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Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin.

Frontiers in immunology

Sun JB, Holmgren J, Larena M, Terrinoni M, Fang Y, Bresnick AR, Xiang Z.
PMID: 28951732
Front Immunol. 2017 Sep 11;8:1119. doi: 10.3389/fimmu.2017.01119. eCollection 2017.

The calcium-binding protein S100A4 has been described to promote pathological inflammation in experimental autoimmune and inflammatory disorders and in allergy and to contribute to antigen presentation and antibody response after parenteral immunization with an alum-adjuvanted antigen. In this study,...

S100 proteins as therapeutic targets.

Biophysical reviews

Bresnick AR.
PMID: 30382555
Biophys Rev. 2018 Dec;10(6):1617-1629. doi: 10.1007/s12551-018-0471-y. Epub 2018 Oct 31.

The human genome codes for 21 S100 protein family members, which exhibit cell- and tissue-specific expression patterns. Despite sharing a high degree of sequence and structural similarity, the S100 proteins bind a diverse range of protein targets and contribute...

Showing 1 to 2 of 2 entries