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PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform.

Frontiers in molecular neuroscience

Dhingra A, Tummala SR, Lyubarsky A, Vardi N.
PMID: 25018695
Front Mol Neurosci. 2014 Jun 27;7:60. doi: 10.3389/fnmol.2014.00060. eCollection 2014.

The ubiquitous second messenger cGMP is synthesized by guanylyl cyclase and hydrolyzed by phosphodiesterase (PDE). cGMP mediates numerous signaling pathways in multiple tissues. In the retina, cGMP regulates signaling in nearly every cell class including photoreceptors, bipolar cells, amacrine...

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Dhingra A, Tummala SR, Lyubarsky A, et al. PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform. Front Mol Neurosci. 2014;7:60doi: 10.3389/fnmol.2014.00060.
Dhingra, A., Tummala, S. R., Lyubarsky, A., & Vardi, N. (2014). PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform. Frontiers in molecular neuroscience, 760. https://doi.org/10.3389/fnmol.2014.00060
Dhingra, Anuradha, et al. "PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform." Frontiers in molecular neuroscience vol. 7 (2014): 60. doi: https://doi.org/10.3389/fnmol.2014.00060
Dhingra A, Tummala SR, Lyubarsky A, Vardi N. PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform. Front Mol Neurosci. 2014 Jun 27;7:60. doi: 10.3389/fnmol.2014.00060. eCollection 2014. PMID: 25018695; PMCID: PMC4073215.
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The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.

Frontiers in cellular neuroscience

Albalawi F, Lu W, Beckel JM, Lim JC, McCaughey SA, Mitchell CH.
PMID: 28848393
Front Cell Neurosci. 2017 Aug 08;11:227. doi: 10.3389/fncel.2017.00227. eCollection 2017.

Inflammatory responses play a key role in many neural pathologies, with localized signaling from the non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to chronic inflammation....

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Albalawi F, Lu W, Beckel JM, et al. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci. 2017;11:227doi: 10.3389/fncel.2017.00227.
Albalawi, F., Lu, W., Beckel, J. M., Lim, J. C., McCaughey, S. A., & Mitchell, C. H. (2017). The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Frontiers in cellular neuroscience, 11227. https://doi.org/10.3389/fncel.2017.00227
Albalawi, Farraj, et al. "The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain." Frontiers in cellular neuroscience vol. 11 (2017): 227. doi: https://doi.org/10.3389/fncel.2017.00227
Albalawi F, Lu W, Beckel JM, Lim JC, McCaughey SA, Mitchell CH. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci. 2017 Aug 08;11:227. doi: 10.3389/fncel.2017.00227. eCollection 2017. PMID: 28848393; PMCID: PMC5550720.
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Improvement in vision: a new goal for treatment of hereditary retinal degenerations.

Expert opinion on orphan drugs

Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K.
PMID: 26246977
Expert Opin Orphan Drugs. 2015 May 04;3(5):563-575. doi: 10.1517/21678707.2015.1030393.

No abstract available.

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Jacobson SG, Cideciyan AV, Aguirre GD, et al. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opin Orphan Drugs. 2015;3(5):563-575doi: 10.1517/21678707.2015.1030393.
Jacobson, S. G., Cideciyan, A. V., Aguirre, G. D., Roman, A. J., Sumaroka, A., Hauswirth, W. W., & Palczewski, K. (2015). Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert opinion on orphan drugs, 3(5), 563-575. https://doi.org/10.1517/21678707.2015.1030393
Jacobson, Samuel G, et al. "Improvement in vision: a new goal for treatment of hereditary retinal degenerations." Expert opinion on orphan drugs vol. 3,5 (2015): 563-575. doi: https://doi.org/10.1517/21678707.2015.1030393
Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opin Orphan Drugs. 2015 May 04;3(5):563-575. doi: 10.1517/21678707.2015.1030393. PMID: 26246977; PMCID: PMC4487613.
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The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance.

