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APEX2-enhanced electron microscopy distinguishes sigma-1 receptor localization in the nucleoplasmic reticulum.

Oncotarget

Mavlyutov TA, Yang H, Epstein ML, Ruoho AE, Yang J, Guo LW.
PMID: 28881650
Oncotarget. 2017 May 16;8(31):51317-51330. doi: 10.18632/oncotarget.17906. eCollection 2017 Aug 01.

The sigma-1 receptor (Sig1R) is an endoplasmic reticulum chaperonin that is attracting tremendous interest as a potential anti-neurodegenerative target. While this membrane protein is known to reside in the inner nuclear envelope (NE) and influences transcription, apparent Sig1R presence...

Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo.

Scientific reports

Das A, Sudhahar V, Chen GF, Kim HW, Youn SW, Finney L, Vogt S, Yang J, Kweon J, Surenkhuu B, Ushio-Fukai M, Fukai T.
PMID: 27666810
Sci Rep. 2016 Sep 26;6:33783. doi: 10.1038/srep33783.

Copper (Cu), an essential nutrient, promotes wound healing, however, target of Cu action and underlying mechanisms remain elusive. Cu chaperone Antioxidant-1 (Atox1) in the cytosol supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in...

An inexpensive modified weight-bearing device assembled in-house for high throughput unbiased behavioral pain assessment in mice.

HardwareX

Drackley B, Holtz M, Yang J.
PMID: 30775639
HardwareX. 2018 Oct;4. doi: 10.1016/j.ohx.2018.e00031. Epub 2018 May 19.

Assessment of pain in rodents is essential for analgesic development and investigations of fundamental neurobiology of pain. We have previously reported on a modified weight bearing apparatus we call VASIC (voluntarily accessed static incapacitance chamber) enabling unbiased and high...

dCas9-mediated transcriptional activation of tissue inhibitor of metalloproteinases.

Metalloproteinases in medicine

Duellman T, Doll A, Chen X, Wakamiya R, Yang J.
PMID: 28979918
Metalloproteinases Med. 2017;4:63-73. doi: 10.2147/MNM.S146752. Epub 2017 Sep 19.

Selective gene activation with the dCas9 (deactivated clustered regularly interspaced short palindromic repeats [CRISPR] associated protein 9)/CRISPR targeting of a transcriptional activator effector is now well established. However, the optimal targeting of guide RNA (gRNA) for a given gene...

Showing 1 to 4 of 4 entries