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Das A, Sudhahar V, Chen GF, et al. Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo. Sci Rep. 2016;6:33783doi: 10.1038/srep33783.
Das, A., Sudhahar, V., Chen, G. F., Kim, H. W., Youn, S. W., Finney, L., Vogt, S., Yang, J., Kweon, J., Surenkhuu, B., Ushio-Fukai, M., & Fukai, T. (2016). Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo. Scientific reports, 633783. https://doi.org/10.1038/srep33783
Das, Archita, et al. "Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo." Scientific reports vol. 6 (2016): 33783. doi: https://doi.org/10.1038/srep33783
Das A, Sudhahar V, Chen GF, Kim HW, Youn SW, Finney L, Vogt S, Yang J, Kweon J, Surenkhuu B, Ushio-Fukai M, Fukai T. Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo. Sci Rep. 2016 Sep 26;6:33783. doi: 10.1038/srep33783. PMID: 27666810; PMCID: PMC5036036.
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Sci Rep. 2016 Sep 26;6:33783. doi: 10.1038/srep33783.

Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo.

Scientific reports

Archita Das, Varadarajan Sudhahar, Gin-Fu Chen, Ha Won Kim, Seock-Won Youn, Lydia Finney, Stefan Vogt, Jay Yang, Junghun Kweon, Bayasgalan Surenkhuu, Masuko Ushio-Fukai, Tohru Fukai

Affiliations

  1. Departments of Medicine (Section of Cardiology) and Pharmacology, Center for Cardiovascular Research, Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago IL60612, USA.
  2. Jesse Brown Veterans Affairs Medical Center, IL60612, Chicago, USA.
  3. Department of Pharmacology, Center for Lung and Vascular Biology, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago IL60612, USA.
  4. X-ray Science Division, Argonne National Laboratory, Argonne, IL60439, USA.
  5. Department of Anesthesiology, University of Wisconsin, Madison, WI 53726, USA.

PMID: 27666810 PMCID: PMC5036036 DOI: 10.1038/srep33783

Abstract

Copper (Cu), an essential nutrient, promotes wound healing, however, target of Cu action and underlying mechanisms remain elusive. Cu chaperone Antioxidant-1 (Atox1) in the cytosol supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in the nucleus functions as a Cu-dependent transcription factor. Using mouse cutaneous wound healing model, here we show that Cu content (by X-ray Fluorescence Microscopy) and nuclear Atox1 are increased after wounding, and that wound healing with and without Cu treatment is impaired in Atox1

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