Purinergic signalling

Mitchell CH, Lu W, Hu H, Zhang X, Reigada D, Zhang M.
PMID: 19241145
Purinergic Signal. 2009 Jun;5(2):241-9. doi: 10.1007/s11302-009-9142-6. Epub 2009 Feb 25.

Retinal ganglion cells process the visual signal and transmit it along their axons in the optic nerve to the brain. Molecular, immunohistochemical, and functional analyses indicate that the majority of retinal ganglion cells express the ionotropic P2X(7) receptor. Stimulation...

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Mitchell CH, Lu W, Hu H, et al. The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance. Purinergic Signal. 2009;5(2):241-9doi: 10.1007/s11302-009-9142-6.
Mitchell, C. H., Lu, W., Hu, H., Zhang, X., Reigada, D., & Zhang, M. (2009). The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance. Purinergic signalling, 5(2), 241-9. https://doi.org/10.1007/s11302-009-9142-6
Mitchell, Claire H, et al. "The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance." Purinergic signalling vol. 5,2 (2009): 241-9. doi: https://doi.org/10.1007/s11302-009-9142-6
Mitchell CH, Lu W, Hu H, Zhang X, Reigada D, Zhang M. The P2X(7) receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance. Purinergic Signal. 2009 Jun;5(2):241-9. doi: 10.1007/s11302-009-9142-6. Epub 2009 Feb 25. PMID: 19241145; PMCID: PMC2686831.
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Joint effects of illumination geometry and object shape in the perception of surface reflectance.

i-Perception

Olkkonen M, Brainard DH.
PMID: 23145259
Iperception. 2011;2(9):1014-34. doi: 10.1068/i0480. Epub 2011 Dec 14.

Surface properties provide useful information for identifying objects and interacting with them. Effective utilization of this information, however, requires that the perception of object surface properties be relatively constant across changes in illumination and changes in object shape. Such...

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Olkkonen M, Brainard DH. Joint effects of illumination geometry and object shape in the perception of surface reflectance. Iperception. 2011;2(9):1014-34doi: 10.1068/i0480.
Olkkonen, M., & Brainard, D. H. (2011). Joint effects of illumination geometry and object shape in the perception of surface reflectance. i-Perception, 2(9), 1014-34. https://doi.org/10.1068/i0480
Olkkonen, Maria, and Brainard, David H. "Joint effects of illumination geometry and object shape in the perception of surface reflectance." i-Perception vol. 2,9 (2011): 1014-34. doi: https://doi.org/10.1068/i0480
Olkkonen M, Brainard DH. Joint effects of illumination geometry and object shape in the perception of surface reflectance. Iperception. 2011;2(9):1014-34. doi: 10.1068/i0480. Epub 2011 Dec 14. PMID: 23145259; PMCID: PMC3485792.
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Erratum: Non-invasive assessment of human cone photoreceptor function: erratum.

Biomedical optics express

Cooper RF, Tuten WS, Dubra A, Brainard DH, Morgan JIW.
PMID: 29676401
Biomed Opt Express. 2018 Mar 22;9(4):1842. doi: 10.1364/BOE.9.001842. eCollection 2018 Apr 01.

[This corrects the article on p. 5098 in vol. 8, PMID: 29188106.].

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Cooper RF, Tuten WS, Dubra A, et al. Erratum: Non-invasive assessment of human cone photoreceptor function: erratum. Biomed Opt Express. 2018;9(4):1842doi: 10.1364/BOE.9.001842.
Cooper, R. F., Tuten, W. S., Dubra, A., Brainard, D. H., & Morgan, J. I. W. (2018). Erratum: Non-invasive assessment of human cone photoreceptor function: erratum. Biomedical optics express, 9(4), 1842. https://doi.org/10.1364/BOE.9.001842
Cooper, Robert F, et al. "Erratum: Non-invasive assessment of human cone photoreceptor function: erratum." Biomedical optics express vol. 9,4 (2018): 1842. doi: https://doi.org/10.1364/BOE.9.001842
Cooper RF, Tuten WS, Dubra A, Brainard DH, Morgan JIW. Erratum: Non-invasive assessment of human cone photoreceptor function: erratum. Biomed Opt Express. 2018 Mar 22;9(4):1842. doi: 10.1364/BOE.9.001842. eCollection 2018 Apr 01. PMID: 29676401; PMCID: PMC5905927.
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Complexity of the Class B Phenotype in Autosomal Dominant Retinitis Pigmentosa Due to Rhodopsin Mutations.

