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Sun JB, Holmgren J, Larena M, et al. Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin. Front Immunol. 2017;8:1119doi: 10.3389/fimmu.2017.01119.
Sun, J. B., Holmgren, J., Larena, M., Terrinoni, M., Fang, Y., Bresnick, A. R., & Xiang, Z. (2017). Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin. Frontiers in immunology, 81119. https://doi.org/10.3389/fimmu.2017.01119
Sun, Jia-Bin, et al. "Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin." Frontiers in immunology vol. 8 (2017): 1119. doi: https://doi.org/10.3389/fimmu.2017.01119
Sun JB, Holmgren J, Larena M, Terrinoni M, Fang Y, Bresnick AR, Xiang Z. Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin. Front Immunol. 2017 Sep 11;8:1119. doi: 10.3389/fimmu.2017.01119. eCollection 2017. PMID: 28951732; PMCID: PMC5600718.
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Front Immunol. 2017 Sep 11;8:1119. doi: 10.3389/fimmu.2017.01119. eCollection 2017.

Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin.

Frontiers in immunology

Jia-Bin Sun, Jan Holmgren, Maximilian Larena, Manuela Terrinoni, Yu Fang, Anne R Bresnick, Zou Xiang

Affiliations

  1. Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg Vaccine Research Institute (GUVAX), Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
  2. Department of Microbiology and Immunology, Clinical Research Center, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
  3. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, United States.
  4. Faculty of Health and Social Sciences, Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong.

PMID: 28951732 PMCID: PMC5600718 DOI: 10.3389/fimmu.2017.01119

Abstract

The calcium-binding protein S100A4 has been described to promote pathological inflammation in experimental autoimmune and inflammatory disorders and in allergy and to contribute to antigen presentation and antibody response after parenteral immunization with an alum-adjuvanted antigen. In this study, we extend these findings by demonstrating that mice lacking S100A4 have a defective humoral and cellular immune response to mucosal (sublingual) immunization with a model protein antigen [ovalbumin (OVA)] given together with the strong mucosal adjuvant cholera toxin (CT), and that this impairment is due to defective adjuvant-stimulated antigen presentation by antigen-presenting cells. In comparison to wild-type (WT) mice, mice genetically lacking S100A4 had reduced humoral and cellular immune responses after immunization with OVA plus CT, including a complete lack of detectable germinal center reaction. Further, when stimulated

Keywords: S100A4; adjuvant; cholera toxin; dendritic cells; germinal center

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