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Irritant Inhalation Evokes P Wave Morphological Changes in Spontaneously Hypertensive Rats via Reflex Modulation of the Autonomic Nervous System.

Frontiers in physiology

Hooper JS, Taylor-Clark TE.
PMID: 34385930
Front Physiol. 2021 Jul 27;12:642299. doi: 10.3389/fphys.2021.642299. eCollection 2021.

Irritant inhalation is associated with increased incidence of atrial fibrillation (AF) and stroke. Irritant inhalation acutely regulates cardiac function via autonomic reflexes. Increases in parasympathetic and sympathetic reflexes may increase atrial susceptibility to ectopic activity and the initiation of...

Functional evidence of distinct electrophile-induced activation states of the ion channel TRPA1.

Biochemistry and biophysics reports

Parks TA, Bahia PK, Taylor-Clark TE.
PMID: 34189279
Biochem Biophys Rep. 2021 Jun 15;27:101044. doi: 10.1016/j.bbrep.2021.101044. eCollection 2021 Sep.

Transient Receptor Potential Ankyrin 1 (TRPA1) is a tetrameric, nonselective cation channel expressed on nociceptive sensory nerves whose activation elicits nocifensive responses (e.g. pain). TRPA1 is activated by electrophiles found in foods and pollution, or produced during inflammation and...

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