Investigative ophthalmology & visual science

Jacobson SG, McGuigan DB, Sumaroka A, Roman AJ, Gruzensky ML, Sheplock R, Palma J, Schwartz SB, Aleman TS, Cideciyan AV.
PMID: 27654411
Invest Ophthalmol Vis Sci. 2016 Sep 01;57(11):4847-4858. doi: 10.1167/iovs.16-19890.

PURPOSE: Previously, patients with RHO mutations and a class A phenotype were found to have severe early-onset loss of rod function, whereas patients with a class B phenotype retained rod function at least in certain retinal regions. Here class...

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Jacobson SG, McGuigan DB, Sumaroka A, et al. Complexity of the Class B Phenotype in Autosomal Dominant Retinitis Pigmentosa Due to Rhodopsin Mutations. Invest Ophthalmol Vis Sci. 2016;57(11):4847-4858doi: 10.1167/iovs.16-19890.
Jacobson, S. G., McGuigan, D. B., Sumaroka, A., Roman, A. J., Gruzensky, M. L., Sheplock, R., Palma, J., Schwartz, S. B., Aleman, T. S., & Cideciyan, A. V. (2016). Complexity of the Class B Phenotype in Autosomal Dominant Retinitis Pigmentosa Due to Rhodopsin Mutations. Investigative ophthalmology & visual science, 57(11), 4847-4858. https://doi.org/10.1167/iovs.16-19890
Jacobson, Samuel G, et al. "Complexity of the Class B Phenotype in Autosomal Dominant Retinitis Pigmentosa Due to Rhodopsin Mutations." Investigative ophthalmology & visual science vol. 57,11 (2016): 4847-4858. doi: https://doi.org/10.1167/iovs.16-19890
Jacobson SG, McGuigan DB, Sumaroka A, Roman AJ, Gruzensky ML, Sheplock R, Palma J, Schwartz SB, Aleman TS, Cideciyan AV. Complexity of the Class B Phenotype in Autosomal Dominant Retinitis Pigmentosa Due to Rhodopsin Mutations. Invest Ophthalmol Vis Sci. 2016 Sep 01;57(11):4847-4858. doi: 10.1167/iovs.16-19890. PMID: 27654411; PMCID: PMC5032913.
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Hypercoagulability Testing and Hypercoagulable Disorders in Young Central Retinal Vein Occlusion Patients.

Ophthalmology. Retina

Tauqeer Z, Bracha P, McGeehan B, VanderBeek BL.
PMID: 33774219
Ophthalmol Retina. 2022 Jan;6(1):37-42. doi: 10.1016/j.oret.2021.03.009. Epub 2021 Mar 24.

PURPOSE: To determine frequency of hypercoagulability testing and hypercoagulable states in patients with central retinal vein occlusion (CRVO) younger than 50 years.DESIGN: Retrospective cohort study.PARTICIPANTS: Deidentified patients younger than 50 years with newly diagnosed CRVO from a national insurance...

