. J Immunol. 1994 Jul 15;153(2):712-23 - PubMed
  57. Exp Eye Res. 2014 Oct;127:270-9 - PubMed
  58. Nat Med. 2015 Jul;21(7):677-87 - PubMed
  59. J Neurochem. 2005 Mar;92(5):1033-43 - PubMed
  60. J Clin Invest. 2009 Dec;119(12):3502-11 - PubMed
  61. Neurochem Res. 2013 Oct;38(10 ):2072-83 - PubMed
  62. Prog Retin Eye Res. 2000 May;19(3):297-321 - PubMed
  63. Invest Ophthalmol Vis Sci. 2013 Feb 01;54(2):909-17 - PubMed
  64. Br J Pharmacol. 2012 Feb;165(4):978-93 - PubMed

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