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Methylating the DNA of the most repressed: special access required.

Molecular cell

Pikaard CS.
PMID: 23541038
Mol Cell. 2013 Mar 28;49(6):1021-2. doi: 10.1016/j.molcel.2013.03.013.

A new study (Zemach et al., 2013) suggests that the chromatin remodeling ATPase DDM1 is specifically required for cytosine methylation at linker histone H1-associated heterochromatin, facilitating access by three cytosine methyltransferases, including a previously uncharacterized CHH methylase, CMT2.

Arabidopsis Histone Lysine Methyltransferases.

Advances in botanical research

Pontvianne F, Blevins T, Pikaard CS.
PMID: 20703330
Adv Bot Res. 2010 Jan 01;53:1-22. doi: 10.1016/S0065-2296(10)53001-5.

In eukaryotes, changes in chromatin structure regulate the access of gene regulatory sequences to the transcriptional machinery and play important roles in the repression of transposable elements, thereby protecting genome integrity. Chromatin dynamics and gene expression states are highly...

Showing 1 to 2 of 2 entries