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Tauqeer Z, Bracha P, McGeehan B, et al. Hypercoagulability Testing and Hypercoagulable Disorders in Young Central Retinal Vein Occlusion Patients. Ophthalmol Retina. 2021;6(1):37-42doi: 10.1016/j.oret.2021.03.009.
Tauqeer, Z., Bracha, P., McGeehan, B., & VanderBeek, B. L. (2022). Hypercoagulability Testing and Hypercoagulable Disorders in Young Central Retinal Vein Occlusion Patients. Ophthalmology. Retina, 6(1), 37-42. https://doi.org/10.1016/j.oret.2021.03.009
Tauqeer, Zujaja, et al. "Hypercoagulability Testing and Hypercoagulable Disorders in Young Central Retinal Vein Occlusion Patients." Ophthalmology. Retina vol. 6,1 (2022): 37-42. doi: https://doi.org/10.1016/j.oret.2021.03.009
Tauqeer Z, Bracha P, McGeehan B, VanderBeek BL. Hypercoagulability Testing and Hypercoagulable Disorders in Young Central Retinal Vein Occlusion Patients. Ophthalmol Retina. 2022 Jan;6(1):37-42. doi: 10.1016/j.oret.2021.03.009. Epub 2021 Mar 24. PMID: 33774219; PMCID: PMC8460678.
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A Precise Method to Evaluate 360 Degree Measures of Optic Cup and Disc Morphology in an African American Cohort and Its Genetic Applications.

Genes

Addis V, Chen M, Zorger R, Salowe R, Daniel E, Lee R, Pistilli M, Gao J, Maguire MG, Chan L, Gudiseva HV, Zenebe-Gete S, Merriam S, Smith EJ, Martin R, Parker Ostroff C, Gee JC, Cui QN, Miller-Ellis E, O'Brien JM, Sankar PS.
PMID: 34946910
Genes (Basel). 2021 Dec 09;12(12). doi: 10.3390/genes12121961.

(1) Background: Vertical cup-to-disc ratio (CDR) is an important measure for evaluating damage to the optic nerve head (ONH) in glaucoma patients. However, this measure often does not fully capture the irregular cupping observed in glaucomatous nerves. We developed...

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Addis V, Chen M, Zorger R, et al. A Precise Method to Evaluate 360 Degree Measures of Optic Cup and Disc Morphology in an African American Cohort and Its Genetic Applications. Genes (Basel). 2021;12(12)doi: 10.3390/genes12121961.
Addis, V., Chen, M., Zorger, R., Salowe, R., Daniel, E., Lee, R., Pistilli, M., Gao, J., Maguire, M. G., Chan, L., Gudiseva, H. V., Zenebe-Gete, S., Merriam, S., Smith, E. J., Martin, R., Parker Ostroff, C., Gee, J. C., Cui, Q. N., Miller-Ellis, E., O'Brien, J. M., & Sankar, P. S. (2021). A Precise Method to Evaluate 360 Degree Measures of Optic Cup and Disc Morphology in an African American Cohort and Its Genetic Applications. Genes, 12(12), . https://doi.org/10.3390/genes12121961
Addis, Victoria, et al. "A Precise Method to Evaluate 360 Degree Measures of Optic Cup and Disc Morphology in an African American Cohort and Its Genetic Applications." Genes vol. 12,12 (2021). doi: https://doi.org/10.3390/genes12121961
Addis V, Chen M, Zorger R, Salowe R, Daniel E, Lee R, Pistilli M, Gao J, Maguire MG, Chan L, Gudiseva HV, Zenebe-Gete S, Merriam S, Smith EJ, Martin R, Parker Ostroff C, Gee JC, Cui QN, Miller-Ellis E, O'Brien JM, Sankar PS. A Precise Method to Evaluate 360 Degree Measures of Optic Cup and Disc Morphology in an African American Cohort and Its Genetic Applications. Genes (Basel). 2021 Dec 09;12(12). doi: 10.3390/genes12121961. PMID: 34946910; PMCID: PMC8701339.
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Risk of non-infectious uveitis or myasthenia gravis in patients on checkpoint inhibitors in a large healthcare claims database.

The British journal of ophthalmology

Xia T, Brucker AJ, McGeehan B, VanderBeek BL.
PMID: 33087313
Br J Ophthalmol. 2022 Jan;106(1):87-90. doi: 10.1136/bjophthalmol-2020-317060. Epub 2020 Oct 21.

AIM: To determine if checkpoint inhibitors (CPIs) confer an increased risk of non-infectious uveitis or myasthenia gravis (MG) compared to patients on non-checkpoint inhibitor (N-CPI) chemotherapy.METHODS: A retrospective cohort study was performed comparing patients in a large commercial and...

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Xia T, Brucker AJ, McGeehan B, et al. Risk of non-infectious uveitis or myasthenia gravis in patients on checkpoint inhibitors in a large healthcare claims database. Br J Ophthalmol. 2020;106(1):87-90doi: 10.1136/bjophthalmol-2020-317060.
Xia, T., Brucker, A. J., McGeehan, B., & VanderBeek, B. L. (2022). Risk of non-infectious uveitis or myasthenia gravis in patients on checkpoint inhibitors in a large healthcare claims database. The British journal of ophthalmology, 106(1), 87-90. https://doi.org/10.1136/bjophthalmol-2020-317060
Xia, Tian, et al. "Risk of non-infectious uveitis or myasthenia gravis in patients on checkpoint inhibitors in a large healthcare claims database." The British journal of ophthalmology vol. 106,1 (2022): 87-90. doi: https://doi.org/10.1136/bjophthalmol-2020-317060
Xia T, Brucker AJ, McGeehan B, VanderBeek BL. Risk of non-infectious uveitis or myasthenia gravis in patients on checkpoint inhibitors in a large healthcare claims database. Br J Ophthalmol. 2022 Jan;106(1):87-90. doi: 10.1136/bjophthalmol-2020-317060. Epub 2020 Oct 21. PMID: 33087313; PMCID: PMC8173351.
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[No title available]

Genes

Meer E, Qin VL, Gudiseva HV, McGeehan B, Salowe R, Pistilli M, He J, Daniel E, Ying GS, Chavali VRM, O'Brien JM.
PMID: 34440426
Genes (Basel). 2021 Aug 16;12(8). doi: 10.3390/genes12081252.

Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide and has been associated with multiple genetic risk factors. The

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Meer E, Qin VL, Gudiseva HV, et al. . Genes (Basel). 2021;12(8)doi: 10.3390/genes12081252.
Meer, E., Qin, V. L., Gudiseva, H. V., McGeehan, B., Salowe, R., Pistilli, M., He, J., Daniel, E., Ying, G. S., Chavali, V. R. M., & O'Brien, J. M. (2021). . Genes, 12(8), . https://doi.org/10.3390/genes12081252
Meer, Elana, et al. "." Genes vol. 12,8 (2021). doi: https://doi.org/10.3390/genes12081252
Meer E, Qin VL, Gudiseva HV, McGeehan B, Salowe R, Pistilli M, He J, Daniel E, Ying GS, Chavali VRM, O'Brien JM. . Genes (Basel). 2021 Aug 16;12(8). doi: 10.3390/genes12081252. PMID: 34440426; PMCID: PMC8394298.
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Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes.

Genes

Gudiseva HV, Vrathasha V, He J, Bungatavula D, O'Brien JM, Chavali VRM.
PMID: 34946963
Genes (Basel). 2021 Dec 18;12(12). doi: 10.3390/genes12122015.

We intend to identify marker genes with differential gene expression (DEG) and RGC subtypes in cultures of human-induced pluripotent stem cell (iPSC)-derived retinal ganglion cells. Single-cell sequencing was performed on mature and functional iPSC-RGCs at day 40 using Chromium...

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Gudiseva HV, Vrathasha V, He J, et al. Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes. Genes (Basel). 2021;12(12)doi: 10.3390/genes12122015.
Gudiseva, H. V., Vrathasha, V., He, J., Bungatavula, D., O'Brien, J. M., & Chavali, V. R. M. (2021). Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes. Genes, 12(12), . https://doi.org/10.3390/genes12122015
Gudiseva, Harini V, et al. "Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes." Genes vol. 12,12 (2021). doi: https://doi.org/10.3390/genes12122015
Gudiseva HV, Vrathasha V, He J, Bungatavula D, O'Brien JM, Chavali VRM. Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes. Genes (Basel). 2021 Dec 18;12(12). doi: 10.3390/genes12122015. PMID: 34946963; PMCID: PMC8702079.
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Showing 1 to 12 of 99 entries